Top 15 Python developer Jobs in Knoxville, Tn

Software Engineer – Full Stack AI - US-Remote
PerfectServe —Knoxville, TN
- $130,000 - $170,000 a year
- Remote
- 5 years
- Databases
- AWS
- Paid holidays
- Disability insurance
Quick Apply
Full Stack AI Engineer
Cadre5 —Knoxville, TN
- Full-time
- Computer science
- Computer Science
- 5 years
- Health insurance
- Dental insurance
Quick Apply
Full Stack Developer
ITR —Oak Ridge, TN
- Computer science
- Computer Science
- 5 years
Quick Apply
Smart Manufacturing Software Engineer, Backend
Y12 —Oak Ridge, TN
- Computer Science
- Pass drug screening
- Research
- Disability insurance
- Health insurance
8d
Software Configuration Manager
Centrus Energy Corp. —Oak Ridge, TN
- Full-time
- Background check
- Pass drug screening
- Mid-level
Software Engineer I&C
Type One Energy —Knoxville, TN
- Full-time
- Hybrid work
- 5 years
- Laboratory experience
- Master's degree
Quick Apply
Senior Platform Engineer, Delivery & Reliability
RDI Technologies, Inc. —Knoxville, TN
- Full-time
- Azure
- 5 years
- Office
Quick Apply
Lead Systems Engineer (LabVIEW and Automation)
Edgewater Technical Associates —Oak Ridge, TN
- 5 years
- Engineering
- Mentoring
- Disability insurance
- Health insurance
Quick Apply
1d
Software Engineer (AI Platform)
Hive + Co —United States
- From $65 an hour
- Full-time
- Remote
- Azure
- 5 years
- AWS
Quick Apply
22h
Automation Lead
CGI Group, Inc. —United States
- $57,100 - $154,300 a year
- Azure
- 8 years
- Continuous improvement
- Paid parental leave
- Paid holidays
2d
Lead DevSecOps Engineer
CGI Group, Inc. —United States
- $57,100 - $154,300 a year
- Windows
- Continuous improvement
- Mentoring
- Paid parental leave
- Paid holidays
4d

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python developer jobs near knoxville, tn

Software Engineer – Full Stack AI - US-Remote

PerfectServe -
Knoxville, TN

Quick Apply

Job Details

$130,000 - $170,000 a year

Benefits

Paid holidays
Disability insurance
Health insurance
Dental insurance
Paid time off
Vision insurance
401(k) matching
Opportunities for advancement

Qualifications

AI models
Software engineering
Machine learning projects
Information security
Databases
Health information security
Machine learning cloud services
Cloud Native Design
Python

Full Job Description

What is PerfectServe?

PerfectServe is a leading provider of clinical communication and physician scheduling solutions in the health IT space. The company was founded in 1997 and has grown steadily since then, with a notable jump after several major acquisitions were announced in 2019. PerfectServe now has 400+ employees, 30,000+ customers — spanning medical practices, hospitals, and health systems — and $100 million+ in annual revenue.

PerfectServe's mission is to accelerate speed to care by optimizing provider schedules and routing communications — including messages, pages, calls, and alerts — to the right place at the right time in any care setting. By facilitating real-time information sharing, building better schedules, and automating important clinical workflows, we believe we can help our customers advance patient care and improve the well-being of their clinicians.

Leading analyst firms like Gartner® and KLAS Research have consistently validated our approach:

In 2026, PerfectServe was named highest in execution and furthest in vision in the Gartner Magic Quadrant™ for Clinical Communication and Collaboration — the clear segment leader.

PerfectServe also received two Best in KLAS awards in 2026 — one for physician scheduling and another for ambulatory clinical communications. That makes for 11 Best in KLAS awards over the past 9 years.

At PerfectServe, you'll have a unique opportunity to join a collaborative team with decades of experience that finds new ways to delight our customers every day. This involves consistent efforts to stay on the cutting edge of product development, which includes everything from implementing AI in new and existing solutions to brainstorming with customers about novel workflows. But you don't have to be in product to make in impact — everybody at PerfectServe contributes to important work that moves the business forward.

If you're looking for a well-established, tech-forward company full of smart people doing meaningful work, you've found the right place!

PerfectServe is a leading healthcare communications platform that connects providers, patients, and care teams to improve clinical collaboration and patient outcomes. We are seeking a Full Stack AI Engineer to join our R&D organization and play a central role in bringing AI capabilities to production across the platform. This is a core, high-impact role responsible for defining AI architecture standards, shipping production AI features, establishing governance and evaluation frameworks, and partnering directly with R&D leadership to shape the AI roadmap.

Essential Functions

Design AI integration patterns and architecture standards across the SaaS platform
Integrate LLM APIs (OpenAI, Anthropic, AWS Bedrock) into production features
Build RAG systems, vector search, and embedding pipelines
Optimize latency, inference cost, and hallucination guardrails
Establish model evaluation, benchmarking, and observability processes
Define cost controls, usage monitoring, and security/PHI handling constraints
Evaluate use cases with Product for ROI and feasibility
Advise leadership on build vs. buy decisions for AI capabilities

Qualifications:

5+ years software engineering experience with strong Python backend skills
Production experience with LLM APIs, RAG systems, embeddings, and vector databases
Cloud-native architecture experience, preferably AWS
Experience in regulated or security-conscious environments
Product-minded systems thinker, comfortable with ambiguity and executive communication

This is not a research role. This is a builder role.

Why Join PerfectServe?

At PerfectServe, we are transforming healthcare communication and collaboration to help clinicians deliver better care. You'll work with a dedicated and mission-driven team in an environment that values growth, transparency, and innovation.

We offer a salary range of $130,000-170,000 USD per year, with compensation tailored to your background, strengths, and potential to grow within the team. The salary range listed for this role reflects our commitment to pay transparency and is based on market data, internal equity, and the scope of responsibilities. compensation will be determined by a combination of factors, including the candidate's experience, skills, and the specific team or product area they support. We regularly review compensation across the company to ensure fairness and consistency. If you are a current employee and have questions about how your compensation aligns with our ranges, we encourage you to speak with your manager or People Operations.

Benefits:

Remote first work environment
Health, Dental, Vision, Life and Disability Insurance options available day one.
401K - with match and immediately vested.
17 company holidays, 2 floating holidays plus competitive paid time off policy
Internal Advancement Opportunities

PerfectServe offers unified healthcare communication solutions to help physicians, nurses, and care team members provide exceptional patient care. PerfectServe's cloud-based solutions enhance patient safety and reduce provider burnout by automating workflows, speeding time to treatment, optimizing shift schedules, empowering nurse mobility, and engaging patients in their own care.

Quick Apply

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python developer jobs in knoxville, tn

Software Engineer – Full Stack AI - US-Remote

Full Stack AI Engineer

Full Stack Developer

Smart Manufacturing Software Engineer, Backend

Software Configuration Manager

Software Engineer I&C

Senior Platform Engineer, Delivery & Reliability

Lead Systems Engineer (LabVIEW and Automation)

Software Engineer (AI Platform)

Automation Lead

Lead DevSecOps Engineer

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