Top 509 Senior principal scientist Jobs in Somerville, Ma

Product Lifecycle Engineering Principal Scientist - Medical Device & Combination Products
Vertex Pharmaceuticals —Boston, MA
- $145,600 - $218,400 a year
- Full-time
- Management
- Continuous improvement
- Travel
- Loan repayment program
- Dental insurance
Senior Scientist, Stem Cell Biology – Neurobiology (Contract)
Vertex Pharmaceuticals —Boston, MA
- $68 - $72 an hour
- Temporary
- 3 years
- Project management
- Doctor of Philosophy
Stem Cell Principal Research Scientist, T1D Discovery Biology
Vertex Pharmaceuticals —Boston, MA
- $147,200 - $220,800 a year
- Full-time
- Master's degree
- Bachelor's degree
- Doctor of Philosophy
- Loan repayment program
- Dental insurance
Analytical Principal Research Scientist
Vertex Pharmaceuticals —Boston, MA
- $140,800 - $211,200 a year
- Full-time
- Writing skills
- Master's degree
- Bachelor's degree
- Loan repayment program
- Dental insurance
Pathology Senior Principal Research Scientist
Vertex Pharmaceuticals —Boston, MA
- $180,000 - $270,000 a year
- Full-time
- Doctor of Philosophy
- Mentoring
- 1 year
- Loan repayment program
- Dental insurance
Senior Principal Scientist, Analytical Sciences
Eli Lilly —Watertown, MA
- $71,250 - $187,000 a year
- Full-time
- 7 years
- Bachelor of Science
- Analysis skills
- Health insurance
- Dental insurance
10d
Senior Principal Scientist, Immune Cell Depletion Discovery Group, Immunology Discovery Research
AbbVie —Cambridge, MA
- $160,500 - $305,000 a year
- Full-time
- 6 years
- Bachelor of Science
- Bachelor's degree
- Paid holidays
- Health insurance
Senior Principal Scientist
Sanofi —Cambridge, MA
- $148,500 - $214,500 a year
- Hybrid work
- 7 years
- Doctor of Philosophy
- Senior level
- Parental leave
Senior Scientist II/Principal Scientist, Molecular Cloning Technologies
Flagship Pioneering, Inc. —Cambridge, MA
- $143,000 - $214,500 a year
- Data analysis skills
- Doctor of Philosophy
- Mentoring
- Retirement plan
Principal / Senior Principal Scientist, Small Molecule Therapeutics
Lila Sciences —Cambridge, MA
- $156,000 - $246,000 a year
- Bachelor of Science
- Bachelor's degree
- Machine learning
Quick Apply
7d
QC Senior/Principal Scientist, Analytical Method Validation
Genezen —Lexington, MA
- $120,000 - $160,000 a year
- Microsoft Word
- Computer literacy
- 8 years
- Health savings account
- AD&D insurance
Quick Apply
Senior/Principal Scientist, Analytical Cell Line Engineering and Bioassay Development
Takeda Pharmaceutical —Lexington, MA
- $154,400 - $242,550 a year
- Weekends as needed
- 11+ years
- Master's degree
- Bachelor's degree
- Paid holidays
- Disability insurance
Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)
Novartis —Cambridge, MA
- $126,000 - $261,000 a year
- Full-time
- Hybrid work
- 5 years
- English
- Master's degree
- Health insurance
- 401(k) matching
Senior / Principal Scientist, Biochemistry
Treeline Biosciences —Watertown, MA
- $158,000 - $184,000 a year
- 5 years
- Doctor of Philosophy
- Mentoring
Quick Apply
2d
Senior/Principal Scientist, Small Molecule Therapeutics
Lila Sciences —Cambridge, MA
- $148,000 - $208,000 a year
- 6 years
- Bachelor of Science
- Bachelor's degree
Quick Apply
Principal Scientist II/Senior Principal Scientist, PK Sciences Clinical Pharmacology Artificial Intelligence (AI) Lead (dual level posting)
Novartis —Cambridge, MA
- $119,700 - $257,400 a year
- Full-time
- Doctor of Philosophy
- Senior level
- Communication skills
- Health insurance
- 401(k) matching
Senior Principal Scientist / Assoc Director, Oncology Translational Research
Novartis —Cambridge, MA
- $138,600 - $257,400 a year
- Full-time
- 5 years
- Analysis skills
- Doctor of Philosophy
- Health insurance
- 401(k) matching
Senior Principal Scientist/Principal Scientist, Real-World Evidence & Disease Genomics
Sanofi —Cambridge, MA
- $148,500 - $214,500 a year
- AWS
- Doctor of Philosophy
- Senior level
- Parental leave
Process Development Principal Scientist
Amgen —Cambridge, MA
- $141,836.95 - $191,897.05 a year
- 6 years
- Management
- Analysis skills
- Disability insurance
- Health insurance
Senior Scientist, Analytical Development
Aurion Biotech Inc. —Cambridge, MA
- $155,000 - $170,000 a year
- Research
- 3 years
- Doctor of Philosophy
- Health insurance
- Flexible spending account

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Product Lifecycle Engineering Principal Scientist - Medical Device & Combination Products

