Top 70 Principal scientist Jobs in Santa Clara Ca

Principal Scientist I, Molecular Lab Research and Early Development
Roche —Pleasanton, CA
- $111,000 - $206,500 a year
- Online Application
- 5 years
- Doctor of Philosophy
- Mentoring
Principal Scientist (Antibody Engineering)
Grifols —San Carlos, CA
- $165,000 - $205,000 a year
- Full-time
- 8 years
- Bachelor's degree
- Doctor of Philosophy
- Paid holidays
- Health insurance
12d
Principal Applied Scientist, Music Catalog and Search, Amazon Music Search and Catalog
Amazon.com Services LLC —Sunnyvale, CA
- $228,700 - $309,400 a year
- Full-time
- Master's degree
- Doctor of Philosophy
- Mentoring
- AD&D insurance
- Health insurance
Principal Scientist, IVD Reagent Development and Manufacturing
Delfi Diagnostics —Palo Alto, CA
- $180,000 - $230,000 a year
- Full-time
- Management
- Writing skills
- Master's degree
- Health insurance
- Dental insurance
Principal Bioinformatics Scientist I
Roche —Pleasanton, CA
- $121,400 - $225,400 a year
- Online Application
- Master's degree
- Bachelor's degree
- Doctor of Philosophy
4d
Principal Scientist I
MEADOWHAWK BIOLABS INC —Hayward, CA
- $123,000 - $163,000 a year
- 6 years
- Doctoral degree
- Bachelor of Science
Principal Scientist, Analytical Operations
Gilead Sciences —Foster City, CA
- $195,670 - $253,220 a year
- Full-time
- 5 years
- Bachelor of Science
- Bachelor's degree
- Health insurance
- Dental insurance
Principal Machine Learning Scientist - Trajectory Generation
General Motors —Mountain View, CA
- $269,400 - $412,600 a year
- Email
- Computer Science
- Master's degree
- Bachelor's degree
- Health savings account
- Paid holidays
Principal Scientist
Exponent Inc. —Menlo Park, CA
- $225,000 - $275,000 a year
- Email
- Office
- Analysis skills
- Doctor of Philosophy
- 401(k)
Principal AI Scientist - AI Foundation
Intuit —Mountain View, CA
- $273,500 - $369,500 a year
- Computer Science
- Bachelor of Science
- Research
Principal Applied Scientist
Adobe —San Jose, CA
- $206,300 - $388,000 a year
- Full-time
- Computer science
- Computer Science
- System design
Senior/Principal Scientist IHC
Oxford BioTherapeutics —San Jose, CA
- $145,000 - $185,000 a year
- Full-time
- 3 years
- Master's degree
- Analysis skills
- AD&D insurance
- Disability insurance
Quick Apply
Principal Applied Scientist, ML Codesign
Amazon.com Services LLC —Sunnyvale, CA
- $228,700 - $309,400 a year
- Full-time
- Computer science
- Computer Science
- Master's degree
- AD&D insurance
- Health insurance
Principal Applied Scientist, Agentic Automated Reasoning Group
Amazon Development Center U.S., Inc. —Santa Clara, CA
- $198,900 - $269,000 a year
- Full-time
- Computer Science
- Java
- Analysis skills
- AD&D insurance
- Health insurance
Sr. Principal Scientist, Stores Economics and Science
Amazon.com LLC —Palo Alto, CA
- $240,100 - $350,000 a year
- Full-time
- Computer Science
- Analysis skills
- Doctor of Philosophy
- AD&D insurance
- Health insurance
14d
Senior Staff/Principal Scientist, Organic Chemistry & Biochemistry
Lunar Biosciences —Pleasanton, CA
- $175,000 - $200,000 a year
- Full-time
- Management
- Doctor of Philosophy
- Senior level
- Disability insurance
- Health insurance
Quick Apply
Principal Applied Scientist, Amazon Ads Management
Amazon.com Services LLC —Palo Alto, CA
- $218,800 - $309,400 a year
- Full-time
- Computer Science
- 8 years
- Doctor of Philosophy
- AD&D insurance
- Health insurance
Principal Scientist, Analytical Lifecycle Management
Gilead Sciences —Foster City, CA
- $195,670 - $253,220 a year
- Full-time
- 5 years
- Master's degree
- Bachelor's degree
- Health insurance
- Dental insurance
MD/DO Consultant - Principal Investigator - Fremont, CA
Hawthorne Health —Fremont, CA
- $250 an hour
- Contract
- Hybrid work
- Medicine
- BC/BE
- English
- Flextime
Quick Apply
Associate Director/Principal, Machine Learning Scientist
BigHat Biosciences —San Mateo, CA
- $254,000 - $290,000 a year
- Full-time
- Hybrid work
- Computer Science
- 5 years
- AWS
- Paid parental leave
- Paid holidays
Quick Apply

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Principal Scientist I, Molecular Lab Research and Early Development

Roche -
Pleasanton, CA

Apply Now

Job Details

$111,000 - $206,500 a year

Qualifications

Laboratory experiment design
DNA analysis
Assay development
Molecular diagnostic testing
Doctor of Philosophy
Experimental design
Research data analysis
Bioinformatics data analysis
Cross-functional communication
Molecular analysis

Full Job Description

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

At Roche, we are passionate about transforming patients' lives and are bold in both decision and action. We believe that good business means a better world. This is why we come to work each day, committed to scientific rigor, unassailable ethics, and ensuring access to medical innovations for all. We do this today to build a better tomorrow.

