Top 28 Sr. principal systems engineer Jobs in Syracuse Ny

Sr. Principal Systems Engineer
Baxter —Skaneateles Falls, NY
- $128,000 - $176,000 a year
- Engineering
- Continuous improvement
- Mentoring
- Paid parental leave
- Employee stock purchase plan
Principal Systems Engineer
Baxter —Skaneateles Falls, NY
- $112,000 - $154,000 a year
- Continuous improvement
- US work authorization
- Software development
- Paid parental leave
- Employee stock purchase plan
Senior Mechanical Systems Engineer
Carrier —East Syracuse, NY
- $79,000 - $158,000 a year
- Full-time
- Microsoft Excel
- Bachelor of Science
- Engineering
- Wellness program
- Paid jury duty
Principal Mechanical Engineer
Carrier —East Syracuse, NY
- $117,500 - $234,500 a year
- Full-time
- 7 years
- Master's degree
- Analysis skills
- Wellness program
- Paid jury duty
4d
Principal Mechanical Engineer
Baxter —Skaneateles Falls, NY
- $112,000 - $154,000 a year
- 5 years
- Master's degree
- Analysis skills
- Paid parental leave
- Employee stock purchase plan
Senior Staff Systems Engineer
Saab —East Syracuse, NY
- $132,000 - $171,600 a year
- Computer Science
- Engineering
- Pass drug screening
- Paid holidays
- Disability insurance
Senior Systems Engineer
Carrier —East Syracuse, NY
- $79,000 - $158,000 a year
- Full-time
- 3 years
- Bachelor's degree
- US work authorization
- Wellness program
- Paid jury duty
Senior Systems Engineer
Saab —East Syracuse, NY
- $115,700 - $150,500 a year
- Engineering
- Pass drug screening
- Office
- Paid holidays
- Disability insurance
Senior Systems Safety Engineer
Lockheed Martin Corporation —Liverpool, NY
- $89,300 - $157,550 a year
- Full-time
- Computer Science
- Engineering
- System design
- Paid jury duty
- Paid holidays
Senior Systems Engineer
HIDDEN LEVEL INC —Syracuse, NY
- $112,500 - $140,000 a year
- Full-time
- 5 years
- System design
- Office
- Paid parental leave
- Disability insurance
Quick Apply
Senior Integration and Test Engineer - Radar Systems
Lockheed Martin Corporation —Liverpool, NY
- $89,300 - $157,550 a year
- Full-time
- Bachelor of Science
- Engineering
- Mid-level
- Paid jury duty
- Paid holidays
Sr Reliability Engineer
Semper Valens Solutions —Syracuse, NY
- $120,000 - $140,000 a year
- Full-time
- Engineering
- Senior level
- 10 years
Quick Apply
Senior Exchange Online Messaging Engineer
SUNY Upstate Medical University —Syracuse, NY
- Full-time
- Mid-level
- Master's degree
- Bachelor's degree
Senior Network Engineer
Crouse Hospital —Syracuse, NY
- $80,000 a year
- Full-time
- Computer Science
- Hospital
- AWS
- Health insurance
- Dental insurance
Principal Systems Engineer
HIDDEN LEVEL INC —Syracuse, NY
- $162,000 - $210,000 a year
- System design
- 11+ years
- Office
- Paid parental leave
- Disability insurance
Quick Apply
Senior Engineer – Software Engineering (System Test & Systems Integration – HVAC Controls)
Carrier —East Syracuse, NY
- $79,000 - $158,000 a year
- Full-time
- Computer Science
- 3 years
- Continuous improvement
- Wellness program
- Paid jury duty
Certified Epicor Kinetic Senior Consultant
Ludwig Solutions, LLC —United States
- From $100 an hour
- Part-time
- Computer Science
- Up to 50% travel
- Inventory management
Quick Apply
Sr. Mainframe Systems Programmer & Python Engineer
Vibotek LLC —United States
- Contract
- Computer Science
- Bachelor of Science
- System design
Quick Apply
Senior Network Engineer - CONUS
Computer World Services —United States
- Full-time
- Hybrid work
- Windows
- Bachelor's degree
- Mentoring

