Top 346 Senior scientist, oligonucleotide chemist Jobs in San Francisco, Ca

Senior Scientist/Principal Scientist, Translational Immunotherapy
Sift Biosciences —San Carlos, CA
- $130,000 - $160,000 a year
- Full-time
- Management
- 5 years
- Master's degree
- Commuter assistance
- Health insurance
Quick Apply
5d
Senior Scientist, Process Chemistry
Merck —San Francisco, CA
- $131,400 - $206,800 a year
- Full-time
- Doctor of Philosophy
- Travel
- Fair chance
- Paid holidays
- Health insurance
4d
Machine Learning Scientist / Senior Machine Learning Scientist
CALICO —South San Francisco, CA
- $170,000 - $240,000 a year
- Computer Science
- Doctor of Philosophy
- In-person
Sr Scientist/Principal Scientist, Discovery Oncology (in vivo Biology)
Eli Lilly —San Francisco, CA
- $71,250 - $187,000 a year
- Full-time
- Bachelor of Science
- Bachelor's degree
- Mentoring
- Health insurance
- Dental insurance
12d
Senior Data Scientist
Merck —San Francisco, CA
- $159,600 - $251,200 a year
- Full-time
- Computer Science
- Master's degree
- Math
- Paid holidays
- Health insurance
3d
Senior Scientist I
Cytokinetics —San Francisco, CA
- $162,000 - $189,000 a year
- Full-time
- 5 years
- Doctor of Philosophy
- Senior level
Senior Scientist, Antibody Discovery
Merck —San Francisco, CA
- $131,400 - $206,800 a year
- Full-time
- Master's degree
- Analysis skills
- Bachelor's degree
- Paid holidays
- Health insurance
Senior Algorithm Scientist
Oura —San Francisco, CA
- $172,550 - $203,000 a year
- Hybrid work
- Office
- 3 years
- Doctor of Philosophy
- Paid holidays
- Health insurance
Senior Scientist, Antibody Engineering
Soleil Labs, LLC —South San Francisco, CA
- $134,835 - $240,776 a year
- Email
- 5 years
- Office
- Presentation skills
- Health savings account
- Disability insurance
Quick Apply
5d
Scientist II/Senior Scientist, Computational Chemistry, Drug Discovery
Lila Sciences —San Francisco, CA
- $140,800 - $217,800 a year
- Doctor of Philosophy
- Senior level
- Python
Quick Apply
13d
(Senior) ML Scientist
insitro —South San Francisco, CA
- $183,000 - $238,000 a year
- Full-time
- Hybrid work
- Azure
- Computer Science
- Office
- Paid parental leave
- Health insurance
Senior Scientist, Analytical Sciences
ORIC Pharmaceuticals —South San Francisco, CA
- $150,000 - $180,000 a year
- Full-time
- Hybrid work
- 3 years
- Doctor of Philosophy
- Senior level
Quick Apply
Senior Field Scientist
Alembic —San Francisco, CA
- $160,000 - $185,000 a year
- Full-time
- AWS
- Travel
- Mentoring
Senior Scientist, Immunology
Biogen —San Francisco, CA
- $123,000 - $164,000 a year
- Full-time
- Bachelor of Science
- Analysis skills
- Bachelor's degree
- Paid parental leave
- Employee stock purchase plan
Senior Research Scientist
Sciforium —San Francisco, CA
- $190,000 - $250,000 a year
- Full-time
- Computer Science
- 5 years
- Doctor of Philosophy
- Health insurance
- Dental insurance
Senior Scientist I, siRNA Therapeutics – Oncology
AbbVie —South San Francisco, CA
- $96,500 - $183,500 a year
- Full-time
- Bachelor of Science
- Bachelor's degree
- Doctor of Philosophy
- Paid holidays
- Health insurance
SENIOR SCIENTIST, BIOANALYTICS
Sutro Biopharma —South San Francisco, CA
- $174,000 - $208,000 a year
- Full-time
- 7 years
- Analysis skills
- Doctor of Philosophy
Scientist/Sr. Scientist, Chemical Biology
General Proximity —San Francisco, CA
- Email
- Management
- Analysis skills
- Supervising experience
- Health insurance
- Dental insurance
Quick Apply
Senior Scientist I, Oncology Research
CytomX Therapeutics, Inc. —South San Francisco, CA
- $155,000 - $175,000 a year
- Full-time
- Hybrid work
- Doctor of Philosophy
- Travel
- Senior level
Senior Clinical Scientist, ECD
Natera —San Francisco, CA
- $142,800 - $178,500 a year
- Remote
- Medicine
- 6 years
- Analysis skills
- Commuter assistance
- Health insurance

I want to receive the latest job alert for senior scientist, oligonucleotide chemist in san francisco, ca

By signing in to your account, you agree to SimplyHired's Terms of Service and consent to our Cookie and Privacy Policy.

