Join a dynamic structural biology group at the Wertheim UF Scripps Institute, where we push the boundaries of molecular visualization and membrane biology. Our lab integrates cutting-edge cryoEM, membrane biophysics, and infection/immunity research to redefine how receptors like integrins, GPCRs, and adhesion complexes are regulated. This position offers the opportunity to drive high-impact projects, publish in top journals, and grow your expertise in method development and biological discovery.
About this opportunity
Successful candidates will work in a cutting-edge research environment with new state-of-the-art facilities. The laboratory has outstanding cell biology, molecular biology, protein expression, purification, biochemistry, cryogenic electron microscopy, and protein crystallography facilities. The laboratory has access to many exceptional Cores, facilitating basic research and drug development. The unique infrastructure includes the application of unique chemical, genomic, proteomic, informatics, and high-throughput screening and engineering tools for discovering novel biomolecules.
CryoEM at UF-Scripps
Tina Izard installed the first 300 kV cryo Atomic Resolution Microscope (cryoARM300) in the Americas (https://www.youtube.com/watch?v=xdVxAN8xy1w&feature=youtu.be) and has plenty of microscope time dedicated to the laboratory staff. This state-of-the-art transmission electron microscope is a 300 kV high-resolution microscope capable of carrying out cryogenic electron microscopy studies by providing atomic resolution for structural studies involving single particle analyses. The transmission electron microscope is equipped with a new and improved Gatan K3 direct electron detector camera with better DQE, a larger field of view (24 Megapixels – 5,760 x 4,092), and faster (3.75 times that of the K2 camera). The direct detection devices are exquisitely sensitive, produce high signal-to-noise images, and are ideal for high-resolution studies.
X-ray crystallography at UF-Scripps
The lab has access to SER-CAT beamlines at Sector 22 of the Advanced Photon Source, including modern insertion device lines (22-ID-D, variable wavelength, and 22-ID-E, fixed wavelength) as well as a bending magnet line (22-BM) for macromolecular crystallography. These facilities are equipped with updated optics and detectors, and fall under current APS upgrades, ensuring high performance for structural biology projects.
The lab has access to a HighFlux X-ray diffraction system, specifically a Rigaku MicroMax-007 HF, a second-generation microfocus rotating anode generator, and a mar345 Image Plate detector. An Osmic VariMax optics system and the Proteros Free Mounting System can be used to control the humidity and optimize diffraction characteristics, including resolution, mosaicity, anisotropy, and reduced X-ray background.
Intellectual environment
The Wertheim UF Scripps Institute shares its Jupiter campus with the Max Planck Florida Institute for Neuroscience (MPFI), North America's only Max Planck Institute. MPFI is internationally recognized for innovation in imaging and neuroscience, and its presence creates a unique, highly collaborative research environment. Laboratory staff benefit from joint seminars, shared facilities, interdisciplinary collaborations, and daily interaction with world-class scientists across structural biology, chemical biology, and neuroscience. This close partnership expands opportunities for discovery and professional growth beyond what most academic campuses offer.
Why Jupiter, Florida?
The Wertheim UF Scripps Institute is located in Jupiter, Florida, a vibrant coastal community in Palm Beach County. Jupiter offers an outstanding quality of life with year-round sunshine, beautiful beaches, outdoor recreation, and a safe, family-friendly atmosphere. The area combines the advantages of a relaxed lifestyle with proximity to Miami and Orlando for cultural and professional opportunities. Florida has no state income tax, making post-doctoral salaries go further, and the cost of living in northern Palm Beach County is favorable compared to many other significant research hubs. The campus itself is part of a growing biotech corridor that includes Max Planck Florida, providing an interdisciplinary, collaborative environment with cutting-edge science in an exceptional location.
