Top 66 Senior machine learning scientist agentic experience Jobs in San Francisco, Ca

Machine Learning Scientist/Senior Machine Learning Scientist - Agents for Applied Small Molecule Drug Design, AI for Drug Discovery
Genentech —San Francisco, CA
- $147,600 - $297,300 a year
- Online Application
- Computer Science
- Doctor of Philosophy
- Senior level
Senior Machine Learning Scientist, Foundational ML, AI for Biology & Translation (AIBT)
Genentech —San Francisco, CA
- $147,800 - $274,400 a year
- Online Application
- Computer Science
- System design
- Doctor of Philosophy
Senior Machine Learning Engineer
Warner Bros. Discovery —San Francisco, CA
- $159,180 - $295,620 a year
- 5 years
- SQL
- Doctor of Philosophy
- Wellness program
- Paid holidays
Principal/Senior Machine Learning Scientist - Search and Discovery
roblox —San Mateo, CA
- $278,530 - $345,040 a year
- Full-time
- Computer science
- Computer Science
- Bachelor of Science
Senior Machine Learning Scientist, Imaging
insitro —South San Francisco, CA
- $215,000 - $235,000 a year
- Full-time
- Hybrid work
- Computer science
- Azure
- Computer Science
- Paid parental leave
- Health insurance
Lead Product Data Scientist
DocuSign —San Francisco, CA
- $186,100 - $300,550 a year
- Hybrid work
- Bachelor of Science
- 11+ years
- Office
- Paid parental leave
- Paid holidays
Senior / Staff Machine Learning Scientist
Chemify Ltd —San Francisco, CA
- Computer science
- Azure
- Computer Science
Quick Apply
Senior Data Scientist, Creator Platform
Roblox —San Francisco, CA
- $263,670 - $322,820 a year
- Computer Science
- Bachelor of Science
- Office
6d
Senior Machine Learning Engineer, Data Mining
Motional —San Francisco, CA
- $172,000 - $229,000 a year
- Hybrid work
- Computer science
- Azure
- 6 years
Quick Apply
Senior Manager, Data Science - Foundational Models
Stitch Fix —San Francisco, CA
- $200,000 - $246,000 a year
- Remote
- Computer Science
- Master's degree
- Bachelor's degree
Quick Apply
Software Development Engineer/Senior Software Development Engineer, Agentic Systems, AI for Drug Discovery
Genentech —San Francisco, CA
- $110,200 - $264,700 a year
- Online Application
- Computer Science
- 3 years
- Master's degree
5d
Front-End Engineer (Senior/ Staff)
Equilibrium Energy —San Francisco Bay Area, CA
- Remote
- Computer Science
- AWS
- APIs
- Health insurance
- Dental insurance
Senior Data Scientist
Capgemini Sogeti —San Francisco, CA
- Full-time
- Azure
- 5 years
- SQL
- Paid holidays
- Disability insurance
3d
Senior Manager, Data Science - Styling Algorithms
Stitch Fix —San Francisco, CA
- $200,000 - $246,000 a year
- Remote
- Computer Science
- Master's degree
- Bachelor's degree
Quick Apply
Senior Director, AI Engineering -Agentic AI Platform(Remote Eligible)
Information Technology Senior Management Forum —San Francisco, CA
- $286,200 - $392,000 a year
- Email
- Remote
- Azure
- Computer Science
- 5 years
- Health insurance
5d
Senior Software Engineer, Research Biology
Genentech —San Francisco, CA
- $142,500 - $264,700 a year
- Online Application
- Computer science
- Computer Science
- 5 years
Senior MLOps Engineer I
Zeitview —San Francisco, CA
- $170,000 - $180,000 a year
- Remote
- Computer Science
- AWS
- Bachelor's degree
- Health savings account
- Health insurance
Quick Apply
7d
Scientist/Engineer, Machine Learning / Bioinformatics
Moonwalk Biosciences, Inc. —South San Francisco, CA
- $130,000 - $173,000 a year
- Full-time
- Computer Science
- 3 years
- Doctor of Philosophy
Quick Apply
Decision Scientist Lead
Salesforce —San Francisco, CA
- $172,500 - $285,800 a year
- Full-time
- Computer Science
- 8 years
- SQL
- Paid parental leave
- Disability insurance
Principal Applied AI Engineer
Redesign Health —San Francisco, CA
- Full-time
- Hybrid work
- System design
- Research
- Office
4d

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Machine Learning Scientist/Senior Machine Learning Scientist - Agents for Applied Small Molecule Drug Design, AI for Drug Discovery

Genentech -
San Francisco, CA

Apply Now

Job Details

Full-time
$147,600 - $297,300 a year

Qualifications

AI models
Computational research
Reinforcement learning
Statistics
Chemical Engineering
Computer Science
PyTorch
Conference papers
Publishing papers in peer-reviewed journals
Process design
AI platforms (beyond public GPTs)
Computational framework
Computational modeling
Doctoral degree in Computer Science
Machine intelligence
Linear algebra
Drug discovery
Ph.D. in statistics
Doctor of Philosophy
Developing large-scale AI models
Doctoral degree in physics
Physics
Conducting conference presentations
GitHub
Participating in conferences
Open source contribution
Machine learning libraries
Senior level
Machine learning frameworks
Pharmaceutical research experience

Full Job Description

The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche.

