Top 79 Principal scientist Jobs in San Francisco, Ca

Principal Scientist, Biomarker Data Sciences
Biogen —San Francisco, CA
- $141,000 - $188,000 a year
- Full-time
- Hybrid work
- 5 years
- Doctor of Philosophy
- Organizational skills
- Paid parental leave
- Employee stock purchase plan
Principal Scientist, Process Chemistry
CALICO —South San Francisco, CA
- $197,000 - $245,000 a year
- 8 years
- Continuous improvement
- Doctor of Philosophy
Principal Scientist, Clinical Biomarkers
Biogen —San Francisco, CA
- $140,000 - $187,000 a year
- Full-time
- Hybrid work
- 5 years
- Doctor of Philosophy
- Senior level
- Paid parental leave
- Employee stock purchase plan
Principal/Sr. Principal Scientist - Development
Genentech —San Francisco, CA
- $141,500 - $321,490 a year
- Online Application
- 3 years
- Doctor of Philosophy
- Mentoring
Principal Scientist, Antibody Engineering & Rational Design
CALICO —South San Francisco, CA
- $198,000 - $241,000 a year
- 8 years
- Doctor of Philosophy
- Senior level
Principal Scientist, Pathology
Genentech —San Francisco, CA
- $181,200 - $336,400 a year
- Online Application
- 5 years
- Doctor of Philosophy
- Mentoring
Principal Scientist, Bioinformatics Human Genetics
Genentech —San Francisco, CA
- $150,700 - $279,900 a year
- Online Application
- Computer Science
- Doctor of Philosophy
- Quality control
Principal Scientist – Translational Medicine (Tumor Microenvironment)
Genentech —San Francisco, CA
- $141,500 - $262,900 a year
- Online Application
- Medicine
- No experience needed
- 3 years
Principal Scientist I
MEADOWHAWK BIOLABS INC —Hayward, CA
- $123,000 - $163,000 a year
- 6 years
- Doctoral degree
- Bachelor of Science
Principal Scientist, Analytical Development
Sana Biotechnology. —South San Francisco, CA
- $200,000 - $240,000 a year
- Weekends as needed
- Analysis skills
- Doctor of Philosophy
- Team management
- Commuter assistance
- Employee stock purchase plan
Principal Scientist, Purification Process Development
Denali Therapeutics —South San Francisco, CA
- $159,000 - $207,000 a year
- Doctor of Philosophy
- Senior level
- Communication skills
- Employee stock purchase plan
- Health insurance
Principal Scientist – PKDM (Large Molecule Project Team Representative)
Amgen —South San Francisco, CA
- $163,670.05 - $221,435.95 a year
- Medicine
- 3 years
- Bachelor's degree
- Disability insurance
- Health insurance
Principal Scientist, Immunology
Biogen —San Francisco, CA
- $142,000 - $190,000 a year
- Full-time
- Master's degree
- 8 years
- Business development experience
- Paid parental leave
- Employee stock purchase plan
Principal Scientist, Pharmacokinetics
Merck —San Francisco, CA
- $176,200 - $277,300 a year
- Full-time
- 8 years
- Analysis skills
- Doctor of Philosophy
- Paid holidays
- Health insurance
Principal Scientist (Cell Line Development)
Exelixis, Inc. —Alameda, CA
- $150,000 - $213,000 a year
- Email
- 5 years
- Master's degree
- Bachelor's degree
- Paid holidays
- Disability insurance
10h
Principal Scientist, Translational Genomics and Proteomics Center
Genentech —San Francisco, CA
- $143,200 - $266,000 a year
- Online Application
- Doctor of Philosophy
- Mentoring
- Senior level
14d
Principal Scientist, Peptide Therapeutics
Genentech —San Francisco, CA
- $143,200 - $265,900 a year
- Online Application
- 3 years
- Machine learning
- Doctor of Philosophy
Principal Scientist
Exponent Inc. —Menlo Park, CA
- $225,000 - $275,000 a year
- Email
- Office
- Analysis skills
- Doctor of Philosophy
- 401(k)
Technical Development Principal Scientist - Computational Biophysics
Genentech —San Francisco, CA
- $120,800 - $224,300 a year
- Online Application
- Computer science
- Computer Science
- Analysis skills
Principal Scientist I, Biologics Analytical Research and Development
AbbVie —San Francisco, CA
- $124,500 - $236,500 a year
- Full-time
- Management
- Bachelor of Science
- 11+ years
- Paid holidays
- Health insurance

