Top 105 Principal scientist Jobs in Remote

Principal Scientist, Analytical Development, Oligo and Small Molecule
Praxis Precision Medicines, Inc. —Remote
- $165,000 - $185,000 a year
- Email
- Master's degree
- Doctor of Philosophy
- Travel
- AD&D insurance
- Employee stock purchase plan
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Principal Scientist, Algorithm Lead
NeoGenomics Laboratories —Remote
- Remote
- Computer Science
- 8 years
- Doctor of Philosophy
- Employee stock purchase plan
- Paid holidays
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Principal Scientist, Immunology
Jade Biosciences —San Francisco, CA
- $175,000 - $190,000 a year
- Remote
- 8 years
- Doctor of Philosophy
- Travel
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Sr. Principal Scientist - Project Toxicologist
Amgen —Remote
- $168,392.65 - $227,825.35 a year
- Medicine
- 3 years
- Bachelor's degree
- Disability insurance
- Health insurance
Principal Research Scientist
Educational Testing Service (ETS) —Remote
- $162,000 - $203,000 a year
- Full-time
- Remote
- Doctor of Philosophy
- Mentoring
- Senior level
- Paid time off
- Opportunities for advancement
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Principal Machine Learning Scientist
Adaptive Biotechnologies —Remote
- $183,400 - $275,000 a year
- Online Application
- Remote
- Computer Science
- 11+ years
- Master's degree
- Opportunities for advancement
Principal Scientist - Ecological Services
EHS Support, LLC —Remote
- Full-time
- 11+ years
- Master's degree
- Analysis skills
- Disability insurance
- Health insurance
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SBIR Principal Investigator
Burchell Professional Group —Remote
- $75,000 - $1,000,000 a year
- Full-time
- Remote
- Microsoft Excel
- Supervising experience
- Budgeting
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6d
Principal Clinical Scientist
Beckman Coulter Diagnostics —Miami, FL
- $130,000 - $150,000 a year
- Full-time
- Remote
- Clean driving record
- Doctoral degree
- Master's degree
- Health insurance
- Dental insurance
2d
PK/PD Principal Scientist
Zoetis —Remote
- $114,000 - $185,000 a year
- Online Application
- Doctor of Philosophy
- US work authorization
- Senior level
- Profit sharing
- Health insurance
Principal Investigator, Federal Research Projects
DaqScribe Solutions —Centennial, CO
- Email
- Remote
- Management
- Computer Science
- Master's degree
Principal Consulting Epidemiologist
J.S. Held LLC —Redmond, WA
- $150,000 - $300,000 a year
- Full-time
- Remote
- Analysis skills
- Doctor of Philosophy
- Quality control
- Commuter assistance
- Health insurance
Senior Principal Scientist, Drug Substance
Loyal —Remote
- $175,000 - $230,000 a year
- Remote
- 11+ years
- Doctor of Philosophy
- Senior level
- Paid holidays
- Health insurance
Principal Research Scientist ONC -Clinical Development Scientist (Sponsor Dedicated/ Remote US)
Syneos - Clinical and Corporate - Prod —Remote
- $79,800 - $139,600 a year
- Full-time
- Microsoft Excel
- Bachelor of Science
- English
- Employee stock purchase plan
- Health insurance
Principal AI Scientist
Cerence —Remote
- $123,500 - $197,600 a year
- Full-time
- Computer Science
- 11+ years
- Research
- Paid parental leave
- Health savings account
Assoc Principal Bioinformatics Scientist
Illumina —San Diego, CA
- $187,400 - $281,000 a year
- Full-time
- Remote
- Background check
- Research
- Master's degree
- Dental insurance
- Paid time off
Sr. Principal Biostatistician
Biogen —Remote
- $134,000 - $179,000 a year
- Full-time
- 3 years
- Analysis skills
- Continuous improvement
- Paid parental leave
- Employee stock purchase plan
Physics Expert (Professor / Principal Investigator) – AI Trainer
micro1 —Boston, MA
- $80 - $160 an hour
- Contract
- Remote
- Doctor of Philosophy
- Senior level
- Leadership
- Flexible schedule
Principal Navigation Systems Architect (PN&T)
Oxford Global Resources —Remote
- $170,000 - $240,000 a year
- Full-time
- Remote
- Computer Science
- Laboratory experience
- Master's degree
- Health insurance
- Dental insurance
Quick Apply
Principal Machine Learning Scientist
DIESEL LAPTOPS LLC —Foley, AL
- $118 - $126 an hour
- Full-time
- Remote
- 7 years
- Computer Science
- SQL
Quick Apply

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Principal Scientist, Analytical Development, Oligo and Small Molecule

Praxis Precision Medicines, Inc. -
Remote

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Job Details

$165,000 - $185,000 a year

Benefits

AD&D insurance
Employee stock purchase plan
Paid holidays
Health insurance
Dental insurance
401(k)
Paid time off
401(k) 6% Match
Vision insurance
Life insurance

Qualifications

Pharmaceutical company experience

Full Job Description

Location: This position may be performed remotely, but requires the flexibility and willingness to travel as needed.

