Top 131 Principal scientist Jobs in San Leandro, Ca

Senior Scientist/Principal Scientist, Translational Immunotherapy
Sift Biosciences —San Carlos, CA
- $130,000 - $160,000 a year
- Full-time
- Management
- 5 years
- Master's degree
- Commuter assistance
- Health insurance
Quick Apply
1d
Senior Principal Statistician
Jazz Pharmaceuticals —Palo Alto, CA
- $156,000 - $234,000 a year
- Remote
- Analysis skills
- Doctor of Philosophy
- Senior level
- Health insurance
- Dental insurance
Lead, Senior, or Principal Biologist
SWCA Environmental Consultants —Half Moon Bay, CA
- $97,344 - $166,133 a year
- Online Application
- Master's degree
- 8 years
- Supervising experience
- Employee stock ownership plan
- Opportunities for advancement
Principal Scientist, Immunology
Jade Biosciences —San Francisco, CA
- $175,000 - $190,000 a year
- Remote
- 8 years
- Doctor of Philosophy
- Travel
Quick Apply
Principal Scientist
Genentech —San Francisco, CA
- $143,200 - $265,900 a year
- Online Application
- Software troubleshooting
- 3 years
- Doctor of Philosophy
11d
Principal Scientist, Lab Head, Synthetic Immunity
Genentech —San Francisco, CA
- $143,200 - $265,900 a year
- Online Application
- Management
- Doctor of Philosophy
- Senior level
14d
Principal Applied Scientist, Music Catalog and Search, Amazon Music Search and Catalog
Amazon.com Services LLC —San Francisco, CA
- $228,700 - $309,400 a year
- Full-time
- Master's degree
- Doctor of Philosophy
- Mentoring
- AD&D insurance
- Health insurance
Principal Research Scientist - Frontier Industrial AI
Aveva —San Leandro, CA
- $213,500 - $355,500 a year
- Full-time
- Hybrid work
- Background check
- Computer science
- Computer Science
- Health insurance
- Dental insurance
4d
Principal Research Data Scientist
HealthLeap —San Francisco, CA
- $170,000 - $215,000 a year
- Full-time
- Hybrid work
- Presentation skills
- Doctor of Philosophy
- Senior level
- Paid time off
- 401(k) 4% Match
Principal Scientist, Clinical Research - Immunology/Dermatology
Merck —San Francisco, CA
- $255,800 - $402,700 a year
- Full-time
- Medicine
- Management
- 5 years
- Paid holidays
- Health insurance
Principal Scientist, Antibody Engineering & Rational Design
CALICO —South San Francisco, CA
- $198,000 - $241,000 a year
- 8 years
- Doctor of Philosophy
- Senior level
Principal Scientist (Cell Line Development)
Exelixis, Inc. —Alameda, CA
- $150,000 - $213,000 a year
- Email
- 5 years
- Master's degree
- Bachelor's degree
- Paid holidays
- Disability insurance
Principal Scientist - Medicinal Chemistry
Amgen —South San Francisco, CA
- $165,307.15 - $223,650.85 a year
- Hybrid work
- Management
- Doctoral degree
- Master's degree
- Disability insurance
- Health insurance
Principal Scientist, Inflammation
Amgen —South San Francisco, CA
- $153,524.45 - $207,709.55 a year
- Bachelor's degree
- Doctor of Philosophy
- In-person
- Disability insurance
- Health insurance
Principal Scientist, Process Chemistry
CALICO —South San Francisco, CA
- $197,000 - $245,000 a year
- 8 years
- Continuous improvement
- Doctor of Philosophy
Principal Scientist I, Biologics Analytical Research and Development
AbbVie —San Francisco, CA
- $124,500 - $236,500 a year
- Full-time
- Management
- Bachelor of Science
- 11+ years
- Paid holidays
- Health insurance
Senior Staff/Principal Scientist, Organic Chemistry & Biochemistry
Lunar Biosciences —Pleasanton, CA
- $175,000 - $200,000 a year
- Full-time
- Management
- Doctor of Philosophy
- Senior level
- Disability insurance
- Health insurance
Quick Apply
Principal Scientist, Synthetic Molecule Process Chemistry, Genentech Research
Genentech —San Francisco, CA
- $144,900 - $269,100 a year
- Online Application
- Doctor of Philosophy
- Manufacturing
- Senior level
Principal Statistical Methodology Data Scientist
Genentech —San Francisco, CA
- $185,200 - $343,900 a year
- Online Application
- 6 years
- Computer Science
- Analysis skills
4d
Principal Scientist, Lab Head, Immunology, Cell Therapy
Genentech —San Francisco, CA
- $143,200 - $265,900 a year
- Online Application
- Management
- 5 years
- Business development
13d

