Top 51 Sr research scientist Jobs in Columbus

Senior Scientist, Developability & Preformulation
Sarepta Therapeutics —Columbus, OH
- $118,000 - $147,500 a year
- Full-time
- Engineering
- Doctor of Philosophy
- US work authorization
Clinical Genomics Variant Scientist - Next Generation Seq
Nationwide Children's Hospital —Columbus, OH
- Full-time
- Mid-level
- Ability to climb stairs
- Master's degree
Research Senior Technician
The Ohio State University —Columbus, OH
- $17.31 - $22.77 an hour
- Full-time
- Background check
- Computer science
- Computer Science
Cyber Research Scientist (Early Career)
Battelle —Columbus, OH
- $75,000 - $105,000 a year
- Full-time
- Hybrid work
- Computer science
- Computer Science
- Office
- Wellness program
- Health insurance
6d
Laboratory Research Technician - Advanced Materials
Battelle —Columbus, OH
- Full-time
- Hybrid work
- Microsoft Excel
- Writing skills
- Mid-level
- Wellness program
- Health insurance
Post Doctoral Scientist - Institute for Mental and Behavioral Health Research
Nationwide Children's Hospital —Columbus, OH
- Full-time
- Management
- Computer literacy
- Ability to climb stairs
Post Doctoral Scientist - Cardiovascular Research
Nationwide Children's Hospital —Columbus, OH
- Full-time
- Computer literacy
- Ability to climb stairs
- Doctor of Philosophy
Education Program Senior Specialist
The Ohio State University —Columbus, OH
- $51,500 - $67,250 a year
- Full-time
- Background check
- Classroom
- Pass drug screening
6d
Post Doctoral Scientist - AAV Gene Therapy/Extracellular Vesicles/Translational Research
Nationwide Children's Hospital —Columbus, OH
- Full-time
- Computer literacy
- Ability to climb stairs
- Doctor of Philosophy
R&D Senior Associate, Federal Tax Consulting Services
Crowe —Columbus, OH
- $75,500 - $149,600 a year
- Full-time
- Hybrid work
- CPA
- Engineering
- Mid-level
Quick Apply
8d
Sr. Environmental Planner - (ODOT)
Jacobs —Columbus, OH
- $111,100 - $173,500 a year
- Hybrid work
- Clean driving record
- Microsoft Excel
- Research
- Paid holidays
- Health insurance
Director of Antibody Therapeutics (Professor)
The Ohio State University Wexner Medical Center —Columbus, OH
- Online Application
- Background check
- Medicine
- Pass drug screening
- Health insurance
- Dental insurance
20h
Senior Data Scientist, Emerging Technology and Innovation
The Hartford —Columbus, OH
- $110,720 - $166,080 a year
- Full-time
- Hybrid work
- Azure
- Computer Science
- 5 years
Post Doctoral Scientist - Cardiovascular Development
Nationwide Children's Hospital —Columbus, OH
- Full-time
- Computer literacy
- Ability to climb stairs
- Doctor of Philosophy
Physician - Department of Urology, Vice Chair for Research (Open Rank/Track Faculty)
The Ohio State University Wexner Medical Center —Columbus, OH
- Online Application
- Background check
- Medicine
- Pass drug screening
- 403(b) matching
- Relocation assistance
20h
Chemical Engineer
Battelle —Columbus, OH
- Full-time
- Hybrid work
- Background check
- Bachelor of Science
- Office
- Wellness program
- Health insurance
Faculty Position– Center for Childhood Cancer Research and Scientific Director of Brain Tumor Program
Nationwide Children's Hospital —Columbus, OH
- Full-time
- Medicine
- OSHA
- Adults
Faculty - Center for Innate Immunity and Inflammation, OSU Comprehensive Cancer Center (Open Rank/Track)
The Ohio State University Wexner Medical Center —Columbus, OH
- Online Application
- Background check
- Medicine
- Pass drug screening
- Health insurance
- Dental insurance
20h
Lead Data Scientist
Safelite Group —Columbus, OH
- Full-time
- Hybrid work
- Computer Science
- Office
- Mentoring
12d
IGM Bioinformatics Scientist Senior
Nationwide Children's Hospital —Columbus, OH
- Full-time
- Computer Science
- 5 years
- Ability to climb stairs

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sr research scientist jobs near columbus

Senior Scientist, Developability & Preformulation

Sarepta Therapeutics -
Columbus, OH

Apply Now

Job Details

Full-time
$118,000 - $147,500 a year

Qualifications

Drug development research projects
Laboratory experiment design
Stability testing
Biochemistry
Data visualization software proficiency
Chemical Engineering
Developing new product formulations
Handling proteins
Stability studies in drug product development
Engineering
Design of experiments
Protein analysis (analytical chemistry specialty)
Biomedical Engineering
Formulation chemistry
Technical report writing
Chemical scale-up projects
Biochemical Engineering
Collaboration with product development teams
Doctor of Philosophy
Scientific protocols
Technology transfer (scale-up process)
Master of Science
Pharmaceutical analysis
Engineering research
Capillary electrophoresis
Mass spectrometers (MS)
Chemistry, manufacturing & controls
Collaboration with manufacturing teams
Regulatory submission editing and review
Research assistant mentoring

Full Job Description

Why Sarepta? Why Now?

