Top 3 Senior microscope engineer Jobs in Novato Ca

Senior Microscope Engineer
Eon Systems —San Francisco, CA
- $140,000 - $200,000 a year
- Full-time
- System design
- Senior level
Senior Metallurgy Engineer
United Airlines —San Francisco, CA
- $100,415 - $130,758 a year
- Full-time
- 5 years
- Analysis skills
- Bachelor's degree
- Paid holidays
- Disability insurance
Senior Full Stack Software Engineer
Vivodyne —San Francisco, CA
- $204,400 - $285,600 a year
- Computer Science
- 5 years
- Master's degree

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senior microscope engineer jobs near novato ca

Senior Microscope Engineer

Eon Systems -
San Francisco, CA

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Job Details

Full-time
$140,000 - $200,000 a year

Qualifications

Image processing
Digital imaging
System design
System design for system development
Microscope proficiency

Full Job Description

About us

Eon is building the infrastructure for large-scale connectomics data collection, reconstruction, and brain simulation. Our mission is to enable the safe and scalable development of brain emulation technology, beginning with digital twins of model organisms.

We are developing an end-to-end platform that spans tissue preparation, high-throughput microscopy, large-scale image processing, neural reconstruction, connectome-based modeling, and embodied simulation. We are looking for exceptional engineers and scientists who can help turn biological brain data into usable computational systems.

Role

We are seeking a Senior Microscope Engineer to build and scale the imaging systems at the heart of our connectomics pipeline. You will design, build, and bring up custom high-throughput optical microscopes optimized for imaging expanded brain tissue, take our current prototype through to a production-ready instrument, and lead its replication into a small fleet for large-scale acquisition.

This is a hands-on role for someone who has personally built high-throughput microscopes end to end — optics, optomechanics, illumination, detection, and control — and who is comfortable moving between instrument design, day-to-day acquisition, and the practical problem-solving that scaling a novel imaging system demands.

Responsibilities

Design and build custom, cost-effective, high-throughput optical microscopes (e.g., spinning-disk confocal) optimized for expanded tissue.
Take a working prototype to a production-ready instrument: motorized staging, optimized acquisition, and validated performance.
Operate microscopes to acquire high-resolution 3D image volumes of expanded neural tissue, sustaining high throughput and high instrument uptime.
Produce complete build documentation — bills of materials, budgets, timelines, and assembly SOPs a technician can follow — and lead replication toward a small fleet.
Troubleshoot imaging issues and perform routine maintenance on microscopy equipment.

Skills and Qualifications

5+ years designing and building optical microscopy instruments such as spinning-disk confocal or lightsheet systems, with at least one high-throughput microscope built end to end.
Strong optical design and alignment skills, and hands-on optomechanical build experience (CAD and rapid prototyping a plus).
Practical command of illumination sources, objective/optics selection, and cameras/detectors.
Ability to code for instrument control, automation, and image processing and analysis.
Ability to work collaboratively in a dynamic, fast-paced research environment.

Nice to have

High-speed image-sensor integration, FPGA or custom data-acquisition electronics e
Experience with the storage and data pipelines required for large-scale imaging.

Representative projects

Bringing a prototype microscope to production and validating its performance on expanded tissue.
Scaling from a single validated instrument to a small fleet for large-scale acquisition.
Developing robust mounting and handling for large expanded samples.

Salary and Benefits

$140,000–$200,000 base salary depending on experience, plus equity and benefits.

Opportunity to work in a cutting-edge field that impacts neuroscience and AI safety.

Apply Now

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senior microscope engineer jobs in novato ca

Senior Microscope Engineer

Senior Metallurgy Engineer

Senior Full Stack Software Engineer