Top 537 Senior principal scientist Jobs in Danvers Ma

MSAT Process Science Senior Scientist, Investigations
Vertex Pharmaceuticals —Boston, MA
- $120,800 - $181,200 a year
- Full-time
- Hybrid work
- 5 years
- Engineering
- Master's degree
- Loan repayment program
- Dental insurance
Stem Cell Principal Research Scientist, T1D Discovery Biology
Vertex Pharmaceuticals —Boston, MA
- $147,200 - $220,800 a year
- Full-time
- Master's degree
- Bachelor's degree
- Doctor of Philosophy
- Loan repayment program
- Dental insurance
Senior Principal Scientist, Immune Cell Depletion Discovery Group, Immunology Discovery Research
AbbVie —Cambridge, MA
- $160,500 - $305,000 a year
- Full-time
- 6 years
- Bachelor of Science
- Bachelor's degree
- Paid holidays
- Health insurance
QC Senior/Principal Scientist, Analytical Method Validation
Genezen —Lexington, MA
- $120,000 - $160,000 a year
- Microsoft Word
- Computer literacy
- 8 years
- Health savings account
- AD&D insurance
Quick Apply
Senior Principal Scientist
Sanofi —Cambridge, MA
- $148,500 - $214,500 a year
- Hybrid work
- 7 years
- Doctor of Philosophy
- Senior level
- Parental leave
Senior/Principal Scientist, Analytical Cell Line Engineering and Bioassay Development
Takeda Pharmaceutical —Lexington, MA
- $154,400 - $242,550 a year
- Weekends as needed
- 11+ years
- Master's degree
- Bachelor's degree
- Paid holidays
- Disability insurance
10d
Senior Scientist II/Principal Scientist, Molecular Cloning Technologies
Flagship Pioneering, Inc. —Cambridge, MA
- $143,000 - $214,500 a year
- Data analysis skills
- Doctor of Philosophy
- Mentoring
- Retirement plan
Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)
Novartis —Cambridge, MA
- $126,000 - $261,000 a year
- Full-time
- Hybrid work
- 5 years
- English
- Master's degree
- Health insurance
- 401(k) matching
Senior Principal Scientist, Analytical Sciences
Eli Lilly —Watertown, MA
- $71,250 - $187,000 a year
- Full-time
- 7 years
- Bachelor of Science
- Analysis skills
- Health insurance
- Dental insurance
4d
Senior/Principal Scientist, Small Molecule Therapeutics
Lila Sciences —Cambridge, MA
- $148,000 - $208,000 a year
- 6 years
- Bachelor of Science
- Bachelor's degree
Quick Apply
Senior Principal Scientist I - Functional Biomarkers
Sanofi —Cambridge, MA
- $148,500 - $214,500 a year
- 7 years
- Master's degree
- Analysis skills
- Parental leave
Senior Principal Scientist/Principal Scientist, Real-World Evidence & Disease Genomics
Sanofi —Cambridge, MA
- $148,500 - $214,500 a year
- AWS
- Doctor of Philosophy
- Senior level
- Parental leave
Senior/Principal Scientist Cell Based Potency Assay
Takeda Pharmaceutical —Lexington, MA
- $154,400 - $242,550 a year
- Full-time
- Bachelor of Science
- 3 years
- Bachelor's degree
- Paid holidays
- Disability insurance
4d
Senior / Principal Scientist, Immunology & Pharmacology
PharmaEssentia U.S.A. —Bedford, MA
- $160,000 - $190,000 a year
- Full-time
- 6 years
- Analysis skills
- Doctor of Philosophy
- Health insurance
- 401(k) matching
Senior Principal Scientist / Assoc Director, Oncology Translational Research
Novartis —Cambridge, MA
- $138,600 - $257,400 a year
- Full-time
- 5 years
- Analysis skills
- Doctor of Philosophy
- Health insurance
- 401(k) matching
Principal / Senior Principal Scientist, Small Molecule Therapeutics
Lila Sciences —Cambridge, MA
- $156,000 - $246,000 a year
- Bachelor of Science
- Bachelor's degree
- Machine learning
Quick Apply
20h
Principal Scientist II/Senior Principal Scientist, PK Sciences Clinical Pharmacology Artificial Intelligence (AI) Lead (dual level posting)
Novartis —Cambridge, MA
- $119,700 - $257,400 a year
- Full-time
- Doctor of Philosophy
- Senior level
- Communication skills
- Health insurance
- 401(k) matching
Contract Research Associate/Sr. Research Associate (Discover Chemistry)
Commonwealth Sciences —Burlington, MA
- Contract
- Bachelor of Science
- Bachelor's degree
- Entry level
20h
Sr. Development Chef
The Artisan Chef Mfg Co. —Lawrence, MA
- $50.00 - $57.69 an hour
- Weekends as needed
- 8 years
- Travel
- Budgeting
- Health insurance
- Dental insurance
Quick Apply
Senior Research Scientist - AI Trainer
DataAnnotation —Lynn, MA
- $50 - $100 an hour
- Part-time
- Remote
- Computer Science
- Writing skills
- English
- Flexible schedule
Quick Apply
8d

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senior principal scientist jobs near danvers ma

MSAT Process Science Senior Scientist, Investigations

Vertex Pharmaceuticals -
Boston, MA

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Job Details

Full-time
$120,800 - $181,200 a year

Benefits

Loan repayment program
Dental insurance
Tuition reimbursement
Paid time off
Vision insurance
401(k) matching

