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Day (United States of America)
Seeking Breakthrough Makers
Children’s Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.
At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care—and your career.
CHOP does not discriminate on the basis of race, color, sex, national origin, religion, or any other legally protected categories in any employment, training, or vendor decisions or programs. CHOP recognizes the critical importance of a workforce rich in varied backgrounds and experiences and engages in ongoing efforts to achieve that through equally varied and non-discriminatory means.
A Brief Overview
The Research Technician III will support basic science research projects within the Leukodystrophy Center, a cutting-edge translational program at the Children's Hospital of Philadelphia. The translational researchers in the Leukodystrophy Center are currently focused on uncovering novel genetic etiologies within this group of disorders, identifying key biomarkers, and developing a repository of natural history data to support clinical trial development. Current projects leverage both in vivo and in vitro models for key conditions such as Hypomyelination and Atrophy of Basal Ganglia and Cerebellum (H-ABC), Aicardi-Goutières Syndrome (AGS), and Alexander Disease.
The Research Technician III will work under the supervision of more experienced research technicians, assistants, post-doctoral fellows, and investigators to support the day-to-day operation of the Leukodystrophy Center’s translational research program. The Research Technician III will be expected to gain proficiency in the maintenance and expansion of human induced pluripotent stem cells (iPSC), as well as differentiation of iPSCs into neural stem cells to further develop them into neuronal and glial lineage lines. Other routine responsibilities may include receiving research samples obtained from outpatient clinic or inpatient unit, sample accessioning and processing (inc. DNA/RNA extraction, PBMC purification, etc.), maintaining one or more online sample databases, coordinating incoming/outgoing sample shipments with external collaborators, etc.
The Leukodystrophy Center’s research program is high-volume and fast-paced, and a successful candidate must be able to demonstrate an ability to multi-task with little to no errors. Prior experience in a laboratory setting is preferred. Outstanding written and oral communication skills are essential, as the position involves regular contact with collaborators within and externally to the Children’s Hospital of Philadelphia. The Leukodystrophy Center is a founding member of the Global Leukodystrophy Initiative Clinical Trials Network (GLIA-CTN), a Rare Diseases Clinical Research Network (RDCRN) consortium funded under grant number U54NS115052 as a collaboration between the National Center for Advancing Translational Sciences (NCATS) and the National Institute of Neurological Disorders and Stroke (NINDS).
What you will do
Performs research procedures on experimental samples with minimal supervision
Formulates and performs complex lab experiments and analyzes/ reports the data
Performs tasks that require knowledge of advanced techniques and lab equipment
Performs advanced calculations and maintains appropriate log and lab notebooks
Assists with planning specific research protocols and procedures
Assists in development & troubleshooting of new techniques and ideas
May be required to modify scientific methods and protocols (in conjunction with PI)
Checks others' results for completeness and accuracy
May be responsible for training and mentoring new staff
May assist in the preparation of grants journal articles, posters and oral presentations
May perform routine and non-routine tests / experiments as needed
Maintains office, lab area, reagents, supplies and equipment
Performs routine maintenance on lab equipment
Coordinates schedules of tests & procedures
Attends courses, seminars, and lab meetings to expand knowledge of research and laboratory techniques
Records results, organizes data and maintains lab notebook in an organized manner
Conducts literary searches as required
Education Qualifications
Experience Qualifications
At least two (2) years of related classroom experience or successful completion of a technical training program (eg. Wistar, WPSI) and research laboratory experience - Required
At least three (3) years of related classroom experience or successful completion of a technical training program (eg. Wistar, WPSI) and research laboratory experience - Preferred
Skills and Abilities
Advanced understanding of lab procedures, protocols, and equipment.
Intermediate proficiency with lab specific experiments / techniques.
Intermediate scientific analysis skills.
Excellent verbal and written communications skills
Excellent organizational skills
Strong critical thinking / problem-solving skills
Strong analytical skills
To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must receive an annual influenza vaccine. Learn more.
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SALARY RANGE:
$48,200.00 - $60,200.00 Annually
Salary ranges are shown for full-time jobs. If you're working part-time, your pay will be adjusted accordingly.
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At CHOP, we are committed to fair and transparent pay practices. Factors such as skills and experience could result in an offer above the salary range noted in this job posting. Click here for more information regarding CHOP's Compensation and Benefits.
