Top 16 Staff software engineer Jobs in Chesterfield, Mo

Staff Software Engineer
Merck KGaA —St. Louis, MO
- $110,500 - $165,900 a year
- Computer Science
- System design
- Mid-level
- Health insurance
- Paid time off
3d
Java Developer (web services) - 100% Remote - Public Trust
ATTAINX INC —Saint Charles, MO
- $75,000 - $92,000 a year
- Remote
- Computer Science
- System design
- Mid-level
- Disability insurance
- Health insurance
1d
Senior Embedded Software Engineer
Leonardo DRS —Bridgeton, MO
- $93,121 - $125,713 a year
- Full-time
- Hybrid work
- Computer Science
- 5 years
- Office
- Paid parental leave
- Health savings account
Manager Software Engineering
Leonardo DRS —Bridgeton, MO
- $130,828 - $176,618 a year
- Full-time
- Hybrid work
- Computer science
- 5 years
- Office
- Paid parental leave
- Health savings account
14d
Web Developers
Swip Systems —St. Louis, MO
- Email
- Customer service
- Mid-level
- Office
Embedded Software Engineer
Avery Weigh-Tronix —St. Louis, MO
- $78,400 - $130,000 a year
- Full-time
- Remote
- Engineering
- Analysis skills
- Math
Software Developer - Intermediate
RIVIDIUM —St. Louis, MO
- Full-time
- Management
- Computer Science
- Mid-level
ADMS Engineer
Ameren —St. Louis, MO
- $84,400 - $204,400 a year
- Full-time
- Hybrid work
- Computer science
- Computer Science
- System design
- Paid parental leave
- Paid holidays
Grid Solutions Engineer
Ameren —St. Louis, MO
- $84,400 - $204,400 a year
- Full-time
- Hybrid work
- Computer science
- Computer Science
- System design
- Paid parental leave
- Paid holidays
1d
Software Developer III - DEW/Electrical Engineering Software (C#, Big Data)
National Information Solutions Cooperative (NISC) —St. Louis, MO
- Hybrid work
- Computer science
- Computer Science
- Research
- Health savings account
- Paid holidays
1d
Staff GTM Engineer
Buildkite —Pacific, MO
- System design
- SQL
- Senior level
- Opportunities for advancement
Sr. Application Developer
Sovereign Technologies —St. Louis, MO
- Computer science
- Computer Science
- Mid-level

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Staff Software Engineer

Merck KGaA -
St. Louis, MO

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Job Details

$110,500 - $165,900 a year
3 days ago

Benefits

Health insurance
Paid time off

Qualifications

AI models
Containerization systems
TensorFlow
Data model design
Statistics
Software engineering
Data Integration (Data management)
Computer Science
Continuous Delivery (CD) implementation
Data modeling projects
Data validation techniques
PyTorch
Data quality assurance
NumPy
System design
NoSQL
Git
Public Cloud
Mid-level
AI platforms (beyond public GPTs)
Scalable systems
Computational framework
Schema design
3 years
SQL
Pandas
Event-driven architecture
Data Architecture Design (Architecture design skills)
Production systems
Collaboration with product development teams

Full Job Description

Work Your Magic with us! Start your next chapter and join MilliporeSigma.

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.

Your Role:

We are looking for a Staff Applied AI Engineer to build scalable, production-grade backend applications that leverage large and complex datasets. This role is software engineering first, with a strong emphasis on designing reliable systems that ingest, process, and serve data to power modern applications and AI-driven solutions.

You will work closely with product managers, software engineers, data scientists, and ML engineers to build robust backend services, data-intensive applications, and production AI systems. Success in this role requires strong software engineering fundamentals, practical experience working with data throughout its lifecycle, and the ability to design systems that are scalable, maintainable, and reliable in production.

Essential Job Functions:

Lead technical strategy for AI/LLM systems across multiple products
Architect retrieval, orchestration, agentic, and evaluation systems that run reliably in production
Set the standards for AI safety, evaluation, observability, and responsible rollout in a regulated context
Mentor Junior-level engineers into strong AI engineers; Employ AI Native development skills to multiply the productivity (Claude, etc.)
Lead the frontier: evaluate new models, techniques, and tools, and bring the right ones into the team
Design, develop, and maintain scalable Python applications and backend services.
Build systems that ingest, validate, transform, and manage structured and unstructured data in production environments.
Design data models and storage solutions that support scalable, high-performance applications.
Develop reusable components for data processing, validation, enrichment, and feature generation.

Who You Are

Minimum Qualifications:

Bachelor’s degree in Computer Science, Engineering, Data Science, or a related quantitative field.
At least 3 years of hands-on experience in machine learning, data science, search relevance, or ranking systems.

Preferred Qualifications:

10+ years of software engineering experience, with deep recent time leading production AI/LLM systems
Proven expertise in Python and ML frameworks (MLFlow, TensorFlow, PyTorch, Scikit- learn, or equivalent).
Strong background in statistical analysis, data exploration, and working with large-scale datasets.
Experience with feature engineering, data preprocessing, and data
Seasoned hands-on coder; still writes production Python regularly
Seasoned system designer for AI systems at scale — retrieval, agents, evaluation, latency, and cost, vector databases/pipelines
Strong experience building and maintaining production-grade backend applications.
Experience designing and developing RESTful APIs and distributed systems.
Strong SQL skills and experience working with relational databases; familiarity with NoSQL databases or modern data storage technologies is a plus.
Solid understanding of data engineering fundamentals, including data quality, validation, transformation, modeling, and efficient storage.
Experience designing systems that process large datasets reliably and efficiently.
Experience with cloud platforms such as Google Cloud Platform (GCP) or AWS.
Experience using Docker, Git, CI/CD pipelines, automated testing frameworks, and modern software engineering best practices.
Core engineering stack
Languages: Python, REST API, Pandas, NumPy
Cloud and infrastructure: AWS Services and/or GCP, Kubernetes, Bedrock
Distributed systems: event-driven architectures, including Kafka
Orchestration Frameworks: LangGraph, LangChain, AirFlow, etc.
Vector Databases like Qdrant

Nice to have Skills:

Experience with Kubernetes and container orchestration.
Familiarity with event-driven architectures and messaging platforms such as Kafka.
Familiarity with ML model deployment and inference pipelines

Location

This role can be based in either our St. Louis, MO or Burlington, MA office and requires a weekly onsite presence

Pay Range for this position: $110,500 - $165,900. The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here: https://careers.emdgroup.com/us/en/benefits

What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!

Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!

Apply Now

Refine Your Search

staff software engineer jobs in chesterfield, mo

Staff Software Engineer

Java Developer (web services) - 100% Remote - Public Trust

Senior Embedded Software Engineer

Manager Software Engineering

Web Developers

Embedded Software Engineer

Software Developer - Intermediate

ADMS Engineer

Grid Solutions Engineer

Software Developer III - DEW/Electrical Engineering Software (C#, Big Data)

Staff GTM Engineer

Sr. Application Developer

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