Qualifications

Statistics
Six Sigma methodology implementation
Corrective and preventive actions (CAPA)
GMP
Pharmaceutical company experience
Statistical analysis tools
Pharmaceutical manufacturing facility experience

Full Job Description

Job Description

General Summary:

The MSAT Senior Scientist (Investigations and Strategic Projects) is responsible for leading complex technical investigations, driving strategic process improvements, and fostering a culture of continuous improvement within manufacturing operations. This role will leverage Six Sigma methodologies, including DMAIC, and lead complex technical investigations utilizing statistical methods and multivariate analysis to understand and identify contributing factors influencing manufacturing outcomes. In addition, this position will drive strategic improvement initiatives across manufacturing operations as a form of continuous improvement. The incumbent will collaborate cross-functionally with Quality, Engineering, Manufacturing, Process Development and Regulatory teams to ensure robust root cause analysis (RCA), effective corrective and preventive actions (CAPAs), and sustainable process improvements are deployed that align with business and regulatory expectations.

Key Duties and Responsibilities:

Lead and manage high-impact technical investigations, applying structured problem-solving methodologies such as DMAIC to ensure thorough root cause analysis and CAPA implementation.
Act as a subject matter expert (SME) in major investigations related to deviations, out-of-specifications (OOS), or out-of trends (OOT), and process failures, ensuring alignment with regulatory expectations.
Utilize a data-driven approach to investigations, leveraging statistical analysis and multivariate data analysis to identify root cause, systemic issues and identify options to prevent recurrence.
Develop and present investigation reports to senior leadership and regulatory agencies as needed.
Lead strategic improvement projects focused on improving process control, process efficiency, and manufacturing robustness using DMAIC principles.
Identify, prioritize, and execute initiatives that reduce process variability, increase yield, and enhance compliance through data-driven decision-making.
Collaborate with cross-functional teams to implement innovative solutions, integrating Lean and Six Sigma methodologies to drive sustainable improvements.

Knowledge and Skills:

Previous experience working in a highly matrixed environment.
Extensive experience with cell and gene therapy, biologics process development and cGMP manufacturing.
Strong documentation skills to support risk analysis, protocol development, and report documentation.
Experience with cGMP regulations/guidance and regulatory agency inspections.
Experience authoring/reviewing CMC product submissions and post-approval changes.
Experience with continuous improvement, proficiency with operational excellence preferred.
Experience working with external manufacturing partners (CDMOs/CMOs), suppliers, and service providers.
Ability to travel, nationally and internationally, up to 10%.
Flexibility to work on site a minimum of 3 days per week.

Education and Experience:

Bachelor’s, Master’s, or Ph.D. in Engineering, Biotechnology, Biochemistry, or a related scientific field.
5-7+ years of experience in a GMP-regulated biopharmaceutical or pharmaceutical manufacturing environment, with a focus on MSAT, process investigations, and improvement initiatives.
Strong expertise in Six Sigma methodologies, including DMAIC; Lean Six Sigma Yellow Belt,/ Green Belt preferred.
Demonstrated experience leading major investigations and implementing effective CAPAs in a regulated environment.
Proficiency in statistical tools (JMP, Statistica, etc.) and data-driven decision-making to drive process optimization.
Proven ability to work within cross-functional teams and manage multiple high-impact projects simultaneously.
Strong communication and presentation skills, with experience delivering technical reports and presentations to development teams, senior leadership, and regulatory bodies.
Experience working with external manufacturing partners (CDMOs/CMOs), suppliers, and service providers.

Preferred Qualifications:

Experienced with advanced analytics and digital tools.
Lean Six Sigma Yellow belt, Green Belt or Black Belt certification.
Experience with technology transfer, scale-up, and process validation activities.

Pay Range:

$120,800 - $181,200

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid : work remotely up to two days per week; or select
2. On-Site : work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected]

Apply Now

Refine Your Search

senior principal scientist jobs in danvers ma

MSAT Process Science Senior Scientist, Investigations

Stem Cell Principal Research Scientist, T1D Discovery Biology

Senior Principal Scientist, Immune Cell Depletion Discovery Group, Immunology Discovery Research

QC Senior/Principal Scientist, Analytical Method Validation

Senior Principal Scientist

Senior/Principal Scientist, Analytical Cell Line Engineering and Bioassay Development

Senior Scientist II/Principal Scientist, Molecular Cloning Technologies

Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)

Senior Principal Scientist, Analytical Sciences

Senior/Principal Scientist, Small Molecule Therapeutics

Senior Principal Scientist I - Functional Biomarkers

Senior Principal Scientist/Principal Scientist, Real-World Evidence & Disease Genomics

Senior/Principal Scientist Cell Based Potency Assay

Senior / Principal Scientist, Immunology & Pharmacology

Senior Principal Scientist / Assoc Director, Oncology Translational Research

Principal / Senior Principal Scientist, Small Molecule Therapeutics

Principal Scientist II/Senior Principal Scientist, PK Sciences Clinical Pharmacology Artificial Intelligence (AI) Lead (dual level posting)

Contract Research Associate/Sr. Research Associate (Discover Chemistry)

Sr. Development Chef

Senior Research Scientist - AI Trainer

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