The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.

We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.

What Sarepta Offers

At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:

Physical and Emotional Wellness
Financial Wellness
Support for Caregivers

For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us

The Importance of the Role

The Early Research and Process Development (ERPD) group is seeking a Senior Scientist with deep expertise in biologics preformulation and developability assessment, with a focus on proteins, antibodies, and antibody-oligonucleotide conjugates (AOCs). This individual will be responsible for assessing the developability of lead molecules through comprehensive evaluations, including biophysical characterization, forced degradation, and short-term, long-term, and in-use stability studies.

The successful candidate will leverage high-throughput formulation tools and workflows to characterize product stability across a broad range of conditions, including process buffers, excipients, concentrations, hold times, and temperatures. In collaboration with Analytical Development, the candidate will help define quality attributes and implement stability-indicating assays appropriate for early-stage programs. The Senior Scientist will also consider route-of-administration factors, such as subcutaneous delivery, during early formulation assessments (e.g., stability and viscosity at high concentrations, potential enabling approaches).

This role requires strong cross-functional engagement, working closely with Upstream and Downstream Process Development, High-Throughput Automation, Nonclinical Manufacturing, and CMC Drug Substance/Drug Product teams to foster a collaborative environment that enables the advancement of robust and scalable manufacturing processes. The Senior Scientist will provide formulation guidance to research, pilot-scale, and commercial-scale manufacturing groups generating scientifically rigorous data packages to inform preclinical and early clinical development and enable downstream CMC strategy for Sarepta’s genetic therapy engine.

Sarepta provides a creative culture that invites you to be the best that you can be and is committed to making a difference in patient’s lives. Join us at the Genetic Therapy Center of Excellence here in Easton, Ohio.

The Opportunity to Make a Difference

Plan and execute formulation experiments to assess and optimize the stability of key intermediates and final products throughout the manufacturing process.
Establish developability profiles for candidate molecules, incorporating considerations for route-of-administration.
Identify formulation-relevant critical quality attributes for key intermediates and drug product candidates, and guide the development of stability-indicating assays to monitor them.
Provide expert guidance on formulation technologies and instrumentation to support informed decision-making.
Offer product handling guidance to cross-functional teams.
Prepare and review methods, protocols, and technical reports for regulatory submissions or technology transfer.
Train and mentor Research Associates in process design, experimental execution, troubleshooting, and data interpretation.

More about You

Degree in Biochemistry, Biochemical Engineering, Bioengineering, or Chemical Engineering Ph.D. with 4 years of biologics formulation experience, or M.S. with

- 9 years.
- Experience with AOCs or antibody-drug conjugates (ADCs) is a plus.
Proven technical expertise in protein formulation technologies (e.g., Unchained Labs Big Tuna/Big Kahuna/Junior, Sartorius AMBR Crossflow, Pendotech 5TFF, Repligen KR2i, etc.).
Expertise in stability and analytical assays to monitor product quality, including SEC, RP, CE-SDS, cIEF, DLS, DSF, MALS, and mass spectrometry.
Experience with high-concentration formulation challenges (e.g., viscosity mitigation strategies, excipient screening, protein-protein interaction understanding)
Experience applying Design of Experiments (DoE) principles to formulation development is a plus.
Track record of cross-functional collaboration and providing scientifically informed guidance to internal and external teams.
Proficiency in statistical or data analysis tools (e.g., JMP, GraphPad, SigmaPlot) is a plus.
Prior experience in therapeutic protein discovery or biochemistry research.
Excellent written and verbal communication skills.

What Now?

We’re always looking for solution-oriented, critical thinkers.

So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.

#LI-Onsite

Blank

This position requires work on site at one of Sarepta’s facilities in the United States.

The targeted salary range for this position is $118,000 - $147,500 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.

Apply Now

Refine Your Search

sr research scientist jobs in columbus

Senior Scientist, Developability & Preformulation

Clinical Genomics Variant Scientist - Next Generation Seq

Research Senior Technician

Cyber Research Scientist (Early Career)

Laboratory Research Technician - Advanced Materials

Post Doctoral Scientist - Institute for Mental and Behavioral Health Research

Post Doctoral Scientist - Cardiovascular Research

Education Program Senior Specialist

Post Doctoral Scientist - AAV Gene Therapy/Extracellular Vesicles/Translational Research

R&D Senior Associate, Federal Tax Consulting Services

Sr. Environmental Planner - (ODOT)

Director of Antibody Therapeutics (Professor)

Senior Data Scientist, Emerging Technology and Innovation

Post Doctoral Scientist - Cardiovascular Development

Physician - Department of Urology, Vice Chair for Research (Open Rank/Track Faculty)

Chemical Engineer

Faculty Position– Center for Childhood Cancer Research and Scientific Director of Brain Tumor Program

Faculty - Center for Innate Immunity and Inflammation, OSU Comprehensive Cancer Center (Open Rank/Track)

Lead Data Scientist

IGM Bioinformatics Scientist Senior

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