We are seeking aPrincipal Scientist I to join our Molecular Lab, Research and Early Development Team, Oncology and Genetics. Within the Roche Diagnostics organization, our Research and Early Development teams are committed to making a tangible impact on the future of healthcare. ThePrincipal Scientist Ibrings technical depth and breadth, curiosity, and the creativity to be an important contributor in developing novel molecular diagnostic assays. The goal will be to build sequencing assays on our revolutionary Axelios Sequencing platform and translating the immense potential of our Sequencing by Expansion (SBX) technology into real-world assays that can benefit patients. This is a hands-on, lab-based role where scientific excellence and a proactive, results-oriented mindset are paramount. You will spearhead innovative projects and key collaborations, driving the science from the initial idea to a fully realized solution.

This is an opportunity for a visionary scientist to not only pioneer new workflows but to help shape the next generation of medical innovation.

The Opportunity

You will join a diverse local team of dedicated and curious scientists where you will role-model leadership qualities, mentor junior scientists, and champion a culture of scientific rigor and innovation.
You will prototype and optimize different sequencing assay workflows by aligning pharma project needs, designing and implementing rigorous experiments, and applying established and innovative procedures to enable end-to-end solutions; You will proactively highlight issues, troubleshoot assays, and resolve technical challenges by applying broad knowledge of molecular biology techniques and accumulated experience
You will work closely with the commercial team, external pharma partners, and internal bioinformatics colleagues to implement and analyze novel workflows to further pharma collaborations. You'll translate complex data into meaningful interpretations for internal and external stakeholders.
You will support the adoption of Axelios sequencing technology and the growth of the pharma service business by executing pilot collaboration projects, creating technical documentations including standard operating protocols, and supporting assay transfer to the CLIA laboratory.
You will identify and champion new technological opportunities, contributing to the strategic direction of the R organization.

This position is based on-site (4+ days) in Pleasanton, CA.
There is no relocation support.

Who You Are:
(Required)

You have a PhD in Bioengineering, Molecular Biology, Genetics, Biochemistry, (or a related field) with 5+ years of relevant industry experience
You have a deep understanding of molecular biology in NGS workflows beyond routine preparation of sequencing libraries.
You have demonstrated experience designing and optimizing novel NGS workflows.
You have demonstrated the ability to critically examine assay workflows and troubleshoot unknown and unfamiliar issues.
You have experience with diagnostic assay development, including a high level understanding of the regulatory framework for RUO, LDT, or IVD assays
You have demonstrated proficiency in interpreting standard bioinformatics pipeline outputs and sequencing metrics for genomic analysis.
You have excellent interpersonal and communication skills, with a proven ability to identify areas of misalignment and collaborate effectively within and across teams.
You have excellent organizational skills, including the ability to efficiently evaluate, prioritize and handle multiple changing projects and priorities; you complete work in a timely, accurate and thorough manner

Preferred:

You have experience beyond standard library preparation from DNA or RNA, such as single-cell sequencing, protein detection by sequencing, or spatial sequencing.
You have experience working with different NGS instruments (e.g. Element, Ultima, Pacbio, Oxford)
You have experience with automating sequencing workflow on systems like the Hamilton or Tecan
You have a strong record of innovation, demonstrated by publications and patents.
You are proficient in technical writing

The expected salary range for this position is based on the primary location of Pleasanton, CA is $111,000 - $206,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

This position also qualifies for the benefits detailed at the link provided below.
Benefits

#NMK62026DIA

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this formAccommodations for Applicants.

Apply Now

Refine Your Search

principal scientist jobs in santa clara ca

Principal Scientist I, Molecular Lab Research and Early Development

Principal Scientist (Antibody Engineering)

Principal Applied Scientist, Music Catalog and Search, Amazon Music Search and Catalog

Principal Scientist, IVD Reagent Development and Manufacturing

Principal Bioinformatics Scientist I

Principal Scientist I

Principal Scientist, Analytical Operations

Principal Machine Learning Scientist - Trajectory Generation

Principal Scientist

Principal AI Scientist - AI Foundation

Principal Applied Scientist

Senior/Principal Scientist IHC

Principal Applied Scientist, ML Codesign

Principal Applied Scientist, Agentic Automated Reasoning Group

Sr. Principal Scientist, Stores Economics and Science

Senior Staff/Principal Scientist, Organic Chemistry & Biochemistry

Principal Applied Scientist, Amazon Ads Management

Principal Scientist, Analytical Lifecycle Management

MD/DO Consultant - Principal Investigator - Fremont, CA

Associate Director/Principal, Machine Learning Scientist

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