Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.
The Division of Cardiovascular Medicine at the University of Michigan is expanding a nationally and internationally funded research program at the cutting edge of cardiovascular medicine. Led by Drs. Venkatesh Murthy and Sascha Goonewardena - whose work has appeared in leading journals including NEJM AI, JAMA, and Circulation - the program fuses artificial intelligence, advanced cardiac imaging, multiomics (proteomics, metabolomics, and genomics), and cardiometabolic disease biology to develop precision diagnostics and identify novel therapeutic approaches, with a particular focus on coronary microvascular disease and other cardiovascular conditions that disproportionately affect women and remain poorly served by existing diagnostic tools. This is a rare opportunity to join a high-impact, well-funded program doing science that matters.
This position serves as the primary multiomics computational scientist for the program. The incumbent will build and maintain proteomics and multi-omic analysis pipelines, deploy AI model inferences at scale in large population biobanks, and apply causal and genetic inference methods to identify biological mechanisms underlying cardiometabolic disease. This is an infrastructure and pipeline-focused role: the incumbent constructs the computational frameworks and cross-cohort data systems that make population-scale discovery possible, working closely with the postdoctoral scientist who leads the hypothesis-driven analyses and manuscript development. This is one of two senior data scientist roles; the two positions serve complementary, non-overlapping functions.
- Build, implement, and maintain proteomics and multi-omic analysis pipelines integrating high-throughput proteomic data with metabolomic, genomic, and clinical datasets from large prospective cohort studies
- Deploy AI models to biobank datasets
- Build and maintain cross-cohort data harmonization and proteomic cross-walk tools across derivation and validation datasets
- Perform causal and genetic inference analyses (including Mendelian randomization and mediation analysis) to identify disease mechanisms
- Evaluate pipeline and signature performance; prepare written and code-based analytical reports (Python or R)
- Contribute to manuscripts, grant applications, and presentations
- Coordinate data sharing and computational workflows with collaborative network partners and other research partners
- Other duties as assigned
- Masters or doctoral degree in bioinformatics, computational biology, biostatistics, systems biology, or a closely related field
- Demonstrated experience analyzing large-scale proteomic datasets from high-throughput platforms (Olink or SomaScan)
- Proficiency in R and/or Python for statistical analysis and pipeline development
- Experience with multi-omic data integration combining at least two of: proteomics, metabolomics, genomics, transcriptomics
- Familiarity with statistical methods for high-dimensional biological data (dimensionality reduction, regularized regression, survival analysis
- Strong organizational skills and attention to detail
- Ability to prepare and present written and code-based (Python or R) analytical reports
- Strong scientific writing skills; ability to contribute to manuscripts and grant applications
- Experience with large prospective cohort or biobank datasets (e.g., CARDIA, MESA, Framingham Heart Study, UK Biobank, or similar)
- Experience with mediation analysis, causal inference, or Mendelian randomization methods in an omics context
- Background in cardiovascular biology, vascular biology, or cardiometabolic disease
- Experience with cloud or HPC computing environments, including Slurm-based job scheduling
- Familiarity with SQL or PostgreSQL for data querying and management
- Track record of peer-reviewed publications as a computational contributor to biomedical research
- Familiarity with endothelial biology, inflammation, or microvascular disease
- Experience with Git and reproducible research practices ? Experience building reproducible pipelines using workflow managers (Snakemake, Nextflow, or equivalent)
Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world's most distinguished academic health systems. In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.
What Benefits can you Look Forward to?
- Excellent medical, dental and vision coverage effective on your very first day
- 2:1 Match on retirement savings
Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.
Work Schedule: Monday through Friday, standard business hours. This is an onsite position.
We, the staff and faculty of the U-M Cardiovascular Center (CVC) team, are committed to advancing medicine and serving humanity through living and teaching our core values of Respect and Compassion; Collaboration; Innovation; and Commitment to Excellence. Each CVC employee is expected to understand and demonstrate that in every interaction we represent our entire organization in the care we provide and in the courtesies we extend to patients, families, and each respective team member. The CVC is dedicated to partnering with patients and families to deliver the safest and highest quality of health care.
The Division of Cardiovascular Medicine is firmly committed to advancing inclusion, diversity, equity, accessibility, and belonging, which are core to the culture and values of the Medical School Office of Research. Our community supports recruiting and cultivating a diverse workforce as a reflection of our commitment to serve the diverse people of Michigan and the world. We strive to create a work culture where each team member feels respected, valued, and safe.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
The University of Michigan is an Equal Opportunity Employer. We are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants, including protected veterans and individuals with disabilities.