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Senior Scientist/Principal Scientist, Translational Immunotherapy

Sift Biosciences
San Carlos, CA

Quick Apply

Job Details

Full-time
$130,000 - $160,000 a year
1 day ago

Benefits

Commuter assistance
Health insurance
Dental insurance
401(k)
Paid time off
Parental leave
Vision insurance
Flexible schedule

Qualifications

Biology
Biotechnology
Technical documentation
Formulation chemistry
Cell Biology
Master's degree
Doctor of Philosophy
Pharmaceutical company experience
In vivo studies
Pharmaceutical research experience

Full Job Description

Senior Scientist/Principal Scientist, Translational Immunotherapy

Sift Bio is building a cutting-edge proprietary platform that combines AI, metagenomics, and high-throughput T-cell screening to discover epitopes that drastically amplify pre-existing immune memory responses, unlocking targeted, effective, and safe treatment for cancers and autoimmune diseases where current therapies fall short. Spinning out of UC Berkeley, the Sift Bio team brings together AI-driven discovery and deep translational immunology, with a proven track record of advancing novel immunotherapies from early concept through IND-enabling development. Collectively, the team has built and scaled high-throughput discovery platforms and led T-cell, peptide, and cell-based immunotherapy programs across leading academic labs, biotech startups, and biopharma. Merging this experience with proprietary datasets and computational pipelines, Sift Bio is shaping a new frontier in immunotherapy, unlocking the power of pre-existing immunity to create a fundamentally new class of treatments for immune dysfunctions. Our ultimate goal is to bring durable disease control to every patient.

We are seeking a Senior Scientist/Principal Scientist to work on our lead oncology program, leading the path from hit-to-lead generation to DC nomination for an off-the-shelf, memory-recall-based immunotherapy: designing, executing, and interpreting primary-cell assays that establish mechanism, potency, and safety. This role will report to the CTO and be fully onsite at 733 Industrial Road, San Carlos, CA.

KEY RESPONSIBILITIES:

Drive the identification, engineering, and functional optimization of lead immunotherapeutic candidates from early discovery through to DC nomination.
Design and execute cell-based assays (e.g., multi-parameter flow cytometry, cytotoxicity, cytokine profiling) to evaluate memory-recall, T-cell activation, and target engagement.
Characterize primary human T-cells and PBMCs (e.g. phenotyping) both prior and following response to stimulation.
Navigate challenges in working with, and characterizing, polyclonal T-cell responses, and is aware of how these challenges differ from monoclonal T-cell products.
Develop and support assays to forecast off-target events that leverage cross-reactivity as a method for overcoming antigen tolerance.
Benchwork to include profiling antigen-specific T-cells using IFN-γ ELISpot, and activation-induced marker (AIM) assays, and intracellular cytokine staining, with matrix/pool deconvolution design.
Develop assays to forecast off-target events in a system that leverages cross-reactivity as a method for overcoming antigen tolerance.
Oversee tetramer/dextramer and multimer staining, including executing high-avidity, peptide-MHC (pMHC) assays and employing DNA-barcoded multimers.
Running standard cytotoxicity readouts (e.g. IncuCyte).
Interpreting immunopeptidomics (LC-MS/MS HLA-ligand) data generated by collaborators/CROs and translate it into epitope-processing and presentation decisions.
Investigate the biological mechanisms (MoA) underlying the therapy’s ability to drive vigorous, durable anti-tumor memory.
Oversee in vivo and ex vivo studies to define the therapeutic's efficacy, pharmacodynamics (PD), and pharmacokinetics (PK).
Partner with the R&D team to de-risk assets prior to IND-enabling studies.
Manage direct reports/vendor/collaborators, present data to cross-functional teams, and author technical reports and regulatory documents to support governance reviews.
Interpret, analyze, present, and properly record data.
Prepare documents and presentations that encompass project progression.

