Top 67 Principal scientist Jobs in Silicon Valley Ca

Senior Principal Statistician
Jazz Pharmaceuticals —Palo Alto, CA
- $156,000 - $234,000 a year
- Remote
- Analysis skills
- Doctor of Philosophy
- Senior level
- Health insurance
- Dental insurance
Principal Scientist
Grifols —San Carlos, CA
- $165,000 - $205,000 a year
- Full-time
- 8 years
- Bachelor's degree
- Doctor of Philosophy
- Paid holidays
- Health insurance
17h
Principal Performance Modeling Engineer
Advanced Micro Devices, Inc —Santa Clara, CA
- Computer Science
- 5 years
- System design
7d
Principal Applied Scientist
Adobe —San Jose, CA
- $206,300 - $388,000 a year
- Full-time
- Computer science
- Computer Science
- System design
Principal Scientist I
MEADOWHAWK BIOLABS INC —Hayward, CA
- $123,000 - $163,000 a year
- 6 years
- Doctoral degree
- Bachelor of Science
Principal Machine Learning Scientist - Trajectory Generation
General Motors —Mountain View, CA
- $269,400 - $412,600 a year
- Email
- Computer Science
- Master's degree
- Bachelor's degree
- Health savings account
- Paid holidays
Principal Virologist, Responsible Development and Innovation, DeepMind
DeepMind —Mountain View, CA
- $307,000 - $428,000 a year
- Full-time
- 11+ years
- Doctor of Philosophy
- Senior level
13d
Principal Scientist
Exponent Inc. —Menlo Park, CA
- $225,000 - $275,000 a year
- Email
- Office
- Analysis skills
- Doctor of Philosophy
- 401(k)
Principal Silicon Failure Analysis Engineer
NVIDIA —Santa Clara, CA
- $200,000 - $322,000 a year
- Full-time
- Senior level
- Leadership
- Communication skills
Principal Developer, AI Networking
NVIDIA —Santa Clara, CA
- $272,000 - $488,750 a year
- Full-time
- Computer science
- Computer Science
- Bachelor of Science
Principal Software Engineer, Mapping - Autonomous Vehicles
NVIDIA —Santa Clara, CA
- $272,000 - $431,250 a year
- Full-time
- Computer Science
- Bachelor of Science
- 11+ years
11d
Lead Principal Applied Scientist
Oracle —Santa Clara, CA
- Full-time
- Management
- Mentoring
- Senior level
11d
Principal AI Scientist - AI Foundation
Intuit —Mountain View, CA
- $273,500 - $369,500 a year
- Computer Science
- Bachelor of Science
- Research
Principal / Staff Applied Research Scientist
Snowflake —Menlo Park, CA
- $236,000 - $339,200 a year
- Computer science
- Computer Science
- Doctor of Philosophy
- Health savings account
- Paid holidays
8d
Principal Applied Scientist, Music Catalog and Search, Amazon Music Search and Catalog
Amazon.com Services LLC —Sunnyvale, CA
- $228,700 - $309,400 a year
- Full-time
- Master's degree
- Doctor of Philosophy
- Mentoring
- AD&D insurance
- Health insurance
Principal Applied Scientist, ML Codesign
Amazon.com Services LLC —Sunnyvale, CA
- $228,700 - $309,400 a year
- Full-time
- Computer science
- Computer Science
- Master's degree
- AD&D insurance
- Health insurance
Principal Scientist Analytical Development & Quality Control, Small Molecule
Retro —Redwood City, CA
- $185,000 - $225,000 a year
- Full-time
- 7 years
- Senior level
- Paid parental leave
- Health insurance
Quick Apply
8d
Principal Researcher
Fujitsu —Santa Clara, CA
- $187,500 - $210,000 a year
- Office
- 3 years
- Analysis skills
- 401(k)
Principal Applied Scientist, Agentic Automated Reasoning Group
Amazon Development Center U.S., Inc. —Santa Clara, CA
- $198,900 - $269,000 a year
- Full-time
- Computer Science
- Java
- Analysis skills
- AD&D insurance
- Health insurance
Principal GPU Memory Simulation Architect
NVIDIA —Santa Clara, CA
- $272,000 - $431,250 a year
- Full-time
- Hybrid work
- Computer science
- Computer Science
- Writing skills

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Senior Principal Statistician

Jazz Pharmaceuticals -
Palo Alto, CA

Apply Now

Job Details

$156,000 - $234,000 a year

Benefits

Health insurance
Dental insurance
401(k)
Vision insurance

Qualifications

Hypothesis testing
Biostatistics-based research
SAS
Design of experiments
R
Drug regulation
SAS language
ICH guidelines
Inferential statistics
Pharmaceutical company experience
CDISC standards
Clinical data analysis
Clinical trial support in drug product development
Project leadership
Statistical significance testing
Biostatistical modeling

Full Job Description

The Senior Principal Statistician, Biostatistics will be a lead statistician on individual studies, across related studies, and for integrated summaries and will design and report Phase I to IV clinical studies and regulatory filings under the supervision of a more senior statistician. This role is responsible for all statistical aspects of study design, study analysis and validation, and study documentation. The Senior Principal Statistician will provide timely and scientifically sound statistical expertise to clinical development projects and develop and execute statistical strategy, design, and analyses for clinical trials. This position will work collaboratively with clinical development, pharmacology, pharmacovigilance, clinical drug supply, project management, regulatory affairs, medical writing, clinical data management, and clinical operations. The Senior Principal Statistician will manage work done by statistics and programming external vendors.