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Check out jobs in cities near your current location, Columbus

Senior Windows Administator / Platform Engineer IV
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Exceptional communication and interpersonal skills, with the ability to communicate technical information effectively to non-technical stakeholders.
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Cardinal Health —Dublin, OH
Application Development & Maintenance performs configuration or coding to develop, enhance and sustain the organization's software systems in a cross-functional…
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Sr. Principal Systems Engineer

Baxter -
Skaneateles Falls, NY

Apply Now

Job Details

$128,000 - $176,000 a year

Benefits

Paid parental leave
Employee stock purchase plan
Paid holidays
Disability insurance
Health insurance
Dental insurance
401(k)
Flexible spending account
Tuition reimbursement
Paid time off
Parental leave
Employee assistance program
Employee discount

Qualifications

Bachelor's degree in engineering
Quality risk management

Full Job Description

Req # 201898 Location Skaneateles Falls, New York, United States Job Category Research and Development Date posted 06/29/2026

Overview

This is where new knowledge is discovered. Baxter’s Research and Development teams work cross functionally to innovate, develop and introduce creative solutions for patients needs globally. From Scientists to Engineers, your work creates the products that save and sustain lives.

Support for Parents
Continuing Education/ Professional Development
Employee Heath & Well-Being Benefits
Paid Time Off
2 Days a Year to Volunteer

Success Profile

What makes a successful Research and Development team member at Baxter? Take a look at some of the top traits we’re looking for and see if you’re a fit.

Courage
Action Oriented
Collaborates
Cultivates Innovation
Manages Ambiguity
Drives Results

This is where your work makes a difference.

At Baxter, we believe every person—regardless of who they are or where they are from—deserves a chance to live a healthy life. It was our founding belief in 1931 and continues to be our guiding principle. We are redefining healthcare delivery to make a greater impact today, tomorrow, and beyond.

Our Baxter colleagues are united by our Mission to Save and Sustain Lives. Together, our community is driven by a culture of courage, trust, and collaboration. Every individual is empowered to take ownership and make a meaningful impact. We strive for efficient and effective operations, and we hold each other accountable for delivering exceptional results.

Here, you will find more than just a job—you will find purpose and pride.

Your role at Baxter

As a Sr. Principal Systems Engineer at Baxter, you will serve as a technical leader driving both sustainment and New Product Development (NPD) within the Front Line Care Exam Diagnostics portfolio. You will lead system architecture, risk management, and lifecycle execution across complex, multi-disciplinary programs while influencing product strategy and ensuring alignment with customer, business, and regulatory requirements.

What you will be doing:

Lead system-level design and risk management activities in accordance with ISO 14971
Translate customer, clinical, business, and regulatory needs into clear, verifiable system requirements
Drive technical strategy, product roadmaps, and design concepts for current and future solutions
Anticipate technical risks and lead proactive mitigation strategies
Guide cross-functional teams through complex technical challenges, design decisions, and issue resolution
Ensure adherence to FDA, ISO, and IEC design control requirements
Drive lifecycle management excellence across development and post-market phases
Influence alignment across engineering, quality, regulatory, and business functions
Serve as a technical expert and mentor, elevating team capability and performance
Contribute to intellectual property (IP) and support regulatory and audit readiness activities

What you will bring:

Bachelor’s degree in Engineering (Mechanical, Electrical, Software, or related field); advanced degree preferred
8+ years of engineering experience, preferably in medical devices or regulated industries
Deep knowledge of: ISO 14971 (Risk Management for Medical Devices) IEC 62304 (Medical Device Software Lifecycle) IEC/TR 80002-1 (Software Risk Management Guidance)
Proven ability to lead complex, cross-functional programs and make critical technical decisions
Strong systems thinking with the ability to solve ambiguous, high-impact problems
Demonstrated influence on technical strategy and product direction
Broad understanding of clinical, user, and business needs
Excellent communication skills with ability to tailor messaging to diverse stakeholders
Strong business acumen and ability to balance technical, financial, and timeline considerations
Recognized technical expertise and ability to mentor and develop others
Continuous improvement mindset; challenges the status quo to drive better solutions

Why Join Us

In this role, you will shape the future of the Exam Diagnostics portfolio—driving innovative, compliant, and high-quality solutions that improve patient outcomes globally.

