Top 87 Principal scientist Jobs in San Francisco, Ca

Principal Scientist, Immunology
Jade Biosciences —San Francisco, CA
- $175,000 - $190,000 a year
- Remote
- 8 years
- Doctor of Philosophy
- Travel
Quick Apply
Principal Scientist, Biomarker Data Sciences
Biogen —San Francisco, CA
- $141,000 - $188,000 a year
- Full-time
- Hybrid work
- 5 years
- Doctor of Philosophy
- Organizational skills
- Paid parental leave
- Employee stock purchase plan
Principal Scientist – Translational Medicine (Tumor Microenvironment)
Genentech —San Francisco, CA
- $141,500 - $262,900 a year
- Online Application
- Medicine
- No experience needed
- 3 years
Principal Scientist, Process Chemistry
CALICO —South San Francisco, CA
- $197,000 - $245,000 a year
- 8 years
- Continuous improvement
- Doctor of Philosophy
Associate Principal Scientist, Clinical Research
Merck —San Francisco, CA
- $142,400 - $224,100 a year
- Full-time
- 3 years
- Master's degree
- Analysis skills
- Paid holidays
- Health insurance
Principal Computational Scientist, Discovery Chemistry
Genentech —San Francisco, CA
- $144,900 - $269,100 a year
- Online Application
- Computer Science
- Doctor of Philosophy
- Organizational skills
Principal Scientist, Clinical Biomarkers
Biogen —San Francisco, CA
- $140,000 - $187,000 a year
- Full-time
- Hybrid work
- 5 years
- Doctor of Philosophy
- Senior level
- Paid parental leave
- Employee stock purchase plan
Principal Scientist, Bioinformatics
Nkarta, Inc. —South San Francisco, CA
- $180,000 - $215,000 a year
- Hybrid work
- Management
- 5 years
- Office
- Employee stock purchase plan
- Paid holidays
Quick Apply
Principal Scientist, Pharmacokinetics
Merck —San Francisco, CA
- $176,200 - $277,300 a year
- Full-time
- 8 years
- Analysis skills
- Doctor of Philosophy
- Paid holidays
- Health insurance
Principal/Sr. Principal Scientist - Development
Genentech —San Francisco, CA
- $141,500 - $321,490 a year
- Online Application
- 3 years
- Doctor of Philosophy
- Mentoring
Senior Scientist / Principal Scientist, Complex in Vitro Systems
Genentech —San Francisco, CA
- $120,700 - $262,900 a year
- Online Application
- 5 years
- Doctor of Philosophy
- Senior level
Principal Scientist, Computational Chemistry
Cytokinetics —San Francisco, CA
- $202,500 - $236,250 a year
- Full-time
- 11+ years
- Doctor of Philosophy
- Mentoring
Principal Scientist, Pathology
Genentech —San Francisco, CA
- $181,200 - $336,400 a year
- Online Application
- 5 years
- Doctor of Philosophy
- Mentoring
Senior/ Principal Scientist, Synthetic Molecule Analytical Chemistry
Genentech —San Francisco, CA
- $124,300 - $265,900 a year
- Online Application
- Master's degree
- Bachelor's degree
- Doctor of Philosophy
Technical Development Principle Scientist
Genentech —San Francisco, CA
- $120,800 - $224,300 a year
- Online Application
- Bachelor of Science
- Bachelor's degree
- Doctor of Philosophy
Principal Scientist - Cell Therapy Drug Product Process Development
Genentech —San Francisco, CA
- $120,800 - $224,300 a year
- Online Application
- Bachelor of Science
- Bachelor's degree
- Doctor of Philosophy
Principal Research Scientist – Scaling
Databricks —San Francisco, CA
- $280,000 - $350,000 a year
- Mentoring
- Senior level
- Leadership
Principal, Pharmacovigilance / Device Vigilance
Natera —San Francisco, CA
- $160,700 - $200,850 a year
- Google Workspace
- Software troubleshooting
- Computer literacy
- Commuter assistance
- Health insurance
Principal Scientist, Peptide Therapeutics
Genentech —San Francisco, CA
- $143,200 - $265,900 a year
- Online Application
- 3 years
- Machine learning
- Doctor of Philosophy
Principal Scientist I
MEADOWHAWK BIOLABS INC —Hayward, CA
- $123,000 - $163,000 a year
- 6 years
- Doctoral degree
- Bachelor of Science

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Principal Scientist, Immunology

Jade Biosciences
San Francisco, CA

Quick Apply

Job Details

$175,000 - $190,000 a year

Qualifications

Doctor of Philosophy

Full Job Description

About Jade Biosciences

Jade Biosciences is a clinical-stage biotechnology company focused on developing best-in-class therapies that address critical unmet needs in autoimmune diseases. Jade's lead candidate, JADE101, targets the cytokine APRIL, and is currently being evaluated in a Phase 1 clinical trial for the treatment of immunoglobulin A nephropathy. Jade's pipeline also includes JADE201, an afucosylated anti-BAFF-R monoclonal antibody, as well as JADE301, an undisclosed antibody candidate, both currently in preclinical development. Jade was launched based on assets licensed from Paragon Therapeutics, an antibody discovery engine founded by Fairmount. For more information, visit JadeBiosciences.com and follow the Company on LinkedIn.

