Top 23 Medicinal chemist Jobs in California

Scientist, Peptide Chemistry
CALICO —South San Francisco, CA
- $135,000 - $145,000 a year
- Analysis skills
- Doctor of Philosophy
- Team management
Scientist, Organic Chemistry
Kodiak Sciences Inc. —Palo Alto, CA
- Full-time
- Doctor of Philosophy
- Senior level
- Communication skills
Computational Medicinal Chemist
Novartis —San Diego, CA
- $126,000 - $257,400 a year
- Full-time
- 3 years
- Doctor of Philosophy
- Senior level
- Health insurance
- 401(k) matching
3d
Principal Scientist, Medicinal Chemistry
Iambic Therapeutics, Inc —San Diego, CA
- $152,000 - $190,000 a year
- Full-time
- Bachelor of Science
- Office
- 8 years
- Flexible spending account
- 401(k) matching
Director, Medicinal Chemistry
Protagonist Therapeutics —Newark, CA
- $210,000 - $250,000 a year
- Doctor of Philosophy
- Mentoring
- Pediatrics
Quick Apply
Staff Scientist, Chemistry
Cellanome —Foster City, CA
- $140,000 - $200,000 a year
- 5 years
- Doctor of Philosophy
- Quality control
- Health insurance
- 401(k)
Senior Scientist, Medicinal Chemistry (On-site)
Neomorph, Inc. —San Diego, CA
- $164,000 - $186,000 a year
- Management
- Bachelor of Science
- 11+ years
- Paid parental leave
- Health savings account
Sr Associate Scientist I or II, Medicinal Chemistry
Iambic Therapeutics, Inc —San Diego, CA
- $84,000 - $120,000 a year
- Full-time
- Bachelor of Science
- 3 years
- Bachelor's degree
- Flexible spending account
- 401(k) matching
Medicinal Chemists/Adjunct Professor Series*
UC San Francisco Academic —San Francisco, CA
- $112,500 - $297,200 a year
- Online Application
- University
- Doctor of Philosophy
- Mentoring
Principal Scientist, Medicinal Chemistry
Neurocrine Bioscience —San Diego, CA
- $130,800 - $179,000 a year
- Full-time
- Psychiatry
- Computer literacy
- Bachelor of Science
- Paid holidays
- Health insurance
Senior Scientist / Principal Scientist – Process Chemistry
Treeline Biosciences —San Diego, CA
- $166,380 - $189,533 a year
- 3 years
- Doctor of Philosophy
- Travel
Quick Apply
Principal Scientist, Peptide Therapeutics
Genentech —San Francisco, CA
- $143,200 - $265,900 a year
- Online Application
- 3 years
- Machine learning
- Doctor of Philosophy
Director/Senior Director, Medicinal Chemistry
Iambic Therapeutics, Inc —San Diego, CA
- $196,000 - $280,000 a year
- Full-time
- Bachelor of Science
- 11+ years
- Office
- Flexible spending account
- 401(k) matching
Senior Principal Scientist, Peptide Therapeutics
Genentech —San Francisco, CA
- $168,600 - $313,000 a year
- Online Application
- 7 years
- Analysis skills
- Doctor of Philosophy
Senior Scientist, Organic Chemistry - San Diego, CA
dsm-firmenich —San Diego, CA
- Online Application
- 5 years
- English
- Analysis skills
- Health insurance
- Paid time off
Scientist II/Senior Scientist, Medicinal Chemistry
General Proximity —San Francisco, CA
- Email
- 3 years
- Analysis skills
- Doctor of Philosophy
- Health insurance
- Dental insurance
Quick Apply
Senior Research Associate 1 (Contract)
Eikon Therapeutics —Millbrae, CA
- $48 - $58 an hour
- Contract
- Mid-level
- Master's degree
- Bachelor's degree
- AD&D insurance
- Paid holidays
Quick Apply
2d
Scientist, Life Science Organic Chemistry - San Diego, CA
dsm-firmenich —San Diego, CA
- Online Application
- 5 years
- English
- Analysis skills
- Opportunities for advancement
Postdoctoral Scientist
Eli Lilly —San Diego, CA
- $58,000 - $123,200 a year
- Full-time
- Doctor of Philosophy
- US work authorization
- Senior level
- Health insurance
- Dental insurance
11d
Analytical Chemistry Principal Research Associate
Vertex Pharmaceuticals —San Diego, CA
- $85,700 - $128,500 a year
- Full-time
- 5 years
- Writing skills
- Mid-level
- Loan repayment program
- Dental insurance

I want to receive the latest job alert for medicinal chemist in california

By signing in to your account, you agree to SimplyHired's Terms of Service and consent to our Cookie and Privacy Policy.

