Top 12 Lead application systems engineer Jobs in Columbus

Lead Automation Engineer, MES & Digital Systems - Project Farma
PerkinElmer —Columbus, OH
- $80,000 - $198,000 a year
- Full-time
- Remote
- Engineering
- Travel
- Mentoring
Lead Enterprise Systems Engineer
Northwest Bank —Columbus, OH
- Weekends as needed
- Azure
- System design
- Research
Quick Apply
2d
Lead Electrical Systems Engineer
Leidos —Ohio
- $131,300 - $237,350 a year
- Full-time
- Hybrid work
- Engineering
- Master's degree
- Team management
3d
Lead Electrical Systems Engineer
Leidos —Ohio
- $131,300 - $237,350 a year
- Full-time
- Hybrid work
- Engineering
- Master's degree
- Team management
3d
Lead Electrical Systems Engineer
Leidos —Ohio
- $131,300 - $237,350 a year
- Full-time
- Hybrid work
- Engineering
- Master's degree
- Team management
3d
Network Engineer, ENS Strategic Lead
Meta —New Albany, OH
- $193,000 - $271,000 a year
- Computer science
- Computer Science
- 5 years
3d
Real Time Operations Solutions Engineer Principal- Lead
AEP Service Corporation —New Albany, OH
- $116,255 - $177,503 a year
- Overtime
- 6 years
- Research
- Office
- Tuition reimbursement
4d
Lead Control Systems Engineer
Thermo Systems LLC —Pataskala, OH
- $76,140 - $105,500 a year
- Full-time
- Bachelor of Science
- Travel
- US work authorization
- Travel reimbursement
- Paid holidays
Quick Apply
Global Engineering Process Lead, Sr. Manager
Vertiv —Westerville, OH
- Office
- Master's degree
- Analysis skills
1d
Tech Lead (Shopify eCommerce Platform)
Vertiv —Westerville, OH
- Computer science
- Oracle
- Computer Science

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Lead Automation Engineer, MES & Digital Systems - Project Farma
PerkinElmer —Columbus, OH
We cannot employ anyone with an invalid driver's license. The Lead Automation Engineer, MES & Digital Systems provides subject matter expertise in the design,…
$80,000 - $198,000 a year
Lead Enterprise Systems Engineer
Northwest Bank —Columbus, OH
Ability to establish courses of action for self to accomplish specific goals, develop and use tracking systems for monitoring own work progress, and effectively…
Quick Apply
2d

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lead application systems engineer jobs near columbus

Lead Automation Engineer, MES & Digital Systems - Project Farma

PerkinElmer -
Columbus, OH

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Job Details

Full-time
$80,000 - $198,000 a year

Qualifications

Systems integration
Industrial automation
GAMP
Requirements specification
Requirements design
FDA 21 CFR Part 11
CMMS
Manufacturing facility experience
Bachelor's degree in engineering
Pharmaceutical company experience
Requirements analysis
Enterprise Integration
Batch records
Systems engineering
Supervisory control and data acquisition (SCADA)
Data integration architecture
Biomedical regulatory compliance
Systems architecture experience within manufacturing
Design (software development lifecycle)
Product design documentation
Pharmaceutical manufacturing facility experience

Full Job Description

Project Farma will consider candidates' ranging from 4 - 16+ years' relevant experience. The successful candidate will reside in one of Project Farma's primary markets and be willing to travel domestically, to meet client project requests.

Market locations include but are not limited to: Boston, Philadelphia, DMV, Northern New Jersey, Chicago, Indianapolis, Columbus, St Louis, Kansas City, Raleigh-Durham, Houston, Dallas, Boulder, Portland, San Francisco, San Diego, and Los Angeles.

The Lead Automation Engineer, MES & Digital Systems provides subject matter expertise in the design, implementation, and lifecycle management of digital systems across biologics, pharmaceutical, and novel therapy manufacturing facilities. This is a fully billable role, requiring experience with various MES platforms, Data Repositories, Serialization and integration to manufacturing applications (ERP, LIMS, CMMS, etc) and the ability to author, interpret, and lead documentation such as URS, FRS, Functional Narratives, and detailed system architecture designs.

