Top 104 Senior chemist Jobs in California

Senior Scientist 1, Analytical Development
Crinetics Pharmaceuticals —San Diego, CA
- $117,000 - $146,000 a year
- Full-time
- 5 years
- Master's degree
- Bachelor's degree
- Employee stock purchase plan
- Paid holidays
Senior Scientist, Medicinal Chemistry (On-site)
Neomorph, Inc. —San Diego, CA
- $164,000 - $186,000 a year
- Management
- Bachelor of Science
- 11+ years
- Paid parental leave
- Health savings account
Senior/ Principal Scientist, Synthetic Molecule Analytical Chemistry
Genentech —San Francisco, CA
- $124,300 - $265,900 a year
- Online Application
- Master's degree
- Bachelor's degree
- Doctor of Philosophy
Senior Technician- Analytical
Novoloop —Menlo Park, CA
- $85,000 - $95,000 a year
- Full-time
- Bachelor of Science
- Mid-level
- 3 years
- Health savings account
- Health insurance
Quick Apply
13d
Senior Scientist, Analytical Sciences
ORIC Pharmaceuticals —South San Francisco, CA
- $150,000 - $180,000 a year
- Full-time
- Hybrid work
- 3 years
- Doctor of Philosophy
- Senior level
Quick Apply
Senior Scientist, Analytical Development
Neurocrine Bioscience —San Diego, CA
- $110,800 - $151,000 a year
- Full-time
- Psychiatry
- Bachelor of Science
- 3 years
- Paid holidays
- Health insurance
Analytical Sr Scientist
Amgen —Thousand Oaks, CA
- $126,066.05 - $170,559.95 a year
- Management
- 3 years
- Analysis skills
- Disability insurance
- Health insurance
12d
Senior Scientist I
Cytokinetics —San Francisco, CA
- $162,000 - $189,000 a year
- Full-time
- 5 years
- Doctor of Philosophy
- Senior level
Senior Scientist - Bioanalytical
Protagonist Therapeutics —Newark, CA
- $140,000 - $160,000 a year
- 5 years
- Bachelor of Science
- Bachelor's degree
Quick Apply
Senior Scientist, Analytical Development & Quality Control (ADQC)
Ionis Pharmaceuticals, Inc. —Carlsbad, CA
- $113,856 - $150,241 a year
- Hybrid work
- Doctor of Philosophy
- Senior level
- 2 years
Quick Apply
Process Development Senior Scientist
Amgen —Thousand Oaks, CA
- $126,066.05 - $170,559.95 a year
- Master's degree
- High school diploma or GED
- Analysis skills
- Disability insurance
- Health insurance
Senior Scientist, Oligonucleotide Chemist
LGC Group —Petaluma, CA
- $120,000 - $145,000 a year
- Full-time
- English
- Master's degree
- Analysis skills
Quick Apply
Sr. Analytical Chemist – Organics in Water by GC/MS
Entech Instruments Inc —Simi Valley, CA
- Full-time
- English
- Analysis skills
- Doctor of Philosophy
- Health insurance
- Dental insurance
Quick Apply
Senior Associate Scientist, Analytical Operations
Gilead Sciences —Foster City, CA
- $126,820 - $164,120 a year
- Full-time
- Master's degree
- Bachelor's degree
- Training & development
- Health insurance
- Dental insurance
Senior Scientist, Process Chemistry
ORIC Pharmaceuticals —South San Francisco, CA
- $175,000 - $200,000 a year
- Full-time
- Hybrid work
- Doctor of Philosophy
- Senior level
- Communication skills
Quick Apply
Scientist II/Senior Scientist, Medicinal Chemistry
General Proximity —San Francisco, CA
- Email
- 3 years
- Analysis skills
- Doctor of Philosophy
- Health insurance
- Dental insurance
Quick Apply
Sr. Scientist, Quality Control
Codexis Inc —Redwood City, CA
- $160,000 - $175,000 a year
- Full-time
- Bachelor of Science
- Analysis skills
- Bachelor's degree
- Wellness program
- Paid parental leave
Quick Apply
12d
Sr. Principal Scientist, Tech Transfer
Neurocrine Bioscience —San Diego, CA
- $156,900 - $214,000 a year
- Full-time
- Psychiatry
- Computer literacy
- Bachelor of Science
- Paid holidays
- Health insurance
Senior Scientist- 1232
Millennium Health —San Diego, CA
- $115,000 - $135,000 a year
- Full-time
- HIPAA
- Doctor of Philosophy
- Mentoring
- Paid holidays
- Disability insurance
Quick Apply
Senior Associate Scientist, Chemistry
Bristol-Myers Squibb —San Diego, CA
- $95,505 - $115,730 a year
- Email
- 5 years
- Bachelor of Science
- Analysis skills
- Paid holidays
- Disability insurance

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Senior Scientist 1, Analytical Development

Crinetics Pharmaceuticals -
San Diego, CA

Apply Now

Job Details

Full-time
$117,000 - $146,000 a year

Benefits

Stock options
Employee stock purchase plan
Paid holidays
Health insurance
Dental insurance
Paid time off
Vision insurance
401(k) matching
Life insurance

Qualifications

Stability testing
Content creation for technical audiences
Stability studies in drug product development
Technical documentation
Spreadsheets
High-performance liquid chromatographs
Presentations for conferences or internal meetings
X-ray diffraction
Microscope proficiency
ICH guidelines
Gas chromatographs
Pharmaceutical analysis
Materials analysis (analytical chemistry specialty)
Physical analysis
Productivity software
GMP for research safety and compliance
Technical writing experience within technology
Chemical testing
Research findings presentation
Technical Proficiency
Data analysis software
Method validation

Full Job Description

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.

