Top 542 Senior principal scientist Jobs in Framingham Ma

Principal Scientist/ Associate director Cell Line Development
EPM Scientific —Southborough, MA
- $130,000 - $160,000 a year
- Contract
- Analysis skills
- Mentoring
- Senior level
Quick Apply
23h
Contract Research Associate/Sr. Research Associate (Discovery Chemistry)
Commonwealth Sciences —Burlington, MA
- Contract
- Bachelor of Science
- Bachelor's degree
- Entry level
Quick Apply
4d
Research Senior Scientific Director, Head of Hit ID and Sample Management (Automation)
Takeda Pharmaceutical —Boston, MA
- $212,000 - $333,190 a year
- Hybrid work
- Bachelor of Science
- 11+ years
- Presentation skills
- Paid holidays
- Disability insurance
AIRx, Sr. Director, Nonclinical Safety Lead
Takeda Pharmaceutical —Boston, MA
- $212,000 - $333,190 a year
- Call employer
- Hybrid work
- 11+ years
- Business development
- Doctor of Philosophy
- Paid holidays
- Disability insurance
Principal Scientist Upstream Process Development - Biologics
EPM Scientific —Southborough, MA
- $120,000 - $150,000 a year
- Contract
- Bachelor of Science
- Bachelor's degree
- Continuous improvement
Quick Apply
23h
Senior Scientist, Drug Product and Formulation Development
Ultragenyx Pharmaceutical —Woburn, MA
- $160,300 - $198,000 a year
- Full-time
- Master's degree
- 8 years
- Doctor of Philosophy
- Gym membership
16h
Senior Director, Drug Safety & Pharmacovigilance – Development
Klein Hersh International —Boston, MA
- Email
- Medicine
- 5 years
- Contracts
Sr. Director/Director Precision Oncology
Aitia —Cambridge, MA
- $180,000 - $240,000 a year
- Full-time
- 7 years
- Doctor of Philosophy
- Computer skills
Sr. Director/Director Precision Oncology
Aitia —Cambridge, MA
- $180,000 - $240,000 a year
- Full-time
- 7 years
- Doctor of Philosophy
- Computer skills
Senior Director, AIRx Medicinal Chemistry
Takeda Pharmaceutical —Boston, MA
- $212,000 - $333,190 a year
- Full-time
- Hybrid work
- Management
- 11+ years
- Doctor of Philosophy
- Paid holidays
- Disability insurance
12d
Product Lifecycle Engineering Principal Scientist - Medical Device & Combination Products
Vertex Pharmaceuticals —Boston, MA
- $145,600 - $218,400 a year
- Full-time
- Management
- Continuous improvement
- Travel
- Loan repayment program
- Dental insurance
Sr. R&D Food Scientist
Home Market Foods —Norwood, MA
- $90,000 - $110,000 a year
- Microsoft Excel
- Microsoft Outlook
- Customer service
- Relocation assistance
- Health insurance
Quick Apply
13d
Pathology Senior Principal Research Scientist
Vertex Pharmaceuticals —Boston, MA
- $180,000 - $270,000 a year
- Full-time
- Doctor of Philosophy
- Mentoring
- 1 year
- Loan repayment program
- Dental insurance
Principal Scientist, Separation Methods Expert, Analytical Science and Technology (AS&T), Vertex Pharmaceuticals (Boston)
Vertex Pharmaceuticals —Boston, MA
- $138,400 - $207,600 a year
- Full-time
- Hybrid work
- Master's degree
- Bachelor's degree
- Doctor of Philosophy
- Loan repayment program
- Dental insurance
Aseptic Control Principal Scientist, MSAT
Vertex Pharmaceuticals —Boston, MA
- $145,500 - $218,300 a year
- Full-time
- Hybrid work
- Office
- 8 years
- Continuous improvement
- Loan repayment program
- Dental insurance
Senior Principal Toxicologist
Keurig Dr Pepper —Burlington, MA
- $130,700 - $190,000 a year
- Email
- Doctor of Philosophy
- Travel
- Senior level
- Mileage reimbursement
- Paid parental leave
Senior Manager, Clinical Study Quality Lead (Hybrid)
Vertex Pharmaceuticals —Boston, MA
- $137,800 - $206,800 a year
- Full-time
- Hybrid work
- 6 years
- Project management
- Bachelor's degree
- Loan repayment program
- Dental insurance
Sr. Quality Control Analyst
Pace Analytical Life Sciences —Waltham, MA
- $35 - $50 an hour
- Full-time
- English
- Master's degree
- Bachelor's degree
- Wellness program
- Health savings account
Geologist / Sr. Environmental Scientist
Resource Options Inc. —Woburn, MA
- $90,000 - $110,000 a year
- 5 years
- Bachelor of Science
- Pass drug screening
Quick Apply
Senior Director, AIRx Discovery Biology Lead
Takeda Pharmaceutical —Boston, MA
- $212,000 - $333,190 a year
- Full-time
- Hybrid work
- Management
- 11+ years
- Doctor of Philosophy
- Paid holidays
- Disability insurance