Vertex Pharmaceuticals -
Boston, MA

Apply Now

Job Details

Full-time
$145,600 - $218,400 a year

Benefits

Loan repayment program
Dental insurance
Tuition reimbursement
Paid time off
Vision insurance
401(k) matching

Qualifications

Developing medical devices
Content creation for technical audiences
Management
GxP
ISO standards
Technical writing experience within manufacturing
Collaboration with product development teams
Bachelor's degree in engineering
Quality risk management
Packaging
Leading team collaboration initiatives
Collaboration with manufacturing teams
Engineering product development
Design for manufacturability (DFM)
Design controls
Biomedical regulatory compliance
Engineering design modification
Cross-functional team management
Manufacturing company experience
Product design documentation
Cross-functional communication
Engineering manufacturing support
Engineering quality assurance

Full Job Description

Job Description

As the Product Lifecycle Engineering Principal Scientist, you will focus on the sustaining activity with drug delivery devices and combination products. You will ensure design and development processes and risk documentation associated with drug delivery systems are maintained throughout commercialization post-market lifecycle. The successful candidate will work closely with Process Development, Quality Assurance, Regulatory Affairs, Analytical, and Manufacturing functions, as required. The position will be on-site in Boston, MA.

Key Responsibilities

Collaborate with highly cross-functional teams to Lead sustaining engineering activities for commercialized medical devices and drug delivery combination products.
Maintain and update design history documentation, engineering records, and lifecycle deliverables in accordance with internal procedures and regulatory expectations.
Ensure risk management documentation is current and aligned with post-market product changes, investigations, and ongoing commercialization needs.
Support engineering assessments related to design changes, component updates, supplier changes, and product improvements.
Partner with Quality Assurance, Regulatory Affairs, Process Development, Analytical, Labeling, and Manufacturing to assess product impact and implement lifecycle changes effectively.
Evaluate technical issues arising during commercialization and post-market support, and drive timely resolution.
Provide engineering input to change control, deviation investigations, CAPA, and nonconformance activities, as applicable.
Support continued compliance with applicable design control, risk management, and medical device / combination product requirements.
Contribute to product robustness, reliability, and manufacturability through data-driven engineering decisions.
Participate in cross-functional reviews to ensure product lifecycle activities are appropriately documented and executed.
Identify opportunities for continuous improvement in sustaining engineering processes, documentation practices, and cross-functional workflows.
Serve as a technical resource for lifecycle management activities associated with commercial drug delivery systems.
Support Regulatory activities including authoring regulatory submission documentation.

Experience

Must have experience with product development of combination products, specifically drug delivery systems.
Must have experience with design controls and risk management as it pertains to FDA, EU MDR, and associated harmonized standards (ISO 13485, ISO 14971, 21CFR.820 and 21CFR Part 4) and a thorough understanding of GxP principles and practices.
Must have experience leading technical teams and projects in highly matrixed environments.

Required Qualifications

Bachelor’s degree in Mechanical Engineering, Biomedical Engineering, Chemical Engineering, Materials Engineering, or related scientific/engineering discipline.
Minimum of 10 years of experience working within a regulated medical device, drug delivery, and combination product environment.
Strong knowledge of design controls and risk management for regulated products.
Demonstrated experience in sustaining engineering, product lifecycle management, or post-market design assurance in collaboration with cross-functional product support from Quality, Regulatory, and Manufacturing teams.
Working knowledge of process engineering and manufacturing methods, analytical methods, labeling and packaging, and systems engineering.
Strong technical writing, problem-solving, and communication skills.
Ability to manage multiple priorities and work effectively across teams.
Experience supporting change assessments and design updates in a structured quality system.

May require occasional travel to other Vertex locations

Pay Range:

$145,600 - $218,400

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected]

Apply Now

Refine Your Search

senior principal scientist jobs in somerville, ma

Product Lifecycle Engineering Principal Scientist - Medical Device & Combination Products

Senior Scientist, Stem Cell Biology – Neurobiology (Contract)

Stem Cell Principal Research Scientist, T1D Discovery Biology

Analytical Principal Research Scientist

Pathology Senior Principal Research Scientist

Senior Principal Scientist, Analytical Sciences

Senior Principal Scientist, Immune Cell Depletion Discovery Group, Immunology Discovery Research

Senior Principal Scientist

Senior Scientist II/Principal Scientist, Molecular Cloning Technologies

Principal / Senior Principal Scientist, Small Molecule Therapeutics

QC Senior/Principal Scientist, Analytical Method Validation

Senior/Principal Scientist, Analytical Cell Line Engineering and Bioassay Development

Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)

Senior / Principal Scientist, Biochemistry

Senior/Principal Scientist, Small Molecule Therapeutics

Principal Scientist II/Senior Principal Scientist, PK Sciences Clinical Pharmacology Artificial Intelligence (AI) Lead (dual level posting)

Senior Principal Scientist / Assoc Director, Oncology Translational Research

Senior Principal Scientist/Principal Scientist, Real-World Evidence & Disease Genomics

Process Development Principal Scientist

Senior Scientist, Analytical Development

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