Top 1890 Vice president, r&d engineering Jobs in Pleasanton, Ca

Senior Scientist/Principal Scientist, Translational Immunotherapy
Sift Biosciences —San Carlos, CA
- $130,000 - $160,000 a year
- Full-time
- Management
- 5 years
- Master's degree
- Commuter assistance
- Health insurance
Quick Apply
8d
Lead Applications Engineer, Innovation Center (Customer Facing)
recruitAbility —San Jose, CA
- $150,000 - $175,000 a year
- Full-time
- Java
- Presentation skills
- Senior level
VP, Financial Consultant- Fremont, CA
Charles Schwab —Fremont, CA
- $75,000 - $120,000 a year
- Background check
- Senior level
- Paid parental leave
- Employee stock purchase plan
13d
Property Manager
Intrepidus Talent Solutions —Menlo Park, CA
- $50 - $60 an hour
- Temporary
- Office
- Finance
- Bachelor's degree
Quick Apply
4d
Senior Physical Design Engineer
Capgemini —Santa Clara, CA
- $82,082 - $193,440 a year
- Full-time
- Analysis skills
- In-person
- Senior level
- Paid holidays
- Disability insurance
13d
Thermal Test Engineer
Chroma ATE, Inc. —Milpitas, CA
- $90,000 - $120,000 a year
- Full-time
- Mid-level
- 3 years
- Master's degree
- Paid parental leave
- Health savings account
Quick Apply
IT Architect – DevOps Applications & Developer Platforms
ASML —San Jose, CA
- $130,500 - $217,500 a year
- Full-time
- Hybrid work
- Computer science
- Computer Science
- 5 years
- Paid holidays
- Health insurance
1d
Overseas Market Manager – Co-Packaged Optics (CPO)
Hans Laser Corp —San Jose, CA
- $80,000 - $150,000 a year
- Full-time
- Bilingual
- Background check
- Contracts
- Health insurance
- Dental insurance
Quick Apply
Test Technicians
Volt Workforce Solutions —Fremont, CA
- $25 an hour
- Overtime
- Background check
- Computer Science
- Pass drug screening
- AD&D insurance
- Dental insurance
Quick Apply
12h
Regional Vice President
Asset Living Corporate Team —San Mateo, CA
- Full-time
- Hybrid work
- Up to 50% travel
- Public speaking
- Residential
Quick Apply
4d
Overseas Market Manager – Advanced Semiconductor Packaging Equipment
Hans Laser Corp —San Jose, CA
- $80,000 - $150,000 a year
- Full-time
- Bilingual
- Office
- Presentation skills
- Health insurance
- Dental insurance
Quick Apply
Data Center Electrical Design Engineer
EZSVS USA Inc. —Sunnyvale, CA
- $55,000 - $60,000 a year
- Full-time
- Engineering
- Mid-level
- Office
- Health insurance
- Dental insurance
Quick Apply
Senior Industrial Hygienist
Trinity Consultants —Sunnyvale, CA
- From $115,000 a year
- Full-time
- Hybrid work
- Background check
- 5 years
- Bachelor of Science
Quick Apply
HVAC Assembly Technician
Rune —Mountain View, CA
- Full-time
- Mid-level
- Residential
- Plumbing
Quick Apply
Vice President - GPUaaS
Everforth, Cybercoders —Santa Clara, CA
- $300,000 - $400,000 a year
- Full-time
- Management
- Office
- 8 years
- Health insurance
- 401(k)
Quick Apply
6d
Silicon Photonics Application Engineer (8141 )
Advantest —San Jose, CA
- $104,680 - $161,780 a year
- Full-time
- Background check
- Bachelor of Science
- Java
- Health savings account
- Paid holidays
Quick Apply
Hardware Validation Engineer
Volt Workforce Solutions —Fremont, CA
- $43 - $47 an hour
- Urgently hiring
- Background check
- Management
- Computer Science
- AD&D insurance
- Dental insurance
Quick Apply
10h
Vice President, Oral Health Services
Delta Dental —Oakland, CA
- $249,470 - $399,152 a year
- Full-time
- Hybrid work
- Background check
- Master's degree
- Supervising experience
- Paid holidays
- Health insurance
AI Research Scientist- World Model
Bosch Group —Sunnyvale, CA
- $165,000 - $185,000 a year
- Full-time
- Computer Science
- English
- Master's degree
- Health insurance
- Paid time off
Electrical Engineer
Therm-x of California —Hayward, CA
- $85,000 - $95,000 a year
- Full-time
- Microsoft Outlook
- Bachelor of Science
- Mid-level
Quick Apply

