Top 263 Biology Jobs in San Jose Ca

Senior Scientist/Principal Scientist, Translational Immunotherapy
Sift Biosciences —San Carlos, CA
- $130,000 - $160,000 a year
- Full-time
- Management
- 5 years
- Master's degree
- Commuter assistance
- Health insurance
Quick Apply
13d
Field Sales Representative - Biotechnology Laboratory Supplies
USA Scientific, Inc. —San Jose, CA
- $75,000 - $90,000 a year
- Full-time
- Background check
- 5 years
- Laboratory experience
- Travel reimbursement
- Health insurance
Field Sales Representative - Biotechnology Laboratory Supplies
USA Scientific, Inc. —Palo Alto, CA
- $75,000 - $90,000 a year
- Full-time
- Background check
- 5 years
- Laboratory experience
- Travel reimbursement
- Health insurance
3d
Principal Scientist, Antibody Discovery
Kelly Services —Mountain View, CA
- $130,000 - $170,000 a year
- Full-time
- 3 years
- Analysis skills
- Doctor of Philosophy
- Paid holidays
- Disability insurance
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Research Scientist - AI Trainer
DataAnnotation —California
- $50 - $100 an hour
- Part-time
- Remote
- Computer Science
- English
- Mid-level
- Flexible schedule
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Laboratory Technician
NVIGEN —Sunnyvale, CA
- High school diploma or GED
- Bachelor's degree
- Organizational skills
Research Associate
AccuScan Sciences —Milpitas, CA
- Full-time
- Computer literacy
- Bachelor's degree
- 1 year
- Health insurance
- Dental insurance
Quick Apply
Assistant Clinical Research Coordinator
Stanford University —Redwood City, CA
- Extended hours
- Hybrid work
- Vital signs
- Office
- Administrative experience
Clinical Research Coordinator Associate
Stanford University —Stanford, CA
- $34.56 - $40.30 an hour
- Overtime
- Mid-level
- University
- Psychology
Research Assistant
Stanford University —Stanford, CA
- Extended hours
- Computer literacy
- Maintenance
- Mid-level
Life Science Research Professional 1
Stanford University —Stanford, CA
- Extended hours
- Computer literacy
- Surgery
- Ability to lift 50 pounds
Neuroimaging Research Assistant
Stanford University —Stanford, CA
- $38.55 - $46.68 an hour
- Extended hours
- English
- Mid-level
- Databases
Lab Technician II - QC - Day Shift
Stanford Health Care —Palo Alto, CA
- $44.59 - $50.05 an hour
- Full-time
- Mid-level
- High school diploma or GED
- Military encouraged
5d
Molecular Biologist - Academic Graduate Appointee
Lawrence Livermore National Laboratory —Livermore, CA
- $6,748 - $7,718 a month
- Full-time
- Background check
- Bachelor of Science
- Pass drug screening
- Relocation assistance
- 401(k)
2d
Laboratory Tech
Luminary Life Sciences —San Jose, CA
- $27 an hour
- Urgently hiring
- Microsoft Outlook
- Computer literacy
- Bachelor of Science
- Paid parental leave
- Paid holidays
Quick Apply
14d
Research associate or Sr Research associate
GeneGenieDx —Pleasanton, CA
- $71,000 - $100,000 a year
- Full-time
- Bachelor of Science
- Mid-level
- Bachelor's degree
- Health insurance
- Dental insurance
Quick Apply
Microbiologist *PC 609
Miltenyi Biotec, Inc. —San Jose, CA
- $47.29 - $55.63 an hour
- Microsoft Outlook
- 5 years
- Bachelor's degree
- Health insurance
- Dental insurance
Quick Apply
2h
Research Associate
BillionToOne —Menlo Park, CA
- $75,029 - $85,748 a year
- Bachelor of Science
- Office
- Analysis skills
- Paid parental leave
- Paid time off
3d
Digital Biology Specialist
Anatomage, Inc. —Santa Clara, CA
- $80,000 - $100,000 a year
- Full-time
- Customer service
- Engineering
- Mid-level
- Commuter assistance
- Paid holidays
Quick Apply
Wildlife Biologist (On-Call)
AECOM —San Jose, CA
- $32 - $40 an hour
- Part-time
- Construction site
- Mid-level
- Analysis skills
- AD&D insurance
- Employee stock purchase plan

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biology jobs near san jose ca

Senior Scientist/Principal Scientist, Translational Immunotherapy

Sift Biosciences
San Carlos, CA

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Job Details

Full-time
$130,000 - $160,000 a year
13 days ago

Benefits

Commuter assistance
Health insurance
Dental insurance
401(k)
Paid time off
Parental leave
Vision insurance
Flexible schedule

Qualifications

Biology
Biotechnology
Technical documentation
Formulation chemistry
Cell Biology
Master's degree
Doctor of Philosophy
Pharmaceutical company experience
In vivo studies
Pharmaceutical research experience

Full Job Description

Senior Scientist/Principal Scientist, Translational Immunotherapy

Sift Bio is building a cutting-edge proprietary platform that combines AI, metagenomics, and high-throughput T-cell screening to discover epitopes that drastically amplify pre-existing immune memory responses, unlocking targeted, effective, and safe treatment for cancers and autoimmune diseases where current therapies fall short. Spinning out of UC Berkeley, the Sift Bio team brings together AI-driven discovery and deep translational immunology, with a proven track record of advancing novel immunotherapies from early concept through IND-enabling development. Collectively, the team has built and scaled high-throughput discovery platforms and led T-cell, peptide, and cell-based immunotherapy programs across leading academic labs, biotech startups, and biopharma. Merging this experience with proprietary datasets and computational pipelines, Sift Bio is shaping a new frontier in immunotherapy, unlocking the power of pre-existing immunity to create a fundamentally new class of treatments for immune dysfunctions. Our ultimate goal is to bring durable disease control to every patient.

