Top 30 Principal scientist Jobs in Rockville Md

Principal Scientist Drug Product Development
AstraZeneca —Gaithersburg, MD
- $183,768.80 - $275,653.20 a year
- 11+ years
- Doctor of Philosophy
- Organizational skills
- Health insurance
- Dental insurance
2d
Principal Scientist
Mission Support and Test Services —Andrews AFB, MD
- $121,867.20 - $185,848.00 a year
- Full-time
- Senior level
- Paid holidays
- Health insurance
Senior / Principal Scientist: Synthetic Chemistry & Bioconjugation
Autonomous Therapeutics, Inc. —Rockville, MD
- $100,000 - $180,000 a year
- Full-time
- No experience needed
- Doctor of Philosophy
- Team management
- Relocation assistance
- Health insurance
Quick Apply
14d
Principal Scientist
Galois, Inc. —Arlington, VA
- Full-time
- Hybrid work
- Computer Science
- Office
- Math
- Paid parental leave
- Health savings account
Quick Apply
Principal Geospatial Scientist (Remote Sensing)
Integrity Management Consulting —Tysons, VA
- $140,000 - $150,000 a year
- Full-time
- Remote
- Master's degree
- High school diploma or GED
- Bachelor's degree
Quick Apply
Principal Computer Scientist
Analytic Services Inc —Washington, DC
- $195,000 - $235,000 a year
- Computer science
- Computer Science
- 11+ years
Quick Apply
Principal Research Scientist: Signal Processing
RTX Corporate —Arlington, VA
- $118,300 - $224,900 a year
- Full-time
- 3 years
- Supervising experience
- Doctor of Philosophy
- Paid holidays
- Disability insurance
Principal AI/ML Scientist
Everforth ECS —Arlington, VA
- $140,000 - $180,000 a year
- Azure
- Computer Science
- 5 years
Sr. Materials/Physics Scientist/Principal Investigator
Enig Associates —Rockville, MD
- Full-time
- 5 years
- Office
- Math
- Health insurance
- Dental insurance
Cell Culture Bioproduction Manager/Principle Scientist
GeneCopoeia —Rockville, MD
- Email
- Management
- Doctor of Philosophy
- Organizational skills
Associate Principal, Indirect Treatment Comparison (ITC), Evidence Synthesis
IQVIA —Rockville, MD
- $125,800 - $350,300 a year
- Full-time
- Remote
- 5 years
- English
- Analysis skills
- Work from home
9d
Deputy Director, Principal Scientist or Engineer
Arlington, VA
- Hybrid work
- 18 years or older
- System design
- 11+ years
- Employee stock ownership plan
Staff Principal Scientist/Senior Economic Security Analyst
AMERICAN SYSTEMS —Alexandria, VA
- $160,000 - $180,000 a year
- Full-time
- Remote
- Office
- Analysis skills
- Bachelor's degree
- Retirement plan
Principal Research Scientist - AI/ML, Applied Statistics & Advanced Analytics
Two Six Technologies —Washington, DC
- $150,000 - $230,000 a year
- Email
- SQL
- Analysis skills
- Math
Quick Apply
Principal Regulatory Scientist
Exponent Inc. —Washington, DC
- $200,250 - $244,750 a year
- Email
- Office
- Master's degree
- Doctor of Philosophy
- 401(k)
Principal Quantum Systems Architect
Microsoft —Washington, DC
- $165,600 - $331,200 a year
- Full-time
- Background check
- 6 years
- Doctoral degree
Principal Investigator - Immediate Need!
Eagle Technologies, Inc. —Arlington, VA
- Urgently hiring
- 6 years
- Management
- Addiction Medicine
Quick Apply
Principal Research Associate- Long-Term and Post-Acute Care Policy
Westat —Bethesda, MD
- $120,000 - $142,000 a year
- Full-time
- Hybrid work
- Background check
- Computer science
- Management
- Paid parental leave
- Health savings account
3d
Principal Signal Processing Researcher
STR —Washington, DC
- $220,000 - $260,000 a year
- Email
- Bachelor of Science
- System design
- Business development
Principal, Policy
Avalere Health —Washington, DC
- $195,000 - $215,000 a year
- Full-time
- Hybrid work
- Microsoft Excel
- Mentoring
- Organizational skills
- Disability insurance
- Health insurance
Quick Apply

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principal scientist jobs near rockville md

Principal Scientist Drug Product Development

AstraZeneca -
Gaithersburg, MD

Apply Now

Job Details

$183,768.80 - $275,653.20 a year
2 days ago

Benefits

Health insurance
Dental insurance
Paid time off

Qualifications

FDA submissions
Stability testing
Product lifecycle strategy
Program design
Program management
Stability studies in drug product development
Clinical development
Cold chain logistics
Chemical scale-up projects
Technology transfer (scale-up process)
Data interpretation
Chemistry, manufacturing & controls
Engineering product development
Regulatory submission editing and review
Biomedical regulatory compliance
Communication with regulatory authorities for clinical trials
Sterile products production
GMP for research safety and compliance
Chemical new product development projects
Legal compliance
Pharmaceutical research experience
Pharmaceutical manufacturing facility experience

Full Job Description

Location Gaithersburg, Maryland, United States Job ID R-257412 Date posted 29/07/2026

AstraZeneca is seeking a strategic, innovative, and highly experienced Principal ScientistDrug Product Development, to support drug product development and platform strategy for our expanding Cell Therapy portfolio. This role will be responsible for establishing and advancing next-generation lentiviral vector (LVV) drug product platforms that support both ex vivo and in vivo CAR-T and other cell and gene therapy modalities.

