Top 38 structural biology Jobs in boston ma

Senior Director, AIRx Computational Chemistry
Takeda Pharmaceutical —Boston, MA
- $212,000 - $333,190 a year
- Full-time
- Hybrid work
- 11+ years
- Doctor of Philosophy
- Senior level
- Paid holidays
- Disability insurance
Research Scientist
Vertex Pharmaceuticals —Boston, MA
- $104,000 - $156,000 a year
- Full-time
- 5 years
- Bachelor of Science
- Bachelor's degree
- Loan repayment program
- Health insurance
Scientist I, Genotox (Contract)
Tessera Therapeutics —Somerville, MA
- $52 - $58 an hour
- Contract
- Bachelor of Science
- Bachelor's degree
- Doctor of Philosophy
Scientist I – Fischer Lab
Dana-Farber Cancer Institute —Boston, MA
- $80,000 - $95,900 a year
- Full-time
- Doctor of Philosophy
- Mentoring
- In-person
Sarcoma Computational Biologist
Dana-Farber Cancer Institute —Boston, MA
- $85,000 - $105,000 a year
- Full-time
- Computer Science
- Master's degree
- Analysis skills
Research Associate II/ Senior Research Associate
Generate Biomedicines —Andover, MA
- $85,000 - $111,000 a year
- Bachelor of Science
- Mid-level
- Bachelor's degree
Principal Machine Learning Scientist
Bayer —Cambridge, MA
- $123,760 - $185,640 a year
- 5 years
- Analysis skills
- Doctor of Philosophy
- Health insurance
- Dental insurance
Scientist, Research
Visterra —Waltham, MA
- $142,000 - $167,000 a year
- Full-time
- Bachelor of Science
- Office
- 8 years
Quick Apply
Neurodegenerative Disease Senior Scientist
Convergent Research —Watertown, MA
- $86,000 - $119,000 a year
- Full-time
- Analysis skills
- Doctor of Philosophy
- Mentoring
- Paid parental leave
- AD&D insurance
Senior Scientist
Sanofi —Cambridge, MA
- $85,500 - $123,500 a year
- Hybrid work
- System design
- Master's degree
- Presentation skills
- Parental leave
11d
Principal Scientist, Computational Protein Design
Moderna, Inc. —Cambridge, MA
- $142,500 - $256,500 a year
- Full-time
- Office
- Doctor of Philosophy
- Mentoring
- Health insurance
- Paid time off
Senior Scientist, Computational Protein Design
Abiologics —Boston, MA
- $146,000 - $209,000 a year
- Machine learning
- Doctor of Philosophy
- Scripting
- Retirement plan
AI/ML Scientist, Protein Foundation Models
Manifold Bio —Boston, MA
- $140,000 - $225,000 a year
- Email
- In-person
- Senior level
- 2 years
- Paid holidays
- Health insurance
In Vitro Pharmacologist — Molecule Discovery
Lilly —Boston, MA
- $163,500 - $281,600 a year
- Full-time
- Bachelor of Science
- Bachelor's degree
- Doctor of Philosophy
- Health insurance
- Dental insurance
1d
Scientific Fellow, AI-Enabled Molecular Design
Sanofi —Cambridge, MA
- $232,500.00 - $335,833.33 a year
- 7 years
- Doctor of Philosophy
- Mentoring
- Parental leave
Computational Scientist I- Center for Genomic Medicine
Broad Institute —Cambridge, MA
- $88,000 - $124,000 a year
- Full-time
- Hybrid work
- Computer Science
- Analysis skills
- Doctor of Philosophy
- Health savings account
- Paid holidays
Senior Scientist, Computational Biotherapeutics Engineering
Pfizer —Cambridge, MA
- $93,600 - $156,000 a year
- Online Application
- Hybrid work
- Bachelor of Science
- 3 years
- Master's degree
- Paid holidays
- Relocation assistance
8d
Director/Senior Director, Analytical Methods (Methods4Insight)
Lilly —Boston, MA
- $193,500 - $338,800 a year
- Full-time
- 6 years
- Management
- Computer Science
- Health insurance
- Dental insurance
Principal Scientist, Protein Design
Moderna, Inc. —Cambridge, MA
- $142,500 - $256,500 a year
- Full-time
- 5 years
- Office
- Doctor of Philosophy
- Health insurance
- Paid time off
Postdoctoral Research Fellow - Jones Lab
Dana-Farber Cancer Institute —Boston, MA
- $72,000 - $76,385 a year
- Full-time
- Doctor of Philosophy
- In-person
- Senior level

I want to receive the latest job alert for structural biology in boston ma

By signing in to your account, you agree to SimplyHired's Terms of Service and consent to our Cookie and Privacy Policy.

