Top 11 Scientist/senior scientist, protein engineering Jobs in Seattle, Wa

Scientist/Senior Scientist, Protein Engineering
SystImmune —Redmond, WA
- $90,000 - $130,000 a year
- Full-time
- Doctor of Philosophy
- Ability to sit for extended periods
- Senior level
- Paid holidays
- Disability insurance
Scientist I Biopreservation
Biolife Solutions, Inc. —Bothell, WA
- $109,593 - $158,910 a year
- Full-time
- Background check
- Bachelor of Science
- Pass drug screening
- Disability insurance
- Health insurance
Scientist, Immuno-Oncology
SystImmune —Redmond, WA
- $90,000 - $110,000 a year
- Full-time
- Analysis skills
- Doctor of Philosophy
- Data entry
- Paid holidays
- Disability insurance
Technical Advisor & Chief of Staff to the VP of Applied Science, Alexa AI , Alexa AI
Amazon.com Services LLC —Bellevue, WA
- $179,900 - $243,400 a year
- Full-time
- Bachelor's degree
- Machine learning
- Product management
- AD&D insurance
- Health insurance
Research Scientist/Engr 1
University of Washington —Seattle, WA
- $56,448 - $58,008 a year
- Full-time
- University
- Bachelor's degree
- Computer skills
Director, Protein Engineering
SystImmune —Redmond, WA
- $180,000 - $240,000 a year
- Full-time
- Presentation skills
- Doctor of Philosophy
- Mentoring
- Paid holidays
- Disability insurance
Scientist/Senior Scientist, Companion Diagnostics (CDx) – IHC Development
SystImmune —Redmond, WA
- $90,000 - $140,000 a year
- Full-time
- Bachelor of Science
- Mid-level
- Bachelor's degree
- Paid holidays
- Disability insurance
Associate Director, Bioreactor Process Design
Evotec —Redmond, WA
- $154,000 - $180,000 a year
- Full-time
- Bachelor of Science
- Engineering
- Supervising experience
- Commuter assistance
- Paid holidays
Research Scientist/Engineer 3 - Department of Medicine, Division of Hematology & Oncology
University of Washington —Seattle, WA
- $88,800 - $103,200 a year
- Weekends as needed
- Office
- Analysis skills
- University
Scientist – Electrochemical Enzyme Assay Development and Testing
Arzeda —Seattle, WA
- $101,000 - $140,000 a year
- Full-time
- Master's degree
- Presentation skills
- Doctor of Philosophy
- Commuter assistance
- Health savings account
Quick Apply
Senior Geologist/Senior Environmental Scientist/Professional Engineer
HYDRO-ENVIRONMENTAL TECHNOLOGIES INC —Seattle, WA
- $75,000 - $110,000 a year
- Full-time
- Hybrid work
- Analysis skills
- Senior level
- Professional Engineer
- Profit sharing
- Health insurance
Quick Apply

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Scientist I Biopreservation
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scientist/senior scientist, protein engineering jobs near seattle, wa

Scientist/Senior Scientist, Protein Engineering

SystImmune -
Redmond, WA

Apply Now

Job Details

Full-time
$90,000 - $130,000 a year

Benefits

Paid holidays
Disability insurance
Health insurance
Dental insurance
Paid time off
Vision insurance
401(k) matching

Qualifications

Immunological assays
Immunological laboratory techniques
Flow cytometers
Biochemical laboratory techniques
Doctor of Philosophy
Technical troubleshooting support
Cytometry
Cross-functional communication
Data analysis software

Full Job Description

Redmond, WA

Full Time

Protein Engineering

Experienced

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

We are seeking an innovative Scientist or Senior Scientist with industry experience in protein biochemistry, cell biology, and biologics drug development. In this laboratory-based role, you will be responsible for designing novel reagents, cell lines, and assays in support of functional screening of biologics leads. Furthermore, you will be executing display-based campaigns while interfacing with other members of the research team to achieve protein design goals. The position reports to the Director of Protein Engineering. The ideal candidate will have broad experience in one or more of the following fields: protein biochemistry, molecular biology, cell biology, immunology, and assay development.

This position is full-time onsite in Redmond, WA and will transition to our new Bothell, WA facility in fall 2026.

Key Responsibilities:

Design and generate novel cell-based and biochemical assays as well as associated cell lines for use in functional screening of lead biologics (e.g. reporter assays for specific target signaling).
Develop and implement high throughput cell-free expression of antigens and Ab-based binder molecules for fast screening of lead molecules
Design and execute on display-based protein engineering campaigns of binder and effector molecules including affinity modulation, stability optimization, and development of novel properties (e.g. pH, epitope masking, etc.).
Optimize methods to efficiently execute functional screening and protein engineering campaigns (e.g. library generation and sample preparation, NGS sequencing, flow cytometry-based lead selection, etc.).
Design novel platforms for faster evaluation and screening of immune-based repertoires from immunized animal sources or display methods for use in both discovery and protein engineering campaigns.
Utilize data analysis tools to evaluate large datasets to inform iterative protein design.
Stay updated on advancements in instrumentation, software, and methodologies, currently utilized in high throughput screening and display-based protein engineering.
Troubleshoot technical issues and implement solutions to optimize lead molecules, ensuring data quality and integrity throughout the discovery and optimization process. Utilize LIMS system and maintain accurate and timely records and meet internal reporting standards.
Write and review Standard Operating Procedures (SOP), perform general laboratory duties, prepare experiment designs and execute data analyses.

Required Qualifications:

PhD in bioengineering, biochemistry, structural biology, molecular biology, cell biology, or a related field. 3+ year industrial drug development experience preferred.
2+ years of experience using generating novel cell lines and/or assay development
Experience in utilizing display technologies (yeast/phage) to discover and engineer novel binders and lead molecules of different classes (e.g. Ab, Fab, scFv, VHHs, etc.)
Extensive experience in FACS-based selection and sorting
Demonstrated proficiency in one or more of the following workstreams: library design and generation, display-based selection, protein engineering, and assay development
Experience with data analysis software (e.g., GraphPad Prism, FlowJo,) and statistical analysis of experimental results.
Excellent problem-solving skills, with the ability to troubleshoot technical issues and implement effective solutions
Outstanding organizational skills, attention to detail, and the ability to manage multiple projects simultaneously in a fast-paced environment
Strong communication and interpersonal skills, with the ability to collaborate effectively within multidisciplinary teams
On-site work is mandatory.

Work Environment:

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

This individual will work in cell culture laboratory alongside other scientists and in a standard business office with desktop business equipment and a moderate noise level.

Physical Demands:

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

While performing the duties of this job, the employee is regularly required to sit for long periods of time. This individual must be able to operate standard laboratory and business equipment.

Compensation and Benefits:
The expected base salary range for this position is $90,000 - $130,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills.
While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.

Apply Now

Refine Your Search

scientist/senior scientist, protein engineering jobs in seattle, wa

Scientist/Senior Scientist, Protein Engineering

Scientist I Biopreservation

Scientist, Immuno-Oncology

Technical Advisor & Chief of Staff to the VP of Applied Science, Alexa AI , Alexa AI

Research Scientist/Engr 1

Director, Protein Engineering

Scientist/Senior Scientist, Companion Diagnostics (CDx) – IHC Development

Associate Director, Bioreactor Process Design

Research Scientist/Engineer 3 - Department of Medicine, Division of Hematology & Oncology

Scientist – Electrochemical Enzyme Assay Development and Testing

Senior Geologist/Senior Environmental Scientist/Professional Engineer

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