Top 41 Principal investigator Jobs in Texas

Principal Investigator | Multi-therapeutic Research Site | Irving, TX
James Grey Research —Irving, TX
- $250,000 - $325,000 a year
- Part-time
- Medicine
- Doctoral degree
- Neurology
- Relocation assistance
- Health insurance
Quick Apply
3d
Principal Investigator (Pediatrics)
Professional Case Management —Dallas, TX
- $156,600 - $266,700 a year
- Medicine
- 5 years
- Analysis skills
- Health savings account
- Disability insurance
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Principal Investigator
Care Access —Houston, TX
- $200,000 - $400,000 a year
- Medicine
- Pass drug screening
- Travel
- Health savings account
- Paid holidays
Principal Investigator (Gastroenterology)
Professional Case Management —Dallas, TX
- $156,600 - $266,700 a year
- Medicine
- 5 years
- Analysis skills
- Health savings account
- Disability insurance
Quick Apply
Principal Investigator (Neurology)
Professional Case Management —Dallas, TX
- $156,600 - $266,700 a year
- Medicine
- 5 years
- Analysis skills
- Health savings account
- Disability insurance
Quick Apply
Principal Investigator Pharmacy - Dallas and Houston, TX
UnitedHealthcare —Houston, TX
- $72,800 - $130,000 a year
- Full-time
- Remote
- Microsoft Word
- Up to 50% travel
- Pass drug screening
Principal Investigator - (MD/DO)
DM CLINICAL RESEARCH GROUP —Irving, TX
- $90 - $130 an hour
- Medicine
- BC/BE
- Writing skills
Sr. Principal, Medical Science Liaison - Northeast
Alcon —Fort Worth, TX
- $152,150 - $196,900 a year
- Full-time
- Up to 50% travel
- High school
- 11+ years
- Health insurance
7d
Archaeological Principal Investigator
WESTWOOD PROFESSIONAL SERVICES INC —Plano, TX
- $70,000 - $90,000 a year
- Management
- 5 years
- Travel
Principal Investigator
HDR —Austin, TX
- Weekends as needed
- Up to 50% travel
- 5 years
- Office
Principal Investigator
Poulos & Bennett —San Antonio, TX
- Extended hours
- Analysis skills
- Mentoring
- Senior level
11d
Principal Investigator (MD/DO) – Clinical Research - Austin, TX
The IMA Group —Austin, TX
- Part-time
- Medicine
- BC/BE
- Senior level
- Paid holidays
- Paid time off
Quick Apply
Principal Investigator – Archaeology (Texas)
VRX, Inc. —Texas
- Full-time
- Hybrid work
- Ability to walk for extended periods
- Master's degree
- Driver's License
- Health insurance
- Dental insurance
Quick Apply
Principal Investigator
Chloeta —Fort Worth, TX
- Contract
- Hybrid work
- Ability to walk for extended periods
- 3 years
- Master's degree
Quick Apply
Sr. Principal, Medical Science Liaison - Mid Atlantic
Alcon —Fort Worth, TX
- Full-time
- Up to 50% travel
- High school
- 11+ years
- Health insurance
6d
Senior Principal Investigator, Crypto Asset Investigations - Tokenized Securities Markets
Financial Industry Regulatory Authority, Inc. —Dallas, TX
- $114,200 - $248,700 a year
- Full-time
- Hybrid work
- Office
- Bachelor's degree
- Organizational skills
- Paid jury duty
- Commuter assistance
Quick Apply
4d
Sr. Principal, Patient Safety & Experience
Alcon —Fort Worth, TX
- Full-time
- Medicine
- High school
- 11+ years
- Health insurance
Principal Investigator - Houston, TX
Pinnacle Clinical Research, LLC —Houston, TX
- Weekends as needed
- Spanish
- Vital signs
- Computer literacy
- Paid holidays
- Disability insurance
Quick Apply
Senior Principal Investigator
Colliers Engineering & Design —Texas
- Full-time
- Ability to walk for extended periods
- English
- Office
Quick Apply
Principal Investigator - CNS (Alzheimer's/Dementia focused) - San Antonio, Dallas, Houston
Pinnacle Clinical Research, LLC —San Antonio, TX
- Weekends as needed
- Spanish
- Patient monitoring
- Computer literacy
Quick Apply

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Principal Investigator | Multi-therapeutic Research Site | Irving, TX