Baxter is committed to supporting the needs for flexibility in the workplace. We do so through our flexible workplace policy which includes a required minimum number of days a week onsite. This policy provides the benefits of connecting and collaborating in-person in support of our Mission. The flexible workplace policy is subject to local laws and legal requirements. At its discretion, Baxter may decide to adjust, suspend, or discontinue as business needs change.

We understand compensation is an important factor as you consider the next step in your career. At Baxter, we are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. The estimated base salary for this position is $128,000 to $176,000 annually. The estimated range is meant to reflect an anticipated salary range for the position. We may pay more or less than of the anticipated range based upon market data and other factors, all of which are subject to change. Individual pay is based on upon location, skills and expertise, experience, and other relevant factors. This position may also be eligible for discretionary bonuses. For questions about this, our pay philosophy, and available benefits, please speak to the recruiter if you decide to apply and are selected for an interview.

Applicants must be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment visa at this time.

#LI-OM1

US Benefits at Baxter (except for Puerto Rico)

This is where your well-being matters. Baxter offers comprehensive compensation and benefits packages for eligible roles. Our health and well-being benefits include medical and dental coverage that start on day one, as well as insurance coverage for basic life, accident, short-term and long-term disability, and business travel accident insurance. Financial and retirement benefits include the Employee Stock Purchase Plan (ESPP), with the ability to purchase company stock at a discount, and the 401(k) Retirement Savings Plan (RSP), with options for employee contributions and company matching. We also offer Flexible Spending Accounts, educational assistance programs, and time-off benefits such as paid holidays, paid time off ranging from 20 to 35 days based on length of service, family and medical leaves of absence, and paid parental leave. Additional benefits include commuting benefits, the Employee Discount Program, the Employee Assistance Program (EAP), and childcare benefits. Join us and enjoy the competitive compensation and benefits we offer to our employees. For additional information regarding Baxter US Benefits, please speak with your recruiter or visit our Benefits site: Benefits | Baxter

Equal Employment Opportunity

Baxter is an equal opportunity employer. Baxter evaluates qualified applicants without regard to race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, protected veteran status, disability/handicap status or any other legally protected characteristic.

Know Your Rights: Workplace Discrimination is Illegal

Reasonable Accommodations

Baxter is committed to working with and providing reasonable accommodations to individuals with disabilities globally. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application or interview process, please click on the link here and let us know the nature of your request along with your contact information.

Recruitment Fraud Notice

Baxter has discovered incidents of employment scams, where fraudulent parties pose as Baxter employees, recruiters, or other agents, and engage with online job seekers in an attempt to steal personal and/or financial information. To learn how you can protect yourself, review our Recruitment Fraud Notice.

Apply Now

Refine Your Search

sr. principal systems engineer jobs in syracuse ny

Sr. Principal Systems Engineer

Principal Systems Engineer

Senior Mechanical Systems Engineer

Principal Mechanical Engineer

Principal Mechanical Engineer

Senior Staff Systems Engineer

Senior Systems Engineer

Senior Systems Engineer

Senior Systems Safety Engineer

Senior Systems Engineer

Senior Integration and Test Engineer - Radar Systems

Sr Reliability Engineer

Senior Exchange Online Messaging Engineer

Senior Network Engineer

Principal Systems Engineer

Senior Engineer – Software Engineering (System Test & Systems Integration – HVAC Controls)

Certified Epicor Kinetic Senior Consultant

Sr. Mainframe Systems Programmer & Python Engineer

Senior Network Engineer - CONUS

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