Explore jobs in more locations

senior scientist, oligonucleotide chemist jobs near san francisco, ca

Machine Learning Engineer jobs in San Francisco, CA

Senior Scientist jobs in South San Francisco, CA

Senior Scientist jobs in San Francisco, CA

Scientist jobs in San Francisco, CA

Machine Learning Engineer jobs in South San Francisco, CA

Senior Data Scientist jobs in San Francisco, CA

Senior Research Scientist jobs in South San Francisco, CA

Machine Learning Engineer jobs in Alpharetta, GA

Social Emotional Learning Specialist jobs in Texas

Machine Learning Engineer jobs in Reston, VA

Machine Learning Engineer jobs in Chicago, IL

Machine Learning jobs in San Francisco Bay Area, CA

Water Wastewater Engineer jobs in Chicago, IL

Machine Learning Engineer jobs in Raleigh, NC

Senior Scientist jobs in White Plains, NY

Data Scientist jobs in Kansas City, MO

Medical Laboratory Scientist jobs in Kansas

Housekeeping Senior Living jobs in Saint Paul, MN

Senior Scientist jobs in Oak Ridge, TN

Senior Scientist jobs in Kansas City, MO

Senior Scientist/Principal Scientist, Translational Immunotherapy

Sift Biosciences
San Carlos, CA

Quick Apply

Job Details

Full-time
$130,000 - $160,000 a year
5 days ago

Benefits

Commuter assistance
Health insurance
Dental insurance
401(k)
Paid time off
Parental leave
Vision insurance
Flexible schedule

Qualifications

Biology
Biotechnology
Technical documentation
Formulation chemistry
Cell Biology
Master's degree
Doctor of Philosophy
Pharmaceutical company experience
In vivo studies
Pharmaceutical research experience

Full Job Description

Senior Scientist/Principal Scientist, Translational Immunotherapy

Sift Bio is building a cutting-edge proprietary platform that combines AI, metagenomics, and high-throughput T-cell screening to discover epitopes that drastically amplify pre-existing immune memory responses, unlocking targeted, effective, and safe treatment for cancers and autoimmune diseases where current therapies fall short. Spinning out of UC Berkeley, the Sift Bio team brings together AI-driven discovery and deep translational immunology, with a proven track record of advancing novel immunotherapies from early concept through IND-enabling development. Collectively, the team has built and scaled high-throughput discovery platforms and led T-cell, peptide, and cell-based immunotherapy programs across leading academic labs, biotech startups, and biopharma. Merging this experience with proprietary datasets and computational pipelines, Sift Bio is shaping a new frontier in immunotherapy, unlocking the power of pre-existing immunity to create a fundamentally new class of treatments for immune dysfunctions. Our ultimate goal is to bring durable disease control to every patient.

We are seeking a Senior Scientist/Principal Scientist to work on our lead oncology program, leading the path from hit-to-lead generation to DC nomination for an off-the-shelf, memory-recall-based immunotherapy: designing, executing, and interpreting primary-cell assays that establish mechanism, potency, and safety. This role will report to the CTO and be fully onsite at 733 Industrial Road, San Carlos, CA.

KEY RESPONSIBILITIES:

Drive the identification, engineering, and functional optimization of lead immunotherapeutic candidates from early discovery through to DC nomination.
Design and execute cell-based assays (e.g., multi-parameter flow cytometry, cytotoxicity, cytokine profiling) to evaluate memory-recall, T-cell activation, and target engagement.
Characterize primary human T-cells and PBMCs (e.g. phenotyping) both prior and following response to stimulation.
Navigate challenges in working with, and characterizing, polyclonal T-cell responses, and is aware of how these challenges differ from monoclonal T-cell products.
Develop and support assays to forecast off-target events that leverage cross-reactivity as a method for overcoming antigen tolerance.
Benchwork to include profiling antigen-specific T-cells using IFN-γ ELISpot, and activation-induced marker (AIM) assays, and intracellular cytokine staining, with matrix/pool deconvolution design.
Develop assays to forecast off-target events in a system that leverages cross-reactivity as a method for overcoming antigen tolerance.
Oversee tetramer/dextramer and multimer staining, including executing high-avidity, peptide-MHC (pMHC) assays and employing DNA-barcoded multimers.
Running standard cytotoxicity readouts (e.g. IncuCyte).
Interpreting immunopeptidomics (LC-MS/MS HLA-ligand) data generated by collaborators/CROs and translate it into epitope-processing and presentation decisions.
Investigate the biological mechanisms (MoA) underlying the therapy’s ability to drive vigorous, durable anti-tumor memory.
Oversee in vivo and ex vivo studies to define the therapeutic's efficacy, pharmacodynamics (PD), and pharmacokinetics (PK).
Partner with the R&D team to de-risk assets prior to IND-enabling studies.
Manage direct reports/vendor/collaborators, present data to cross-functional teams, and author technical reports and regulatory documents to support governance reviews.
Interpret, analyze, present, and properly record data.
Prepare documents and presentations that encompass project progression.

REQUIRED EXPERIENCE:

PhD in Immunology, Cell Biology, or a related field, plus 5+ years of post-doctoral or industry experience. Alternatively, a Master’s degree with 8 to 10+ years of biotech experience. Job title will commensurate with experience.
Excited by and scientifically driven to overcome complex technical challenges that will contribute to safe treatment for cancers and autoimmune diseases.
Strong T-cell biology expertise, with extensive experience characterizing low frequency (<0.1%) CD8 and CD4 responses, and knowledge of how to improve readouts of rare T-cell responses.
Working knowledge of HLA biology, supertypes, population coverage logic, and HLA-matched experimental systems.
Immunotherapy drug development experience is a must.
Prior cancer-vaccine or general vaccine development experience, including peptide, protein-subunit, or nucleic-acid modalities, spanning antigen selection through in vivo immunogenicity.
Familiarity with adjuvants (TLR agonists, saponins, poly-ICLC) and how formulation shapes the T-cell response.
Experience with HLA-transgenic mouse models and/or human PBMC xenograft/humanized models, and familiarity with readouts both in flight and downstream of animal studies.
Proven ability to contribute to the scientific direction of a project.
Strong written and oral communication skills for technical and non-technical audiences.
Conscientious team member with experience taking and giving constructive feedback.
Must be comfortable with executing lab work full time in a preclinical-stage startup environment, and capable of finding solutions to tough problems with limited resources.

Sift Bio is pleased to offer competitive:

Medical, Dental, and Vision health plans.
Flexible time off.
Bonus and Equity plans.
Commuter transit benefit.
401(k) retirement plan.

Sift Bio is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind as outlined by applicable laws.

Pay: $130,000.00 - $160,000.00 per year

Benefits:

401(k)
Flexible schedule
Health insurance
Paid time off
Parental leave
Vision insurance

Application Question(s):

Please tell us about your experience with cancer-vaccine or general vaccine development experience, including peptide, protein-subunit, or nucleic-acid modalities, spanning antigen selection through in vivo immunogenicity.

Experience:

T cell biology : 5 years (Required)

Location:

San Carlos, CA 94070 (Preferred)

Work Location: In person

Quick Apply

Refine Your Search

senior scientist, oligonucleotide chemist jobs in san francisco, ca

Senior Scientist/Principal Scientist, Translational Immunotherapy

Senior Scientist, Process Chemistry

Machine Learning Scientist / Senior Machine Learning Scientist

Sr Scientist/Principal Scientist, Discovery Oncology (in vivo Biology)

Senior Data Scientist

Senior Scientist I

Senior Scientist, Antibody Discovery

Senior Algorithm Scientist

Senior Scientist, Antibody Engineering

Scientist II/Senior Scientist, Computational Chemistry, Drug Discovery

(Senior) ML Scientist

Senior Scientist, Analytical Sciences

Senior Field Scientist

Senior Scientist, Immunology

Senior Research Scientist

Senior Scientist I, siRNA Therapeutics – Oncology

SENIOR SCIENTIST, BIOANALYTICS

Scientist/Sr. Scientist, Chemical Biology

Senior Scientist I, Oncology Research

Senior Clinical Scientist, ECD

I want to receive the latest job alert for senior scientist, oligonucleotide chemist in san francisco, ca

Related Searches

Explore jobs in more locations

Job Seeker Tools

Employer Tools

Browse

Stay Connected