Position Summary

The Principal Scientist, Analytical Development will play a critical role in advancing Praxis' clinical and commercial pipeline by translating analytical strategies from development into manufacturing across our virtual network of CMOs and external partners.
This role is particularly focused on advancing oligonucleotide-based therapeutics, while also supporting small molecule programs across the portfolio. The individual will bring deep expertise in analytical method development, qualification, validation, troubleshooting, and GMP testing for oligonucleotide drug substances and drug products, with the ability to apply phase-appropriate analytical strategies across multiple modalities.
This is a highly cross-functional, hands-on leadership role requiring close partnership with Drug Substance, Drug Product, Quality, Regulatory, and Manufacturing teams to ensure robust, scalable, and compliant analytical control strategies. The successful candidate will help shape an agile, forward-looking analytical development function capable of supporting innovative CNS therapies from early development through commercialization.

Primary Responsibilities

Serve as Analytical Lead across CMC programs, with primary responsibility for oligonucleotide analytical development activities and support for small molecule programs
Lead analytical method development, qualification, validation, transfer, and GMP testing activities across internal teams and external partners
Drive technical troubleshooting, data interpretation, method lifecycle management, and review of analytical documentation including validation reports, stability reports, specifications, and CoAs
Design and implement phase-appropriate analytical control strategies, specifications, and stability programs for oligonucleotide and small molecule drug substances and drug products
Direct and manage CRO/CMO analytical partners to ensure high-quality execution, strong communication, and continuous operational improvement
Collaborate cross-functionally to strengthen CMC operations, improve processes, and establish scalable technical and business practices across the analytical function
Contribute strategic and technical expertise to support regulatory filings, commercialization readiness, and ongoing product lifecycle management

Qualifications and Key Success Factors

Advanced degree (PhD preferred; Master's with significant industry experience considered) in Analytical Chemistry or related discipline with 5–7+ years of industry experience
Strong industry experience in analytical development for oligonucleotide drug substances and/or drug products required
Experience supporting small molecule drug substances and solid oral dosage forms strongly preferred
Deep knowledge of analytical techniques relevant to oligonucleotides, including impurity characterization, stability assessment, and GMP control strategies
Strong understanding of US and EU cGMP requirements and analytical best practices for drug substance and drug product development
Experience supporting CMC development across multiple stages of development, including regulatory submissions, validation, and commercialization activities
Experience managing external CRO/CMO analytical networks and building productive technical partnerships
Strong working knowledge of quality systems, reference standards, stability programs, and compendial testing requirements

Key Success Factors

Brings deep technical curiosity and strong scientific judgment, particularly in emerging oligonucleotide modalities
Operates with high ownership and accountability in fast-moving, ambiguous environments
Balances strategic thinking with hands-on execution and problem solving
Communicates clearly and collaborates effectively across functions and external partners
Continuously challenges assumptions and looks for smarter, more scalable ways of working
Thrives in agile environments that require adaptability, rigor, and urgency
Highly organized, detail-oriented, and motivated by delivering high-quality outcomes that advance therapies for patients

Compensation & Benefits

At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans. We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future? We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP. We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let's achieve the impossible together!

Company Overview

Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.

Diversity, Equity & Inclusion
Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.

Attention: Job Scam Alert
Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to [email protected].

Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.

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Refine Your Search

principal scientist jobs in remote

Principal Scientist, Analytical Development, Oligo and Small Molecule

Principal Scientist, Algorithm Lead

Principal Scientist, Immunology

Sr. Principal Scientist - Project Toxicologist

Principal Research Scientist

Principal Machine Learning Scientist

Principal Scientist - Ecological Services

SBIR Principal Investigator

Principal Clinical Scientist

PK/PD Principal Scientist

Principal Investigator, Federal Research Projects

Principal Consulting Epidemiologist

Senior Principal Scientist, Drug Substance

Principal Research Scientist ONC -Clinical Development Scientist (Sponsor Dedicated/ Remote US)

Principal AI Scientist

Assoc Principal Bioinformatics Scientist

Sr. Principal Biostatistician

Physics Expert (Professor / Principal Investigator) – AI Trainer

Principal Navigation Systems Architect (PN&T)

Principal Machine Learning Scientist

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