Description
Senior Clinical Project Manager – Inflammation/ Phase 2b (Sponsor Dedicated - Remote; Preference for Hybrid Foster City, CA )
Syneos Health® is a leading fully-integrated life sciences services organization built to accelerate customer success. We partner with innovators at every point across the drug development and commercialization continuum, helping them navigate complexity, anticipate change and accelerate progress.
Our Clinical Solutions team members act with a drug development mindset, applying their years of experience and deep expertise to truly understand customer needs and represent those in the solutions we shape.
Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to deliver – for one another, our customers, and, most importantly, for those in need.
Discover what your 25,000 future colleagues already know:
Why Syneos Health
- We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
- We are committed to building an inclusive culture – where you can authentically be yourself. Central to this is our purpose – Driven to Deliver – which captures the passion of our colleagues to show up each day and shape solutions that have the ability to dramatically impact someone’s life.
- We are continuously building the company we all want to work for and our customers want to work with. Why? Because we know that when we bring together smart colleagues from across the world, we can shape the future of healthcare, driving impact for customers and defining the pace of patient progress.
Job Responsibilities
Preference for Hybrid Foster City, CA-Based Candidates
Are you a senior clinical operations professional who knows how to independently lead complex global clinical trials from start-up through closeout — while still staying deeply connected to the operational details that drive execution success?
This is a highly visible opportunity supporting large-scale global Phase 2b inflammation programs within a sponsor-dedicated environment, as a U.S.-based Global Study Lead. These pivotal programs span North America, Europe, APAC, Japan, and China, offering the opportunity to lead large-scale international clinical trials with significant visibility and impact.
We are seeking an experienced Senior Clinical Project Manager / Global Study Lead with a proven track record of leading pivotal global Phase 2b studies and driving trial execution with minimal oversight. Operating within a small, highly collaborative team, the successful candidate will bring demonstrated experience leading complex global programs, driving cross-functional accountability, navigating operational challenges, and delivering results in a matrixed environment.
This role is ideal for a seasoned clinical project leader who thrives in a high-ownership environment, is comfortable making critical decisions, influencing stakeholders, and taking full accountability for the successful delivery of global clinical trials.
**While remote/home-based candidates may be considered, priority will be given to candidates located in or near Foster City, California, with the ability to work onsite 2–3 days per week.**
Lead pivotal, highly complex global Phase 2b inflammation studies
Serve as Global Study Lead across North America, Europe, APAC, Japan, and China
Operate with significant ownership and autonomy in a sponsor-dedicated environment
Join a lean, highly collaborative team where independent leadership and sound decision-making are valued
Partner directly with Sponsor stakeholders and senior leadership
Play a visible role in the successful execution of critical clinical development programs
Influence study strategy while maintaining hands-on operational leadership
Contribute to globally significant programs with meaningful impact on patient care and drug development
Global Study Leadership
Serve as the Global Study Lead for complex, pivotal Phase 2b inflammation studies
Lead global study execution across North America, Europe, APAC, Japan, and China
Provide strategic and operational leadership throughout study start-up, conduct, and closeout
Act as the primary point of accountability for study delivery, quality, timelines, and execution
Lead cross-functional global teams and drive alignment across internal stakeholders, vendors, and external partners
Manage interdisciplinary clinical research programs in compliance with GCP, ICH guidelines, SOPs, and applicable regulatory requirements
Serve as the primary liaison between the Sponsor and project stakeholders throughout the study lifecycle
Maintain accountability for study deliverables, milestones, risks, budgets, and overall project performance
Independently drive decision-making and execution while ensuring stakeholder alignment and operational excellence
Operational Oversight
Coordinate activities and deliverables across CROs, vendors, and project partners
Lead proactive risk identification, mitigation planning, and issue resolution activities
Maintain oversight of project timelines, study trackers, key milestones, and critical deliverables
Oversee inspection readiness activities, including Trial Master File strategy and oversight
Ensure implementation of project plans in accordance with study requirements and controlled documents
Anticipate operational challenges and independently develop solutions to maintain study timelines and quality standards
Drive accountability across study teams to ensure successful execution and delivery
Leadership & Communication
Lead global cross-functional teams and foster a culture of accountability, collaboration, and performance
Independently prepare, coordinate, and present project materials during Sponsor, governance, and executive-level meetings
Facilitate project-related discussions, issue escalation, and decision-making forums
Direct activities of assigned project support staff and functional team members
Mentor project management team members and clinical operations staff as appropriate
Build strong working relationships across geographically dispersed teams and stakeholder groups