Explore jobs in more locations

structural biology jobs near boston ma

Senior Director, AIRx Computational Chemistry

Takeda Pharmaceutical -
Boston, MA

Apply Now

Job Details

Full-time
$212,000 - $333,190 a year

Benefits

Paid holidays
Disability insurance
Health insurance
Dental insurance
Tuition reimbursement
Paid time off
Vision insurance
401(k) matching
Volunteer time off
Life insurance

Qualifications

Computational research
Molecular dynamics simulations
Simulation modeling (chemistry)
Drug discovery
Model deployment
Simulation tools
Bioinformatics tools
Pharmaceutical research
Python

Full Job Description

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Senior Director, Computational Chemistry

Takeda Research is constructing the Discovery Automation & Robotics (DAR) group built on AI, automation, new ways of working, and talent with the singular vision of delivering differentiated medicines to the clinic at speed and cost. To catalyze these efforts, Takeda is creating two complementary units: AI Research Accelerator (AIRx) and The Discovery Automation & Robotics (DAR) group.

AIRx will consist of a dedicated group of experienced drug hunters with the autonomy of a biotech and the resources of a leading pharmaceutical company. It is designed to incubate the future AI-powered operating models and deliver candidates to the clinic at industry leading speed and success rates.

Purpose

Reporting to the Head of AIRx, the AIRx Computational Chemist sits at the scientific heart of AIRx's AI-first operating model. This role drives in silico molecular design, leverages predictive models, and applies generative chemistry to power rapid DMTA cycles — directly enabling the speed and precision that define the AIRx incubator In AIRx, computational chemistry is a first-order decision-making function — generative proposals from this role directly shape what gets synthesized, what gets deprioritized, and ultimately what reaches the clinic. The role is deeply hands-on, with a unique opportunity to directly shape candidates that advance to the clinic through close collaboration with the wider AIRx design team.

Accountabilities

Apply generative AI, structure-based design, free energy perturbation, and predictive ML models to design and prioritize chemical matter
Partner closely with Medicinal Chemists to translate computational outputs into actionable synthesis priorities; challenge and be challenged in equal measure
Lead and oversee virtual screening campaigns, ADMET predictions, and selectivity assessments to inform and accelerate design decisions
Contribute to building and refining AI/ML model training datasets from AIRx experimental outputs
Develop and maintain computational workflows that increase team speed and reproducibility
Interpret and integrate structural biology data (X-ray, cryo-EM) into computational design strategies
Communicate complex computational findings clearly to cross-disciplinary colleagues and governance forums
Stay current with advances in generative AI, protein structure prediction, and ML methods; proactively apply new approaches

Qualifications & Competencies

PhD in computational chemistry, cheminformatics, biophysics, or closely related discipline
12–15+ years of drug discovery experience with demonstrated track record of computational impact on programs
Proficiency across computational tools: molecular docking, MD simulation, FEP, QSAR/ADMET modeling
Strong coding skills (Python required); experience building and deploying ML models in a drug discovery context
Experience with structure-based drug design; ability to interpret crystallography or cryo-EM data
Experience applying generative AI or large language models to molecular design preferred
Collaborative, communicative, and comfortable at the wet/dry scientific interface

ADDITIONAL INFORMATION

The position will be based in Cambridge, MA. This position is currently classified as “hybrid” by Takeda’s Hybrid and Remote Work policy

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$212,000.00 - $333,190.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Apply Now

Refine Your Search

structural biology jobs in boston ma

Senior Director, AIRx Computational Chemistry

Research Scientist

Scientist I, Genotox (Contract)

Scientist I – Fischer Lab

Sarcoma Computational Biologist

Research Associate II/ Senior Research Associate

Principal Machine Learning Scientist

Scientist, Research

Neurodegenerative Disease Senior Scientist

Senior Scientist

Principal Scientist, Computational Protein Design

Senior Scientist, Computational Protein Design

AI/ML Scientist, Protein Foundation Models

In Vitro Pharmacologist — Molecule Discovery

Scientific Fellow, AI-Enabled Molecular Design

Computational Scientist I- Center for Genomic Medicine

Senior Scientist, Computational Biotherapeutics Engineering

Director/Senior Director, Analytical Methods (Methods4Insight)

Principal Scientist, Protein Design

Postdoctoral Research Fellow - Jones Lab

I want to receive the latest job alert for structural biology in boston ma

Explore jobs in more locations

Job Description

Locations

Worker Type

Worker Sub-Type

Time Type

Job Seeker Tools

Employer Tools

Browse

Stay Connected