Top 55 Principal scientist Jobs in Remote

Principal Scientist, CMC Analytical
Loyal —Remote
- $150,000 - $190,000 a year
- Doctor of Philosophy
- Mentoring
- Senior level
- Paid holidays
- Health insurance
6d
Principal Scientist
Parsons —Remote
- $88,400 - $154,700 a year
- Bachelor's degree
- Senior level
- Communication skills
- Wellness program
- Paid holidays
11h
Principal Applied Machine Learning Scientist
Omada Health —Remote
- $235,200 - $338,100 a year
- Remote
- Computer Science
- Master's degree
- Doctor of Philosophy
- Health insurance
- Dental insurance
Quick Apply
6d
PK/PD Principal Scientist
Zoetis —Remote
- $114,000 - $185,000 a year
- Online Application
- Doctor of Philosophy
- US work authorization
- Senior level
- Profit sharing
- Health insurance
Senior Principal Scientist, Drug Substance
Loyal —Remote
- $175,000 - $230,000 a year
- Remote
- 11+ years
- Doctor of Philosophy
- Senior level
- Paid holidays
- Health insurance
Principal Biostatistician (Remote)
Everest Clinical Research —Bridgewater, NJ
- $150,000 - $200,000 a year
- Remote
- 7 years
- Master's degree
- Continuous improvement
- AD&D insurance
- Disability insurance
Quick Apply
Principal Scientist, Immunology
Jade Biosciences —San Francisco, CA
- $175,000 - $190,000 a year
- Remote
- 8 years
- Doctor of Philosophy
- Travel
Quick Apply
Sr. Principal Scientist - Project Toxicologist
Amgen —Remote
- $168,392.65 - $227,825.35 a year
- Medicine
- 3 years
- Bachelor's degree
- Disability insurance
- Health insurance
Principal Machine Learning Scientist
Adaptive Biotechnologies —Remote
- $183,400 - $275,000 a year
- Online Application
- Remote
- Computer Science
- 11+ years
- Master's degree
- Opportunities for advancement
Principal Geospatial Scientist (Remote Sensing)
Integrity Management Consulting —Tysons, VA
- $140,000 - $150,000 a year
- Full-time
- Remote
- Master's degree
- High school diploma or GED
- Bachelor's degree
Quick Apply
Principal Applied Scientist, Agentic AI
Zillow.com —Remote
- $181,800 - $305,700 a year
- Full-time
- Remote
- Computer science
- Computer Science
- Writing skills
AV Simulation Domain Expert (Sr. Principal) - US (Remote) or Chicago, IL
HERE Technologies —Remote
- $170,600 - $250,000 a year
- Full-time
- Computer Science
- Doctor of Philosophy
- Fair chance
- Health insurance
- Dental insurance
Software Engineer (Engineer III to Principal) - Formal Methods
CertiK —New York, NY
- $115,000 - $230,000 a year
- Full-time
- Remote
- Computer science
- Computer Science
- Master's degree
- Health savings account
- AD&D insurance
Quick Apply
Principal Engineer
Motional —Remote
- $240,000 - $330,000 a year
- Remote
- Computer Science
- Master's degree
- C++
Quick Apply
Principal AI Scientist
Cerence —Remote
- $123,500 - $197,600 a year
- Full-time
- Computer Science
- 11+ years
- Research
- Paid parental leave
- Health savings account
Sr. Principal Biostatistician
Biogen —Remote
- $134,000 - $179,000 a year
- Full-time
- 3 years
- Analysis skills
- Continuous improvement
- Paid parental leave
- Employee stock purchase plan
Principal Engineer, Autonomy
AeroVect —Remote
- $300,000 - $350,000 a year
- Full-time
- Remote
- System design
- 11+ years
- C++
Principal Consulting Epidemiologist
J.S. Held LLC —Redmond, WA
- $150,000 - $300,000 a year
- Full-time
- Remote
- Analysis skills
- Doctor of Philosophy
- Quality control
- Commuter assistance
- Health insurance
Quick Apply
Principal Scientist Algorithm Lead
NeoGenomics Laboratories —Remote
- Remote
- Computer Science
- 8 years
- Doctor of Philosophy
- Employee stock purchase plan
- Paid holidays
Quick Apply
Principal Data Manager I
Everest Clinical Research —Bridgewater, NJ
- $130,000 - $165,000 a year
- Remote
- Bachelor of Science
- Bachelor's degree
- Training & development
- AD&D insurance
- Disability insurance
Quick Apply

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Principal Scientist, CMC Analytical

Loyal -
Remote

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Job Details

$150,000 - $190,000 a year
6 days ago

Benefits

Paid holidays
Health insurance
Dental insurance
Vision insurance

Qualifications

ICH guidelines
Doctor of Philosophy
Pharmaceutical analysis
Materials analysis (analytical chemistry specialty)
Test validation method

Full Job Description

About Loyal

Loyal is a clinical-stage veterinary medicine company developing longevity drugs for dogs. Our mission is to help dogs live longer, healthier lives.

We're pioneering a new category of veterinary prescription drugs that proactively and preventatively target the underlying drivers of aging, delaying the onset of disease and preserving quality of life as dogs age. We've already made significant progress in our mission to develop the first FDA-approved drugs to extend canine lifespan: as of early 2026 we've completed two of three major FDA review sections for our lead program, LOY-002, and are targeting submission of the third and final section later this year.

Loyal is a well-funded startup with teams of scientists, veterinarians, engineers, operators, and creatives. You'll help us continue on our path of earning FDA approval for the first lifespan extension medicine for any species, and change what's possible for the dogs we love.

