Top 20 Senior applied Jobs in Madison Wi

Senior Scientist I, DMPK
Arrowhead Pharmaceuticals —Madison, WI
- $115,000 - $140,000 a year
- 3 years
- Doctor of Philosophy
- US work authorization
Senior Associate Scientist - Analytical Development
Catalent —Madison, WI
- Weekends as needed
- Bachelor of Science
- High school diploma or GED
- Mentoring
- Paid holidays
- Health insurance
Cook
Milestone Senior Living Stoughton —Stoughton, WI
- $18 - $21 an hour
- Part-time
- Mid-level
- High school diploma or GED
- 2 years
- Disability insurance
- Health insurance
Quick Apply
14d
Senior Scientist I, Mechanical Engineering
AbbVie —Madison, WI
- $96,500 - $183,500 a year
- Full-time
- Microsoft Excel
- No experience needed
- Master's degree
- Paid holidays
- Health insurance
12d
Sr Workforce Analyst
Abbott Laboratories —Madison, WI
- $78,000 - $156,000 a year
- Full-time
- PMP
- HIPAA
- English
- Health insurance
- Tuition reimbursement
3d
Sr. Staff Program Manager
Thermo Fisher Scientific —Madison, WI
- Full-time
- Microsoft Excel
- Office
- Business development
20h
Senior Pega Developer
ATTAINX INC —Madison, WI
- $130,000 - $139,000 a year
- Full-time
- Remote
- Computer Science
- 5 years
- SQL
- Disability insurance
- Health insurance
School Psychologist-Senior (Project)
State of Wisconsin - Public Instruction —Madison, WI
- $30.00 - $43.66 an hour
- Part-time
- Current TB test
- Criminal background check
- Psychology
- Health insurance
- Employee assistance program
Senior Researcher
SLIPSTREAM GROUP INC —Madison, WI
- $75,000 - $105,000 a year
- Hybrid work
- 5 years
- Residential
- Ability to climb stairs
- Work from home
Senior Applied ML Engineer
Paradigm —Middleton, WI
- $125,250 - $183,700 a year
- Full-time
- Hybrid work
- Azure
- Computer Science
- 5 years
Quick Apply
Senior Research Engineer
SLIPSTREAM GROUP INC —Madison, WI
- $90,000 - $115,000 a year
- Hybrid work
- Management
- Ability to climb stairs
- 8 years
- Work from home
Senior Systems Engineering Compliance Engineer
ACCURAY —Madison, WI
- Overtime
- 7 years
- Office
- Analysis skills
Quick Apply
12d
Senior Software Engineer (Quantum Computing)
Infleqtion —Madison, WI
- $106,000 - $145,000 a year
- Full-time
- Hybrid work
- Computer Science
- 5 years
- System design
- Paid parental leave
- Health savings account
Quick Apply
Senior Design Engineer- New Product Development
Sub-Zero Group, Inc. —Madison, WI
- Background check
- Laboratory experience
- 3 years
- Profit sharing
- Health insurance
Quick Apply
Senior Design Engineer - Electronic Integration
Sub-Zero Group, Inc. —Madison, WI
- Background check
- Laboratory experience
- 3 years
- Profit sharing
- Health insurance
Quick Apply
Sr Project Engineer HVAC
ERDMAN —Madison, WI
- Full-time
- Office
- Microsoft Office
- 8 years
Quick Apply
Sr. Associate, Product Management – Applied AI Platforms
Baker Tilly Advisory Group, LP —Madison, WI
- $66,100 - $114,020 a year
- Full-time
- Remote
- Computer Science
- English
- Mid-level
Quick Apply

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Senior Scientist I, DMPK

Arrowhead Pharmaceuticals -
Madison, WI

Apply Now

Job Details

$115,000 - $140,000 a year

Qualifications

Biochemistry
Organic chemistry
Drug-drug interaction analysis
In vitro studies
Pre-clinical study projects
Doctor of Philosophy
Biochemistry
Mass spectrometers (MS)
In vivo studies
Research findings presentation
Pharmaceutical research experience
Liquid chromatography machines
Assays

Full Job Description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Arrowhead Pharmaceuticals is seeking an accomplished Senior Scientist, DMPK to play a key role in advancing our growing pipeline of RNAi-based therapeutics. As a senior member of the Drug Metabolism and Pharmacokinetics (DMPK) function, you will partner closely with multidisciplinary teams of chemists, biologists, and translational scientists to shape strategies that enable successful candidate nomination and IND submissions.

In this high-impact role, you will lead the design and execution of preclinical DMPK studies, guide interpretation of complex PK/PD data, oversee internal and external study activities, and ensure delivery of high-quality datasets that meet regulatory expectations. The ideal candidate brings deep technical expertise, strong problem-solving skills, and the ability to thrive in a fast-paced, collaborative environment dedicated to scientific excellence and innovative drug development.

Responsibilities

Develop and implement in vitro and in vivo DMPK strategies to support preclinical development for compounds across multiple indications and routes of administration.
Manage all DMPK activities, including oversight of internal resources and CRO partners to ensure high-quality and timely data delivery.
Design, supervise, and execute preclinical PK studies, including non-compartmental analysis (NCA), data interpretation, reporting, and communication of PK/PD insights to project teams.
Prepare and deliver IND-enabling DMPK packages, ensuring compliance with regulatory expectations and contributing to regulatory submissions.
Apply working knowledge of GLP/GCP principles and ensure appropriate documentation for regulated studies.
Support GLP toxicokinetic (TK) study design, analysis, and reporting.
Oversee metabolite identification in preclinical and clinical samples using high-resolution mass spectrometry (HRMS).
Contribute to a dynamic, fast-paced DMPK team by offering scientific leadership, troubleshooting support, and cross-functional collaboration.
Maintain a current understanding of clinical pharmacology literature and regulatory guidance for oligonucleotide/RNAi therapeutics.

Requirements

PhD in Pharmacometrics, Drug Metabolism, Pharmaceutical Sciences, or a related discipline with at least 3 years of industry experience.
Deep and broad expertise in DMPK, with working knowledge of nucleotide or oligonucleotide drug metabolism and distribution highly desired.
Hands-on experience with in vitro ADME assays, in vivo PK studies, drug–drug interaction (DDI) evaluations, and Phoenix WinNonlin.
Experience with LC–MS/MS and HRMS, ideally applied to oligonucleotide therapeutics.
Strong background in organic chemistry, biochemistry, and drug biotransformation.
Demonstrated experience in drug development and understanding of regulatory processes.
Excellent interpersonal, verbal, and written communication skills, with the ability to interpret and present complex scientific data clearly.

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.

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senior applied jobs in madison wi

Senior Scientist I, DMPK

Senior Associate Scientist - Analytical Development

Cook

Senior Scientist I, Mechanical Engineering

Sr Workforce Analyst

Sr. Staff Program Manager

Senior Pega Developer

School Psychologist-Senior (Project)

Senior Researcher

Senior Applied ML Engineer

Senior Research Engineer

Senior Systems Engineering Compliance Engineer

Senior Software Engineer (Quantum Computing)

Senior Design Engineer- New Product Development

Senior Design Engineer - Electronic Integration

Sr Project Engineer HVAC

Sr. Associate, Product Management – Applied AI Platforms

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