Top 6 Principal scientist Jobs in New Haven, Ct

Principal Scientist – Antibody Discovery/Protein Design
EVOLVEIMMUNE THERAPEUTICS INC —Branford, CT
- Full-time
- Doctor of Philosophy
- Mentoring
- Organizational skills
- Paid time off
Quick Apply
Principal Microbiologist
Henkel —Trumbull, CT
- $110,000 - $120,000 a year
- Full-time
- Hybrid work
- Bachelor's degree
- Home Health
- Mentoring
- Paid holidays
- Health insurance
Quick Apply
Principal Scientist - Safety Surveillance and Risk Assessment
Altria —United States
- $132,500 - $202,100 a year
- Full-time
- Presentation skills
- Doctor of Philosophy
- Senior level
- Profit sharing
- Paid parental leave
Senior Principal AI Scientist
Recruits Lab —United States
- $300,000 a year
- Full-time
- Doctoral degree
- Research
- Senior level
- Paid holidays
- Disability insurance
Quick Apply

Discover related jobs

Based on your search for principal scientist jobs.

Microbiologist 1
Certified Group —Melville, NY
BS degree in microbiology or related field with 2-3 years of lab experience. FSNS Certification & Audit – Provides accredited third-party auditing and…
$20 - $25 an hour
Quick Apply
12d
Genetics Counselor
Middlesex Health —Middletown, CT
Assess the risk that the patient will develop cancer, the risk that the patient carries a germline mutation in a cancer susceptibility gene, and provide…

Show more related jobs

Explore jobs in cities nearby

Check out jobs in cities near your current location, Columbus

Principal Food Scientist
Schwan's Company —Gahanna, OH
Apply food science expertise to develop, improve, and optimize products, ingredients, processes, packaging, and preservation methods while ensuring quality,…
$107,000 - $178,000 a year
Quick Apply
6d
Principal Scientist - Safety Surveillance and Risk Assessment
Altria —United States
Have a degree in Toxicology or related field with experience in adverse event management and conducting toxicological risk assessments? What you'll be doing:
$132,500 - $202,100 a year

Show more jobs in cities nearby

I want to receive the latest job alert for principal scientist in new haven, ct

By signing in to your account, you agree to SimplyHired's Terms of Service and consent to our Cookie and Privacy Policy.

Explore jobs in more locations

principal scientist jobs near new haven, ct

Principal Scientist – Antibody Discovery/Protein Design

EVOLVEIMMUNE THERAPEUTICS INC
Branford, CT

Quick Apply

Job Details

Full-time

Benefits

Paid time off

Qualifications

AI models
Protein purification
Antibody screening & identification
Computational research
Machine learning/AI-based analysis
Handling proteins
In silico prediction
Handling antibodies
Doctor of Philosophy
Structural modeling
Data interpretation
Experimental design
Experience in a research and development laboratory environment
AI
Cross-functional collaboration
Cross-functional communication

Full Job Description

Join a company where your science will directly shape the future of cancer immunotherapy

Who We Are

EvolveImmune Therapeutics is a privately-held, next-generation immuno-oncology company pioneering a new class of T cell engager therapies to transform cancer patient outcomes compared to current immunotherapies. Our first-in-category biotherapeutic EVOLVE platform utilizes integrated T cell costimulation to directly target tumor cells to deliver durable anti-tumor adaptive immune responses. Our lead asset, EVOLVE104, entered clinical trials in late 2025. Additional collaboration pipeline programs (with Abbvie) and wholly owned programs are progressing toward candidate nomination. EvolveImmune’s team consists of ~50 FTEs in R&D, business development, people & culture, finance and operations. Our newly expanded, state-of-the-art 20,000+ square foot laboratory and office space located in the New Haven, CT biotechnology corridor is convenient to the amenities of the Connecticut shoreline, the city of New Haven and easy travel options throughout the Boston/New York City corridor.

We're hiring a Principal Scientist to join our Biotherapeutics group focused on designing and advancing first-in-class immune-engaging biologics. If you’re a protein engineer with expertise in computational protein design with experimental experience in protein discovery and optimization through antibody display technologies with an interest in advancing drug candidate toward first-in-patient evaluation, this role offers real opportunity, purpose, and scientific challenge.

What You’ll Work on

Design and optimize novel antibody-based multispecifics targeting domains using AI/ML-model-based de novo sequence discovery
Lead antibody engineering and antibody display-based screening from idea to experimental execution including screening, hit prioritization, and initial characterization.
Optimize developability in lead optimization through computational and biophysical insights
Expand company computational protein design tools and capabilities
Collaborate across functional teams to support candidate selection and preclinical development
Present findings in a clear, compelling way to multidisciplinary teams
Mentor junior scientists and help shape our growing discovery efforts

_______________________________________

What You Bring

PhD in biochemistry, computational biology, or structural biology, and postdoctoral fellowship in a related field with 5+ years of antibody and biotherapeutic engineering industry experience
Foundation in protein design and molecular modeling using AI/ML
Yeast or alternative antibody display technologies experience from design through screening
Expertise in bispecific or multispecific protein design, expression, purification, and biophysical characterization
Strong communication, data interpretation, and cross-functional collaboration skills

________________________________________

What You’ll Gain

A hands-on, high-impact role shaping the design of next-generation immunotherapies
Opportunity to see your work move rapidly from concept to clinic
A visible position within the Biotherapeutics team, contributing directly to platform and pipeline innovation
A chance to collaborate across disciplines and influence key program decisions
Professional growth through exposure to diverse scientific challenges and cross-functional projects
Optional mentorship opportunities and the ability to help shape a growing discovery organization
A mission-driven, fast-paced biotech environment that values bold thinking and scientific excellence
A supportive, open culture built on collaboration, trust, and shared purpose

________________________________________

Why You’ll Love Working Here

Direct impact: Your science will influence platform design and shape next-generation clinical programs.
Cutting-edge science: Help pioneer new approaches to T cell redirection in solid tumors.
Personal growth: Gain exposure to every stage of early discovery in a collaborative biotech setting.
Collaborative culture: Join a supportive, curious, and driven team aligned around scientific innovation and patient outcomes.
Top-tier facilities: Work in a brand-new, purpose-built lab and office space near New Haven, CT.
Mission with meaning: Join a company working to give more patients real hope in the fight against cancer.

________________________________________

Additional Info

This is a full-time, onsite position based in Branford, CT
EvolveImmune requires COVID-19 vaccination; medical and religious accommodations will be considered
We offer competitive salary, benefits, equity, and paid time off
We are an equal opportunity employer and value diverse perspectives in all aspects of our work
Learn more about our science and our team at www.evolveimmune.com

________________________________________

Search Keywords

Quick Apply

Refine Your Search

principal scientist jobs in new haven, ct

Principal Scientist – Antibody Discovery/Protein Design

Principal Microbiologist

Principal Scientist - Safety Surveillance and Risk Assessment

Senior Principal AI Scientist

Discover related jobs

Explore jobs in cities nearby

I want to receive the latest job alert for principal scientist in new haven, ct

Explore jobs in more locations

Job Seeker Tools

Employer Tools

Browse

Stay Connected