Top 32 Head of operational risk Jobs in San Diego, Ca

Head of R&D Portfolio & Project Management
Illumina —San Diego, CA
- $205,100 - $307,700 a year
- Full-time
- Hybrid work
- Background check
- 11+ years
- Doctor of Philosophy
- Dental insurance
- Paid time off
Director, HR Operations
EōS Fitness —San Diego, CA
- $125,000 - $150,000 a year
- Full-time
- 7 years
- Analysis skills
- Bachelor's degree
- Paid holidays
- Dental insurance
Quick Apply
Head of Core & Premium Accountant Support
Intuit —San Diego, CA
- 11+ years
- Bachelor's degree
- Experience equivalent to degree accepted
Contract Specialist
San Diego Metropolitan Transit System —San Diego, CA
- $65,822 - $93,468 a year
- Holidays
- Pass drug screening
- English
- Mid-level
- Paid training
- Paid jury duty
Quick Apply
5d
Technical Support Operations Lead
Orb Group —San Diego, CA
- $80,000 - $100,000 a year
- Night shift
- Remote
- 5 years
- Writing skills
- English
- Paid parental leave
- Paid holidays
Business Operations Manager
AEVEX —San Diego, CA
- $122,200 - $149,100 a year
- Full-time
- 5 years
- Office
- Analysis skills
- Disability insurance
- Health insurance
Quick Apply
AML OVERSIGHT & FINANCIAL INTELLIGENCE Manager
Intuit —San Diego, CA
- $146,000 - $251,000 a year
- Office
- Analysis skills
- Bachelor's degree
14d
Senior Project Manager - Associate Director, CMC
CALIDI BIOTHERAPEUTICS INC —San Diego, CA
- $125,000 - $165,000 a year
- Full-time
- Bachelor of Science
- Basic math
- Laboratory experience
- Health insurance
- Dental insurance
Quick Apply
Financial Analyst
Infinium Spirits, Inc. —San Diego, CA
- $78,000 - $85,000 a year
- Microsoft Outlook
- Mid-level
- Office
- Paid holidays
- Health insurance
5d
Business Operations Manager
AEVEX AEROSPACE —Solana Beach, CA
- $122,200 - $149,100 a year
- Full-time
- 5 years
- Office
- Analysis skills
- Disability insurance
- Health insurance
Head of Clinical Data Management
Neurocrine Bioscience —San Diego, CA
- $192,500 - $263,000 a year
- Full-time
- Psychiatry
- Bachelor of Science
- Master's degree
- Paid holidays
- Health insurance
Aviation Program Safety Manager - San Diego, CA
Safework Inc —San Diego, CA
- Full-time
- Construction site
- Continuous improvement
- Senior level
Quick Apply
Associate Director, Strategic Finance (San Diego / Foster City)
Illumina —San Diego, CA
- $155,600 - $233,400 a year
- Full-time
- Hybrid work
- Background check
- 7 years
- Office
- Relocation assistance
- Dental insurance
8d
Complex Director of Finance
Lodging Dynamics —San Diego, CA
- $115,000 - $130,000 a year
- Full-time
- Google Workspace
- 7 years
- Microsoft Excel
Quick Apply
ORCA Team Lead
Epsilon Systems Solutions Inc —San Diego, CA
- $90,000 - $130,000 a year
- Full-time
- 7 years
- Engineering
- Office
Oracle Supply Chain Senior Manager
Deloitte —San Diego, CA
- $158,900 - $292,900 a year
- Full-time
- Oracle
- Up to 50% travel
- 11+ years
Head of Clinical Operations
Kumquat Biosciences Inc —San Diego, CA
- $225,000 - $325,000 a year
- Nursing
- 11+ years
- Bachelor's degree
Quick Apply
Director of Finance
Estancia La Jolla, A Noble House Hotel —La Jolla, CA
- $130,000 - $150,000 a year
- Weekends as needed
- Microsoft Outlook
- CPA
- ERP systems
- Health insurance
- 401(k) matching
VP, Enterprise AI & Automation
Redion —San Diego, CA
- $180,000 - $250,000 a year
- Overtime
- Hybrid work
- Travel
- Experience equivalent to degree accepted
- Senior level
- Travel reimbursement
- Paid parental leave
Quick Apply
AI Enablement & Governance Lead
Axos Bank —San Diego, CA
- $150,000 - $180,000 a year
- Full-time
- Background check
- Computer Science
- Pass drug screening
- Health savings account
- Health insurance

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Head of R&D Portfolio & Project Management

Illumina -
San Diego, CA

Apply Now

Job Details

Full-time
$205,100 - $307,700 a year

Benefits

Dental insurance
Paid time off
Vision insurance
Retirement plan

Qualifications

Talent management
Product development projects
Managing projects
Research and development project management
Research & development
Project risk management
Project stakeholder communication
Stakeholder relationship building
Stakeholder management

Full Job Description

What if the work you did every day could impact the lives of people you know? Or all of humanity?

