Top 28 Principal mechanical engineer Jobs in Santa Clara, Ca

Principal Mechanical Engineer -29378_G
BEPC Inc —Santa Clara, CA
- $78.24 - $81.24 an hour
- Full-time
- 3 years
- Master's degree
- Supervising experience
- Health insurance
- Dental insurance
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Principal Mechanical Engineer
Commonwealth Fusion Systems —Milpitas, CA
- $150,000 - $225,000 a year
- Weekends as needed
- 11+ years
- Master's degree
- Assembly
- Dental insurance
- Parental leave
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Principal Mechanical Engineer
PDF Solutions —Milpitas, CA
- $150,000 - $235,000 a year
- Full-time
- Master's degree
- Analysis skills
- Continuous improvement
Senior/Principal Facilities Mechanical Engineer, CA Onsite
Sandia National Laboratories —Livermore, CA
- $121,900 - $237,800 a year
- Full-time
- Pass drug screening
- Master's degree
- 8 years
- Relocation assistance
- Health insurance
1d
Senior Principal Mechanical Engineer
Hewlett Packard Enterprise —Sunnyvale, CA
- $153,500 - $310,500 a year
- Full-time
- Customer service
- Bachelor of Science
- Laboratory experience
Principal Mechanical Engineer - Optical Solutions
Molex —Fremont, CA
- $180,000 - $260,000 a year
- Pass drug screening
- Master's degree
- Analysis skills
- Paid parental leave
- Health savings account
Principal Thermal Mechanical Engineer
Cadence Design Systems —San Jose, CA
- $136,500 - $253,500 a year
- Full-time
- Bachelor of Science
- Office
- Analysis skills
- Employee stock purchase plan
- Paid holidays
Principal, Platform Thermal Engineer Lead
Advanced Micro Devices, Inc —Santa Clara, CA
- Hybrid work
- Master's degree
- Analysis skills
- Senior level
Principal Mechanical Engineer
Onto Innovation —Milpitas, CA
- $144,000 - $216,000 a year
- Full-time
- 7 years
- Travel
- Mentoring
- Employee stock purchase plan
- Disability insurance
Principal Motor Engineer
Matic —Menlo Park, CA
- $160,000 - $240,000 a year
- Full-time
- CAD
- 5 years
- Continuous improvement
- Health insurance
- Dental insurance
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Assoc. Principal (Mechanical)
AlfaTech —San Jose, CA
- $135,000 - $175,000 a year
- Full-time
- Hybrid work
- Customer service
- Office
- 8 years
Quick Apply
Principal Mechanical Engineer Metals and Materials
Intuitive Surgical —Sunnyvale, CA
- $187,000 - $330,000 a year
- Day shift
- 11+ years
- Analysis skills
- Continuous improvement
Sr Principal Engineer, Enclosures Design
Bloom Energy —San Jose, CA
- $196,000 - $282,000 a year
- Full-time
- 11+ years
- Office
- Senior level
Principal Mechanical Engineer
Muon Space —San Jose, CA
- $222,000 - $250,000 a year
- Full-time
- Hybrid work
- Bachelor of Science
- 11+ years
- Office
- Paid parental leave
- Paid holidays
Principal Launch Engineer
Molex —Fremont, CA
- $150,000 - $300,000 a year
- Up to 50% travel
- Engineering
- Pass drug screening
- Paid parental leave
- Health savings account
Principal Mechanical Engineer (Robotics / Mechatronics for Fab Solutions)
Brooks Automation —Fremont, CA
- $138,764.29 - $187,739.92 a year
- Full-time
- 3 years
- Agile
- Senior level
- Paid holidays
- Disability insurance
Principal Opto-Mechanical Engineer
ASML —San Jose, CA
- $177,000 - $265,500 a year
- Doctor of Philosophy
- Travel
- Manufacturing
- Paid holidays
- Dental insurance
Principal Optomechanical Design Engineer
Neurophos —San Mateo, CA
- $245,000 - $290,000 a year
- Full-time
- Analysis skills
- Doctor of Philosophy
- In-person
- Health savings account
- Health insurance
Quick Apply
Principal Engineer - CFD/Thermal
Bloom Energy —San Jose, CA
- $176,300 - $253,700 a year
- Full-time
- 8 years
- Doctor of Philosophy
- Senior level
Principal Mechanical Engineer- Video Collaboration
Logitech —San Jose, CA
- $160,000 - $210,000 a year
- Online Application
- Hybrid work
- System design
- Master's degree
- 8 years
- Work from home

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principal mechanical engineer jobs near santa clara, ca

Principal Mechanical Engineer -29378_G

BEPC Inc -
Santa Clara, CA

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Job Details

Full-time | Contract
$78.24 - $81.24 an hour

Benefits

Health insurance
Dental insurance
Vision insurance
Life insurance

Qualifications

Rapid prototyping
Mechanical valves
Thermal analysis
Instrumentation troubleshooting
Teamwork
3D modeling software
Electro-mechanical components
Thermal control
Equipment troubleshooting
CNC tooling
Master's degree
3D modeling for product design
System design for system development
Mechanical drawings
Bachelor's degree
Design engineering
Prototype creation
Blueprint creation using CAD software
Organizational skills
Pneumatic systems
Technical troubleshooting support
Manufacturing engineering
Control systems
Design of individual components
Project leadership
Instrumentation design
Prototypes
Sensors
Python
CNC

Full Job Description

BEPC has an open position for a Principal Mechanical Engineer

Location: Santa Clara, CA

Benefits: Medical, Dental, Vision, and Life Insurance

Pay Rate: $78.24 - $81.24 Per hour based on experience (Paid Weekly)

Term: 6-month contract with possible extensions

Shift: Monday – Friday, 8:00 AM – 5:00 PM

Requirements: BA required, Masters Degree Preferred / Deep hands-on expertise in complex mechanical, electro-mechanical, and pneumatic system design, ideally for life science or diagnostic instrumentation.

