Top 43 Structural biology Jobs in Boston Ma

Research Scientist I - Protein Sciences and Structural Biology
Broad Institute —Cambridge, MA
- $88,000 - $124,000 a year
- Full-time
- Analysis skills
- Doctor of Philosophy
- Communication skills
- Health savings account
- Paid holidays
9d
Process Development Associate Scientist- Biological and Structural Characterization
Amgen —Cambridge, MA
- $90,442.55 - $122,363.45 a year
- Mid-level
- Master's degree
- Bachelor's degree
- Disability insurance
- Health insurance
14d
Mass Spectrometry Research Associate (multiple levels)
Convergent Research —Watertown, MA
- $72,400 - $85,000 a year
- Full-time
- Mid-level
- Bachelor's degree
- 2 years
- Paid parental leave
- AD&D insurance
Senior Associate Scientist
Sanofi —Cambridge, MA
- $75,000.00 - $108,333.33 a year
- Microsoft Excel
- Bachelor of Science
- Bachelor's degree
- Parental leave
6d
Scientist I – Fischer Lab
Dana-Farber Cancer Institute —Boston, MA
- $80,000 - $95,900 a year
- Full-time
- Doctor of Philosophy
- Mentoring
- In-person
Advisor - Genomic Sciences, RNA Therapeutics
Eli Lilly —Boston, MA
- $138,000 - $224,400 a year
- Full-time
- Analysis skills
- Doctor of Philosophy
- Mentoring
- Health insurance
- Dental insurance
Cryo-FIB/SEM Staff Scientist, CryoEM Facility
MIT —Cambridge, MA
- Full-time
- Master's degree
- Analysis skills
- Doctor of Philosophy
Senior Scientist, AI Computational Structural Biology
Bristol-Myers Squibb —Cambridge, MA
- $141,770 - $179,601 a year
- Email
- Hybrid work
- Computer Science
- Master's degree
- Presentation skills
- Paid holidays
- Disability insurance
Scientist, Biochemistry
HotSpot Therapeutics —Boston, MA
- Full-time
- Bachelor of Science
- Project management
- Bachelor's degree
- Paid holidays
Principal Scientist I, Soluble Biomarkers- Molecular & Cellular Sciences (MCS)
Novartis —Cambridge, MA
- $108,500 - $201,500 a year
- Full-time
- Master's degree
- Doctor of Philosophy
- Senior level
- Health insurance
- 401(k) matching
12d
Data Scientist Infectious Disease
Tufts University —Boston, MA
- $106,100 - $159,100 a year
- Computer Science
- 5 years
- No experience needed
13d
Scientist
BPG Bio, Inc —Waltham, MA
- $105,000 - $115,000 a year
- Full-time
- Microsoft Word
- Microsoft Excel
- Analysis skills
Quick Apply
AIRx Director, Computational & AI Biologics Design Lead
Takeda Pharmaceutical —Boston, MA
- $177,000 - $278,080 a year
- Hybrid work
- Computer Science
- Doctor of Philosophy
- Mentoring
- Paid holidays
- Disability insurance
Senior Director, AIRx Medicinal Chemistry
Takeda Pharmaceutical —Boston, MA
- $212,000 - $333,190 a year
- Full-time
- Hybrid work
- Management
- 11+ years
- Doctor of Philosophy
- Paid holidays
- Disability insurance
7d
Director, AIRx Medicinal Chemistry
Takeda Pharmaceutical —Boston, MA
- $177,000 - $278,080 a year
- Hybrid work
- Management
- Bachelor of Science
- 11+ years
- Paid holidays
- Disability insurance
11d
Research Associate - Metabolomics/Lipidomics
BPG Bio, Inc —Waltham, MA
- $65,000 - $75,000 a year
- Full-time
- Microsoft Word
- Microsoft Excel
- Bachelor of Science
Quick Apply
Principal Scientist, Computational Protein Design
Moderna, Inc. —Cambridge, MA
- $142,500 - $256,500 a year
- Full-time
- Office
- Doctor of Philosophy
- Mentoring
- Health insurance
- Paid time off
Distinguished Scientist, Group Head Biochemistry
Sanofi —Cambridge, MA
- $178,500.00 - $257,833.33 a year
- 5 years
- Machine learning
- Continuous improvement
- Parental leave
Scientific Fellow, AI-Enabled Molecular Design
Sanofi —Cambridge, MA
- $232,500.00 - $335,833.33 a year
- 7 years
- Doctor of Philosophy
- Mentoring
- Parental leave
Scientist I / Scientist II, Computational Protein Design
Generate Biomedicines —Somerville, MA
- $154,000 - $216,000 a year
- Hybrid work
- Computer Science
- Mid-level
- Office

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structural biology jobs near boston ma

