Top 58 Principal scientist Jobs in New York, Ny

Principal, Data & Analytics
Roivant Sciences —New York, NY
- $130,000 - $220,000 a year
- Full-time
- Analysis skills
- Senior level
- Commercial
Principal Scientist- Search
Thomson Reuters —New York, NY
- $212,100 - $393,900 a year
- Full-time
- Hybrid work
- Computer Science
- Office
- Databases
- Commuter assistance
- Health savings account
Clinical Imaging Scientist (Principal Scientist), Remote
Merck —Rahway, NJ
- $173,200 - $272,600 a year
- Full-time
- Remote
- Bachelor's degree
- Travel
- Fair chance
- Paid holidays
- Health insurance
4d
Principal Research Scientist - Risk
Neara —New York, NY
- $180,000 - $220,000 a year
- Full-time
- Hybrid work
- Computer Science
- Math
- Doctor of Philosophy
- Flexible schedule
Principal, Biostatistician
Roivant Sciences —New York, NY
- $130,000 - $220,000 a year
- Full-time
- Senior level
- Commercial
Principal Biostatistician
Kenvue —Summit, NJ
- Hybrid work
- Management
- Doctor of Philosophy
- Senior level
- Paid holidays
10h
Member of Technical Staff, Principal Biostatistician
Ataraxis AI —New York, NY
- $100,000 - $300,000 a year
- Full-time
- Analysis skills
- Doctor of Philosophy
- Mentoring
Principal Scientist, Biostatistics
Merck —Rahway, NJ
- $190,800 - $300,300 a year
- Full-time
- 6 years
- Analysis skills
- Doctor of Philosophy
- Paid holidays
- Health insurance
Associate Principal Scientist, Biostatistics
Merck —Rahway, NJ
- $142,400 - $224,100 a year
- Full-time
- 3 years
- Master's degree
- Doctor of Philosophy
- Paid holidays
- Health insurance
Associate Principal Scientist, Process Chemistry
Merck —Rahway, NJ
- $142,400 - $224,100 a year
- Full-time
- Doctor of Philosophy
- Travel
- Mentoring
- Paid holidays
- Health insurance
10d
Principal Investigator/Research Scientist – iPSC and Organoid Modeling
Tisch MS Research Center of New York —New York, NY
- $70,000 - $100,000 a year
- Urgently hiring
- Doctor of Philosophy
- Senior level
- Communication skills
Principal Investigator/Research Scientist
Tisch Multiple Sclerosis Research Center Of New York Inc —New York, NY
- $70,000 - $100,000 a year
- Urgently hiring
- Doctor of Philosophy
- Neurology
- Senior level
Senior/Principal Machine Learning Scientist, Structure and Simulation (AI for Drug Discovery)
Genentech —New York, NY
- $147,800 - $320,200 a year
- Online Application
- Computer science
- Computer Science
- Bachelor of Science
Principal Research Scientist, Amazon Connect
Amazon.com Services LLC —New York, NY
- $208,300 - $281,800 a year
- Full-time
- Computer science
- Computer Science
- Doctor of Philosophy
- AD&D insurance
- Health insurance
3d
Principal Scientist, Pharmaceutical Analytical Sciences
Merck —Rahway, NJ
- $156,900 - $247,000 a year
- Full-time
- 7 years
- Master's degree
- Bachelor's degree
- Paid holidays
- Health insurance
Principal Scientist, Upstream Development
Merck —Rahway, NJ
- $173,200 - $272,600 a year
- Full-time
- Master's degree
- 8 years
- Bachelor's degree
- Paid holidays
- Health insurance
10d
Principal Applied Scientist, Amazon Braket
Amazon Development Center U.S., Inc. —New York, NY
- $198,900 - $295,900 a year
- Full-time
- Computer Science
- Java
- Analysis skills
- AD&D insurance
- Health insurance
Senior / Principal Machine Learning Scientist, Scientific Reasoning Models, AI for Drug Discovery
Genentech —New York, NY
- $167,400 - $310,800 a year
- Online Application
- Computer Science
- Continuous improvement
- Doctor of Philosophy
Principal Scientist, DDT-Lab Automation, Digital Lab and Automation Strategy
Merck —Rahway, NJ
- $173,200 - $272,600 a year
- Full-time
- 6 years
- Bachelor of Science
- Bachelor's degree
- Paid holidays
- Health insurance
Principal Scientist, Upstream Process Development
Merck —Rahway, NJ
- $173,200 - $272,600 a year
- Full-time
- 6 years
- Master's degree
- Doctor of Philosophy
- Paid holidays
- Health insurance
11d

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Principal, Data & Analytics

Roivant Sciences -
New York, NY

Apply Now

Job Details

Full-time
$130,000 - $220,000 a year

Qualifications

Data-driven problem-solving

Full Job Description

Roivant is a biopharmaceutical company that aims to improve the lives of patients by accelerating the development and commercialization of medicines that matter. Roivant advances its pipeline by creating nimble subsidiaries or “Vants” to develop and commercialize medicines and technologies. Since its inception in 2014, Roivant has achieved the following critical milestones in support of its vision: built over 20 Vants; 12 consecutive positive Phase 3 trials; 8 FDA approvals; 5 successful IPOs; >$6B in capital raised; >$10B in global pharma partnerships and proceeds; and continued pipeline expansion across various modalities and therapeutic areas through in-licensing and acquisition of novel product candidates and technology platforms. In addition to a robust clinical stage pipeline, Roivant also incubates discovery-stage companies and health technology startups complementary to its biopharmaceutical business.