REQUIRED EXPERIENCE:

PhD in Immunology, Cell Biology, or a related field, plus 5+ years of post-doctoral or industry experience. Alternatively, a Master’s degree with 8 to 10+ years of biotech experience. Job title will commensurate with experience.
Excited by and scientifically driven to overcome complex technical challenges that will contribute to safe treatment for cancers and autoimmune diseases.
Strong T-cell biology expertise, with extensive experience characterizing low frequency (<0.1%) CD8 and CD4 responses, and knowledge of how to improve readouts of rare T-cell responses.
Working knowledge of HLA biology, supertypes, population coverage logic, and HLA-matched experimental systems.
Immunotherapy drug development experience is a must.
Prior cancer-vaccine or general vaccine development experience, including peptide, protein-subunit, or nucleic-acid modalities, spanning antigen selection through in vivo immunogenicity.
Familiarity with adjuvants (TLR agonists, saponins, poly-ICLC) and how formulation shapes the T-cell response.
Experience with HLA-transgenic mouse models and/or human PBMC xenograft/humanized models, and familiarity with readouts both in flight and downstream of animal studies.
Proven ability to contribute to the scientific direction of a project.
Strong written and oral communication skills for technical and non-technical audiences.
Conscientious team member with experience taking and giving constructive feedback.
Must be comfortable with executing lab work full time in a preclinical-stage startup environment, and capable of finding solutions to tough problems with limited resources.

Sift Bio is pleased to offer competitive:

Medical, Dental, and Vision health plans.
Flexible time off.
Bonus and Equity plans.
Commuter transit benefit.
401(k) retirement plan.

Sift Bio is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind as outlined by applicable laws.

Pay: $130,000.00 - $160,000.00 per year

Benefits:

401(k)
Flexible schedule
Health insurance
Paid time off
Parental leave
Vision insurance

Application Question(s):

Please tell us about your experience with cancer-vaccine or general vaccine development experience, including peptide, protein-subunit, or nucleic-acid modalities, spanning antigen selection through in vivo immunogenicity.

Experience:

T cell biology : 5 years (Required)

Location:

San Carlos, CA 94070 (Preferred)

Work Location: In person

Quick Apply

Refine Your Search

principal scientist jobs in san leandro, ca

Senior Scientist/Principal Scientist, Translational Immunotherapy

Senior Principal Statistician

Lead, Senior, or Principal Biologist

Principal Scientist, Immunology

Principal Scientist

Principal Scientist, Lab Head, Synthetic Immunity

Principal Applied Scientist, Music Catalog and Search, Amazon Music Search and Catalog

Principal Research Scientist - Frontier Industrial AI

Principal Research Data Scientist

Principal Scientist, Clinical Research - Immunology/Dermatology

Principal Scientist, Antibody Engineering & Rational Design

Principal Scientist (Cell Line Development)

Principal Scientist - Medicinal Chemistry

Principal Scientist, Inflammation

Principal Scientist, Process Chemistry

Principal Scientist I, Biologics Analytical Research and Development

Senior Staff/Principal Scientist, Organic Chemistry & Biochemistry

Principal Scientist, Synthetic Molecule Process Chemistry, Genentech Research

Principal Statistical Methodology Data Scientist

Principal Scientist, Lab Head, Immunology, Cell Therapy

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