This position reports directly to Craig Forester, MD, PhD, and will work within the Forester Lab, a component of the School of Medicine’s Pediatric Hematology, Oncology and BMT. This position is involved in studies aimed at understanding the role of transcriptional gene regulation in hematopoietic stem cells and mutations found in pediatric bone marrow failure. Specifically, the Fellow will help investigate the role of Taspase1 mutations in early hematopoietic failure. The Fellow is expected to conduct research projects, to think independently, be highly motivated, design and carry out experiments, analyze data, and interpret and publish results. It is the Fellow’s responsibility to fully understand the technical details of Dr. Foresters’ projects as well as how each applies within the larger context of defining novel therapeutic agents in Hematological Research and broadening our understanding of mechanisms underpinning pediatric marrow failure.
Key Responsibilities:
This position is expected to work independently under the guidance of the principal investigator. Projects will involve work with research animals and extensive development and use of cutting-edge flow cytometry, molecular biology and cell biology assays on rare bone marrow-derived hematopoietic populations and induced pluripotent stem cells. Specific duties include:
Design and Performance of Research Experiments (75% of Time Spent)
Mechanism based discovery of aberrant transcription in pluripotent tissues.
Characterization of hematopoietic differentiation from iPSCs.
Use of animal model systems to study hematopoietic engraftment.
Engage in self-directed work with bioinformatic core to develop expertise in analysis of nascent transcription, CUT&Run and protoeomics (if not already proficient)
Analysis and Publication of Research Data (20% of Time Spent)
Mentoring of students and technical staff (5% of Time Spent)
Prepare data and manuscripts for publication
Prepare grant proposals to obtain independent post-doctoral funding
Actively participate in and present data at group meetings, journal clubs and conferences
Work in conjunction with the PI and other lab staff to achieve programmatic goals, including student supervision
Other duties as assigned
To fulfill job requirements, candidates must receive training and adhere to institutional standards of best practice in: animal care and handling, radiation and chemical safety, laboratory safety and other areas as determined by the institution and/or PI.
This description is a summary only and describes the general level of work being performed, it is not intended to be all-inclusive. The duties of this position may change from time to time and/or based on business need. We reserve the right to add or delete duties and responsibilities at the discretion of the supervisor and/or hiring authority.