Essential Functions

Participate in department and cross-functional meetings to optimize clinical study designs, endpoints, and analysis strategies in protocols.
Collaborate with cross-functional team members to meet study any recurring report timelines.
Support the development and implementation of study protocols.
Review and provide input to data capture systems and participate in their validation.
Develop statistical programs as necessary to simulate clinical trial design operating characteristics, perform analysis, prepare data displays, verify data accuracy and validity of analyses performed by statistical programming.
Write statistical analysis plans, review statistical analysis plans written by other statisticians, perform and oversee data analysis and validation, and interpret analyses.
Prepare for and attend meetings with regulatory agencies.
Work with biostatistics compound/therapeutic area lead, peer management, and employees to develop, implement, and maintain department standards and practices.
Review timelines and analysis plans for CRO work to ensure timeliness and quality deliveries.

Review and validate CRO deliverables.
Act as the statistical subject matter expert with medical writers and other colleagues in the production of clinical reports, integrated summaries, and other documents.
Respond to statistical questions from regulatory agencies.

Required Knowledge, Skills, and Abilities

Knowledge of clinical trial design and analysis, including experience with complex statistical methods and models, including statistical principles and methodology and principles of statistical inference, including hypothesis testing and deriving estimates, parametric and non-parametric models and techniques, principles of sample size calculations for comparing two arms, principles of design of experiments in introducing conditions designed to affect an outcome of interest, and phase II-IV clinical trial data analysis.
Experience in using SAS and R; knowledge of other statistical applications and programming languages a plus.
Knowledge of applicable regulatory requirements and guidelines, e.g., ICH Guidelines and drug development regulatory requirements as they relate to statistics, including statistical contributions to marketing applications and CDISC standards.
Able to work in a fast-paced, flexible, team-oriented environment.
Possess excellent interpersonal and communication skills (written and verbal).
Strong attention to detail with a view to bring studies to a quality conclusion.
Flexible, positive, creative thinker, good communicator.
Work without close supervision. Well-developed time management skills are important.

Required/Preferred Education and Licenses

MS or MPH in statistics, mathematics, or a related discipline with a statistical focus and > 4 years of experience in pharmaceutical or biotechnology industry.
PhD in statistics, mathematics, or a related discipline with a statistical focus and > 2 years of experience in the pharmaceutical or biotechnology industry.
Knowledge of drug development regulations pertinent to statistical analysis.
Knowledge of the oncology or hematology therapeutic area is preferred
Bayesian and adaptive design experience is preferred.
Proficient SAS & R programming skills, solid understanding of CDISC models and standards.
Excellent writing and communication skills, demonstrated leadership abilities and excellent interpersonal skills.

#LI-Remote

Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law.

FOR US BASED CANDIDATES ONLY

Jazz Pharmaceuticals, Inc. is committed to fair and equitable compensation practices and we strive to provide employees with total compensation packages that are market competitive. For this role, the full and complete base pay range is: $156,000.00 - $234,000.00

Individual compensation paid within this range will depend on many factors, including qualifications, skills, relevant experience, job knowledge, and other pertinent factors. The goal is to ensure fair and competitive compensation aligned with the candidate's expertise and contributions, within the established pay framework and our Total Compensation philosophy. Internal equity considerations will also influence individual base pay decisions. This range will be reviewed on a regular basis.

At Jazz, your base pay is only one part of your total compensation package. The successful candidate may also be eligible for a discretionary annual cash bonus or incentive compensation (depending on the role), in accordance with the terms of the Company's Global Cash Bonus Plan or Incentive Compensation Plan, as well as discretionary equity grants in accordance with Jazz's Long Term Equity Incentive Plan.

The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, 401k retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here: https://careers.jazzpharma.com/benefits.html.

Apply Now

Refine Your Search

principal scientist jobs in silicon valley ca

Senior Principal Statistician

Principal Scientist

Principal Performance Modeling Engineer

Principal Applied Scientist

Principal Scientist I

Principal Machine Learning Scientist - Trajectory Generation

Principal Virologist, Responsible Development and Innovation, DeepMind

Principal Scientist

Principal Silicon Failure Analysis Engineer

Principal Developer, AI Networking

Principal Software Engineer, Mapping - Autonomous Vehicles

Lead Principal Applied Scientist

Principal AI Scientist - AI Foundation

Principal / Staff Applied Research Scientist

Principal Applied Scientist, Music Catalog and Search, Amazon Music Search and Catalog

Principal Applied Scientist, ML Codesign

Principal Scientist Analytical Development & Quality Control, Small Molecule

Principal Researcher

Principal Applied Scientist, Agentic Automated Reasoning Group

Principal GPU Memory Simulation Architect

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