Research Scientist I - Protein Sciences and Structural Biology

Broad Institute -
Cambridge, MA

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Job Details

Full-time
$88,000 - $124,000 a year
9 days ago

Benefits

Health savings account
Paid holidays
Disability insurance
Health insurance
Dental insurance
401(k)
Paid time off
Family leave
Parental leave
Employee assistance program
Vision insurance

Qualifications

Cell line culture
Bacterial culture
Protein analysis (analytical chemistry specialty)
Molecular cloning
Biochemical laboratory techniques
Doctor of Philosophy
Polyacrylamide gel electrophoresis
Mass spectrometers (MS)
Cross-functional collaboration
Cross-functional communication

Full Job Description

General information

Location

Cambridge, MA

Ref #

44535

Job Family

Research

Date published

07/14/2026

Time Type

Full time

Pay Range

$88,000.00/yr - $124,000.00/yr

Description & Requirements

Embedded within the Broad Institute, the Center for the Development of Therapeutics (CDoT) is a highly collaborative organization of professional drug discovery scientists. Our mission is to translate cutting edge biological insights originating from the Broad community into impactful drug discovery projects. We partner with faculty from MIT, Harvard, and the Harvard teaching hospitals together with industry partners in pharmaceutical, biotechnology and venture capital firms to validate druggable targets and identify leads. We combine our deep expertise in drug discovery with the knowledge and unique capabilities of the Broad Institute to explore drug discovery projects in a wide range of disease areas (including oncology, cardiovascular, psychiatry, infectious and rare diseases). We use systematic approaches in genomics, biology, high content imaging, chemistry, and machine learning coupled with the Broad's culture of creativity, risk taking, and open sharing, to successfully advance science and develop new treatments for patients.

We are seeking a passionate and highly motivated Research Scientist I to join CDoT’s Protein Technologies team. The successful candidate will have a solid understanding of protein construct design, expression, purification, and quality assessment. Experience in structural biology is advantageous.

Principle Duties and Responsibilities:

Developing and executing strategies to clone and express recombinant proteins in a variety of expression systems
Purifying tagged or native proteins using standard purification (FPLC systems and column chromatography) and analytical techniques (SDS-PAGE, Western blot, light scattering, and protein LC/MS)
With training, produce high quality protein crystal structures and co-crystal structures, carrying out the process from crystallization screening through to structure refinement
Initiating and completing routine protein construct design and production in an independent and efficient manner
Demonstrating the ability to interpret experimental outcomes and proposing follow-up studies
Troubleshooting and solving scientific problems related to protein production independently
Operating and maintaining lab equipment independently, including protein purification systems like an AKTA pure
Investigating new technologies related to protein expression and purification
Documenting work and effectively presenting results in cross-functional project teams

Requirements:

Ph.D in Biophysics, Biochemistry, Molecular Biology, Structural Biology or related life science field with 0-2+ years of research experience in an industrial or academic setting
Expertise in recombinant protein purification using chromatography (affinity, ion exchange, and size exclusion)
Significant experience with cloning and expressing proteins using different vectors, tags, and various cell culture systems (mammalian, insect, bacterial, yeast)
Significant experience with protein characterization (analytical size exclusion chromatography, mass spectrometry, light scattering, western blot and biophysical binding studies)
Experience in protein crystallography and crystallographic data processing, model refinement, and structural analysis is a plus
Experience with biophysical characterization of proteins (ITC, DSC, SPR, NMR etc.) is a plus
A proven record of successful interaction with project team members, external customers or vendors

The successful candidate will be a results-focused, team-oriented, creative bench scientist able to excel in a fast-track environment. She or he must be self-motivated, detail-oriented and exhibit strong problem solving skills. In addition, the successful candidate should be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with project teams, peers, and management in identifying and achieving research goals.

The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.

At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.

The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.

Should you need a reasonable accommodation to complete the application or interview process, please contact [email protected] for assistance.

Apply Now

Refine Your Search

structural biology jobs in boston ma

Research Scientist I - Protein Sciences and Structural Biology

Process Development Associate Scientist- Biological and Structural Characterization

Mass Spectrometry Research Associate (multiple levels)

Senior Associate Scientist

Scientist I – Fischer Lab

Advisor - Genomic Sciences, RNA Therapeutics

Cryo-FIB/SEM Staff Scientist, CryoEM Facility

Senior Scientist, AI Computational Structural Biology

Scientist, Biochemistry

Principal Scientist I, Soluble Biomarkers- Molecular & Cellular Sciences (MCS)

Data Scientist Infectious Disease

Scientist

AIRx Director, Computational & AI Biologics Design Lead

Senior Director, AIRx Medicinal Chemistry

Director, AIRx Medicinal Chemistry

Research Associate - Metabolomics/Lipidomics

Principal Scientist, Computational Protein Design

Distinguished Scientist, Group Head Biochemistry

Scientific Fellow, AI-Enabled Molecular Design

Scientist I / Scientist II, Computational Protein Design

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