I want to receive the latest job alert for vice president, r&d engineering in pleasanton, ca

By signing in to your account, you agree to SimplyHired's Terms of Service and consent to our Cookie and Privacy Policy.

Explore jobs in more locations

vice president, r&d engineering jobs near pleasanton, ca

Senior Scientist/Principal Scientist, Translational Immunotherapy

Sift Biosciences
San Carlos, CA

Quick Apply

Job Details

Full-time
$130,000 - $160,000 a year
8 days ago

Benefits

Commuter assistance
Health insurance
Dental insurance
401(k)
Paid time off
Parental leave
Vision insurance
Flexible schedule

Qualifications

Biology
Biotechnology
Technical documentation
Formulation chemistry
Cell Biology
Master's degree
Doctor of Philosophy
Pharmaceutical company experience
In vivo studies
Pharmaceutical research experience

Full Job Description

Senior Scientist/Principal Scientist, Translational Immunotherapy

Sift Bio is building a cutting-edge proprietary platform that combines AI, metagenomics, and high-throughput T-cell screening to discover epitopes that drastically amplify pre-existing immune memory responses, unlocking targeted, effective, and safe treatment for cancers and autoimmune diseases where current therapies fall short. Spinning out of UC Berkeley, the Sift Bio team brings together AI-driven discovery and deep translational immunology, with a proven track record of advancing novel immunotherapies from early concept through IND-enabling development. Collectively, the team has built and scaled high-throughput discovery platforms and led T-cell, peptide, and cell-based immunotherapy programs across leading academic labs, biotech startups, and biopharma. Merging this experience with proprietary datasets and computational pipelines, Sift Bio is shaping a new frontier in immunotherapy, unlocking the power of pre-existing immunity to create a fundamentally new class of treatments for immune dysfunctions. Our ultimate goal is to bring durable disease control to every patient.

We are seeking a Senior Scientist/Principal Scientist to work on our lead oncology program, leading the path from hit-to-lead generation to DC nomination for an off-the-shelf, memory-recall-based immunotherapy: designing, executing, and interpreting primary-cell assays that establish mechanism, potency, and safety. This role will report to the CTO and be fully onsite at 733 Industrial Road, San Carlos, CA.

KEY RESPONSIBILITIES:

Drive the identification, engineering, and functional optimization of lead immunotherapeutic candidates from early discovery through to DC nomination.
Design and execute cell-based assays (e.g., multi-parameter flow cytometry, cytotoxicity, cytokine profiling) to evaluate memory-recall, T-cell activation, and target engagement.
Characterize primary human T-cells and PBMCs (e.g. phenotyping) both prior and following response to stimulation.
Navigate challenges in working with, and characterizing, polyclonal T-cell responses, and is aware of how these challenges differ from monoclonal T-cell products.
Develop and support assays to forecast off-target events that leverage cross-reactivity as a method for overcoming antigen tolerance.
Benchwork to include profiling antigen-specific T-cells using IFN-γ ELISpot, and activation-induced marker (AIM) assays, and intracellular cytokine staining, with matrix/pool deconvolution design.
Develop assays to forecast off-target events in a system that leverages cross-reactivity as a method for overcoming antigen tolerance.
Oversee tetramer/dextramer and multimer staining, including executing high-avidity, peptide-MHC (pMHC) assays and employing DNA-barcoded multimers.
Running standard cytotoxicity readouts (e.g. IncuCyte).
Interpreting immunopeptidomics (LC-MS/MS HLA-ligand) data generated by collaborators/CROs and translate it into epitope-processing and presentation decisions.
Investigate the biological mechanisms (MoA) underlying the therapy’s ability to drive vigorous, durable anti-tumor memory.
Oversee in vivo and ex vivo studies to define the therapeutic's efficacy, pharmacodynamics (PD), and pharmacokinetics (PK).
Partner with the R&D team to de-risk assets prior to IND-enabling studies.
Manage direct reports/vendor/collaborators, present data to cross-functional teams, and author technical reports and regulatory documents to support governance reviews.
Interpret, analyze, present, and properly record data.
Prepare documents and presentations that encompass project progression.