As a key scientific leader, you will define and execute drug product development strategies spanning formulation, fill-finish, characterization, stability, technology transfer, and regulatory support from early research through clinical and commercial manufacturing. You will work with cross-functional teams and external partnerships to accelerate development timelines while ensuring product quality, scalability, and regulatory compliance.

This role requires strong technical depth in viral vector drug product development combined with demonstrated strategic thinking, long range planning, and the ability to influence across a complex matrix organization.

Key Responsibilities

Drug Product Platform Development Strategy

Help to define and execute the long-term drug product platform strategy for lentiviral vectors supporting AstraZeneca’s In-vivo Cell Therapy pipeline.
Establish scalable and robust drug product technologies that enable rapid progression from research through clinical and commercial manufacturing.
Serve as the subject matter expert and scientific leader for viral vector formulation and drug product development.

Formulation Development

Lead the design, optimization, and characterization of novel LVV formulations for ex vivo and in vivo applications.
Develop formulation strategies that maximize product stability, potency, infectivity, and manufacturability.
Identify critical formulation attributes and establish platform approaches to support multiple therapeutic programs.

Fill-Finish and Drug Product Process Development

Establish clinical and commercial drug product manufacturing strategies including filling, storage, packaging, labeling, and distribution.
Lead development of fill-finish processes across pilot, clinical, and commercial scales.
Oversee evaluation of container closure systems, cryogenic storage solutions, particle characterization methodologies, and shipping strategies.
Drive implementation of advanced fill-finish technologies and automation solutions.

Product Characterization & Stability

Develop comprehensive drug product characterization strategies and analytical toolboxes.
Establish stability-indicating methodologies and generate robust stability packages to support regulatory submissions and product shelf-life claims.
Collaborate with Analytical Development to define critical quality attributes (CQAs) and product specifications.

Technology Transfer & Commercial Readiness

Support drug product technology transfer activities from development to GMP manufacturing sites and external CDMOs.
Develop representative scale-down models and comparability strategies to support process transfers and lifecycle management.
Partner with Manufacturing and Quality organizations to ensure successful process implementation and commercialization readiness.

Regulatory & CMC Leadership

Provide technical oversight for drug product CMC sections of regulatory submissions, including INDs, IMPDs, BLAs, and MAAs.
Interface with Regulatory Affairs to support agency interactions and responses to health authority questions.
Ensure development activities are aligned with current FDA, EMA, and global regulatory expectations for cell and gene therapy products.

External Partnerships & Innovation

Serve as the primary scientific lead for external collaborations, CDMOs, and technology partners.
Evaluate emerging drug product technologies, formulation innovations, and manufacturing solutions.
Drive adoption of novel approaches that improve productivity, robustness, quality, and speed-to-patient.

Qualifications

Education

Ph.D. in Pharmaceutical Sciences, Chemical Engineering, Biochemistry, Bioprocess Engineering, or related field with 12+ years of relevant industry experience; OR
M.S. with 15+ years of relevant industry experience.

Experience

Extensive experience leading drug product development programs for lentiviral vectors, AAV, adenoviral vectors, vaccine products, or complex biologics.
Proven track record advancing products from research through IND-enabling studies, clinical development, and commercialization.
Experience managing external development and manufacturing partners.

Technical Expertise

Deep knowledge of:
- Viral vector formulation development
- UF/DF and drug product process development
- Fill-finish operations and aseptic processing
- Container closure systems
- Particle characterization
- Cryopreservation and cold-chain strategies
- Stability program design and data interpretation
- Technology transfer and process validation

Regulatory & Quality

Strong understanding of cGMP, Quality Systems, and lifecycle management principles.
Experience supporting regulatory submissions and agency interactions.
Familiarity with FDA, EMA, and global regulations for cell therapy, gene therapy, and biologics.

Preferred Qualifications

Prior experience leading drug product development for commercial-stage cell or gene therapy products.
Experience establishing platform technologies across multiple programs.
Knowledge of emerging in vivo CAR-T and genetic medicine delivery systems.
Experience authoring regulatory filings and supporting health authority inspections and audits.

The annual base pay for this position ranges from $183,768.80 - $275,653.20. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Date Posted

30-Jul-2026

Closing Date

13-Aug-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

Apply Now

Refine Your Search

principal scientist jobs in rockville md

Principal Scientist Drug Product Development

Principal Scientist

Senior / Principal Scientist: Synthetic Chemistry & Bioconjugation

Principal Scientist

Principal Geospatial Scientist (Remote Sensing)

Principal Computer Scientist

Principal Research Scientist: Signal Processing

Principal AI/ML Scientist

Sr. Materials/Physics Scientist/Principal Investigator

Cell Culture Bioproduction Manager/Principle Scientist

Associate Principal, Indirect Treatment Comparison (ITC), Evidence Synthesis

Deputy Director, Principal Scientist or Engineer

Staff Principal Scientist/Senior Economic Security Analyst

Principal Research Scientist - AI/ML, Applied Statistics & Advanced Analytics

Principal Regulatory Scientist

Principal Quantum Systems Architect

Principal Investigator - Immediate Need!

Principal Research Associate- Long-Term and Post-Acute Care Policy

Principal Signal Processing Researcher

Principal, Policy

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