Top 111 Research chemist Jobs in Cambridge, Ma

Senior Director, AIRx Medicinal Chemistry
Takeda Pharmaceutical —Boston, MA
- $212,000 - $333,190 a year
- Full-time
- Hybrid work
- Management
- 11+ years
- Doctor of Philosophy
- Paid holidays
- Disability insurance
8d
Technologist - Research & Development
TalentBurst, Inc. —Marlborough, MA
- $19.31 - $25.52 an hour
- Contract
- Bachelor of Science
- Mid-level
- Bachelor's degree
- Health insurance
- Dental insurance
Quick Apply
Analytical Development Senior Research Associate
Vertex Pharmaceuticals —Boston, MA
- $72,000 - $108,000 a year
- Full-time
- Writing skills
- Mid-level
- Master's degree
- Loan repayment program
- Dental insurance
2d
Scientist I, ASO Process Development and Manufacturing
Biogen —Cambridge, MA
- $103,000 - $134,000 a year
- Full-time
- Bachelor of Science
- Bachelor's degree
- Continuous improvement
- Paid parental leave
- Employee stock purchase plan
Biochemistry Research Scientist
Spectrix Analytical Services, LLC —Cambridge, MA
- $32 - $45 an hour
- Full-time
- Bachelor of Science
- Mid-level
- Bachelor's degree
- Disability insurance
- Health insurance
Quick Apply
9.1. R&D Analytical Chemist
Phoenix Tailings —Woburn, MA
- $70,000 - $90,000 a year
- Full-time
- Mid-level
- Master's degree
- Bachelor's degree
- Health insurance
- Dental insurance
Scientist I, Formulations
Flagship Pioneering, Inc. —Cambridge, MA
- $100,000 - $126,500 a year
- Mid-level
- Master's degree
- Bachelor's degree
- Retirement plan
Research & Process Development Scientist
Parker Hannifin Corporation —Woburn, MA
- $100,300 - $166,900 a year
- Full-time
- Bachelor of Science
- Mid-level
- Bachelor's degree
- Paid parental leave
- Paid holidays
Senior Scientist, Medicinal Chemistry, Integrated Drug Discovery
Sanofi —Cambridge, MA
- $100,500.00 - $145,166.66 a year
- Master's degree
- Bachelor's degree
- Doctor of Philosophy
- Parental leave
Scientist, Preclinical Development (Onsite)
Merck —Boston, MA
- $98,000 - $154,300 a year
- Full-time
- Bachelor of Science
- Mid-level
- 3 years
- Paid holidays
- Health insurance
1d
Formulation/Research Scientist
Apogee Technology —Norwood, MA
- Email
- Bachelor of Science
- Mid-level
- Bachelor's degree
Senior Scientist, Analytical Development
Aurion Biotech Inc. —Cambridge, MA
- $155,000 - $170,000 a year
- Research
- 3 years
- Doctor of Philosophy
- Health insurance
- Flexible spending account
Mass Spectrometry Research Associate (multiple levels)
Convergent Research —Watertown, MA
- $72,400 - $85,000 a year
- Full-time
- Mid-level
- Bachelor's degree
- 2 years
- Paid parental leave
- AD&D insurance
Research Associate, Library Synthesis
X-Chem —Waltham, MA
- Bachelor of Science
- Bachelor's degree
- Continuous improvement
- Free parking
- Health savings account
Associate Scientist (Process R&D)
Cambrex —Waltham, MA
- Full-time
- Bachelor of Science
- Mid-level
- Analysis skills
Scientist
BPG Bio, Inc —Waltham, MA
- $105,000 - $115,000 a year
- Full-time
- Microsoft Word
- Microsoft Excel
- Analysis skills
Quick Apply
Research Chemist
RevBio, Inc. —Lowell, MA
- $85,000 - $100,000 a year
- Full-time
- Engineering
- Mid-level
- Master's degree
- Health insurance
- Dental insurance
Quick Apply
10d
Scientist - HPLC / KF / GC
Thermo Fisher Scientific —Boston, MA
- $35 - $43 an hour
- Full-time
- Microsoft Word
- Background check
- Pass drug screening
- Commuter assistance
- Paid parental leave
Scientist I
Kula Bio —Natick, MA
- $95,000 - $115,000 a year
- Full-time
- Mid-level
- Doctor of Philosophy
- Paid holidays
- Health insurance
Quick Apply
Research Associate, Analytical Technical Operations
Moderna, Inc. —Norwood, MA
- $63,200 - $100,900 a year
- Full-time
- Bachelor of Science
- Bachelor's degree
- Entry level
- Paid time off
- Adoption assistance

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Senior Director, AIRx Medicinal Chemistry