Communicate effectively with senior leadership and executive stakeholders regarding study progress, risks, and mitigation strategies
Business & Strategic Support
Participate in bid defense meetings as a potential project lead
Support relationship development with current clients and stakeholders
Maintain awareness of therapeutic area trends, competitive intelligence, and clinical development strategies within inflammation
Contribute strategic insights that support successful study delivery and long-term program objectives
Partner with leadership to identify opportunities for process improvements and operational efficiencies
Required Experience
5+ years of global clinical project management experience
Demonstrated experience serving as the Global Study Lead for pivotal Phase 2b clinical trials
Direct experience leading complex global studies across North America, Europe, APAC, Japan, and China
Proven ability to independently lead global clinical trials with minimal oversight
Demonstrated track record of autonomously leading complex global studies, driving cross-functional accountability, navigating operational challenges, and delivering successful outcomes within a global matrix environment
Experience overseeing CROs, vendors, and external partners
Strong pharmaceutical, biotechnology, CRO, or clinical research industry experience
Experience managing study budgets, timelines, risks, and operational deliverables at a global level
Technical & Leadership Expertise
Deep understanding of GCP, ICH guidelines, global regulatory requirements, drug development processes, and clinical trial operations
Demonstrated success leading large, geographically dispersed global teams
Strong strategic thinking, problem-solving, and decision-making capabilities
Excellent communication, presentation, stakeholder management, and interpersonal skills
Ability to influence without authority and drive accountability across cross-functional teams
Strong organizational, planning, and project leadership skills
Ability to effectively manage multiple priorities and deadlines in a fast-paced environment
Comfortable operating independently while maintaining strong collaboration across stakeholders
Experience navigating complex global clinical development environments with minimal supervision
Proficiency with clinical trial systems, project management tools, and emerging technologies
The ideal candidate is a seasoned Global Study Lead with a proven history of successfully leading pivotal Phase 2b clinical trials on a global scale. They are highly autonomous, strategically minded, and comfortable operating in a lean team environment where independent leadership, sound judgment, and operational excellence are essential.
This individual possesses a demonstrated ability to lead complex global studies, drive cross-functional accountability, proactively manage risks, influence stakeholders at all levels, and deliver successful outcomes with minimal oversight. They thrive in environments that require ownership, initiative, and the ability to navigate ambiguity while maintaining focus on study quality, timelines, and overall program success.
If you are looking for an opportunity to lead globally visible inflammation programs, take full ownership of study execution, and play a critical role in the delivery of pivotal Phase 2b trials, we would welcome the opportunity to speak with you!
At Syneos Health, we believe in providing an environment and culture in which Our People can thrive, develop and advance. We reward and recognize our people by providing valuable benefits and a quality-of-life balance. The benefits for this position may include a company car or car allowance, Health benefits to include Medical, Dental and Vision, Company match 401k, eligibility to participate in Employee Stock Purchase Plan, Eligibility to earn commissions/bonus based on company and individual performance, and flexible paid time off (PTO) and sick time. Because certain states and municipalities have regulated paid sick time requirements, eligibility for paid sick time may vary depending on where you work. Syneos complies with all applicable federal, state, and municipal paid sick time requirements.
Salary Range:
$114,000.00 - $210,900.00
The base salary range represents the anticipated low and high of the Syneos Health range for this position. Actual salary will vary based on various factors such as the candidate’s qualifications, skills, competencies, and proficiency for the role.
Get to know Syneos Health
Over the past 5 years, we have worked with 94% of all Novel FDA Approved Drugs, 95% of EMA Authorized Products and over 200 Studies across 73,000 Sites and 675,000+ Trial patients.
No matter what your role is, you’ll take the initiative and challenge the status quo with us in a highly competitive and ever-changing environment. Learn more about Syneos Health.
http://www.syneoshealth.com
Additional Information
Tasks, duties, and responsibilities as listed in this job description are not exhaustive. The Company, at its sole discretion and with no prior notice, may assign other tasks, duties, and job responsibilities. Equivalent experience, skills, and/or education will also be considered so qualifications of incumbents may differ from those listed in the Job Description. The Company, at its sole discretion, will determine what constitutes as equivalent to the qualifications described above. Further, nothing contained herein should be construed to create an employment contract. Occasionally, required skills/experiences for jobs are expressed in brief terms. Any language contained herein is intended to fully comply with all obligations imposed by the legislation of each country in which it operates, including the implementation of the EU Equality Directive, in relation to the recruitment and employment of its employees. The Company is committed to compliance with the Americans with Disabilities Act, including the provision of reasonable accommodations, when appropriate, to assist employees or applicants to perform the essential functions of the job.
