Top 26 Principal software Jobs in Thousand Oaks Ca

Principal Software Engineer
Amgen —Thousand Oaks, CA
- $157,020.50 - $212,439.50 a year
- Computer science
- Azure
- Doctoral degree
- Disability insurance
- Health insurance
Principal Staff Engineer - Web Platform
PlanetArt —Calabasas, CA
- $130,000 - $195,000 a year
- Full-time
- Hybrid work
- 7 years
- System design
- Office
- Paid holidays
- Health insurance
Quick Apply
Principal Software Engineer
Disney Entertainment and ESPN Product & Technology —Santa Monica, CA
- $184,300 - $258,900 a year
- Computer science
- Computer Science
- Data analysis skills
Principal Enterprise Data & AI Information Architect
Xperi —Calabasas, CA
- $157,940 - $209,271 a year
- Full-time
- Azure
- 11+ years
- In-person
- Employee discount
7d
Principal IT Business Analyst – R&D PLM
MiniMed —Northridge, CA
- $109,000 - $205,000 a year
- Full-time
- Computer Science
- CAD
- Office
- Health savings account
- Employee stock purchase plan
7d
Sr. Principal Engineer, Manufacturing Infrastructure
Marvell —Westlake Village, CA
- $158,600 - $234,650 a year
- Full-time
- 11+ years
- Senior level
- Electrical Engineering
- Employee stock purchase plan
Principal Software Engineer (Backend)
Veradigm —North Hills, CA
- $130,241 - $189,502 a year
- Full-time
- Computer science
- Azure
- Computer Science
- Health insurance
- Dental insurance
Principal IT Technologist -Salesforce
MiniMed —Northridge, CA
- $184,558 - $189,558 a year
- Full-time
- 5 years
- Java
- JavaScript
- Health savings account
- Employee stock purchase plan
13d
Senior Principal Integration Architect
MiniMed —Northridge, CA
- $164,000 - $278,000 a year
- Full-time
- System design
- Office
- 8 years
- Health savings account
- Employee stock purchase plan
Principal/Sr. Principal Project Management
Northrop Grumman —Camarillo, CA
- $94,200 - $176,300 a year
- Overtime
- Microsoft Excel
- 3 years
- Master's degree
- Paid holidays
- Disability insurance
Principal Network Firewall Engineer (Flex-Hybrid)
UCLA Health —Los Angeles, CA
- $116,300 - $264,600 a year
- 7 years
- Senior level
- No travel
- Travel reimbursement
Principal Engagement Manager, Professional Services, US SDT EM Services Practice
Amazon Web Services, Inc. —Santa Monica, CA
- $182,700 - $247,200 a year
- Full-time
- Computer science
- Computer Science
- HIPAA
- AD&D insurance
- Health insurance
Principal Game Designer, Competitive Systems - VALORANT
Riot Games —Los Angeles, CA
- 7 years
- Research
- Analysis skills
- Health insurance
- Dental insurance
Quick Apply
Experienced principal blockchain engineer with payment and exchange building experience
Travoom —Santa Monica, CA
- Full-time
- Computer Science
- 5 years
- Travel
Quick Apply
Principal Game Designer, Meta Systems and Progression - League of Legends
Riot Games —Los Angeles, CA
- 8 years
- Analysis skills
- Mentoring
- Health insurance
- Dental insurance
Quick Apply
Principal Solution Architect - US Enterprise, Amazon Shipping
Amazon.com Services LLC —Santa Monica, CA
- $182,800 - $272,000 a year
- Full-time
- Computer science
- Computer Science
- ERP systems
- AD&D insurance
- Health insurance
PMC: Principal Analytic Engineer
Penske Media Corp. —Los Angeles, CA
- $150,000 - $170,000 a year
- On call
- 6 years
- Office
- SQL
- Paid parental leave
- Disability insurance
Quick Apply
Principal Technical Lead
Knipper HEALTH —United States
- $130,000 - $160,000 a year
- Full-time
- Computer science
- Computer Science
- HIPAA
- Paid parental leave
- Health insurance

More jobs to discover

Find similar jobs that you might be interested in.