James Grey Research
Irving, TX

Quick Apply

Job Details

Part-time | Full-time
$250,000 - $325,000 a year
3 days ago

Benefits

Relocation assistance
Health insurance
Paid time off
Retirement plan

Qualifications

Doctoral degree
Leading team collaboration initiatives
Medical License

Full Job Description

We are a premier multi-therapeutic clinical research site network with over 30 locations across the US seeking a Principal Investigator (PI) to lead clinical trials at our Dallas research site. The PI will provide medical and scientific oversight for Phase I–IV clinical studies across our core therapeutic areas, ensuring the highest standards of patient safety, protocol adherence, regulatory compliance, and data integrity. This role is central to our mission of advancing clinical research through operational excellence, patient-centered care, and high-quality scientific execution.

KEY RESPONSIBILITIES

Clinical Oversight & Patient Safety

Serve as the medically responsible investigator for assigned clinical trials.
Perform physical exams, medical evaluations, eligibility assessments, and adverse event reviews.
Ensure participant’s safety and oversee proper informed consent procedures.
Provide ongoing medical supervision throughout the study lifecycle.

Protocol Execution & Study Conduct

Review and fully understand each study protocol, Investigator’s Brochure (IB), and study-specific requirements.
Ensure trials are conducted in compliance with ICH-GCP, FDA regulations, IRB requirements, and Clinical SOPs.
Lead and participate in Site Initiation Visits (SIVs), Investigator Meetings, and monitoring visits.
Oversee study-specific assessments, dosing procedures, safety follow-up, and documentation.

Collaboration & Leadership

Work closely with Site Directors, Clinical Research Coordinators, Study Nurses, Regulatory staff, and central leadership.
Communicate proactively with sponsors, CROs, and monitors regarding safety assessments, study conduct, and medical oversight.
Support recruitment planning and subject engagement strategies to meet or exceed enrollment goals.
Provide ongoing training and guidance to site staff on protocol-related procedures and study-specific best practices.

Documentation & Compliance

Ensure accurate, complete, and timely entry and review of source documents, eCRFs, medical notes, and safety reports.
Document all study-related medical decisions and maintain oversight logs.
Report SAEs and medically significant events promptly and in accordance with sponsor and regulatory requirements.

Quality & Performance

Drive high-quality study execution and audit-ready documentation.
Participate in quality audits and implement CAPA plans when applicable.
Maintain an up-to-date understanding of clinical trial regulations and therapeutic area developments.

QUALIFICATIONS

Required

MD or DO with active, unrestricted medical license in the state of Texas.
Board certification (or eligibility) in Internal Medicine, Family Medicine, Endocrinology, Pulmonology, Infectious Disease, Gastroenterology, Neurology, Psychiatry, or another relevant specialty.
Prior experience as a Sub-Investigator or Principal Investigator preferred; clinical research experience strongly valued.
Strong clinical judgment, patient-first approach, and commitment to regulatory compliance.
Excellent communication, leadership, and collaboration skills.

Preferred

Experience conducting Phase II–III outpatient clinical trials.
Familiarity with electronic systems such as CTMS, eSource, eCRF platforms.
Prior work with high-enrolling therapeutic areas.

Pay: $250,000.00 - $325,000.00 per year

Benefits:

Health insurance
Paid time off
Relocation assistance
Retirement plan

Education:

Doctorate (Required)

Experience:

Research Investigator: 2 years (Preferred)

License/Certification:

Texas Medical License (Required)

Work Location: In person

Quick Apply

Refine Your Search

principal investigator jobs in texas

Principal Investigator | Multi-therapeutic Research Site | Irving, TX

Principal Investigator (Pediatrics)

Principal Investigator

Principal Investigator (Gastroenterology)

Principal Investigator (Neurology)

Principal Investigator Pharmacy - Dallas and Houston, TX

Principal Investigator - (MD/DO)

Sr. Principal, Medical Science Liaison - Northeast

Archaeological Principal Investigator

Principal Investigator

Principal Investigator

Principal Investigator (MD/DO) – Clinical Research - Austin, TX

Principal Investigator – Archaeology (Texas)

Principal Investigator

Sr. Principal, Medical Science Liaison - Mid Atlantic

Senior Principal Investigator, Crypto Asset Investigations - Tokenized Securities Markets

Sr. Principal, Patient Safety & Experience

Principal Investigator - Houston, TX

Senior Principal Investigator

Principal Investigator - CNS (Alzheimer's/Dementia focused) - San Antonio, Dallas, Houston

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