Top 26 Principal scientist Jobs in Rockville, Md

Senior / Principal Scientist: Synthetic Chemistry & Bioconjugation
Autonomous Therapeutics, Inc. —Rockville, MD
- $100,000 - $180,000 a year
- Full-time
- No experience needed
- Doctor of Philosophy
- Team management
- Relocation assistance
- Health insurance
Quick Apply
Principal Scientist
Mission Support and Test Services —Andrews AFB, MD
- $121,867.20 - $185,848.00 a year
- Full-time
- Senior level
- Paid holidays
- Health insurance
Principal Computer Scientist
Analytic Services Inc —Washington, DC
- $195,000 - $235,000 a year
- Computer science
- Computer Science
- 11+ years
Quick Apply
Clinical Research & Development Associate Principal Scientist
AstraZeneca —Gaithersburg, MD
- Management
- Master's degree
- Bachelor's degree
6d
Principal Health Scientist
TRC Companies, Inc. —Washington, DC
- $175,000 - $275,000 a year
- Full-time
- Doctoral degree
- 11+ years
- Analysis skills
- Paid holidays
- Disability insurance
3d
Principal Regulatory Scientist
Noblis —Reston, VA
- $115,500 - $180,525 a year
- Full-time
- Hybrid work
- Medicine
- Office
- Analysis skills
- Health insurance
- Tuition reimbursement
11d
Sr. Materials/Physics Scientist/Principal Investigator
Enig Associates —Rockville, MD
- Full-time
- 5 years
- Office
- Math
- Health insurance
- Dental insurance
Principal Scientist
Galois, Inc. —Arlington, VA
- Full-time
- Hybrid work
- Computer Science
- Office
- Math
- Paid parental leave
- Health savings account
Quick Apply
Principal Regulatory Scientist
Exponent Inc. —Washington, DC
- $200,250 - $244,750 a year
- Email
- Office
- Master's degree
- Doctor of Philosophy
- 401(k)
Deputy Director, Principal Scientist or Engineer
Arlington, VA
- Hybrid work
- 18 years or older
- System design
- 11+ years
- Employee stock ownership plan
Principal RF Research Scientist (RFML/DSP/SDR)
Peraton —College Park, MD
- $176,000 - $282,000 a year
- Full-time
- Computer science
- Computer Science
- Java
- Health savings account
- Paid holidays
Staff Principal Scientist/Senior Economic Security Analyst
AMERICAN SYSTEMS —Alexandria, VA
- $160,000 - $180,000 a year
- Full-time
- Remote
- Office
- Analysis skills
- Bachelor's degree
- Retirement plan
Cell Culture Bioproduction Manager/Principle Scientist
GeneCopoeia —Rockville, MD
- Email
- Management
- Doctor of Philosophy
- Organizational skills
Principal, Policy
Avalere Health —Washington, DC
- $195,000 - $215,000 a year
- Full-time
- Hybrid work
- Microsoft Excel
- Mentoring
- Organizational skills
- Disability insurance
- Health insurance
Quick Apply
Principal Applied Scientist - TS/SCI
Vantor Services Inc. —Herndon, VA
- $140,000 - $205,700 a year
- Full-time
- 11+ years
- Master's degree
- Math
- 401(k) matching
- Pet insurance
Quick Apply
1d
Associate Principal, Indirect Treatment Comparison (ITC), Evidence Synthesis
IQVIA —Rockville, MD
- $125,800 - $350,300 a year
- Full-time
- Remote
- 5 years
- English
- Analysis skills
- Work from home
Principle Investigator, Clinical Research
RE:Cognition Health, Inc —Fairfax, VA
- Contract
- Clinic
- Neurology
- Senior level
Quick Apply
Senior Research Methodologist — Principal Investigator, Multimodal Survey Experiment
ICF —Reston, VA
- $119,323 - $202,850 a year
- Full-time
- Remote
- 11+ years
- Master's degree
- Analysis skills
Principal Signal Processing Researcher
STR —Washington, DC
- $220,000 - $260,000 a year
- Email
- Bachelor of Science
- System design
- Business development
Principal Investigator - Immediate Need!
Eagle Technologies, Inc. —Arlington, VA
- Urgently hiring
- 6 years
- Management
- Addiction Medicine
Quick Apply

I want to receive the latest job alert for principal scientist in rockville, md

By signing in to your account, you agree to SimplyHired's Terms of Service and consent to our Cookie and Privacy Policy.

Explore jobs in more locations

principal scientist jobs near rockville, md

Senior / Principal Scientist: Synthetic Chemistry & Bioconjugation

Autonomous Therapeutics, Inc. -
Rockville, MD

Quick Apply

Job Details

Full-time
$100,000 - $180,000 a year

Benefits

Relocation assistance
Health insurance
Dental insurance
401(k)
Paid time off
Vision insurance
401(k) matching
Flexible schedule

Qualifications

Scientific publications
Analytical chemistry
Doctor of Philosophy
Chemistry
Manufacturing
Research & development

Full Job Description

About Us:

Autonomous Therapeutics (Autonomous) is a venture-backed biotech founded in 2017 by scientists from Harvard Medical School and UCSF. Autonomous develops precision nucleic acid medicines for currently incurable viruses and metastatic cancers.

Our technology leverages synthetic biology and nucleic acid chemistry to achieve a simple goal: target-activated (precision) medicines that only activate in diseased cells. Imagine a chemotherapy that detects your cancer cells but actively avoids your healthy cells.

You would join a team of 25 PhD chemists, synthetic biologists, cell biologists, and in vivo biologists in our 20,000 square foot R&D facility outside Washington, D.C.