Principal Staff Engineer - Web Platform
PlanetArt —Calabasas, CA
Ownership Mentality: Self-directed engineer with strong operational instincts, excellent judgment, and the ability to independently own critical technical…
$130,000 - $195,000 a year
Quick Apply
Senior Staff Software Engineer (Remote)
Rula —Los Angeles, CA
Operating as a strategic partner to the Senior Director, the incumbent will be responsible for setting the technical roadmap, establishing engineering standards…
$240,550 - $283,000 a year
6d

Show more similar jobs

Explore jobs in cities nearby

Check out jobs in cities near your current location, Columbus

Principal Software Engineer
Liberty Mutual —Columbus, OH
Remotely distributed team to develop, maintain and improve performance of application and/or software from user stories and technical/architectural…
$120,000 - $225,000 a year
3d
Principal Software Engineer
The Hartford —Columbus, OH
Operating at the intersection of strategy and execution, this role influences architectural standards and engineering practices across teams while remaining…
$168,400 - $252,600 a year
8d

Show more jobs in cities nearby

I want to receive the latest job alert for principal software in thousand oaks ca

By signing in to your account, you agree to SimplyHired's Terms of Service and consent to our Cookie and Privacy Policy.

Explore jobs in more locations

principal software jobs near thousand oaks ca

Principal Software Engineer jobs in Los Angeles, CA

Firewall Engineer jobs in Los Angeles, CA

Principal Software Engineer jobs in Thousand Oaks, CA

Project Manager jobs in Camarillo, CA

School Principal jobs in New Hampshire

School Principal jobs in Vermont

Principal It Architect jobs in Carol Stream, IL

Principal It Architect jobs in Bethel, CT

Principal It Architect jobs in Minneapolis, MN

Director It jobs in Remote

School Principal jobs in Detroit, MI

Principal It Architect jobs in Phoenix, AZ

Educational Principal jobs in West Virginia

Principal Software Engineer jobs in New Hampshire

Principal Software Engineer jobs in Victorville, CA

School Principal jobs in Illinois

School Principal jobs in Maryland

Principal Software Engineer jobs in Columbus, OH

Principal Software Engineer jobs in University Park, IL

Software Engineering Intern jobs in Irvine, CA

Principal Software Engineer

Amgen -
Thousand Oaks, CA

Apply Now

Job Details

$157,020.50 - $212,439.50 a year

Benefits

Disability insurance
Health insurance
Dental insurance
Flexible spending account
Vision insurance
Retirement plan

Qualifications

AI models
Software engineering
Continuous Delivery (CD) implementation
Generative models
System design
Application deployment
Scalable systems
Team development
Reducing cloud infrastructure costs
Production systems
Machine learning cloud services
Machine intelligence
Docker
Data pipeline scheduling
Model deployment
Developing large-scale AI models
Mentoring
Systems engineering
Cloud Native Design
Scalability
Model training
Distributed computing
DevOps automation
Design (software development lifecycle)
MLOps
Generative AI

Full Job Description

US - Florida - Tampa

JOB ID: R-240843 LOCATION: US - Florida - Tampa ; US - California - Thousand Oaks WORK LOCATION TYPE: Flex Commuter / Hybrid DATE POSTED: Jun. 10, 2026 CATEGORY: Information Systems SALARY RANGE: 157,020.50USD -212,439.50 USD

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Software Engineer

What you will do

Let’s do this. Let’s change the world. In this vital role you will play a pivotal role in building and scaling our machine learning models from development to production. Your expertise in both machine learning and operations will be essential in creating efficient and reliable ML pipelines. A background in data engineering, including experience with data pipelines and distributed data processing, is a strong plus.

Roles & Responsibilities:

Lead the end-to-end design, development, and delivery of machine learning and Generative AI (GenAI) solutions, from problem framing to production deployment and business impact realization.
Act as the technical owner for large-scale ML/GenAI initiatives, driving architecture decisions, scalability, reliability, and long-term maintainability.
Design and implement advanced agentic AI systems, including multi-agent architectures, reasoning workflows, tool integration, and autonomous decision-making systems.
Define and institutionalize evaluation, validation, and governance frameworks for ML/GenAI systems, including model performance, prompt evaluation, safety guardrails, hallucination mitigation, and compliance.
Partner directly with business stakeholders and product leaders to understand objectives, translate them into AI/ML solutions, and ensure measurable value delivery.
Establish and enforce best practices in MLOps, LLMOps, and DevOps, including CI/CD, monitoring, observability, reproducibility, and cost optimization.
Architect and oversee scalable cloud-based ML/GenAI platforms leveraging AWS, GCP, or Azure.
Drive experimentation strategy, including A/B testing, prompt optimization, and iterative improvement of models and agent workflows.
Provide technical leadership and mentorship to L4 and L5 engineers, including design reviews, code reviews, and career guidance.
Lead cross-functional collaboration across data science, engineering, product, and business teams to deliver integrated AI solutions.
Stay at the forefront of advancements in machine learning, Generative AI, and agentic systems, and drive adoption of new technologies and approaches.
Design, develop, and implement robust data architectures and platforms to support ML Operation.
Ensuring data integrity, accuracy, and consistency through rigorous quality checks and monitoring.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a Software Engineer with these qualifications.