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Principal Scientist, Biomarker Data Sciences

Biogen -
San Francisco, CA

Apply Now

Job Details

Full-time
$141,000 - $188,000 a year

Benefits

Paid parental leave
Employee stock purchase plan
Paid holidays
Disability insurance
Health insurance
Dental insurance
Tuition reimbursement
Parental leave
Vision insurance
401(k) matching
Gym membership
Life insurance

Qualifications

Doctor of Philosophy
Cross-functional collaboration
Clinical data analysis
Cross-functional communication

Full Job Description

About This Role:

As a Principal Scientist in Biomarker Data Sciences within the Clinical Biomarkers group at the West Coast Hub, you will lead the charge in multi-omics analyses of extensive clinical trial datasets, with a particular focus on NGS and proteomics. This role is pivotal in generating biological insights that will directly inform clinical development strategies. You will be advancing the understanding of CD38 immune cell–driven biology, collaborating closely with clinical teams, biostatistics, medical affairs, and key medical experts. Your ability to translate complex data into impactful insights will bring immense value to our business, ensuring our developments are both innovative and effective. With a seat at the heart of our operations, you will contribute strategically to our clinical biomarker initiatives, aligning closely with our overarching business goals.

What You’ll Do:

Lead and execute integrative multi-omics analyses from large clinical cohorts.

Translate complex NGS and proteomics data into actionable biological and clinical insights.

Partner closely with clinical teams, medical experts, biostatistics, and medical affairs to address critical clinical trial questions.

Contribute to biomarker strategy, exploratory endpoints, and interpretation of clinical trial results.

Communicate findings clearly and effectively to cross-functional, clinical, and scientific stakeholders.

Who You Are:

You are a highly collaborative individual with outstanding communication skills. Your ability to clearly translate complex data into impactful insights sets you apart. You thrive in cross-functional environments, where your expertise in bioinformatics and your passion for advancing clinical research drive you. Your approach is both analytical and creative, enabling you to contribute significantly to clinical biomarker strategies. Your enthusiasm for working with diverse teams and your commitment to excellence make you an invaluable asset to our organization.

Required Skills:

PhD in Bioinformatics, Computational Biology, Immunology, or a related field.

5+ years of relevant industry experience.

Hands-on experience analyzing NGS and/or proteomics data from large clinical datasets.

Outstanding written and verbal communication skills and a demonstrated ability to work in highly collaborative, cross-functional environments.

Preferred Skills:

Relevant postdoctoral training.

Background in immunology and/or autoimmune disease biology.

Experience supporting biomarker discovery and mechanism-of-action studies in clinical trials.

Job Level: Management

Additional Information

The base compensation range for this role is: $141,000.00-$188,000.00

Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well-being ; including, but not limited to:

Medical, Dental, Vision, & Life insurances
Fitness & Wellness programs including a fitness reimbursement
Short- and Long-Term Disability insurance
A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
Up to 12 company paid holidays + 3 paid days off for Personal Significance
80 hours of sick time per calendar year
Paid Maternity and Parental Leave benefit
401(k) program participation with company matched contributions
Employee stock purchase plan
Tuition reimbursement of up to $10,000 per calendar year

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about Biogen.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.

Apply Now

Refine Your Search

principal scientist jobs in san francisco, ca

Principal Scientist, Biomarker Data Sciences

Principal Scientist, Process Chemistry

Principal Scientist, Clinical Biomarkers

Principal/Sr. Principal Scientist - Development

Principal Scientist, Antibody Engineering & Rational Design

Principal Scientist, Pathology

Principal Scientist, Bioinformatics Human Genetics

Principal Scientist – Translational Medicine (Tumor Microenvironment)

Principal Scientist I

Principal Scientist, Analytical Development

Principal Scientist, Purification Process Development

Principal Scientist – PKDM (Large Molecule Project Team Representative)

Principal Scientist, Immunology

Principal Scientist, Pharmacokinetics

Principal Scientist (Cell Line Development)

Principal Scientist, Translational Genomics and Proteomics Center

Principal Scientist, Peptide Therapeutics

Principal Scientist

Technical Development Principal Scientist - Computational Biophysics

Principal Scientist I, Biologics Analytical Research and Development

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