Top 6 Principal scientist Jobs in Reading, Pa

Scientist/Sr. Scientist/Principal Scientist
Frontage Laboratories —Exton, PA
- Full-time
- Continuous improvement
- Doctor of Philosophy
- Mentoring
- Disability insurance
- Health insurance
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8d
Principal Scientist
Frontage Laboratories —Exton, PA
- Full-time
- 5 years
- Doctor of Philosophy
- Senior level
- Disability insurance
- Health insurance
Quick Apply
Senior Scientist/Principal Scientist- Biotransformation/Met ID
Frontage Laboratories —Exton, PA
- Full-time
- Doctor of Philosophy
- Senior level
- Communication skills
Quick Apply
Principal Toxicologist
Altria —United States
- $119,600 - $173,450 a year
- 5 years
- Analysis skills
- Presentation skills
- Profit sharing
- Paid parental leave

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Principal Research Scientist, Product Development & Innovation - Nutrition - Columbus, OH
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Principal Toxicologist
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The selected candidate will use their scientific and technical expertise in preclinical toxicology to conduct toxicological studies in the support of reduced-…
$119,600 - $173,450 a year

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principal scientist jobs near reading, pa

Scientist/Sr. Scientist/Principal Scientist

Frontage Laboratories -
Exton, PA

Quick Apply

Job Details

Full-time
8 days ago

Benefits

Disability insurance
Health insurance
Dental insurance
401(k)
Life insurance

Qualifications

Research project team leadership
Employee onboarding
Regulatory documents
Master's degree in chemistry
Chemical process safety
Pharmaceutical laboratory environment
Team leadership
Technical documentation
Pharmaceutical synthesis
Pharmaceutical regulatory compliance
Engineering process optimization
Project timeline management
Investigational new drug (IND) applications
Chemical scale-up projects
Industrial equipment troubleshooting
Team development
Hiring
Research project technical leadership
Policy & process development
Operational risk mitigation
Continuous improvement
Research safety & compliance
Doctor of Philosophy
Pharmaceutical company experience
Technology transfer (scale-up process)
Master of Science
Compliance documentation
Engineering research
Mentoring
Batch records

Full Job Description

Senior/Principal Scientist – Process Chemistry

Senior/Principal Scientist – Process Chemistry
Discovery Chemistry & API GMP Kilo-Lab

Location: Exton, PA

Frontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China, and growing over 30% YOY. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.

Position Summary:

Frontage Laboratories is expanding its API GMP capabilities to support early- and mid-phase development programs for global biotech, pharmaceutical, and academic partners.

We are seeking an experienced Process Chemistry Scientist to lead route scouting, process optimization, scale-up, and GMP batch support for small-molecule APIs. This is a hands-on laboratory role with technical leadership responsibilities and potential advancement to Associate Director, depending on experience.

Key Responsibilities:

Process Development & Scale-Up

- Design, develop, and optimize scalable synthetic routes for small-molecule APIs and intermediates.
- Conduct reaction optimization, impurity profiling, and robustness studies.
- Execute demonstration/engineering batches and support kilogram-scale manufacturing campaigns.

GMP Kilo-Lab Technical Support

- Contribute to batch record drafting, process descriptions, and execute support kilogram-scale manufacturing campaigns.
- Provide on-the-floor technical support during non-GMP and GMP campaigns.
- Troubleshoot process deviations and equipment issues in real time.
- Collaborate with QA, QC, CMC Operations, EHS, and Engineering.

Client Interaction & Project Leadership

- Serve as the technical point-of-contact for client programs.
- Present data clearly, propose development strategies, and manage timelines.
- Support CMC planning, risk mitigation, and tech-transfer discussions.

Documentation & Regulatory

- Prepare process development reports, tech-transfer packages, and supporting CMC documentation.
- Ensure full compliance with non-GMP & GMP requirements and contribute to IND process sections.

Team & Capability Development

- Mentor junior chemists and contribute to building best practices in the new kilo-lab.
- Support implementation of SOPs, equipment capabilities, and continuous improvement initiatives.
- Participate in hiring and onboarding as the group expands.

Qualifications (Flexible for Senior Scientist Associate Director)

Advanced degree (MS or PhD) in Organic Chemistry, or related field, with significant industry experience in process chemistry, CRO/CDMO, or pharmaceutical development.
Strong hands-on expertise in multi-step organic synthesis, route design, process optimization, impurity control, and scale-up.
Working understanding of kilo-lab or pilot-plant operations and GMP manufacturing support.
Experience with analytical data interpretation and process safety considerations.
Demonstrated ability to effectively communicate with cross-functional teams and external clients.
Proven leadership ability — ranging from mentoring peers (Senior Scientist) to providing strategic program direction (Principal Scientist / Associate Director).
Ability to thrive in a fast-paced CRO environment with multiple concurrent client programs.

Salary and Benefits:

Frontage Laboratories offers a competitive compensation and benefits package including health and dental insurance, a 401(k) plan, disability insurance, and life insurance

Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.

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Refine Your Search

principal scientist jobs in reading, pa

Scientist/Sr. Scientist/Principal Scientist

Principal Scientist

Senior Scientist/Principal Scientist- Biotransformation/Met ID

Principal Toxicologist

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