Top 149 Principal scientist Jobs in Hayward Ca

Principal Research Scientist, Cancer Biology
Yoh, A Day & Zimmermann Company —San Francisco, CA
- $70 - $85 an hour
- Contract
- Analysis skills
- Doctor of Philosophy
- Fair chance
- Health savings account
- Disability insurance
Quick Apply
Principal Scientist I
MEADOWHAWK BIOLABS INC —Hayward, CA
- $123,000 - $163,000 a year
- 6 years
- Doctoral degree
- Bachelor of Science
Principal Scientist, Immunology
Jade Biosciences —San Francisco, CA
- $175,000 - $190,000 a year
- Remote
- 8 years
- Doctor of Philosophy
- Travel
Quick Apply
13d
Principal Scientist, Process Chemistry
CALICO —South San Francisco, CA
- $197,000 - $245,000 a year
- 8 years
- Continuous improvement
- Doctor of Philosophy
Senior Principal Statistician
Jazz Pharmaceuticals —Palo Alto, CA
- $156,000 - $234,000 a year
- Remote
- Analysis skills
- Doctor of Philosophy
- Senior level
- Health insurance
- Dental insurance
Principal Scientist, Biomarker Data Sciences
Biogen —San Francisco, CA
- $141,000 - $188,000 a year
- Full-time
- Hybrid work
- 5 years
- Doctor of Philosophy
- Organizational skills
- Paid parental leave
- Employee stock purchase plan
Principal Scientist I, Molecular Lab Research and Early Development
Roche —Pleasanton, CA
- $111,000 - $206,500 a year
- Online Application
- 5 years
- Doctor of Philosophy
- Mentoring
Associate Principal Scientist, Clinical Research
Merck —San Francisco, CA
- $142,400 - $224,100 a year
- Full-time
- 3 years
- Master's degree
- Analysis skills
- Paid holidays
- Health insurance
12d
Principal Scientist, Bioinformatics
Nkarta, Inc. —South San Francisco, CA
- $180,000 - $215,000 a year
- Hybrid work
- Management
- 5 years
- Office
- Employee stock purchase plan
- Paid holidays
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Principal Scientist, Pharmacokinetics
Merck —San Francisco, CA
- $176,200 - $277,300 a year
- Full-time
- 8 years
- Analysis skills
- Doctor of Philosophy
- Paid holidays
- Health insurance
12d
Principal Scientist – Translational Medicine (Tumor Microenvironment)
Genentech —San Francisco, CA
- $141,500 - $262,900 a year
- Online Application
- Medicine
- No experience needed
- 3 years
Principal Scientist
Exponent Inc. —Menlo Park, CA
- $225,000 - $275,000 a year
- Email
- Office
- Analysis skills
- Doctor of Philosophy
- 401(k)
Principal Scientist, Immunology
Biogen —San Francisco, CA
- $142,000 - $190,000 a year
- Full-time
- Master's degree
- 8 years
- Business development
- Paid parental leave
- Employee stock purchase plan
Principal Computational Scientist, Discovery Chemistry
Genentech —San Francisco, CA
- $144,900 - $269,100 a year
- Online Application
- Computer Science
- Doctor of Philosophy
- Organizational skills
Senior Scientist / Principal Scientist, Complex in Vitro Systems
Genentech —San Francisco, CA
- $120,700 - $262,900 a year
- Online Application
- 5 years
- Doctor of Philosophy
- Senior level
12d
Principal Scientist, Clinical Biomarkers
Biogen —San Francisco, CA
- $140,000 - $187,000 a year
- Full-time
- Hybrid work
- 5 years
- Doctor of Philosophy
- Senior level
- Paid parental leave
- Employee stock purchase plan
Senior Staff/Principal Scientist, Organic Chemistry & Biochemistry
Lunar Biosciences —Pleasanton, CA
- $175,000 - $200,000 a year
- Full-time
- Management
- Doctor of Philosophy
- Senior level
- Disability insurance
- Health insurance
Quick Apply
Principal, Pharmacovigilance / Device Vigilance
Natera —San Francisco, CA
- $160,700 - $200,850 a year
- Google Workspace
- Software troubleshooting
- Computer literacy
- Commuter assistance
- Health insurance
Principal/Sr. Principal Scientist - Development
Genentech —San Francisco, CA
- $141,500 - $321,490 a year
- Online Application
- 3 years
- Doctor of Philosophy
- Mentoring
12d
Principal Scientist, Computational Chemistry
Cytokinetics —San Francisco, CA
- $202,500 - $236,250 a year
- Full-time
- 11+ years
- Doctor of Philosophy
- Mentoring

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Principal Research Scientist, Cancer Biology

Yoh, A Day & Zimmermann Company -
San Francisco, CA

Quick Apply

Job Details

Contract
$70 - $85 an hour

Benefits

Health savings account
Disability insurance
Health insurance
Dental insurance
401(k)
Employee assistance program
Vision insurance
Referral program

Qualifications

Immunological assays
Cell line culture
Immunological laboratory techniques
Design of experiments
Flow cytometers
Advanced microscopy techniques
Assay development
RNA isolation
Biochemical laboratory techniques
Doctor of Philosophy
Oncology research
Research data analysis
Gene expression analysis
Cytometry
Molecular analysis

Full Job Description

A growing biotechnology organization is seeking a highly motivated and innovative Principal Research Scientist, Cancer Biology with deep expertise in cancer biology to join a high-priority discovery program focused on elucidating novel mechanisms driving tumor biology. This laboratory-based role will leverage advanced cellular and molecular biology approaches to investigate the mechanistic foundations of a promising therapeutic target and support the advancement of small-molecule drug discovery efforts.

