Top 3 (mass spectrometry) Jobs in Columbus

Scientist-II Developability & Preformulation
Sarepta Therapeutics —Columbus, OH
- $106,400 - $133,000 a year
- Full-time
- 6 years
- Engineering
- Doctor of Philosophy
Chemist
Battelle —Columbus, OH
- Full-time
- Hybrid work
- Background check
- Bachelor of Science
- Bachelor's degree
- Wellness program
- Health insurance
Scientist I, Analytical Development
Forge Biologics —Columbus, OH
- Full-time
- Master's degree
- Bachelor's degree
- Continuous improvement
- Paid parental leave
- Disability insurance
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Scientist-II Developability & Preformulation
Sarepta Therapeutics —Columbus, OH
Proficiency in statistical or data analysis tools (e.g., JMP, GraphPad, SigmaPlot) is a plus. The Scientist II will contribute formulation recommendations to…
$106,400 - $133,000 a year
Chemist
Battelle —Columbus, OH
B.S. or M.S. degree in Chemistry, Material Science, Chemical Engineering, or related field. If applicable, Battelle will provide reasonable accommodations based…

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(mass spectrometry) jobs near columbus

Scientist-II Developability & Preformulation

Sarepta Therapeutics -
Columbus, OH

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Job Details

Full-time
$106,400 - $133,000 a year

Qualifications

Developing new product formulations
Formulation chemistry

Full Job Description

Why Sarepta? Why Now?

The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.

We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.

What Sarepta Offers

At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:

Physical and Emotional Wellness
Financial Wellness
Support for Caregivers

For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us

The Importance of the Role

The Early Research and Process Development (ERPD) group is seeking a Scientist II with experience in biologics preformulation and developability assessment, with a focus on proteins, antibodies, and antibody-oligonucleotide conjugates (AOCs). This individual will support the assessment of developability for lead molecules through comprehensive evaluations, including biophysical characterization, forced degradation, and short-term, long-term, and in-use stability studies.

The successful candidate will leverage high-throughput formulation tools and workflows to characterize product stability across a broad range of conditions, including process buffers, excipients, concentrations, hold times, and temperatures. In collaboration with Analytical Development, the candidate will help define quality attributes and implement stability-indicating assays appropriate for early-stage programs. The Scientist II will also consider route-of-administration factors, such as subcutaneous delivery, during early formulation assessments (e.g., stability and viscosity at high concentrations, potential enabling approaches).

This role requires strong cross-functional engagement, working closely with Upstream and Downstream Process Development, High-Throughput Automation, and CMC Drug Substance/Drug Product teams to foster a collaborative environment that enables the advancement of robust and scalable manufacturing processes. The Scientist II will contribute formulation recommendations to research, pilot-scale, and commercial-scale manufacturing groups and generate scientifically rigorous data packages to inform preclinical and early clinical development and enable downstream CMC strategy for Sarepta’s genetic therapy engine.

Sarepta provides a creative culture that invites you to be the best that you can be and is committed to making a difference in patient’s lives. Join us at the Genetic Therapy Center of Excellence here in Easton, Ohio.

The Opportunity to Make a Difference

- Plan and execute formulation experiments to assess and optimize the stability of key intermediates and final products throughout the manufacturing process.
- Establish developability profiles for candidate molecules, incorporating considerations for route-of-administration.
- Identify formulation-relevant critical quality attributes for key intermediates and drug product candidates and guide the development of stability-indicating assays to monitor them.
- Contribute scientific recommendations regarding formulation technologies and instrumentation.
- Support cross-functional teams by providing recommendations on product handling and storage considerations.
- Prepare and review methods, protocols, and technical reports for regulatory submissions or technology transfer.
- Train and support Research Associates in experimental execution, troubleshooting, and data interpretation.

More about You

Degree in Biochemistry, Biochemical Engineering, Bioengineering, or Chemical Engineering

Ph.D. with 3-5 years or M.S. with 6-8 years of biologics formulation experience,

Experience with biologics formulation (e.g., mAbs) is required. Experience with AOCs or antibody-drug conjugates (ADCs) formulation is a plus.

Hands-on experience with protein formulation technologies (e.g., Unchained Labs Big Tuna/Big Kahuna/Junior, Sartorius AMBR Crossflow, Pendotech 5TFF, Repligen KR2i, etc.).

Experience with stability and analytical assays to monitor product quality, including SEC, RP, CE-SDS, cIEF, DLS, DSF, MALS, and mass spectrometry.

Experience with high-concentration formulation challenges (e.g., viscosity mitigation strategies, excipient screening, protein-protein interaction understanding)

Experience applying Design of Experiments (DoE) principles to formulation development is a plus.

Demonstrated ability to work effectively in cross-functional teams and communicate scientific findings to internal stakeholders.

Proficiency in statistical or data analysis tools (e.g., JMP, GraphPad, SigmaPlot) is a plus.

Prior experience in therapeutic protein discovery or biochemistry research.

Excellent written and verbal communication skills.

What Now?

We’re always looking for solution-oriented, critical thinkers.

So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.

#LI-Onsite

This position requires work on site at one of Sarepta’s facilities in the United States.

The targeted salary range for this position is $106,400 - $133,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.

Apply Now

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(mass spectrometry) jobs in columbus

Scientist-II Developability & Preformulation

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