Description
Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enable us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are agile, science-driven innovators who collaborate to bring new therapies to patients in need.
The Position
Arrowhead Pharmaceuticals is seeking a strategically minded, relationship-driven Key Account Manager (KAM) to lead enterprise engagement across priority health systems, Integrated Delivery Networks (IDNs), and complex accounts within an assigned geography. This role is central to building durable institutional access and driving adoption of Arrowhead's cardiometabolic portfolio, including Plozasiran for rare cardiovascular conditions such as Familial Chylomicronemia Syndrome (FCS).
The Key Account Manager will operate at the intersection of clinical science, health system navigation, and commercial execution. This individual will establish Arrowhead as a trusted partner to health systems by embedding Plozasiran into clinical pathways, supporting formulary access, and ensuring seamless coordination between system-level strategy and field prescriber activation.
Responsibilities:
Enterprise Account Strategy & Execution
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Develop and execute comprehensive account strategies across priority IDNs, health systems, and complex accounts within an assigned geography.
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Build institutional access through formulary engagement, protocol development, and clinical pathway integration.
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Drive integration of Plozasiran into treatment algorithms, order sets and clinical workflows in partnership with key institutional decision-makers.
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Own multi-year account growth plans, including system-level partnership development, opportunity sizing, and sustained execution against account objectives.
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Use adoption, access, and performance data to segment and prioritize accounts, shape engagement strategy, and identify the highest-impact opportunities and barriers.
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Monitor account-level adoption metrics and proactively address access barriers to accelerate pull-through.
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Maintain rigorous account planning discipline, including regular business reviews and updated stakeholder maps.
Stakeholder Engagement & Relationship Development
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Build and maintain trusted relationships with a broad set of institutional stakeholders, including pharmacy leadership, population health leaders, value analysis committees, and clinical champions.
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Engage compliantly in value-based discussions, including health economic, outcomes, and real-world evidence conversations tailored to institutional priorities.
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Ensure alignment between enterprise decision-makers and field-level prescriber activation efforts.
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Navigate multi-layered institutional approval processes with strategic agility and appropriate urgency.
Clinical Science & Patient Identification
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Develop deep clinical fluency in FCS, ApoC-III biology, and the mechanism and evidence base for Plozasiran.
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Educate institutional stakeholders on disease prevalence, diagnostic pathways, and the patient identification opportunity within their system.
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Collaborate with Health IT initiatives to support patient identification tools and clinical workflow integration.
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Serve as a credible clinical and commercial resource within accounts, reinforcing Arrowhead’s scientific leadership.
Cross-Functional Collaboration & Alignment
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Partner closely with Rare Disease Specialists and Regional Sales Directors to coordinate and align account strategy with field execution.
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Collaborate with Market Access, Marketing, Medical Affairs, and Commercial Operations to remove systemic barriers and align institutional messaging.
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Provide timely and actionable field insights regarding competitive dynamics, formulary positioning, and access trends to regional and national leadership.
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Participate constructively in cross-functional planning meetings, commercial launches, and strategic initiatives.
Business Performance & Compliance Accountability
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Own account-level performance targets and adoption objectives within assigned geography.
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Maintain and proactively monitor forecast accuracy and account-level growth indicators.
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Drive disciplined CRM documentation and reporting standards to support territory and business analytics.
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Conduct all enterprise engagements in full compliance with applicable laws, regulations, and Arrowhead's ethical standards.
Travel & Engagement
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Field-based travel required (~60%), including health system meetings, executive engagements, and regional commercial initiatives.
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Participation in regional and national commercial meetings, training programs, and launch initiatives.
Experience:
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Minimum 5+ years of pharmaceutical or biotech experience required.
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Experience in IDN, health system, or complex account management required.
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Demonstrated ability to navigate and influence formulary, protocol, or pathway decisions within complex institutional environments.
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Track record of consistent performance and territory growth in a field-based commercial role.
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Experience in specialty, rare disease, or cardiometabolic therapeutic areas preferred.
Skills & Competencies
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Strong executive presence with the ability to engage senior institutional and clinical stakeholders.
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Advanced account management and enterprise planning skills.
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Solid understanding of health system economics, reimbursement dynamics, and institutional access pathways.
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Ability to translate complex clinical and health economic data into compelling, audience-appropriate value narratives.
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Strong analytical and business acumen with a data-driven approach to prioritization and decision-making.
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High level of resilience, adaptability, and sound judgment in dynamic and ambiguous environments.
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Collaborative mindset with the ability to work effectively across functions, geographies, and organizational levels.
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Exceptional communication, negotiation, and stakeholder navigation skills.
Compensation & Benefits:
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Competitive base salary: $190,000 - $210,000 plus incentive compensation.
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Equity (RSUs) eligibility and car allowance program.
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Comprehensive benefits package including health, dental, vision, and 401(k).