Doctorate degree and 2 years of experience
OR
Master’s degree and 4 years of experience
OR
Bachelor’s degree and 6 years of experience
OR
Associate’s degree and 10 years of experience
OR
High school diploma / GED and 12 years of experience

Deep expertise in machine learning, deep learning, and Generative AI (LLMs, transformers, embeddings, fine-tuning techniques).
Proven track record of leading and delivering production-grade ML/GenAI systems end-to-end with measurable business impact with strong experience in designing scalable system architectures for ML and GenAI, including distributed systems and high-throughput pipelines.
Expertise in MLOps/LLMOps ecosystems (MLflow, Kubeflow, Airflow, CI/CD, Docker, Kubernetes).
Strong system design, architecture, and problem-solving skills with the ability to operate independently and lead large initiatives.

Demonstrated proficiency in leveraging cloud platforms (AWS, Azure, GCP) for data engineering solutions. Strong understanding of cloud architecture principles and cost optimization strategies.
 Proven ability to mentor and guide junior and mid-level engineers (L4/L5).

Good-to-Have Skills:

Degree in computer science, Statistics, and Data Science preferred. Master’s degree and 6+ years experience Or Bachelor’s degree and 8+ years’ experience

Cloud Computing certificate preferred

 Experience with big data ecosystems (Spark, Hadoop) and large-scale data processing.

 Strong background in data engineering and building scalable data platforms.

Advanced proficiency in Python and modern ML/AI frameworks (PyTorch, TensorFlow, Hugging Face, LangChain or similar).
Experience designing robust evaluation and validation systems, including automated evals, human-in-the-loop, safety testing, and monitoring frameworks.
Extensive experience with RAG architectures, vector databases, and knowledge-grounded systems.
Strong understanding of agentic AI frameworks, including orchestration, planning, memory, and tool use.

 Knowledge of advanced statistical modeling, experimentation design, and causal inference.

 Experience with NLP, semantic search, embeddings, and vector search systems.

 Familiarity with Responsible AI practices, including fairness, explainability, governance, and regulatory considerations.

 Experience with cloud-native AI/ML services (AWS, Azure, GCP) and cost/performance optimization.

 Experience with Databricks platform for enterprise-scale ML and GenAI workloads.

 Exposure to advanced evaluation techniques, including red-teaming, adversarial testing, and synthetic data generation.

 Experienced with data modeling and performance tuning for both OLAP and OLTP databases

 Experienced with Apache Spark, Apache Airflow and Databricks platform

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

and make a lasting impact with the Amgen team.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Apply Now

Refine Your Search

principal software jobs in thousand oaks ca

Principal Software Engineer

Principal Staff Engineer - Web Platform

Principal Software Engineer

Principal Enterprise Data & AI Information Architect

Principal IT Business Analyst – R&D PLM

Sr. Principal Engineer, Manufacturing Infrastructure

Principal Software Engineer (Backend)

Principal IT Technologist -Salesforce

Senior Principal Integration Architect

Principal/Sr. Principal Project Management

Principal Network Firewall Engineer (Flex-Hybrid)

Principal Engagement Manager, Professional Services, US SDT EM Services Practice

Principal Game Designer, Competitive Systems - VALORANT

Experienced principal blockchain engineer with payment and exchange building experience

Principal Game Designer, Meta Systems and Progression - League of Legends

Principal Solution Architect - US Enterprise, Amazon Shipping

PMC: Principal Analytic Engineer

Principal Technical Lead

More jobs to discover

Explore jobs in cities nearby

I want to receive the latest job alert for principal software in thousand oaks ca

Explore jobs in more locations

Join Amgen’s Mission of Serving Patients

What you will do

What we expect of you

What you can expect of us

and make a lasting impact with the Amgen team.

careers.amgen.com

Application deadline

Sponsorship

Job Seeker Tools

Employer Tools

Browse

Stay Connected