The Position:

Delivery beyond the liver is a fundamental challenge for nucleic acid medicines.

We are seeking an exceptional synthetic chemist to help develop novel oligonucleotide medicines that achieve efficient extrahepatic delivery.

This is a high-impact role with scientific ownership and independence. You will design, synthesize, and characterize novel oligonucleotide medicines as well as delivery-enabling conjugations and chemistries. You will also work closely with our in-house formulation, cell biology, immunology, and in vivo biology teams to translate your promising chemistries into in vivo-tested therapeutic candidates.

Depending on your experience, you will have the chance to lead independent efforts, mentor junior scientists, and build out our growing synthetic chemistry and bioconjugation team.

This role reports directly to the Head of Chemistry and the CSO.

About You:

You have a PhD in Chemistry, Chemical Biology, Materials Science, or a related discipline, along with strong publications showing a record of scientific achievement.

Exceptional candidates may come from oligonucleotide chemistry or other synthetic chemistry fields—including peptide chemistry, carbohydrate chemistry, polymer chemistry, medicinal chemistry, or bioconjugation chemistry. Direct oligonucleotide synthesis experience is not required.

We are looking for candidates with deep expertise in ONE or more of the following:

- Solid-Phase Synthesis & Characterization
Experience with the solid-phase synthesis, deprotection, purification, and characterization of RNA or DNA oligonucleotides, including siRNAs, ASOs, guide RNAs, aptamers, or related modalities. Expertise in backbone, sugar, base, terminal, or other oligonucleotide modifications is highly valued. Experience with enzymatic or chemoenzymatic oligonucleotide synthesis, ligation, or assembly is also valued, particularly for producing longer or challenging RNA or DNA constructs. Substantial experience with solid-phase peptide synthesis or related platforms is also highly relevant.

- Delivery & Bioconjugation
Experience designing, synthesizing, and optimizing bioconjugates through structure–activity relationship (SAR) studies to improve delivery, biodistribution, pharmacokinetics (PK), cellular uptake, stability, or in vivo potency. Relevant conjugates may incorporate glycans, peptides, antibodies, small molecules, lipids, polymers, or other targeting and delivery moieties. Experience with GalNAc or other established delivery platforms is valued.

- Functionalization & Conjugation Chemistry
Experience developing solid-support, solution-phase, or post-synthetic methods to attach ligands, linkers, or payloads to oligonucleotides, antibodies, small molecules, or other therapeutic modalities, including antibody-drug conjugates (ADCs). Relevant methods may include modified CPGs, phosphoramidites, activated esters, click chemistry, amine- or thiol-reactive handles, site-selective functionalization, orthogonal protecting groups, and other bioorthogonal approaches.

- Analytical Chemistry
Experience with LC-MS, HPLC, anion-exchange chromatography (AEX), reversed-phase chromatography, SEC, PAGE, or related methods to assess candidate purity, identity, yield, and product quality.

Nice to Have (Not Required):

Scale-Up Chemistry. Experience supporting synthetic chemistry scale-up, process development, technology transfer, CDMO management, and cGMP manufacturing.

Inhaled Formulation. Experience with formulation or particle engineering approaches relevant to nucleic acid therapeutics, including spray drying, lyophilization, dry-powder inhalation, or controlled release.

Biology. Experience working across chemistry and biology teams to connect chemical design to cellular or in vivo activity and use biological results to guide subsequent chemical design.

Therapeutic Testing. Experience testing therapeutic candidates using cell-based assays or in vivo for potency, biodistribution, PK, safety, or efficacy.

Why Join Us:

Meaningful Mission. Join a team developing potential life-saving medicines for infectious diseases and metastatic cancers in a fast-paced, well-funded startup environment.

Chemistry to Medicine. Work closely with in-house formulation, immunology, cell biology, and in vivo teams to translate chemical designs into in vivo-tested therapeutic candidates.

Compensation & Benefits. Competitive salary, equity, health, dental, and vision coverage. We also provide 401(k) plans--with employer matching--and paid time off.

Additional Info:

Work Authorization: Candidates must be authorized to work in the United States.
Merit-Based: Autonomous is an Equal Opportunity Employer. Hiring decisions are based on merit, qualifications, and business needs.

Job Type: Full-time

Pay: $100,000.00 - $180,000.00 per year

Benefits:

401(k)
401(k) matching
Dental insurance
Flexible schedule
Health insurance
Paid time off
Relocation assistance
Vision insurance

Work Location: In person

Quick Apply

Refine Your Search

principal scientist jobs in rockville, md

Senior / Principal Scientist: Synthetic Chemistry & Bioconjugation

Principal Scientist

Principal Computer Scientist

Clinical Research & Development Associate Principal Scientist

Principal Health Scientist

Principal Regulatory Scientist

Sr. Materials/Physics Scientist/Principal Investigator

Principal Scientist

Principal Regulatory Scientist

Deputy Director, Principal Scientist or Engineer

Principal RF Research Scientist (RFML/DSP/SDR)

Staff Principal Scientist/Senior Economic Security Analyst

Cell Culture Bioproduction Manager/Principle Scientist

Principal, Policy

Principal Applied Scientist - TS/SCI

Associate Principal, Indirect Treatment Comparison (ITC), Evidence Synthesis

Principle Investigator, Clinical Research

Senior Research Methodologist — Principal Investigator, Multimodal Survey Experiment

Principal Signal Processing Researcher

Principal Investigator - Immediate Need!

I want to receive the latest job alert for principal scientist in rockville, md

Explore jobs in more locations

Job Seeker Tools

Employer Tools

Browse

Stay Connected