The successful candidate will combine strong scientific rigor, technical excellence, and critical thinking to generate meaningful biological insights that inform therapeutic strategy. Working within a collaborative, cross-functional environment, this individual will play a key role in shaping and advancing a pioneering cancer biology research program.

Location: SSF
Pay: $70 - 85/hr. DOE

Key Responsibilities:

Independently design, execute, analyze, and troubleshoot complex in vitro studies to investigate target biology, pathway regulation, and drug mechanisms of action.
Develop and apply cellular models utilizing gene perturbation technologies, including CRISPR, siRNA/shRNA, overexpression systems, and pharmacologic interventions.
Utilize a broad range of molecular and cellular biology techniques to explore oncogenic signaling pathways, protein function, cellular trafficking, immune-relevant phenotypes, and synthetic lethal interactions.
Design and optimize mechanistic assays to interrogate target function and therapeutic response.
Generate high-quality, reproducible datasets and apply rigorous quantitative analysis to derive mechanistic insights.
Integrate data across multiple experimental platforms to develop and test biological hypotheses.
Maintain meticulous experimental records and ensure adherence to high scientific standards.
Partner closely with project teams to align experimental strategies with translational and therapeutic objectives.
Present research findings and recommendations to multidisciplinary teams and senior leadership.
Contribute scientific expertise to program strategy and help guide the evolution of research priorities.
Collaborate effectively with external partners, CROs, and scientific collaborators as needed.

Qualifications:

PhD in Cancer Biology, Molecular Biology, Cell Biology, Genetics, or a related discipline.
4+ years of industry experience
Deep understanding of tumor biology, including cancer genomics, oncogenic signaling, cancer cell biology, synthetic lethality, and therapeutic vulnerabilities.
Proven track record of independently driving hypothesis-based research programs with minimal supervision.
Strong expertise in molecular biology, cellular biology, biochemistry, and quantitative experimental design.
Extensive hands-on experience with mammalian cell culture, cell viability and proliferation assays, and multiparametric flow cytometry.
Proficiency with gene expression analysis (qRT-PCR, RNA isolation/preparation), protein characterization techniques (Western blot, ELISA, HTRF, MSD), confocal microscopy, and functional genomics approaches.
Demonstrated ability to interpret complex datasets, synthesize findings, and communicate scientific conclusions effectively.

Preferred

Experience developing mechanistic assays focused on protein function, degradation, trafficking, or immune signaling pathways.
Familiarity with computational tools for biological data analysis, visualization, and interpretation.
Experience managing or collaborating with CROs and external research partners.

Desired Attributes

Passion for scientific discovery coupled with a pragmatic, results-oriented mindset.
Intellectual curiosity and commitment to rigorous, data-driven decision-making.
Thrives in a fast-paced, discovery-stage research environment.
Adaptable and resilient when navigating scientific uncertainty and evolving priorities.
Strong interpersonal and communication skills, with the ability to influence and collaborate across functions.
Commitment to fostering a culture of accountability, inclusion, innovation, and scientific excellence.

#IND-SPG

Estimated Min Rate: $70.00
Estimated Max Rate: $85.00

What’s In It for You?
We welcome you to be a part of the largest and legendary global staffing companies to meet your career aspirations. Yoh’s network of client companies has been employing professionals like you for over 65 years in the U.S., UK and Canada. Join Yoh’s extensive talent community that will provide you with access to Yoh’s vast network of opportunities and gain access to this exclusive opportunity available to you. Benefit eligibility is in accordance with applicable laws and client requirements. Benefits include:

Medical, Prescription, Dental & Vision Benefits (for employees working 20+ hours per week)
Health Savings Account (HSA) (for employees working 20+ hours per week)
Life & Disability Insurance (for employees working 20+ hours per week)
MetLife Voluntary Benefits
Employee Assistance Program (EAP)
401K Retirement Savings Plan
Direct Deposit & weekly epayroll
Referral Bonus Programs
Certification and training opportunities

Note: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description. All qualified applicants are welcome to apply.

Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

Visit https://www.yoh.com/applicants-with-disabilities to contact us if you are an individual with a disability and require accommodation in the application process.

For California applicants, qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. All of the material job duties described in this posting are job duties for which a criminal history may have a direct, adverse, and negative relationship potentially resulting in the withdrawal of a conditional offer of employment.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

By applying and submitting your resume, you authorize Yoh to review and reformat your resume to meet Yoh’s hiring clients’ preferences. To learn more about Yoh’s privacy practices, please see our Candidate Privacy Notice: https://www.yoh.com/privacy-notice
IND-SPG

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Refine Your Search

principal scientist jobs in hayward ca

Principal Research Scientist, Cancer Biology

Principal Scientist I

Principal Scientist, Immunology

Principal Scientist, Process Chemistry

Senior Principal Statistician

Principal Scientist, Biomarker Data Sciences

Principal Scientist I, Molecular Lab Research and Early Development

Associate Principal Scientist, Clinical Research

Principal Scientist, Bioinformatics

Principal Scientist, Pharmacokinetics

Principal Scientist – Translational Medicine (Tumor Microenvironment)

Principal Scientist

Principal Scientist, Immunology

Principal Computational Scientist, Discovery Chemistry

Senior Scientist / Principal Scientist, Complex in Vitro Systems

Principal Scientist, Clinical Biomarkers

Senior Staff/Principal Scientist, Organic Chemistry & Biochemistry

Principal, Pharmacovigilance / Device Vigilance

Principal/Sr. Principal Scientist - Development

Principal Scientist, Computational Chemistry

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