REQUIRED EXPERIENCE:

PhD in Immunology, Cell Biology, or a related field, plus 5+ years of post-doctoral or industry experience. Alternatively, a Master’s degree with 8 to 10+ years of biotech experience. Job title will commensurate with experience.
Excited by and scientifically driven to overcome complex technical challenges that will contribute to safe treatment for cancers and autoimmune diseases.
Strong T-cell biology expertise, with extensive experience characterizing low frequency (<0.1%) CD8 and CD4 responses, and knowledge of how to improve readouts of rare T-cell responses.
Working knowledge of HLA biology, supertypes, population coverage logic, and HLA-matched experimental systems.
Immunotherapy drug development experience is a must.
Prior cancer-vaccine or general vaccine development experience, including peptide, protein-subunit, or nucleic-acid modalities, spanning antigen selection through in vivo immunogenicity.
Familiarity with adjuvants (TLR agonists, saponins, poly-ICLC) and how formulation shapes the T-cell response.
Experience with HLA-transgenic mouse models and/or human PBMC xenograft/humanized models, and familiarity with readouts both in flight and downstream of animal studies.
Proven ability to contribute to the scientific direction of a project.
Strong written and oral communication skills for technical and non-technical audiences.
Conscientious team member with experience taking and giving constructive feedback.
Must be comfortable with executing lab work full time in a preclinical-stage startup environment, and capable of finding solutions to tough problems with limited resources.

Sift Bio is pleased to offer competitive:

Medical, Dental, and Vision health plans.
Flexible time off.
Bonus and Equity plans.
Commuter transit benefit.
401(k) retirement plan.

Sift Bio is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind as outlined by applicable laws.

Pay: $130,000.00 - $160,000.00 per year

Benefits:

401(k)
Flexible schedule
Health insurance
Paid time off
Parental leave
Vision insurance

Application Question(s):

Please tell us about your experience with cancer-vaccine or general vaccine development experience, including peptide, protein-subunit, or nucleic-acid modalities, spanning antigen selection through in vivo immunogenicity.

Experience:

T cell biology : 5 years (Required)

Location:

San Carlos, CA 94070 (Preferred)

Work Location: In person

Quick Apply

Refine Your Search

vice president, r&d engineering jobs in pleasanton, ca

Senior Scientist/Principal Scientist, Translational Immunotherapy

Lead Applications Engineer, Innovation Center (Customer Facing)

VP, Financial Consultant- Fremont, CA

Property Manager

Senior Physical Design Engineer

Thermal Test Engineer

IT Architect – DevOps Applications & Developer Platforms

Overseas Market Manager – Co-Packaged Optics (CPO)

Test Technicians

Regional Vice President

Overseas Market Manager – Advanced Semiconductor Packaging Equipment

Data Center Electrical Design Engineer

Senior Industrial Hygienist

HVAC Assembly Technician

Vice President - GPUaaS

Silicon Photonics Application Engineer (8141 )

Hardware Validation Engineer

Vice President, Oral Health Services

AI Research Scientist- World Model

Electrical Engineer

I want to receive the latest job alert for vice president, r&d engineering in pleasanton, ca

Related Searches

Explore jobs in more locations

Job Seeker Tools

Employer Tools

Browse

Stay Connected