Top 20 Principal scientist Jobs in Raleigh Nc

Principal, Quantitative Scientist
Pedestal Health —Raleigh, NC
- Remote
- SQL
- Analysis skills
- Doctor of Philosophy
- Paid parental leave
- Paid holidays
Principal Scientist I (ARD)
Cambrex —Durham, NC
- Full-time
- Microsoft Word
- Microsoft Excel
- Computer literacy
10d
Senior or Principal Natural Resources Scientist
Geosyntec Consultants, Inc. —Raleigh, NC
- Full-time
- Hybrid work
- Management
- Driver's License
- Bachelor's degree
Principal Investigator (Flexible / Part-Time) (Physician Partner)
Superior Clinical Research & 1st Choice Homecare & Infusion —Smithfield, NC
- $200 - $350 an hour
- Part-time
- Hybrid work
- Senior level
- Professional development assistance
- Flexible schedule
Quick Apply
1d
Principal Scientist- NMR Spectroscopy
Pace Analytical Services —Morrisville, NC
- $110,000 - $120,000 a year
- Full-time
- Management
- Master's degree
- 8 years
- Wellness program
- Health savings account
Associate Principal, Indirect Treatment Comparison (ITC), Evidence Synthesis
IQVIA —Durham, NC
- $125,800 - $350,300 a year
- Full-time
- Remote
- English
- Master's degree
- Analysis skills
- Work from home
10d
Principal 1, Organic Synthesis Chemistry
Alcon —Durham, NC
- Full-time
- English
- High school diploma or GED
- Doctor of Philosophy
- Health insurance
Principal Statistical Methodologist
UCB —Raleigh, NC
- Doctoral degree
- Office
- 3 years
Principal Scientist, Delivery
Asklepios BioPharmaceutical —Durham, NC
- Full-time
- 8 years
- Analysis skills
- Doctor of Philosophy
Sr. Principal Risk Based Quality Management Data Monitor
Biogen —Research Triangle Park, NC
- Full-time
- Hybrid work
- Nursing
- 7 years
- English
- Paid parental leave
- Employee stock purchase plan
FSP Principal Biostatistician, Safety Analytics
IQVIA —Durham, NC
- $111,000 - $309,000 a year
- Full-time
- Remote
- Doctor of Philosophy
- Senior level
- Leadership
- Work from home
- Flexible schedule
Principal Epidemiologist, Internal Medicine, Inflammation & Immunology (FSP Sponsor Dedicated)
IQVIA —Durham, NC
- $109,200 - $273,000 a year
- Full-time
- Remote
- Internal Medicine
- Master's degree
- Doctor of Philosophy
- Work from home
Principal Statistician
PSI CRO —Durham, NC
- Full-time
- Remote
- Management
- Senior level
- Communication skills
Quick Apply
Senior/ Principal Clinical Data Manager
Fortrea —Durham, NC
- $90,000 - $130,000 a year
- Full-time
- Office
- Bachelor's degree
- Travel
- Disability insurance
- Health insurance
3d
Principal Statistical Methodologist, Raleigh, NC
UCB —Raleigh, NC
- Doctoral degree
- Computer Science
- English
3d

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principal scientist jobs near raleigh nc

Principal, Quantitative Scientist

Pedestal Health
Raleigh, NC

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Job Details

Benefits

Paid parental leave
Paid holidays
Dental insurance
Paid time off
Parental leave
Vision insurance
401(k) matching

Qualifications

Cross-functional communication

Full Job Description

Pedestal Health (formerly Target RWE) combines deep health system partnerships, longitudinal data curation at scale, and modern study design to build continuous, high-quality evidence for life sciences organizations. The company partners with pharmaceutical and biotech companies, providers and payers to generate rigorous, multimodal evidence that supports clinical, regulatory and strategic decision-making across the full lifecycle of care. Pedestal Health is committed to advancing medical decision making to improve outcomes for patients. Pedestal Health is a Highlander Health company. Learn more at pedestalhealth.com.