Role Overview

The Research and Translational Medicine group at Jade is looking to add a Principal Scientist, Translational Research, to our team. This role will provide scientific leadership across immunology-driven research activities that support Jade's pipeline programs, including mechanism-of-action studies, disease biology assessment, indication evaluation, and translational strategy. The Principal Scientist will integrate literature, experimental data, and translational insights to strengthen program rationale, inform clinical development, and identify opportunities for pipeline expansion. This is an exciting opportunity to join a growing, highly collaborative biotech team and contribute to the advancement of potentially best-in-class therapies for autoimmune and inflammatory diseases.

This is a fully remote role, preferably based on the U.S. West Coast, with occasional domestic and international travel. The position reports to the Executive Director, Research and Translational Medicine.

Key Responsibilities

Lead immunology-driven research strategy across pipeline programs to support scientific narrative and indication assessment, integrating literature, experimental data, and translational insights
Design and oversee mechanism-of-action studies to elucidate target biology, pathway modulation, and disease relevance across in vitro, ex vivo, and in vivo models, executed in partnership with CROs
Partner closely with Translational Medicine, Clinical Pharmacology, and Nonclinical teams to ensure alignment of preclinical findings with clinical strategy
Generate and interpret complex datasets (e.g., cellular immunology, cytokine profiling, pathway analysis), ensuring rigorous and hypothesis-driven conclusions
Identify and validate new targets and pathways for pipeline expansion, leveraging deep understanding of disease biology, emerging science, and internal platform capabilities
Evaluate and prioritize new indication opportunities, integrating mechanistic rationale, competitive landscape, and translational feasibility
Support external collaborations and CRO activities, providing scientific direction and technical oversight to ensure high-quality data generation
Author and contribute to scientific documents, including study reports, regulatory sections (e.g., IND-enabling rationale), presentations, and publications
Present findings to internal governance teams and external scientific forums
Stay current with advances in immunology, inflammation, and translational science, applying new insights to strengthen program and pipeline strategy

Qualifications

PhD in Immunology or related field with 8–12+ years of relevant industry experience is required
Deep expertise in immunology and disease biology, particularly in autoimmune and inflammatory disease mechanisms
Strong understanding of drug development, including how preclinical and translational data inform clinical strategy
Experience with immunological assays and platforms (e.g., flow cytometry, ELISA/MSD, cytokine panels, cellular assays); familiarity with advanced platforms (e.g., single-cell, proteomics) is a plus
Experience working in cross-functional teams (e.g., Translational Medicine, Clinical, Nonclinical)
Strong written and verbal communication skills, with a track record of scientific publications and presentations
Ability to operate independently while contributing to a collaborative, fast-paced biotech environment

Position Location

This is a remote role; periodic travel to team and company events is required.

The anticipated salary range for candidates for this role is $175,000 - $190,000. The final salary offered will depend on several factors, which may include, but not limited to, relevant years of experience, educational background, and geography.

As part of the I-9 verification of authorization to work in the United States, Jade Bioscience participates in E-Verify. To learn more about E-Verify please review this poster.

Jade Biosciences is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

Quick Apply

Refine Your Search

principal scientist jobs in san francisco, ca

Principal Scientist, Immunology

Principal Scientist, Biomarker Data Sciences

Principal Scientist – Translational Medicine (Tumor Microenvironment)

Principal Scientist, Process Chemistry

Associate Principal Scientist, Clinical Research

Principal Computational Scientist, Discovery Chemistry

Principal Scientist, Clinical Biomarkers

Principal Scientist, Bioinformatics

Principal Scientist, Pharmacokinetics

Principal/Sr. Principal Scientist - Development

Senior Scientist / Principal Scientist, Complex in Vitro Systems

Principal Scientist, Computational Chemistry

Principal Scientist, Pathology

Senior/ Principal Scientist, Synthetic Molecule Analytical Chemistry

Technical Development Principle Scientist

Principal Scientist - Cell Therapy Drug Product Process Development

Principal Research Scientist – Scaling

Principal, Pharmacovigilance / Device Vigilance

Principal Scientist, Peptide Therapeutics

Principal Scientist I

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