About the role

We're seeking an experienced Principal Scientist, CMC Analytical to serve as the subject matter expert in analytical development for oral solid dosage products. This role provides advanced technical analysis of drug substance and drug product data across release testing, stability testing, and method lifecycle management, and translates findings into actionable insights that inform quality decisions and regulatory strategy. Success requires deep expertise in analytical method development and validation, strong data trending and interpretation skills, and demonstrated regulatory authoring experience.

Your work will ensure that robust, phase-appropriate analytical methods and data packages support product quality, regulatory compliance, and successful advancement of therapies from early development through commercialization.

You will be reporting to our Head of Quality Control/Analytical Development

Your daily work will include:

Lead the analytical development and quality control strategy for one or more programs, setting the technical direction for method development, validation, and lifecycle management to ensure robust, phase-appropriate control of product quality.
Partner with CDMO and contract laboratory partners as the primary technical point of contact, driving resolution of complex analytical or method-related issues and holding partners accountable to scientific and quality standards.
Lead drug substance (API) analytical method development, qualification, and validation, including forced degradation, related substances/impurity profiling, and physicochemical characterization to support process understanding and specification setting.
Perform in-depth review and interpretation of analytical data (HPLC/UPLC, Dissolution, KF, GC, etc) across release and stability programs, and personally lead the resolution of the most complex or ambiguous data issues.
Identify subtle trends, shifts, or outliers in complex data sets that may impact product quality, method robustness, or long-term stability, and translate findings into program-level risk assessments and recommendations for leadership.
Serve as the technical lead and final scientific authority during OOS, OOT, and atypical result investigations, driving root cause determination and ensuring scientifically sound, defensible conclusions.
Own preparation and technical accuracy of the analytical development and quality control data packages supporting regulatory submissions, and author the CMC analytical sections of regulatory documents (e.g., NADA/INAD filings, briefing documents, and responses to health authority questions), ensuring data and method documentation are complete, scientifically sound, and submission-ready.
Mentor and provide technical guidance to junior scientists and analysts, building analytical capability across the team.

About you:

Ph.D. in Analytical Chemistry, Chemistry, Biochemistry or a related field.
10+ years in QC laboratory operations and/or analytical method development with substantial hands-on experience in small-molecule oral solid dosage products. Sponsor-side pharma experience strongly preferred; animal health/veterinary experience a plus.
Deep and broad knowledge of analytical chemistry in support of small molecule drug substance and drug product analytical development and quality control, including release and stability method development, raw material control, in-process control, and characterization .
Prior experience managing CDMO relationships, tech transfer, and Quality Control programs desired.
Deep understanding of cGMP, ICH/VICH, FDA, and EMA analytical expectations.
Proven track record of QC data interpretation and support of regulatory filings.
Creative and thoughtful approach to problem solving technical issues.
Ability to quickly learn new concepts and processes
Adaptability, creativity and high-performer in risk-assessment and strategic thinking
Willing to work and comfortable in a fast-paced startup environment with a dynamic team
Clear and concise communication skills

Salary Range: $150,000 - $190,000

Loyal benefits:

Full-coverage health insurance — medical, dental and vision — for you and your dependents
$1,000 home office equipment stipend
$1,200/year learning budget for books, courses, etc.
$250/month wellness budget for gym, cleaners, spa, food, etc.
All 3-day weekends are turned into 4-day weekends
Unlimited vacation and paid holidays
Paw-ternity leave — adopt a dog and get a day off with your new family member
Competitive salary
Company equity options grant for new hires

Loyal is founded and led by a first-gen female CEO and is proud to be an equal opportunity employer. We do not discriminate against applicants based on gender, race or color, ethnicity or national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, or any other applicable characteristics protected by law.

Our values

Moonshots, derisked methodically

Bringing the first longevity drug to market is an extremely difficult technical and social pursuit. To achieve this we must take bigger bets than the field has historically made, paired with the technical rigor to de-risk them step by step. We plan on both short and extremely long timescales, and we have the conviction to see our vision through to success or failure.

Opportunity is at the intersection

We lean into combining disciplines, expertise, and perspectives not normally adjacent. We design our organization to facilitate cross-pollination and cross-collaboration. We reject silos.

Expertise without ego

Titles do not determine who has a voice. We push back on each other, ask questions instead of issuing orders, and try to prove ourselves wrong. We are emotionally attached to the outcome, not our personal hypotheses, and welcome being challenged instead of treating it as a threat.

High agency, high humility

Most of what we're doing has never been done before, so we can't rely on established precedents to guide our way. We move forward to generate clarity, build strategies resilient to the fact that we don't know what we don't know, and design small experiments where we can fail safely, without jeopardizing the bigger mission.

Lead with transparency and context

We proactively and consistently share the why behind our strategy - not just the what - because we believe sharing context enables great people to make great decisions.

Empathy and respect for all life

Our patients are not just numbers. We deeply respect the value of every life, large and small and take our ethical responsibility to the families we treat extremely seriously.

Apply Now

Refine Your Search

principal scientist jobs in remote

Principal Scientist, CMC Analytical

Principal Scientist

Principal Applied Machine Learning Scientist

PK/PD Principal Scientist

Senior Principal Scientist, Drug Substance

Principal Biostatistician (Remote)

Principal Scientist, Immunology

Sr. Principal Scientist - Project Toxicologist

Principal Machine Learning Scientist

Principal Geospatial Scientist (Remote Sensing)

Principal Applied Scientist, Agentic AI

AV Simulation Domain Expert (Sr. Principal) - US (Remote) or Chicago, IL

Software Engineer (Engineer III to Principal) - Formal Methods

Principal Engineer

Principal AI Scientist

Sr. Principal Biostatistician

Principal Engineer, Autonomy

Principal Consulting Epidemiologist

Principal Scientist Algorithm Lead

Principal Data Manager I

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