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Application Scientist - LC-MS

Advion Interchim
Ithaca, NY

Quick Apply

Job Details

Full-time
$80,000 - $110,000 a year

Benefits

Paid holidays
Disability insurance
Health insurance
Dental insurance
Flexible spending account
Paid time off
Family leave
Employee assistance program
Vision insurance
401(k) matching

Qualifications

Laboratory experiment design
Customer communication
Technical documentation
High-performance liquid chromatographs
Bachelor's degree
Materials analysis (analytical chemistry specialty)
Spectrometer
Mass spectrometers (MS)
Research data analysis
Technical writing experience within technology
Molecular analysis

Full Job Description

Position Summary

Advion Inc. is seeking a full-time LC-MS Application Scientist to support application development, customer demonstrations, technical training, troubleshooting, and sales support for Advion's compact mass spectrometry product line, including the expression® CMS and the ASAP®, Plate Express™, and OPSI direct sampling platforms.

This role focuses on ESI- and APCI-based LC-MS applications, including method development, customer sample analysis, source optimization, data interpretation, and preparation of technical application materials. The ideal candidate will have hands-on LC-MS experience, strong HPLC/UHPLC method development skills, and the ability to communicate technical information clearly to customers and internal teams.

Key Responsibilities

Develop, optimize, and document LC-MS methods using ESI and APCI ionization on Advion compact mass spectrometers.
Support applications for small molecules, APIs, impurities, reaction monitoring, natural products, environmental contaminants, food safety targets, and related compounds.
Optimize LC-MS conditions, including ion mode, source parameters, mobile phase, additives, gradient, flow rate, and sample preparation.
Develop and demonstrate workflows for direct ionization platforms such as ASAP®, Plate Express™, and OPSI where applicable.
Generate high-quality chromatograms, mass spectra, extracted ion chromatograms, calibration data, and method summaries.
Analyze customer samples and perform LC-MS demonstrations to support sales opportunities.
Troubleshoot LC-MS issues related to chromatography, source performance, sensitivity, contamination, carryover, matrix effects, and reproducibility.
Prepare application notes, demo reports, SOPs, training materials, posters, presentations, and customer-facing technical documents.
Work closely with sales, service, R&D, product management, and marketing teams to support customers and identify new application opportunities.

Required Qualifications

Bachelor's degree or higher in Chemistry, Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field.
Hands-on experience with LC-MS using ESI and/or APCI.
Hands-on experience in HPLC/UHPLC and LC-MS method development, including assay development, LC-MS-compatible mobile phase selection, and application to small molecules, peptides, proteins, or related analyte classes.
Practical knowledge of source setup, tuning, optimization, and troubleshooting.
Ability to interpret mass spectra, chromatograms, and method performance data.
Strong technical writing and communication skills.
Ability to work independently and manage multiple application projects.

Work Environment

This position is primarily laboratory- and office-based at Advion Inc.'s Ithaca, NY location. Travel of up to 25% (domestic and international) may be required for customer demonstrations, distributor training, trade shows, and field support.

Benefits

Advion offers a competitive and employee-focused benefits package designed to support your health, financial well-being, and work-life balance. Employees enjoy generous paid time off, 9 paid holidays, flexible "X" days, a 401(k) plan with company matching, life and disability insurance, and access to an Employee Assistance Program. For 2026, medical coverage is provided through the Excellus BCBS Bronze 5 high-deductible plan, with Advion helping offset out-of-pocket costs by funding most of the deductible through a Health Reimbursement Arrangement (HRA). Employees also have access to dental, vision, flexible spending accounts, and family leave benefits

About Advion Inc.

Advion Inc. is a developer of compact mass spectrometry and direct ionization technologies, serving chemistry, pharmaceutical, life science, environmental, food safety, and academic research laboratories. Advion's expression® compact mass spectrometer and direct sampling accessories - including ASAP®, Plate Express™, and OPSI - provide scientists with practical, efficient, and easy-to-use LC-MS workflows.

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Application Scientist - LC-MS

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