*****NO CORP-TO-CORP CANDIDATES WILL BE CONSIDERED*****

About the Program:

A leading biotechnology organization is seeking a Principal Mechanical Engineer tolead the mechanical design, development, characterization, and integration of cutting-edge sequencing systems. The organization is focused on making next-generation sequencing simple and accessible for routine use. By accelerating clinical research, streamlining workflows, and expanding assay capabilities, the team is broadening access to genomic data and lowering barriers to adoption.

From robust sample isolation and preparation tools to novel sequencing technology and advanced bioinformatics, the team is developing highly integrated end-to-end sequencing solutions that enable a “sample-in, result-out” workflow. This role sits within the Systems Technology Group, which focuses on creating and advancing technologies that significantly enhance DNA sequencing workflows. The Principal Mechanical Engineer will be a hands-on technical leader responsible for solving core mechanical challenges in next-generation sequencing platforms. You will concept, design, build, and test novel electro-mechanical, pneumatic, thermal, and fluidic solutions that ensure high performance, reliability, and longevity of complex instrumentation systems. This role requires someone who demonstrates strong motivation, independence, and resourcefulness in solving novel automation and sequencing challenges within a fast-paced, collaborative environment.

Key Responsibilities:

Lead end-to-end mechanical design and development of mechanical subsystems including electro-mechanical, pneumatic, fluidic, and thermal components.
Collaborate with cross-functional engineering teams (electrical, consumables, materials) to define and manage critical technical interfaces.
Develop mechanisms for automated reagent and flow cell loading, clamping, and sealing, ensuring reliability over repeated use.
Architect and design thermal control systems, including heating/cooling elements, sensors, condensation control, and heat management.
Partner with internal and external simulation experts to guide and validate CFD, thermal, and optical models, refining designs using empirical data.
Serve as the technical expert for assigned subsystems during integration, verification, and troubleshooting with systems integration teams.
Lead cross-functional design reviews, driving alignment and resolving technical trade-offs across engineering disciplines.
Drive technical execution and timelines for subsystem deliverables and contribute to overall project planning.
Create and maintain design documentation, including CAD models, drawings, and engineering specifications.
Provide data-driven recommendations to support architecture and technology decisions for future system development.
Present technical progress, analysis, and engineering trade-offs to project teams and stakeholders.

Required Qualifications:

PhD in Mechanical Engineering, Bioengineering, or related field with 3+ years of industry experience, OR
Master’s degree with 4+ years of relevant industry experience, OR
Bachelor’s degree with 7+ years of relevant industry experience
Deep hands-on expertise in complex mechanical, electro-mechanical, and pneumatic system design, ideally for life science or diagnostic instrumentation.
Strong experience with thermal management and precision temperature control systems.
Experience developing fluidic systems including pumps, valves, tubing, sensors, and materials selection.
Strong proficiency in 3D CAD software (e.g., SolidWorks) for detailed design and manufacturing drawings.
Experience designing components for multiple manufacturing processes including machining, injection molding, and additive manufacturing.
Strong troubleshooting skills across hardware, software, and chemistry interfaces.
Hands-on experience with machine shop tools, measurement equipment, and rapid prototyping technologies such as 3D printers, laser cutters, and CNC machines.
Proficiency with Python, LabVIEW, or similar tools for device control and data acquisition.

Preferred Qualifications:

Experience leading technical projects and mentoring engineers.
Experience using simulation tools (CFD, FEA) to guide design decisions.
Experience working with next-generation sequencing (NGS) or genomics instrumentation.
Experience working in a regulated product development environment.
Strong communication skills with the ability to explain technical concepts clearly to diverse audiences.
Excellent organizational skills with the ability to manage multiple priorities and projects effectively.

Application Requirement:

A cover letter is required as part of the application. Candidates should outline their relevant experience and explain their interest in the role.

USOPS

Pay: $78.24 - $81.24 per hour

Expected hours: 40.0 per week

Benefits:

Dental insurance
Health insurance
Life insurance
Vision insurance

Education:

Bachelor's (Required)

Experience:

Mechanical engineering: 5 years (Required)
Pneumatic System Design : 5 years (Required)
3D CAD: 5 years (Required)
CNC: 5 years (Required)

Ability to Commute:

Santa Clara, CA 95050 (Required)

Work Location: In person

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Refine Your Search

principal mechanical engineer jobs in santa clara, ca

Principal Mechanical Engineer -29378_G

Principal Mechanical Engineer

Principal Mechanical Engineer

Senior/Principal Facilities Mechanical Engineer, CA Onsite

Senior Principal Mechanical Engineer

Principal Mechanical Engineer - Optical Solutions

Principal Thermal Mechanical Engineer

Principal, Platform Thermal Engineer Lead

Principal Mechanical Engineer

Principal Motor Engineer

Assoc. Principal (Mechanical)

Principal Mechanical Engineer Metals and Materials

Sr Principal Engineer, Enclosures Design

Principal Mechanical Engineer

Principal Launch Engineer

Principal Mechanical Engineer (Robotics / Mechatronics for Fab Solutions)

Principal Opto-Mechanical Engineer

Principal Optomechanical Design Engineer

Principal Engineer - CFD/Thermal

Principal Mechanical Engineer- Video Collaboration

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