Top 111 Principal scientist Jobs in Waltham Ma

Principal Scientist
Sanofi —Waltham, MA
- $122,250.00 - $176,583.33 a year
- Master's degree
- Doctor of Philosophy
- Senior level
- Parental leave
Senior Principal Scientist, Analytical Sciences
Eli Lilly —Watertown, MA
- $71,250 - $187,000 a year
- Full-time
- 7 years
- Bachelor of Science
- Analysis skills
- Health insurance
- Dental insurance
13h
Principal Scientist II - Pharmacology
Novartis —Cambridge, MA
- $126,000 - $234,000 a year
- Full-time
- Management
- 5 years
- Analysis skills
- Health insurance
- 401(k) matching
Senior/Principal Scientist, Analytical Cell Line Engineering and Bioassay Development
Takeda Pharmaceutical —Lexington, MA
- $154,400 - $242,550 a year
- Weekends as needed
- 11+ years
- Master's degree
- Bachelor's degree
- Paid holidays
- Disability insurance
6d
Sr Scientist/Principal Scientist - Genomics Sciences
Eli Lilly —Boston, MA
- $71,250 - $187,000 a year
- Full-time
- Master's degree
- Bachelor's degree
- Continuous improvement
- Health insurance
- Dental insurance
Principal Development Scientist
Waters Corporation —Milford, MA
- $124,500 - $207,500 a year
- Travel
- Senior level
- Leadership
13d
Process Development Principal Scientist
Amgen —Cambridge, MA
- $141,836.95 - $191,897.05 a year
- 6 years
- Management
- Analysis skills
- Disability insurance
- Health insurance
Temp Principal Scientist
Viridian Therapeutics, Inc. —Waltham, MA
- $78 - $96 an hour
- Full-time
- Hybrid work
- 6 years
- Computer Science
- Office
Quick Apply
12d
Principal Scientist, Biology (Immunology)
C4 Therapeutics Inc —Watertown, MA
- $187,632 - $207,383 a year
- Full-time
- Doctor of Philosophy
- Mentoring
- Senior level
Quick Apply
Principal Scientist, Analytical Development, Oligo and Small Molecule
Praxis Precision Medicines, Inc. —Boston, MA
- $165,000 - $185,000 a year
- Email
- Master's degree
- Continuous improvement
- Doctor of Philosophy
- AD&D insurance
- Employee stock purchase plan
Quick Apply
Principal Scientist - Global Drug Discovery, Obesity Pharmacology (US)
Novo Nordisk —Lexington, MA
- $180 an hour
- Management
- Master's degree
- Bachelor's degree
- Disability insurance
- Health insurance
6d
Principal Scientist I, Soluble Biomarkers- Molecular & Cellular Sciences (MCS)
Novartis —Cambridge, MA
- $108,500 - $201,500 a year
- Full-time
- Master's degree
- Doctor of Philosophy
- Senior level
- Health insurance
- 401(k) matching
10d
Principal Research Scientist
Harvard University —Cambridge, MA
- Full-time
- 5 years
- Office
- University
- Commuter assistance
- Health insurance
Principal Scientist, Pharmacology & Immunology
DeepCure —Boston, MA
- $170,000 - $210,000 a year
- Full-time
- Management
- Office
- 8 years
- Paid parental leave
- Health savings account
Quick Apply
Principal Scientist
Boston Institute of Biotechnology —Southborough, MA
- $120,000 - $150,000 a year
- Email
- Bachelor of Science
- 11+ years
- Bachelor's degree
Principal Scientist, Process Development (Expression Systems)
Moderna, Inc. —Norwood, MA
- $142,500 - $256,500 a year
- Full-time
- 5 years
- Bachelor of Science
- Office
- Health insurance
- Paid time off
Principal Scientist, Computational Protein Design
Moderna, Inc. —Cambridge, MA
- $142,500 - $256,500 a year
- Full-time
- Office
- Doctor of Philosophy
- Mentoring
- Health insurance
- Paid time off
Principal Scientist, Oligonucleotide Analytical Chemistry
GlaxoSmithKline —Cambridge, MA
- $111,375 - $185,625 a year
- Full-time
- Bachelor of Science
- Analysis skills
- Bachelor's degree
- Paid holidays
- Health insurance
Principal Clinical Trial Manager
TransMedics, Inc. —Andover, MA
- $137,100 - $193,700 a year
- Full-time
- Bachelor of Science
- Office
- Master's degree
- Employee stock purchase plan
- Disability insurance
Quick Apply
4d
Principal Biostatistician
Vertex Pharmaceuticals —Boston, MA
- $174,800 - $262,200 a year
- Full-time
- Hybrid work
- 3 years
- Master's degree
- Doctor of Philosophy
- Loan repayment program
- Dental insurance