Overview

We are seeking a Principal to join Pedestal Health's Quantitative Sciences (QS) organization. In this role, you will help shape how we design, execute, and communicate real-world clinical studies using Pedestal's data.

This is a highly cross-functional and client-facing role. You will bring strong analytical and scientific expertise, paired with the ability to apply the right level of methodological rigor for the question at hand, balancing credibility, practicality, and clarity. You will work closely with internal teams and external partners to ensure analyses are scientifically sound, clearly communicated, and aligned with real-world use cases.

You will serve as a key representative of Pedestal's scientific capabilities, engaging directly with pharmaceutical and biotech partners, supporting client discussions, and helping translate complex analytical approaches into clear, actionable insights.

What You'll Do

Applied Methodology and Study Design

You will ensure that Pedestal's analyses are scientifically rigorous, practical, and aligned with real-world use.

Guide the design of observational studies using real-world data, including retrospective and prospective analyses
Apply statistical and epidemiologic methods in a practical, fit-for-purpose way
Develop and review study protocols and statistical analysis plans
Ensure analyses are reproducible, interpretable, and aligned with regulatory and scientific expectations
Partner with internal teams to translate research questions into practical analytic approaches

Client-Facing Scientific Leadership

You will serve as a key scientific voice in client and partner interactions.

Participate in and lead client meetings to explain study design, methodology, and results
Translate complex analytical concepts into clear, accessible language for diverse audiences
Support business development efforts by helping communicate Pedestal's scientific approach and data value
Represent Pedestal in external settings, including conferences, scientific collaborations, and partner discussions
Build trust with clients by providing thoughtful, pragmatic, and credible scientific guidance

Cross-Functional Collaboration

You will connect data, analytics, and business needs across the organization.

Partner closely with Product, Engineering, Medical Science, Clinical Operations, and Commercial teams
Help shape analytic strategies that align with both scientific goals and customer needs
Provide guidance to the Quantitative Sciences team on study design and interpretation
Mentor team members on balancing methodological rigor with practical execution
Contribute to internal best practices for scalable, high-quality evidence generation

What You'll Bring

PhD or MS in biostatistics, epidemiology, health economics, data science, or a related field
10+ years of experience working with real-world data (EMR, claims, registry, or clinical trial data)
Strong foundation in observational study design and applied statistical methods; experience with real-world pragmatic clinical trial designs is a plus
Demonstrated ability to apply methods pragmatically, selecting the right approach for the problem
Willingness to engage directly with data and analyses as needed, with working knowledge of R and/or SQL to support exploratory work, validation, and collaboration with analytic teams
Experience working directly with clients or external partners in life sciences or healthcare
Excellent communication and presentation skills, with the ability to explain complex concepts clearly
Comfortable operating in client-facing settings, including meetings, presentations, and scientific discussions
Strong collaboration skills across technical and non-technical teams

What we offer you

Comprehensive health, dental, and vision for you and your family
401(k) with company match
Generous PTO and company holidays
Paid parental leave

If you are ready to be part of a team where your work truly matters—where your expertise is valued, your growth is supported, and your contributions help shape the future of healthcare—Pedestal Health is the place for you. We're building something meaningful together, and we'd love for you to be a part of it.

Pedestal Health is an equal opportunity employer and seeks candidates from diverse backgrounds and abilities.

Apply Now

Refine Your Search

principal scientist jobs in raleigh nc

Principal, Quantitative Scientist

Principal Scientist I (ARD)

Senior or Principal Natural Resources Scientist

Principal Investigator (Flexible / Part-Time) (Physician Partner)

Principal Scientist- NMR Spectroscopy

Associate Principal, Indirect Treatment Comparison (ITC), Evidence Synthesis

Principal 1, Organic Synthesis Chemistry

Principal Statistical Methodologist

Principal Scientist, Delivery

Sr. Principal Risk Based Quality Management Data Monitor

FSP Principal Biostatistician, Safety Analytics

Principal Epidemiologist, Internal Medicine, Inflammation & Immunology (FSP Sponsor Dedicated)

Principal Statistician

Senior/ Principal Clinical Data Manager

Principal Statistical Methodologist, Raleigh, NC

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