Top 563 Senior principal scientist Jobs in Natick, Ma

Senior / Principal Scientist, Structural Biology — Target Druggability & Structure-Based Drug Design
Schrödinger —Framingham, MA
- $135,000 - $190,000 a year
- Hybrid work
- Doctor of Philosophy
- Senior level
- AI
- Commuter assistance
- Health insurance
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6d
Senior/Principal Scientist, Computational Biology
Cellular Intelligence —Boston, MA
- $150,000 - $225,000 a year
- Full-time
- Computer Science
- 3 years
- Doctor of Philosophy
Principal Scientist II, Immunology
ModeX Therapeutics, Inc. —Weston, MA
- $207,000 - $222,000 a year
- Management
- 11+ years
- Master's degree
13d
Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)
Novartis —Cambridge, MA
- $126,000 - $261,000 a year
- Full-time
- Hybrid work
- 5 years
- English
- Master's degree
- Health insurance
- 401(k) matching
Senior / Principal Scientist, Biochemistry
Treeline Biosciences —Watertown, MA
- $158,000 - $184,000 a year
- 5 years
- Doctor of Philosophy
- Mentoring
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Senior Associate Scientist, Bioprocess Analytics
Sanofi —Framingham, MA
- $75,000.00 - $108,333.33 a year
- Master's degree
- Bachelor's degree
- 1 year
- Parental leave
Senior Director (Senior Principal Scientist), Translational Medicine, Immunology
Merck —Boston, MA
- $286,900 - $451,600 a year
- Full-time
- Medicine
- BC/BE
- Business development
- Paid holidays
- Health insurance
Senior Principal Scientist / Assoc Director, Oncology Translational Research
Novartis —Cambridge, MA
- $138,600 - $257,400 a year
- Full-time
- 5 years
- Analysis skills
- Doctor of Philosophy
- Health insurance
- 401(k) matching
Senior Director, AIRx Medicinal Chemistry
Takeda Pharmaceutical —Boston, MA
- $212,000 - $333,190 a year
- Full-time
- Hybrid work
- Management
- 11+ years
- Doctor of Philosophy
- Paid holidays
- Disability insurance
Contract Scientist/Sr. Scientist – Analytical Development (Cell Therapy)
Commonwealth Sciences —Waltham, MA
- Contract
- Bachelor of Science
- Bachelor's degree
- Continuous improvement
Senior Research Scientist – Battery and Data Center Safety
FM —Norwood, MA
- $121,000 - $173,000 a year
- Full-time
- Math
- Doctor of Philosophy
- Senior level
- 401(k)
- Tuition reimbursement
Physics Expert (Professor / Principal Investigator) – AI Trainer
micro1 —Boston, MA
- $80 - $160 an hour
- Contract
- Remote
- Doctor of Philosophy
- Senior level
- Leadership
- Flexible schedule
Senior Research Scientist –Flammability and Fire Dynamics
FM —Norwood, MA
- $121,000 - $173,000 a year
- Full-time
- Math
- Doctor of Philosophy
- Senior level
- 401(k)
- Tuition reimbursement
Senior Director, AIRx Discovery Biology Lead
Takeda Pharmaceutical —Boston, MA
- $212,000 - $333,190 a year
- Full-time
- Hybrid work
- Management
- 11+ years
- Doctor of Philosophy
- Paid holidays
- Disability insurance
Senior Director, Drug Safety & Pharmacovigilance – Development
Klein Hersh International —Boston, MA
- Email
- Medicine
- 5 years
- Contracts
Research Senior Scientific Director, Head of Hit ID and Sample Management (Automation)
Takeda Pharmaceutical —Boston, MA
- $212,000 - $333,190 a year
- Hybrid work
- Bachelor of Science
- 11+ years
- Presentation skills
- Paid holidays
- Disability insurance
AIRx, Sr. Director, Nonclinical Safety Lead
Takeda Pharmaceutical —Boston, MA
- $212,000 - $333,190 a year
- Call employer
- Hybrid work
- 11+ years
- Business development
- Doctor of Philosophy
- Paid holidays
- Disability insurance
Sr. Manager, R&D
Getinge —Boston, MA
- $160,000 a year
- Full-time
- Engineering
- Critical & Intensive Care
- Travel
- Commuter assistance
- Disability insurance
13d
Senior Principal Toxicologist
Keurig Dr Pepper —Burlington, MA
- $130,700 - $190,000 a year
- Email
- Doctor of Philosophy
- Travel
- Senior level
- Mileage reimbursement
- Paid parental leave
Sr. R&D Food Scientist
Home Market Foods —Norwood, MA
- $90,000 - $110,000 a year
- Microsoft Excel
- Microsoft Outlook
- Customer service
- Relocation assistance
- Health insurance
Quick Apply

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senior principal scientist jobs near natick, ma

Senior / Principal Scientist, Structural Biology — Target Druggability & Structure-Based Drug Design

Schrödinger -
Framingham, MA

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Job Details

$135,000 - $190,000 a year
6 days ago

Benefits

Commuter assistance
Stock options
Health insurance
Dental insurance
Parental leave
Vision insurance
Flexible schedule

Qualifications

Computational research

Full Job Description

Schrödinger seeks a Senior or Principal Scientist in Structural Biology (Target Druggability and Structure-Based Drug Design) to join us in our mission to transform the discovery of therapeutics and materials!