Explore jobs in more locations

medicinal chemist jobs near california

Scientist, Peptide Chemistry

CALICO -
South San Francisco, CA

Apply Now

Job Details

$135,000 - $145,000 a year

Qualifications

Pharmaceutical synthesis
High-performance liquid chromatographs
Simulation modeling (chemistry)
Formulation chemistry
Assay development
Doctor of Philosophy
Cross-functional collaboration
Automated liquid handling systems
Pharmaceutical research experience
Cross-functional communication
Drug formulation
Nuclear magnetic resonance (NMR) spectroscopy
Molecular analysis

Full Job Description

Who We Are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description:

We are seeking a scientist to join our Peptide Chemistry team. In this role, you will drive peptide drug discovery projects that sit at the nexus of empirical medicinal chemistry and Calico’s proprietary Machine Learning (ML) peptide design platform. You will collaborate cross-functionally with ML scientists, medicinal chemists, automation specialists, and biologists to explore structure-activity relationships (SAR). By leveraging a rapid design-make-test cycle, you will accelerate the optimization of therapeutic peptides and contribute to the evolution of a world-class synthetic engine.

Key Responsibilities:

Drive Discovery: Lead peptide drug discovery campaigns from initial hit identification through to IND-enabling studies
Innovate Synthetic Workflows: Onboard and optimize novel chemistries for high-throughput, automated peptide synthesis; troubleshoot complex synthetic challenges to generate high-quality leads, and curate a custom library of building blocks
Cross-Functional Partnership: Collaborate with biology, software, automation, assay, and pharmacology teams to ensure seamless execution of ML platform objectives and drug discovery milestones
Mentorship and Management: Actively mentor junior scientists, fostering a culture of technical excellence, continuous learning, and collaborative innovation
Manage external collaborations and CROs efficiently, including teams of chemists, DMPK scientists and formulation experts

Position Requirements:

Ph.D. in Organic Chemistry, Peptide Chemistry, or a related discipline with 0-2 years of industry experience in drug discovery
Experience in peptide hit discovery, SAR campaigns, ADMET optimization, and peptide formulation
Proven experience building and interpreting complex assay cascades, including biophysical characterization, functional protein/cell-based assays, and ADMET screening
High proficiency in automated synthesis, purification (HPLC, Flash, SPE), and characterization (LCMS, NMR, CD, etc.)
Demonstrated ability to implement diverse chemistries, including backbone-modifications, macrocyclization, stapling, and bioconjugation via solid- or solution-phase strategies
Excellent problem-solving and analytical skills
Exceptional interpersonal and communication skills for effective collaboration across diverse functional groups
Must be willing to work onsite 5 days per week

Nice to Have:

Experience with organic synthesis, including transition metal catalysis and synthesis of non-canonical amino acids, is highly desired
Experience with automation, software, and data-science integration into chemistry workflows
Ability to utilize AI-tools to improve efficiency of research and build programs for data analysis or synthesis
Knowledgeable on the key principles of ML-design for peptide therapeutics
Prior experience with peptide-specific computational tools for hit discovery, SAR prioritization, molecular modeling, and physicochemical characterization

The estimated base salary range for this role is $135,000 - $145,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

Apply Now

Refine Your Search

medicinal chemist jobs in california

Scientist, Peptide Chemistry

Scientist, Organic Chemistry

Computational Medicinal Chemist

Principal Scientist, Medicinal Chemistry

Director, Medicinal Chemistry

Staff Scientist, Chemistry

Senior Scientist, Medicinal Chemistry (On-site)

Sr Associate Scientist I or II, Medicinal Chemistry

Medicinal Chemists/Adjunct Professor Series*

Principal Scientist, Medicinal Chemistry

Senior Scientist / Principal Scientist – Process Chemistry

Principal Scientist, Peptide Therapeutics

Director/Senior Director, Medicinal Chemistry

Senior Principal Scientist, Peptide Therapeutics

Senior Scientist, Organic Chemistry - San Diego, CA

Scientist II/Senior Scientist, Medicinal Chemistry

Senior Research Associate 1 (Contract)

Scientist, Life Science Organic Chemistry - San Diego, CA

Postdoctoral Scientist

Analytical Chemistry Principal Research Associate

I want to receive the latest job alert for medicinal chemist in california

Explore jobs in more locations

Job Seeker Tools

Employer Tools

Browse

Stay Connected