At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.

Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

The Head of R&D Portfolio & Project Management Office (PMO) is accountable for execution excellence across a complex and evolving R&D portfolio. Reporting into the Senior Director of R&D Strategy & Portfolio, this role leads and advances best‑in‑class portfolio, program, and project management capabilities to enable disciplined delivery, predictable outcomes, and transparent execution across R&D.

This leader owns the design, deployment, and continuous improvement of scalable PMO practices, including delivery standards, governance models, and enabling tools. In close partnership with R&D Strategy & Portfolio, the role translates portfolio priorities into integrated execution plans, sequencing, and delivery insights that support effective trade‑offs and decision‑making. This role also builds and sustains strong PMO talent to support increasingly complex, cross‑functional R&D initiatives.

Key Responsibilities:

PMO Leadership & Execution Excellence
- Lead the R&D PMO to ensure execution rigor, predictable delivery, and operational discipline across a complex R&D portfolio
- Ensure initiatives are delivered on time, on budget, and to defined quality standards, with strong risk and dependency management
- Own and continuously improve PMO standards, methodologies, governance and tools, including fit-for-purpose product development and delivery frameworks
- Integrate AI into PMO processes to increase overall project delivery efficiency

Partnership on Portfolio Governance
- Enable effective portfolio governance in partnership with R&D Strategy and Portfolio Operations & Insights, Corporate Strategy, Product Management, and business group leaders
- Operationalize portfolio priorities into executable programs, roadmaps, and capacity-informed plans
- Provide execution-based insights to inform portfolio trade-offs, sequencing, and governance decisions
- Deliver clear, consistent execution reporting, dashboards, and metrics to R&D leadership and cross-functional leadership

Stakeholder Engagement & Influence
- Serve as trusted execution partner to senior executives and cross-functional leaders, in a complex matrixed environment
- Drive cross-R&D alignment and collaboration to manage interdependencies and accelerate delivery
- Champion transparency and accountability through effective reporting and insights

Talent & Culture Leadership
- Attract, develop, and retain top-tier PMO and R&D talent
- Coach and mentor PM talent to strengthen core competencies and career progression
- Foster a high-performing, inclusive culture focused on innovation, adaptability, and measurable outcomes

Core Competencies

Execution excellence: deep expertise in driving delivery rigor across complex, cross-functional portfolios
PMO leadership: proven ability to design, scale, and sustain PMO operating models, standards, and tools
Data-driven decision making: leverage analytics and insights to inform execution and portfolio decisions
Change leadership: effectively lead adoption of new ways of working with minimal disruption
Global mindset: operates effectively across geographies, cultures, and matrixed organizations

Qualifications:

Advanced degree in Life Sciences, Business, or related field; MBA or PhD preferred.
12-15+ years of experience in R&D portfolio / project management and operations leadership
Demonstrated success building PMO capabilities, strengthening delivery performance, and developing PMO talent
Experience running development programs that include different product types: instruments, assays, regulated products, and software
Advanced understanding of stage-gate product development process and risk management
Strong communication, leadership and stakeholder management skills effective in matrixed organizations
Ability to work independently and collaboratively across all levels of the organization
Positive change agent – experience leading effective change management practices
PMP or similar certification preferred

#LI-HYBRID

The estimated base salary range for the Head of R&D Portfolio & Project Management role based in the United States of America is: $205,100 - $307,700. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. The range reflects long‑term growth in the role; therefore, most candidates are hired between the minimum and middle of the range. Placement depends on experience, skills, location, and internal equity. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.

We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact [email protected]. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship.

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Refine Your Search

head of operational risk jobs in san diego, ca

Head of R&D Portfolio & Project Management

Director, HR Operations

Head of Core & Premium Accountant Support

Contract Specialist

Technical Support Operations Lead

Business Operations Manager

AML OVERSIGHT & FINANCIAL INTELLIGENCE Manager

Senior Project Manager - Associate Director, CMC

Financial Analyst

Business Operations Manager

Head of Clinical Data Management

Aviation Program Safety Manager - San Diego, CA

Associate Director, Strategic Finance (San Diego / Foster City)

Complex Director of Finance

ORCA Team Lead

Oracle Supply Chain Senior Manager

Head of Clinical Operations

Director of Finance

VP, Enterprise AI & Automation

AI Enablement & Governance Lead

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