Position Summary:

The Senior Scientist 1, Analytical Development, is responsible for developing, optimizing, and executing analytical methods to support the progression of small molecule drug substance and drug product programs from candidate nomination through regulatory submission and commercial launch.

This is a hands-on, laboratory ‑ based role requiring strong technical expertise in analytical chemistry. The Senior Scientist 1 independently leads analytical activities for assigned projects, including method development, qualification/validation, transfer, and troubleshooting, with oversight of outsourced work conducted at CROs and CDMOs. The role collaborates closely with cross ‑ functional partners across CMC, Technical Operations, Quality, Regulatory Affairs, and external vendors to support development, manufacturing, and regulatory strategies.

Essential Job Functions and Responsibilities:

These may include but are not limited to:

Provide hands-on expertise in chromatographic method development (e.g., HPLC/UPLC), dissolution testing, and small molecule characterization, ensuring methods are phase‑appropriate and aligned with program and regulatory requirements.
Act as a subject matter expert and independently lead analytical development activities for assigned projects.
Develop, optimize, validate, and transfer phase‑appropriate analytical methods to support programs from early development through commercialization using relevant analytical techniques.
Apply phase‑appropriate analytical strategies to method development, stability studies, impurity profiling, forced degradation studies, comparability assessments, and method lifecycle management.
Generate high‑quality, scientifically sound data and apply data‑driven judgment to recommend analytical strategies and development approaches.
Serve as a technical expert for analytical instrumentation and methodologies, with the ability to troubleshoot laboratory, method, and instrumentation issues.
Maintain accurate and detailed laboratory documentation in accordance with company policies and regulatory guidelines.
Work closely with lab operations leader to implement laboratory best practices and provide technical guidance and mentorship to junior team members.
Communicate analytical findings, risks, and recommendations clearly through well‑written technical documents and effective verbal and visual presentations.
Provide scientific oversight, root cause analysis, and technical input for quality events, including OOS/OOT investigations, deviations, and CAPAs.
Collaborate closely with cross‑functional colleagues in Drug Substance, Drug Product, Pharmaceutical Operations, Quality, and Regulatory Affairs to support development and commercialization activities.
Support regulatory filings (e.g., INDs, IMPDs, NDAs, briefing packages, and other regulatory documents), as needed.
Perform other duties as assigned.

Education and Experience:

Required:

Ph.D. in analytical chemistry, or related field, with a minimum of 5 years of relevant hands-on experience in pharmaceutical, biotech laboratory, or CDMOs. (Masters with 13 years of experience or Bachelor’s with 15 years of experience may be considered).
Strong technical expertise in analytical testing, method development, and phase appropriate qualification/validation, characterization and support of stability programs for small molecule API and DP’ s.
Technical proficiency with techniques that include, but are not limited to, HPLC, UPLC, GC, KF, IC, LC-MS, UV-Vis, XRPD, and microbial.
Experience and demonstrated proficiency in additional areas of pharmaceutical development preferred (e.g. solid state analysis, physical characterization, drug product dissolution, or in-use stability studies).
Significant and direct work experience with analytical instruments and techniques such as HPLC/UPLC, and solid-state characterization tools, including DSC, TGA, DVS, XRPD, microscopy, etc.
Knowledge of cGMP requirements and regulatory guidance (FDA, ICH).
Excellent written and oral communication skills, including the drafting and reviewing technical documents and the ability to effectively and accurately present data to peers, management, and external partners.
Excellent ability to work in a goal and team-oriented setting and handle competing priorities.
Flexibility within a rapidly changing environment and high attention to detail.
Well-developed organizational skills and the ability to thrive under pressure.
Intermediate to advanced software skills (e.g., Microsoft Excel, PowerPoint, MS Project).

Physical Demands and Work Environment:

Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.

Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply.

Travel:

You may be required to travel for up to 10% of your time.

Equal Opportunity Employer:

Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws.

Salary Range

The salary range for this position is: $117,000 - $146,000.

In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Apply Now

Refine Your Search

senior chemist jobs in california

Senior Scientist 1, Analytical Development

Senior Scientist, Medicinal Chemistry (On-site)

Senior/ Principal Scientist, Synthetic Molecule Analytical Chemistry

Senior Technician- Analytical

Senior Scientist, Analytical Sciences

Senior Scientist, Analytical Development

Analytical Sr Scientist

Senior Scientist I

Senior Scientist - Bioanalytical

Senior Scientist, Analytical Development & Quality Control (ADQC)

Process Development Senior Scientist

Senior Scientist, Oligonucleotide Chemist

Sr. Analytical Chemist – Organics in Water by GC/MS

Senior Associate Scientist, Analytical Operations

Senior Scientist, Process Chemistry

Scientist II/Senior Scientist, Medicinal Chemistry

Sr. Scientist, Quality Control

Sr. Principal Scientist, Tech Transfer

Senior Scientist- 1232

Senior Associate Scientist, Chemistry

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