We are seeking a Senior Scientist/Principal Scientist to work on our lead oncology program, leading the path from hit-to-lead generation to DC nomination for an off-the-shelf, memory-recall-based immunotherapy: designing, executing, and interpreting primary-cell assays that establish mechanism, potency, and safety. This role will report to the CTO and be fully onsite at 733 Industrial Road, San Carlos, CA.

KEY RESPONSIBILITIES:

Drive the identification, engineering, and functional optimization of lead immunotherapeutic candidates from early discovery through to DC nomination.
Design and execute cell-based assays (e.g., multi-parameter flow cytometry, cytotoxicity, cytokine profiling) to evaluate memory-recall, T-cell activation, and target engagement.
Characterize primary human T-cells and PBMCs (e.g. phenotyping) both prior and following response to stimulation.
Navigate challenges in working with, and characterizing, polyclonal T-cell responses, and is aware of how these challenges differ from monoclonal T-cell products.
Develop and support assays to forecast off-target events that leverage cross-reactivity as a method for overcoming antigen tolerance.
Benchwork to include profiling antigen-specific T-cells using IFN-γ ELISpot, and activation-induced marker (AIM) assays, and intracellular cytokine staining, with matrix/pool deconvolution design.
Develop assays to forecast off-target events in a system that leverages cross-reactivity as a method for overcoming antigen tolerance.
Oversee tetramer/dextramer and multimer staining, including executing high-avidity, peptide-MHC (pMHC) assays and employing DNA-barcoded multimers.
Running standard cytotoxicity readouts (e.g. IncuCyte).
Interpreting immunopeptidomics (LC-MS/MS HLA-ligand) data generated by collaborators/CROs and translate it into epitope-processing and presentation decisions.
Investigate the biological mechanisms (MoA) underlying the therapy’s ability to drive vigorous, durable anti-tumor memory.
Oversee in vivo and ex vivo studies to define the therapeutic's efficacy, pharmacodynamics (PD), and pharmacokinetics (PK).
Partner with the R&D team to de-risk assets prior to IND-enabling studies.
Manage direct reports/vendor/collaborators, present data to cross-functional teams, and author technical reports and regulatory documents to support governance reviews.
Interpret, analyze, present, and properly record data.
Prepare documents and presentations that encompass project progression.

REQUIRED EXPERIENCE:

PhD in Immunology, Cell Biology, or a related field, plus 5+ years of post-doctoral or industry experience. Alternatively, a Master’s degree with 8 to 10+ years of biotech experience. Job title will commensurate with experience.
Excited by and scientifically driven to overcome complex technical challenges that will contribute to safe treatment for cancers and autoimmune diseases.
Strong T-cell biology expertise, with extensive experience characterizing low frequency (<0.1%) CD8 and CD4 responses, and knowledge of how to improve readouts of rare T-cell responses.
Working knowledge of HLA biology, supertypes, population coverage logic, and HLA-matched experimental systems.
Immunotherapy drug development experience is a must.
Prior cancer-vaccine or general vaccine development experience, including peptide, protein-subunit, or nucleic-acid modalities, spanning antigen selection through in vivo immunogenicity.
Familiarity with adjuvants (TLR agonists, saponins, poly-ICLC) and how formulation shapes the T-cell response.
Experience with HLA-transgenic mouse models and/or human PBMC xenograft/humanized models, and familiarity with readouts both in flight and downstream of animal studies.
Proven ability to contribute to the scientific direction of a project.
Strong written and oral communication skills for technical and non-technical audiences.
Conscientious team member with experience taking and giving constructive feedback.
Must be comfortable with executing lab work full time in a preclinical-stage startup environment, and capable of finding solutions to tough problems with limited resources.

Sift Bio is pleased to offer competitive:

Medical, Dental, and Vision health plans.
Flexible time off.
Bonus and Equity plans.
Commuter transit benefit.
401(k) retirement plan.

Sift Bio is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind as outlined by applicable laws.

Pay: $130,000.00 - $160,000.00 per year

Benefits:

401(k)
Flexible schedule
Health insurance
Paid time off
Parental leave
Vision insurance

Application Question(s):

Please tell us about your experience with cancer-vaccine or general vaccine development experience, including peptide, protein-subunit, or nucleic-acid modalities, spanning antigen selection through in vivo immunogenicity.

Experience:

T cell biology : 5 years (Required)

Location:

San Carlos, CA 94070 (Preferred)

Work Location: In person

Quick Apply

Refine Your Search

biology jobs in san jose ca

Senior Scientist/Principal Scientist, Translational Immunotherapy

Field Sales Representative - Biotechnology Laboratory Supplies

Field Sales Representative - Biotechnology Laboratory Supplies

Principal Scientist, Antibody Discovery

Research Scientist - AI Trainer

Laboratory Technician

Research Associate

Assistant Clinical Research Coordinator

Clinical Research Coordinator Associate

Research Assistant

Life Science Research Professional 1

Neuroimaging Research Assistant

Lab Technician II - QC - Day Shift

Molecular Biologist - Academic Graduate Appointee

Laboratory Tech

Research associate or Sr Research associate

Microbiologist *PC 609

Research Associate

Digital Biology Specialist

Wildlife Biologist (On-Call)

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