Top 161 Senior research scientist Jobs in Campbell, Ca

Senior Scientist/Principal Scientist, Regulatory T-cell Immunology
Sift Biosciences —San Carlos, CA
- $130,000 - $160,000 a year
- Full-time
- 5 years
- Master's degree
- Bachelor's degree
- Commuter assistance
- Health insurance
Quick Apply
18h
Senior Analytical Scientist
Advantage Technical —Menlo Park, CA
- $85,000 - $100,000 a year
- Temporary
- 3 years
- Doctor of Philosophy
- Senior level
- Health savings account
- AD&D insurance
Quick Apply
3d
Research Scientist
AccuraGen —Milpitas, CA
- Full-time
- Doctor of Philosophy
- 1 year
- Senior level
- Health insurance
- Dental insurance
Quick Apply
Senior Scientist, Biochemistry
NVIGEN —Sunnyvale, CA
- 3 years
- Doctor of Philosophy
- Senior level
Scientist II, Research and Development
Becton Dickinson —San Jose, CA
- Bachelor's degree
- Senior level
Quick Apply
Sr. Research Scientist (3 Years Fixed-Term)
Stanford University —Stanford, CA
- $105,000 - $125,000 a year
- Full-time
- 5 years
- University
- Doctor of Philosophy
Senior Research Associate/Associate Scientist (Temporary to FT)
Aragen —Morgan Hill, CA
- Temporary
- Master's degree
- Bachelor's degree
- Organizational skills
Quick Apply
6d
Scientist II/Senior Scientist, Protein Science
CEDENT —Menlo Park, CA
- Master's degree
- 8 years
- Bachelor's degree
Senior Research Scientist
Toyota Research Institute —Los Altos, CA
- $180,000 - $258,750 a year
- Full-time
- Doctor of Philosophy
- Fair chance
- Senior level
- Health insurance
- Dental insurance
Senior Scientist, Membrane Protein Biochemistry (Onsite - 2 Year Fixed Term)
Stanford University —Stanford, CA
- Extended hours
- Computer literacy
- Master's degree
- Ability to lift 50 pounds
Scientist/Sr. Scientist
Osanni Bio, Inc. —San Carlos, CA
- $140,000 - $170,000 a year
- Full-time
- Doctor of Philosophy
- Team management
- Mentoring
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Senior Research Associate
Altos Labs —Redwood City, CA
- $109,200 - $140,000 a year
- 5 years
- Master's degree
- Bachelor's degree
Life Science Research Professional 1 (1 year fixed-term)
Stanford University —Stanford, CA
- Full-time
- Computer literacy
- Maintenance
- Bachelor's degree
6d
Senior Research Associate – Scientist II, Molecular Biology & Viral Vector Platforms
Adicet Bio —Redwood City, CA
- $50 - $69 an hour
- Full-time
- Bachelor of Science
- Research
- Bachelor's degree
- Free parking
- Paid parental leave
Senior Scientist, Bioinformatics
NVIGEN —Sunnyvale, CA
- Computer Science
- 5 years
- Databases
Senior Research Associate/Associate Scientist, Cell Process Development & Manufacturing
Retro —Redwood City, CA
- $115,000 - $140,000 a year
- Full-time
- Bachelor of Science
- 3 years
- Bachelor's degree
- Paid parental leave
- Paid holidays
Quick Apply
Senior Scientist, Biochemistry & Research Applications
International Flavors & Fragrances —Palo Alto, CA
- $100,436 - $143,480 a year
- Full-time
- 3 years
- Doctor of Philosophy
- Travel
- Paid parental leave
- Paid holidays
2d
ICP-MS Laboratory Research Scientist
Stanford University —Stanford, CA
- $127,211 - $154,222 a year
- Overtime
- 3 years
- Ability to lift 50 pounds
- Analysis skills
Basic Life Research Scientist
Stanford University —Stanford, CA
- $74,000 - $96,000 a year
- Full-time
- Anatomy knowledge
- 3 years
- University
- Health insurance
- Tuition reimbursement
Research Associate
AccuScan Sciences —Milpitas, CA
- Full-time
- Computer literacy
- Bachelor's degree
- 1 year
- Health insurance
- Dental insurance
Quick Apply

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Senior Scientist/Principal Scientist, Regulatory T-cell Immunology

Sift Biosciences
San Carlos, CA

Quick Apply

Job Details

Full-time
$130,000 - $160,000 a year
18 hours ago

Benefits

Commuter assistance
Health insurance
Dental insurance
401(k)
Paid time off
Parental leave
Vision insurance
Flexible schedule

Qualifications

Advanced cell culture techniques
Assay development
Cell Biology
Master's degree
Bachelor's degree
Doctor of Philosophy
Immunology
Managing projects
Pre-clinical studies in drug product development
Oncology

Full Job Description

Senior Scientist/Principal Scientist, Regulatory T-cell Immunology

Sift Bio is building a cutting-edge proprietary platform that combines AI, metagenomics, and high-throughput T-cell screening to discover epitopes that drastically amplify pre-existing immune memory responses, unlocking targeted, effective, and safe treatment for cancers and autoimmune diseases where current therapies fall short. Spinning out of UC Berkeley, the Sift Bio team brings together AI-driven discovery and deep translational immunology, with a proven track record of advancing novel immunotherapies from early concept through IND-enabling development. Collectively, the team has built and scaled high-throughput discovery platforms and led T-cell, peptide, and cell-based immunotherapy programs across leading academic labs, biotech startups, and biopharma. Merging this experience with proprietary datasets and computational pipelines, Sift Bio is shaping a new frontier in immunotherapy, unlocking the power of pre-existing immunity to create a fundamentally new class of treatments for immune dysfunctions. Our ultimate goal is to bring durable disease control to every patient.