In addition to technical experience, the Lead Automation Engineer, MES & Digital Systems acts as client liaison during delivery of Project Farma service engagements. They are strategically responsible for client satisfaction through project delivery while maintaining and growing client relationships. Key

Responsibilities
Automation Design & Architecture

Develop system architectures and data flows for biologics, pharmaceutical, and advanced therapy manufacturing (DCS, PLC/SCADA, MES, historians, network layers).
Develop product recipe strategies across the full application layer of ERP, MES and DCS Batch.
Detailed knowledge of Master data and how to define and control Master Data.
Create ISA-88/ISA-95-aligned architecture diagrams, inc Application and Data Flow diagrams.
Ensure architecture supports scalability, cybersecurity, data integrity, and multi-product flexibility.

URS / FRS / Design Documentation

Lead the creation, review, and approval of: URS (User Requirements Specifications), FRS (Functional Requirements Specifications), DS / DDS (Design Specifications), Functional & Control Narratives, Recipe Design Documentation (ISA-88 compliant), Automation Standards & Engineering Guidelines
Work cross functionally to translate process requirements into robust digital system design documents.

Digital System Implementation

Configure, program, and deploy Digital System within the manufacturing environment.
Develop, modify, and test MES (eBR, RbE, eLogbooks, Equipment Tracking, Weigh & Dispense), LIMS, Serialization and CMMS application functionality.
Support integration of OEM skids: bioreactors, chromatography systems, filtration skids, CIP/SIP, and fill finish equipment.

Commissioning, Validation & GMP Compliance

Detailed knowledge of FAT, SAT, IQ/OQ, and PQ protocols in alignment with GAMP 5 and 21 CFR Part 11.
2/2
Ensure all changes meet data integrity requirements, change control processes, and validation lifecycle rules.
Lead deviation investigations, CAPAs, and risk assessments related to Digital systems.

Manufacturing & Operations Support

Serve as SME for troubleshooting, system optimization, batch failure analysis, and performance enhancements.
Support 24/7 operations through structured root cause analysis and resolution of Digital System issues.
Develop long-term lifecycle plans for upgrades, patches, and system expansions.

Cross Functional Leadership

Collaborate with IT/OT, process engineering, MSAT, quality, and capital project teams to deliver integrated system solutions.
Manage vendors, system integrators, and OEMs; review design packages and ensure alignment with internal standards.
Mentor junior engineers and act as technical SME during audits and regulatory inspections.

Experience Required

Bachelor’s degree in Engineering (Automation, Electrical, Chemical, Mechanical, or related).
Minimum 4-16+ years in automation engineering within GMP life sciences (biotech, pharma, ATMP).
Expert-level experience with various MES platforms, Data Repositories, Serialization and integration to manufacturing applications (ERP, LIMS, CMMS, etc).
Proven ability to author, interpret, and own URS/FRS/DS documentation.
Experience designing system applications and data flows across the full spectrum of manufacturing applications.
Strong understanding of ISA-88 batch control, ISA-95 manufacturing hierarchy, and GAMP 5.
Hands-on experience supporting biologics and sterile/aseptic manufacturing environments.
Understanding multisite standards for global manufacturers

Other Preferred

Strong communicator and influencer across engineering, quality, IT/OT, and manufacturing.
Structured thinker with advanced troubleshooting and problem solving skills.
Skilled at managing multiple priorities in a high pressure, regulated environment.
Demonstrated leadership and mentorship abilities.

Project Farma is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability status, age, or veteran status or any other characteristics protected by applicable law. PerkinElmer is committed to a culturally diverse workforce.

Applicants must be authorized to work in the United States on a full-time basis. We will not sponsor applicants for current or future work visas for this position. This position may require significant travel to support project and business needs. We cannot employ anyone with an invalid driver's license.

The annual compensation range for this full-time position is $80,000 - $198,000. The final base pay offered to the successful candidate will be determined by factors including internal equity, work location, as well as individual qualifications, such as job-related skills, experience, and relevant education or training.

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lead application systems engineer jobs in columbus

Lead Automation Engineer, MES & Digital Systems - Project Farma

Lead Enterprise Systems Engineer

Lead Electrical Systems Engineer

Lead Electrical Systems Engineer

Lead Electrical Systems Engineer

Network Engineer, ENS Strategic Lead

Real Time Operations Solutions Engineer Principal- Lead

Lead Control Systems Engineer

Global Engineering Process Lead, Sr. Manager

Tech Lead (Shopify eCommerce Platform)

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