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Principal Software Engineer
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- $157,020.50 - $212,439.50 a year
- Computer science
- Management
- Doctoral degree
- Disability insurance
- Health insurance
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Principal Software Engineer

Amgen -
Thousand Oaks, CA

Apply Now

Job Details

$157,020.50 - $212,439.50 a year

Benefits

Disability insurance
Health insurance
Dental insurance
Flexible spending account
Vision insurance
Retirement plan

Qualifications

Software engineering
Management
Presentations for conferences or internal meetings
NoSQL
Team development
Programming languages
JavaScript
Mentoring
Leading team collaboration initiatives
Managing software development teams
Database software proficiency

Full Job Description

US - Florida - Tampa

JOB ID: R-240841 LOCATION: US - Florida - Tampa ; US - California - Thousand Oaks WORK LOCATION TYPE: Flex Commuter / Hybrid DATE POSTED: May. 29, 2026 CATEGORY: Information Systems SALARY RANGE: 157,020.50USD -212,439.50 USD

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Software Engineer

What you will do

Let’s do this. Let’s change the world. In this vital role you will play a pivotal role in shaping our technology strategy and mentoring a team of talented engineers.

Roles & Responsibilities:

Possesses strong rapid prototyping skills and can quickly translate concepts into working code

Provide technical guidance and mentorship to the development team.

Take ownership of complex software projects from conception to deployment.Manage software delivery scope, risk, and timeline

Contribute to both front-end and back-end developmentusing cloud technology.

Develop innovative solution using generative AI technologies

Define and implement robust software architecturesonthecloud, AWS preferred

Lead and motivate a team of engineers to deliver high-quality results.

Conduct code reviews to ensure code quality and adherence to best practices.

Create and maintain documentation on software architecture, design, deployment, disaster recovery, and operations.

Identify and resolve technical challenges effectively.

Stay updated with the latest trends and advancements

Work closely with productteam, business team, and other stakeholders.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a Software engineer with these qualifications.

Basic Qualifications:

Doctorate degree and 2 years of experience
OR
Master’s degree and 4 years of experience
OR
Bachelor’s degree and 6 years of experience
OR
Associate’s degree and 10 years of experience
OR
High school diploma / GED and 12 years of experience

Hands on experience with various cloud services, understand pros and cons of various cloud service inwellarchitected clouddesignprinciples

Hands on experience with Full Stack software development. Proficient in programming language Python(preferred), JavaScript, SQL/NoSQL.

Proven ability to lead and mentor software development teams

Strong problem solving,analytical skills; Ability to learn quickly; Excellent communication and interpersonal skills
Strong presentation and public speaking skills.

Preferred Qualifications:

Experienced with API integration, serverless, microservices architecture.

Experience in SQL/NOSQL database, vector database for large language models

Experience with popular large language models

Experience withLangchainorllamaIndexframework for language models

Experience with prompt engineering, model fine tuning

Experience with Web site development, understand of web site localization processes, which involve adapting content to fit cultural and linguistic contexts.

Experience with DevOps/MLOpsCICD build and deployment pipeline

Experience with design patterns, data structures, test-driven development.

Knowledge of NLP techniques for text analysis and sentiment analysis

Bachelor’s degree in computer science and engineering preferred, otherEngineering field is considered;Master’sdegree and 6+years of software development experienceOrBachelor’s degree and 8+years of software development experience

Cloud Computing certificate preferred

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

and make a lasting impact with the Amgen team.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Apply Now

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principal software engineer jobs in port hueneme ca