Advances in AI, data, and computational sciences are transforming drug discovery and development. Roche’s Research and Early Development organisations at Genentech (gRED) and Pharma (pRED) have demonstrated how these technologies accelerate R&D, leveraging data and novel computational models to drive impact. Seamless data sharing and access to models across gRED and pRED are essential to maximising these opportunities. The new Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness the transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative medicines for patients worldwide.

Join the small-molecule team within AI for Drug Discovery (AI4DD), formerly Prescient Design, at Roche and Genentech’s Computational Sciences Center of Excellence as a Machine Learning Scientist / Senior Machine Learning Scientist building agents for applied small-molecule drug design. You will develop autonomous, LLM-driven agentic workflows that orchestrate ML models, physics-based methods, and cheminformatics tools to accelerate discovery, working with world-class chemists and structural biologists.

The Opportunity:

Design, build, and apply agentic workflows and ML models for key challenges in small-molecule drug design.
Fine-tune foundation models for drug discovery relevant topics using internal and external datasets and tools.
Optimize agent-derived hypotheses in close collaboration with world-class computational and medicinal chemists and structural biologists.
Drive scientific impact through publications, open-source releases, and conference talks.
Collaborate widely with computational and experimental researchers at Roche and with academic partners.

Who you are:

You are experienced developing LLM-driven agents for scientific workflows and you understand how to orchestrate tools and models reliably.
You bring strong machine-learning foundations in linear algebra, probability and optimization, with hands-on experience with GNNs, sequence/language models and reinforcement learning.
You are fluent in Python and modern agentic coding environments such as LangChain, ML frameworks such as PyTorch or JAX, as well as cheminformatics toolkits like RDKit or OpenEye.
You hold a PhD or equivalent research depth in machine learning, computer science, chemical engineering or a related quantitative field such as physics or statistics, with up to 2 years of industry research experience (Scientist) or 2+ years of industry research experience (Senior Scientist).
You have a record of scientific excellence evidenced by journal and conference publications or a public portfolio of relevant projects (e.g. hosted on GitHub/GitLab)..

Preferred:

Hands-on experience orchestrating multi-tool or multi-agent scientific pipelines.
Hand-on experience working along the small molecule drug discovery value chain and an excitement to engage with chemists
Familiarity with structural biology datasets

If you want to put autonomous AI to work discovering the medicines patients need next, apply now and help build the future of drug design at Roche.

Relocation benefits are NOT available for this opportunity

The expected salary range for this position, based on the primary location of San Francisco, is $147,600 - $274,000 for the ML Scientist, and $167,400 - 310,800 for the Senior ML Scientist. For the primary of location of New York City, $141.100 - $262,100 for the ML Scientist, and $160,100 - 297,300 for the Senior ML Scientist. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

#ComputationCoE

#tech4lifeComputationalScience

#tech4lifeAI

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

JOB FACTS

Job Sub Category

Artificial Intelligence & Machine Learning
Schedule

Full time
Job Type

Regular
Posted Date

Jun 22nd 2026
Job ID

202606-115525

Apply Now

Refine Your Search

senior machine learning scientist agentic experience jobs in san francisco, ca

Machine Learning Scientist/Senior Machine Learning Scientist - Agents for Applied Small Molecule Drug Design, AI for Drug Discovery

Senior Machine Learning Scientist, Foundational ML, AI for Biology & Translation (AIBT)

Senior Machine Learning Engineer

Principal/Senior Machine Learning Scientist - Search and Discovery

Senior Machine Learning Scientist, Imaging

Lead Product Data Scientist

Senior / Staff Machine Learning Scientist

Senior Data Scientist, Creator Platform

Senior Machine Learning Engineer, Data Mining

Senior Manager, Data Science - Foundational Models

Software Development Engineer/Senior Software Development Engineer, Agentic Systems, AI for Drug Discovery

Front-End Engineer (Senior/ Staff)

Senior Data Scientist

Senior Manager, Data Science - Styling Algorithms

Senior Director, AI Engineering -Agentic AI Platform(Remote Eligible)

Senior Software Engineer, Research Biology

Senior MLOps Engineer I

Scientist/Engineer, Machine Learning / Bioinformatics

Decision Scientist Lead

Principal Applied AI Engineer

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