We embrace diversity across all dimensions and levels of the organization, and we strive to ensure every employee is supported in reaching their full potential. We hire motivated people with diverse backgrounds, identities, experiences and skillsets. We are committed to fostering an inclusive culture where all employees feel valued, respected and empowered to create value for patients.

To learn more about our story and company culture, please visit us at https://roivant.com/

Position Summary

The Principal, Data & Analytics will own the statistical and quantitative work that connects clinical evidence to the most important decisions Roivant makes across its pipeline. This is not a strategy role — this is a figure-things-out and get-things-done role in a high-stakes environment with substantial ownership. We expect you to get to ground truth on the hardest clinical and scientific questions the company faces, working directly in trial datasets and translating rigorous analysis into recommendations that leadership acts on.

The Principal will pressure-test the clinical assumptions underpinning key pipeline and commercial decisions, build the statistical frameworks needed to evaluate evidence across assets, and ensure Roivant has a clear-eyed view of what its data actually shows. The scope is intentionally broad and is well-suited to a high-potential individual earlier in their career with exceptional upside and a strong desire to take on responsibility.

Responsibilities

Clinical Trial Data & Signal Detection

Work directly in ongoing and completed clinical trial datasets (CSRs, patient-level data, interim readouts) to identify efficacy signals, safety patterns, and subgroup effects that inform go/no-go and commercialization decisions
Build rigorous statistical analyses from scratch: mixed-effects models, longitudinal models, Bayesian frameworks, subgroup analyses, and sensitivity analyses across Roivant's pipeline assets
Monitor emerging safety signals and unexpected findings in real time across ongoing studies; surface and contextualize them for leadership before they become surprises
Pressure-test clinical assumptions: challenge endpoint choices, scrutinize statistical analysis plans, and flag where the data does not support the narrative
Execute focused 1-5 day analytical sprints on the highest-priority questions from Roivant and Vant leadership

Evidence Synthesis & Competitive Intelligence

Develop a deep, differentiated read of the clinical evidence base for Roivant's near-commercial assets: what the data shows, what it does not, and where the science is genuinely uncertain
Analyze competitors' trial data, published and unpublished, with the same rigor applied to Roivant's own: endpoints, patient populations, effect sizes, and durability
Synthesize findings from literature, registries, claims, and proprietary datasets into coherent evidence narratives that hold up under scrutiny

Data Infrastructure & Cross-Platform Work

Drive selection and integration of the data sources needed to support portfolio decisions, including claims, labs, clinical trial data, and genomics
Help build shared analytical infrastructure across Roivant and Vant companies
Identify opportunities to apply consistent statistical frameworks across assets and therapeutic areas

Qualifications

Exceptional record of achievement from a top-tier university
Outstanding analytical ability and a relentless drive to get to the right answer; you do not stop at a plausible one
Strong quantitative foundation and fluency with data; you have used both to answer hard questions under pressure, not just to describe what happened
Genuine curiosity about science, medicine, or health; deep biology training is not required, but the underlying questions need to matter to you
Fast learner who gets up to speed in unfamiliar domains without needing a runway; you are comfortable operating at the edge of your knowledge
A track record of doing work that changed a decision or outcome, not just informed one
Able to communicate complex findings with clarity and confidence to senior stakeholders across disciplines

Context

Roivant is preparing to become the next breakout commercial-stage biotech, with the commercialization of brepocitinib, IMVT-1402, and mosliciguat. Getting those launches right requires an unusually rigorous understanding of the clinical evidence that defines each market: what the data actually shows, not what anyone wishes it showed.

This role ensures that understanding exists. It carries real ownership, direct exposure to senior leadership, and a trajectory that can serve as a foundation for future senior roles across the platform.

Compensation & Benefits

This is a full-time position. The role offers meaningful equity participation and a comprehensive company-sponsored benefits package.

Base salary will be determined during the interview process and will vary based on multiple factors, including prior experience, relevant expertise, current business needs, and market conditions. The expected base salary will generally be between $130,000 to $220,000 per year at commencement of employment, but the final salary offered may be outside this range based on individual circumstances.

This position is at-will and Roivant reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance and business and market conditions.

Roivant Sciences provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

We will not accept unsolicited resumes nor outreach from agencies. Please do not send agency resumes to our website or Roivant Sciences and affiliated employees. Thanks!

Apply Now

Refine Your Search

principal scientist jobs in new york, ny

Principal, Data & Analytics

Principal Scientist- Search

Clinical Imaging Scientist (Principal Scientist), Remote

Principal Research Scientist - Risk

Principal, Biostatistician

Principal Biostatistician

Member of Technical Staff, Principal Biostatistician

Principal Scientist, Biostatistics

Associate Principal Scientist, Biostatistics

Associate Principal Scientist, Process Chemistry

Principal Investigator/Research Scientist – iPSC and Organoid Modeling

Principal Investigator/Research Scientist

Senior/Principal Machine Learning Scientist, Structure and Simulation (AI for Drug Discovery)

Principal Research Scientist, Amazon Connect

Principal Scientist, Pharmaceutical Analytical Sciences

Principal Scientist, Upstream Development

Principal Applied Scientist, Amazon Braket

Senior / Principal Machine Learning Scientist, Scientific Reasoning Models, AI for Drug Discovery

Principal Scientist, DDT-Lab Automation, Digital Lab and Automation Strategy

Principal Scientist, Upstream Process Development

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