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senior principal scientist jobs near framingham ma

Principal Scientist/ Associate director Cell Line Development

EPM Scientific -
Southborough, MA

Quick Apply

Job Details

Contract
$130,000 - $160,000 a year
23 hours ago

Qualifications

Data integrity assurance
FDA submissions
Statistics
Advanced cell culture techniques
Immunological assays
Strategic goal setting
Program design
Resource allocation (project management tasks)
Team leadership
Technical documentation
Immunological laboratory techniques
High-performance liquid chromatographs
Protein analysis (analytical chemistry specialty)
Technical report writing
Investigational new drug (IND) applications
Minitab
Team development
Data integrity and documentation
Research project technical leadership
Analysis skills
ICH guidelines
Production optimization
Biochemical laboratory techniques
Budget planning
Managing teams of scientists
Task prioritization
Scientific protocols
Industry trends
Laboratory standard operating procedures
Mentoring

Full Job Description

Overview

An experienced scientific leader is sought to drive the development and optimization of cell line and microbial expression systems for therapeutic protein production. This individual will lead technical programs, mentor scientific staff, and contribute to strategic planning while playing a critical role in advancing innovation and operational success.

What You'll Do

Scientific & Technical Leadership

Lead the design and execution of experiments supporting mammalian cell line and microbial strain development
Oversee workflows including vector construction, clone screening, transfection, media optimization, stable cell line generation, and cell banking
Guide protein characterization efforts utilizing ELISA, PCR, SDS-PAGE, Western blot, HPLC, and related techniques
Interpret complex datasets and translate findings into actionable development strategies

Program & Strategy Development

Drive multiple projects simultaneously, ensuring alignment with organizational priorities and timelines
Contribute to long-term scientific and operational strategy
Stay current with emerging technologies, industry trends, and scientific literature; assess applicability and potential impact

Regulatory & Compliance

Support preparation of CMC documentation for regulatory submissions (IND, BLA)
Develop and maintain SOPs, protocols, and technical reports in compliance with industry standards
Ensure proper documentation practices and data integrity across all activities

People Leadership & Collaboration

Mentor and develop junior scientists while fostering a culture of scientific excellence
Manage team priorities, resource allocation, and departmental budgets
Collaborate cross-functionally and serve as a technical representative in external meetings when needed

What You Bring

Technical Expertise

Deep experience in mammalian expression systems and cell line development for monoclonal antibodies and recombinant proteins
Familiarity with CHO, HEK, NS0, and microbial systems (e.g., E. coli)
Experience with CHO-GS systems and difficult-to-express proteins preferred

Skills & Capabilities

Strong problem-solving skills with the ability to navigate complex scientific challenges
Working knowledge of GMP/ICH guidelines, PAT technologies, and CMC processes
Proficiency in statistical design and analysis tools (e.g., JMP, Minitab, Design-Expert)
Excellent communication, presentation, and cross-functional collaboration skills
Proven ability to manage competing priorities in a fast-paced environment
Leadership experience with a track record of developing high-performing teams

Quick Apply

Refine Your Search

senior principal scientist jobs in framingham ma

Principal Scientist/ Associate director Cell Line Development

Contract Research Associate/Sr. Research Associate (Discovery Chemistry)

Research Senior Scientific Director, Head of Hit ID and Sample Management (Automation)

AIRx, Sr. Director, Nonclinical Safety Lead

Principal Scientist Upstream Process Development - Biologics

Senior Scientist, Drug Product and Formulation Development

Senior Director, Drug Safety & Pharmacovigilance – Development

Sr. Director/Director Precision Oncology

Sr. Director/Director Precision Oncology

Senior Director, AIRx Medicinal Chemistry

Product Lifecycle Engineering Principal Scientist - Medical Device & Combination Products

Sr. R&D Food Scientist

Pathology Senior Principal Research Scientist

Principal Scientist, Separation Methods Expert, Analytical Science and Technology (AS&T), Vertex Pharmaceuticals (Boston)

Aseptic Control Principal Scientist, MSAT

Senior Principal Toxicologist

Senior Manager, Clinical Study Quality Lead (Hybrid)

Sr. Quality Control Analyst

Geologist / Sr. Environmental Scientist

Senior Director, AIRx Discovery Biology Lead

I want to receive the latest job alert for senior principal scientist in framingham ma

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