Takeda Pharmaceutical -
Boston, MA

Apply Now

Job Details

Full-time
$212,000 - $333,190 a year
8 days ago

Benefits

Paid holidays
Disability insurance
Health insurance
Dental insurance
Tuition reimbursement
Paid time off
Vision insurance
401(k) matching
Volunteer time off
Life insurance

Qualifications

AI models
Drug development research projects
Stress testing simulations
Program management
Management
In silico prediction
Drug development research
AI tools proficiency
Generative models
11+ years
Medicinal chemistry
Data management
Doctor of Philosophy
Pharmaceutical company experience
Experimental design
Chemistry
Senior level
Pharmaceutical research experience
Doctor of Organic Chemistry
Generative AI

Full Job Description

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Senior Director, AIRx Medicinal Chemistry

Takeda Research is constructing the Discovery Automation & Robotics (DAR) group built on AI, automation, new ways of working, and talent with the singular vision of delivering differentiated medicines to the clinic at speed and cost. To catalyze these efforts, Takeda is creating two complementary units: AI Research Accelerator (AIRx) and The Discovery Automation & Robotics (DAR) group.

AIRx will consist of a dedicated group of experienced drug hunters with the autonomy of a biotech and the resources of a leading pharmaceutical company. It is designed to incubate the future AI-powered operating models and deliver candidates to the clinic at industry leading speed and success rates.

Purpose

This is medicinal chemistry as it should be — pure design, at speed, with the best tools available. You will work at the frontier of AI-enabled molecular design: evaluating generative proposals, applying deep SAR judgment, and directing CRO synthesis to close DMTA cycles faster than any traditional discovery team. No synthetic bench. No compound store. Just expert chemistry thinking applied at maximum velocity.

The AIRx Medicinal Chemist is a seasoned drug hunter who thrives in lean, autonomous environments and is excited to work at the frontier of AI-driven drug design. Strong SAR intuition, decisiveness, and the confidence to challenge computational outputs are as important as deep chemistry expertise. We are not looking for someone who will defer to the AI. We are looking for someone who will argue with it, stress-test its proposals against hard-won SAR experience, and make better molecules because of that tension. If you have deep chemistry instinct and genuine curiosity about what generative AI can and cannot do — this is where that combination produces real impact.

Accountabilities

Design and optimize drug candidates using deep SAR intuition, multi-parameter optimization, and ADME-embedded design principles
Integrate AI/ML-generated design proposals with medicinal chemistry judgment — critically evaluating computational outputs, not simply accepting them
Partner closely with Computational Chemistry colleagues to close DMTA cycles rapidly; contribute to defining next design iterations
Provide strategic oversight of CRO synthesis programs: define compound lists, review synthetic routes, and ensure quality and delivery timelines
Embed selectivity, developability, and IP considerations into design decisions from the outset
Interpret structural biology data (X-ray, cryo-EM) in partnership with Structural Biology contacts to guide optimization
Stay current with competitive chemical matter and emerging chemistry approaches; proactively apply new methods
Contribute to AI/ML training datasets by ensuring experimental data is captured in standardized, decision-ready format

Qualifications & Competencies

PhD in medicinal chemistry or organic chemistry
12-15+ years of drug discovery experience with a strong track record in lead optimization and candidate nomination
Demonstrated expertise in SAR-driven design, ADME optimization, and multi-parameter optimization across multiple programs
Experience directing CRO-based chemistry programs; proven vendor oversight and delivery management
Working knowledge of AI/ML design tools; ability to critically interpret and challenge computational outputs
Familiarity with structure-based drug design; ability to read and apply protein-ligand structural data
Experience in one or more therapeutic areas across the Takeda Research portfolio preferred
Has operated in SWAT team, rapid-response, or focused asset team environments and knows the difference between productive urgency and firefighting — and thrives in the former

ADDITIONAL INFORMATION

The position will be based in Cambridge, MA. This position is currently classified as “hybrid” by Takeda’s Hybrid and Remote Work policy

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$212,000.00 - $333,190.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Apply Now

Refine Your Search

research chemist jobs in cambridge, ma

Senior Director, AIRx Medicinal Chemistry

Technologist - Research & Development

Analytical Development Senior Research Associate

Scientist I, ASO Process Development and Manufacturing

Biochemistry Research Scientist

9.1. R&D Analytical Chemist

Scientist I, Formulations

Research & Process Development Scientist

Senior Scientist, Medicinal Chemistry, Integrated Drug Discovery

Scientist, Preclinical Development (Onsite)

Formulation/Research Scientist

Senior Scientist, Analytical Development

Mass Spectrometry Research Associate (multiple levels)

Research Associate, Library Synthesis

Associate Scientist (Process R&D)

Scientist

Research Chemist

Scientist - HPLC / KF / GC

Scientist I

Research Associate, Analytical Technical Operations

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