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principal scientist jobs near waltham ma

Principal Scientist

Sanofi -
Waltham, MA

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Job Details

$122,250.00 - $176,583.33 a year

Benefits

Parental leave

Qualifications

Advanced cell culture techniques
Technical engineering
Pharmaceutical company experience
Bioreactors
Laboratory management

Full Job Description

Job title: Principal Scientist

Location: Waltham, MA

About the Job

The Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant AAV vectors, lentiviral vectors and cell therapy products. Sanofi is looking for an experienced cell culture development professional with experience in cell therapy process development to join the Genomic Medicine Cell Therapy Process Development Group located in Waltham, MA in the role of Senior Scientist. The Genomic Medicine Cell Therapy Development group within Sanofi operates with the mission to develop robust, scalable, and innovative cell culture processes for Sanofi’s genomic medicine pipeline.

This position is a senior individual contributor embedded within the Upstream Scale-Up Laboratory, responsible for execution of cell culture bioprocesses at pilot and manufacturing scales (200L–2000L). This role serves as a technical cornerstone of the scale-up team, driving process understanding, operational excellence, and cross-functional alignment with downstream Scale-Up Laboratory team and manufacturing organizations. While this position carries no direct people management responsibilities, the incumbent is expected to demonstrate strong technical leadership — guiding peers, influencing process strategy, and serving as a subject matter expert (SME) in upstream bioprocessing. The role operates at the intersection of process science, engineering rigor, and operational execution, requiring both hands-on laboratory proficiency and the strategic mindset to translate bench-scale learnings into robust, scalable processes.

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

About Sanofi:

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main responsibilities:

Lead scale-up activities from bench scale to pilot scale (200L–2000L), applying engineering principles (mixing, mass transfer, shear stress, dissolved oxygen control) to ensure process comparability at large scale.
Collaborate with process development scientists to translate laboratory findings into scalable, robust manufacturing processes.
Review and approve JSAs written by equipment owners and provide feedback.
Train employees to adopt best practice for safety, efficiency and operational success.
Build robust internal interfaces with the CMC community and promote the adoption of best practices.
Demonstrate expertise in upstream process operations at all scales.
Lead root cause analysis (RCA) investigations for process deviations, equipment failures at pilot scale.
Present findings and/or results to senior management, external stakeholders, and industry leaders at national/international conferences.

About You

Master’s degree in Chemical Engineering, or related discipline with a minimum of 6 years of relevant experience to large-scale bioreactors, or a Ph.D degree with a minimum of 4 years of industry experience related to large-scale bioreactors.
Strong background in cell culture bioreactor operations and scale-up technologies.
Experience in the biotech/pharmaceutical industry within a cell culture role and an excellent understanding of the operational excellence.
Experience with perfusion process operations at various scales.
Understanding of engineering principles related to cell culture process is required.
Ability to lead matrix teams for operations and lab management.

Preferred Qualifications:

Experience managing cross-functional team and initiatives.
Experience in cell culture process development for AAV manufacturing.
Expertise in mammalian cell culture and related aspects such as cell metabolism/media optimization, engineering fundamentals on cell culture scale-up/down, cell biology/physiology.
Process automation experience.

Why Choose Us

Bring the miracles of science to life alongside a supportive, future-focused team.
Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.
Help improve the lives of millions of people globally by making drug development quicker and more effective.
Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

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Refine Your Search

principal scientist jobs in waltham ma

Principal Scientist

Senior Principal Scientist, Analytical Sciences

Principal Scientist II - Pharmacology

Senior/Principal Scientist, Analytical Cell Line Engineering and Bioassay Development

Sr Scientist/Principal Scientist - Genomics Sciences

Principal Development Scientist

Process Development Principal Scientist

Temp Principal Scientist

Principal Scientist, Biology (Immunology)

Principal Scientist, Analytical Development, Oligo and Small Molecule

Principal Scientist - Global Drug Discovery, Obesity Pharmacology (US)

Principal Scientist I, Soluble Biomarkers- Molecular & Cellular Sciences (MCS)

Principal Research Scientist

Principal Scientist, Pharmacology & Immunology

Principal Scientist

Principal Scientist, Process Development (Expression Systems)

Principal Scientist, Computational Protein Design

Principal Scientist, Oligonucleotide Analytical Chemistry

Principal Clinical Trial Manager

Principal Biostatistician

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