Schrödinger has pioneered a physics-based software platform that enables discovery of high-quality, novel molecules for drug development and materials applications more rapidly and at lower cost compared to traditional methods. The software platform is used by biopharmaceutical and industrial companies, academic institutions, and government laboratories around the world. Our multidisciplinary drug discovery team also leverages the software platform to advance collaborative programs and its own pipeline of novel therapeutics to address unmet medical needs.As a member of our Structural Biology and Target Enablement team in our Therapeutics Group, you'll partner with Molecular Pharmacologists, Biologists, Medicinal Chemists, and Computational Chemists to define target tractability strategies, identify and validate novel and cryptic binding sites, and design and supervise experimental campaigns to solve unprecedented structures that unlock previously intractable targets. Sitting at the interface of computation and experiment, you'll be as comfortable proposing in silico-predicted binding site hypotheses as you are designing and executing the experimental structural biology strategies to test them.

Who will love this job:

A scientist with a track record of success in assessing and expanding oral drug tractability for challenging and undrugged targets
A structural and computational biology expert who's familiar with Schrödinger's platform (Glide, FEP+, BioLuminate, Prime, etc.) or comparable structure-based design software
A veteran of computational-experimental hybrid work in biotech, pharma, or an SBDD-focused software company
A researcher who has worked on modality-switch programs (e.g., biologic-to-small-molecule or PROTAC/molecular glue strategies)
An excellent scientific communicator who has presented target tractability assessments to senior stakeholders and defended hypotheses under scientific scrutiny

What you'll do:

Define druggability hypotheses for difficult-to-drug targets by integrating structural, computational, biophysical, and pharmacological evidence
Apply and advance computational methods, including AI/ML approaches, for structure prediction and refinement, small-molecule binding site identification (including cryptic and transient pockets), pocket druggability scoring, and conformational sampling of target ensembles
Translate structural and computational insights into actionable hypotheses for medicinal chemistry and biology teams, proposing specific experiments (biophysical, structural, or computational) to test and de-risk emerging druggability hypotheses
Evaluate and integrate emerging methods (e.g., generative structure prediction, cryptic pocket detection, MD-based ensemble docking, AI-based binding site/ligandability prediction) into practical workflows
Present target tractability assessments to project teams, portfolio review committees, and leadership, communicating complex structural/computational rationale clearly to non-specialist audiences
Lead experimental structural biology efforts on active target enablement and drug discovery programs, managing work at external CROs, collaborating with our internal Structural Biology team, and/or directly performing hands-on experiments at our internal laboratory
Contribute to Schrödinger's broader platform strategy, feeding practical, target-tractability-driven requirements back into internal software and methods development

What you should have:

PhD (or equivalent industrial experience) in Structural Biology, Biophysics, Computational Chemistry, or a related discipline
Deep, hands-on expertise in structure-based drug design, including practical experience with cryptic/transient binding site identification and pocket druggability assessment
Working fluency in modern computational structural biology methods, such as AI-based structure prediction, MD-based conformational sampling, binding site/pocket detection algorithms, and structure refinement
Direct experience designing, executing, and interpreting cryo-EM and/or X-ray crystallography experiments, including strategies for capturing difficult, dynamic, or novel structural states

Pay and perks:

Schrödinger understands it's people that make a company great. Because of this, we're prepared to offer a competitive salary, stock options, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have catered meals in the office, a company culture that is relaxed but engaged, and over a month of paid vacation time.

Estimated base salary range: $135,000 - $190,000. Actual compensation package is dependent on a number of factors, including, for example, experience, education, degrees held, market data, and business needs. If you have any questions regarding the compensation for this role, do not hesitate to reach out to a member of our Strategic Growth team.

Sound exciting? Apply today and join us!

As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.

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Refine Your Search

senior principal scientist jobs in natick, ma

Senior / Principal Scientist, Structural Biology — Target Druggability & Structure-Based Drug Design

Senior/Principal Scientist, Computational Biology

Principal Scientist II, Immunology

Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)

Senior / Principal Scientist, Biochemistry

Senior Associate Scientist, Bioprocess Analytics

Senior Director (Senior Principal Scientist), Translational Medicine, Immunology

Senior Principal Scientist / Assoc Director, Oncology Translational Research

Senior Director, AIRx Medicinal Chemistry

Contract Scientist/Sr. Scientist – Analytical Development (Cell Therapy)

Senior Research Scientist – Battery and Data Center Safety

Physics Expert (Professor / Principal Investigator) – AI Trainer

Senior Research Scientist –Flammability and Fire Dynamics

Senior Director, AIRx Discovery Biology Lead

Senior Director, Drug Safety & Pharmacovigilance – Development

Research Senior Scientific Director, Head of Hit ID and Sample Management (Automation)

AIRx, Sr. Director, Nonclinical Safety Lead

Sr. Manager, R&D

Senior Principal Toxicologist

Sr. R&D Food Scientist

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