We are seeking a Principal Scientist / Senior Scientist, Regulatory T-Cell Immunology to lead preclinical drug discovery, focusing on exploiting immunosuppressive T-cells to treat autoimmune diseases, cancer, and inflammation. This role will design and direct experiments, engineer novel cell therapies, and guide research strategy, manage project timelines, and collaborate with teams across clinical development, pharmacology, and regulatory affairs. This role will report to CTO and be fully onsite at 733 Industrial Road, San Carlos, CA.

KEY RESPONSIBILITIES:

Build, qualify, troubleshoot, and optimize end-to-end Treg suppression assays, including selection of potency readouts such as proliferation, cytokine production, activation markers, and other functional measures.
Create ex vivo assays that measure how antigen-specific T-cells drive suppression, benchmark findings against competing modalities, and diagnose underperforming Treg expansion programs through rigorous experimental design.
Characterize candidate epitopes using standard cellular, molecular, genetic, and immunological approaches, including antigen-specific Treg detection: tetramer/multimer staining and antigen-driven activation-induced marker (AIM) readouts, with matrix/pool deconvolution design for peptide screening.
Design and direct in vitro, ex vivo, and in vivo studies to evaluate mechanism of action, target biology, therapeutic efficacy, safety, persistence, stability, and suppressive function of candidate epitopes.
Develop and implement multi-parameter flow cytometry panels, functional immune assays, lineage-stability readouts, and disease-relevant models to support target validation, lead selection, and translational decision-making.
Lead external collaborations, CRO studies, and academic partnerships as needed, ensuring scientific rigor, timeline adherence, and data quality.

REQUIRED EXPERIENCE:

PhD in Immunology, Cell Biology, or a related field, plus 5+ years of post-doctoral or industry experience. Alternatively, a Master’s degree with 8 to 10+ years of biotech experience. Job title will commensurate with experience.
Excited by and scientifically driven to overcome complex technical challenges that will contribute to safe treatment for cancers and autoimmune diseases.
Deep hands-on experience with primary human Tregs and peripheral blood mononuclear cells (PBMCs), including working knowledge of best methods for isolation, expansion, and activation of Tregs/PBMCs
Prior experience developing antigen-specific tolerance or Treg-based approaches, peptide, protein, or engineered cell therapy setting, spanning antigen selection through in vivo functional readouts
Strong T-cell biology expertise, with extensive experience characterizing low frequency (<0.1%) CD8 and CD4 responses, and knowledge of how to improve readouts of rare T-cell responses
Knowledge of how to qualify Treg-based assays with known controls, for how to “rank” performance of manipulations -> impact Treg biology, and methods for how to overcome limitations of characterizing rare T-cell populations
Proven ability to contribute to the scientific direction of a project.
Strong written and oral communication skills for technical and non-technical audiences.
Conscientious team member with experience taking and giving constructive feedback.
Must be comfortable with executing lab work full time in a preclinical-stage startup environment, and capable of finding solutions to tough problems with limited resources.

PREFERRED QUALIFICATIONS:

Familiarity with HLA-transgenic mouse models and/or human PBMC xenograft/humanized models, and a clear-eyed view of which models are best suited to readout effects of an antigen-directed tolerance approach
Experience building immunotherapies for oncology or autoimmune disease settings

Sift Bio is pleased to offer competitive:

Medical, Dental, and Vision health plans.
Flexible time off.
Bonus and Equity plans.
Commuter transit benefit.
401(k) retirement plan.

Sift Bio is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind as outlined by applicable laws.

Pay: $130,000.00 - $160,000.00 per year

Benefits:

401(k)
Dental insurance
Flexible schedule
Health insurance
Paid time off
Parental leave
Vision insurance

Application Question(s):

How many years of industry or post-doc experience do you have?
Please tell us about your experience with preclinical drug discovery, focusing on exploiting immunosuppressive T-cells ideally to treat autoimmune diseases, cancer, and inflammation.

Education:

Bachelor's (Required)

Location:

San Carlos, CA 94070 (Preferred)

Ability to Relocate:

San Carlos, CA 94070: Relocate before starting work (Required)

Work Location: In person

Quick Apply

Refine Your Search

senior research scientist jobs in campbell, ca

Senior Scientist/Principal Scientist, Regulatory T-cell Immunology

Senior Analytical Scientist

Research Scientist

Senior Scientist, Biochemistry

Scientist II, Research and Development

Sr. Research Scientist (3 Years Fixed-Term)

Senior Research Associate/Associate Scientist (Temporary to FT)

Scientist II/Senior Scientist, Protein Science

Senior Research Scientist

Senior Scientist, Membrane Protein Biochemistry (Onsite - 2 Year Fixed Term)

Scientist/Sr. Scientist

Senior Research Associate

Life Science Research Professional 1 (1 year fixed-term)

Senior Research Associate – Scientist II, Molecular Biology & Viral Vector Platforms

Senior Scientist, Bioinformatics

Senior Research Associate/Associate Scientist, Cell Process Development & Manufacturing

Senior Scientist, Biochemistry & Research Applications

ICP-MS Laboratory Research Scientist

Basic Life Research Scientist

Research Associate

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