Postdoctoral Fellow: Medicinal Chemistry & Drug Discovery
Wayne State University —Detroit, MI
- $55,000 - $63,480 a year
- Full-time
- Background check
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Postdoctoral Fellow: Medicinal Chemistry & Drug Discovery

Wayne State University -
Detroit, MI

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Job Details

Full-time
$55,000 - $63,480 a year
8 days ago

Qualifications

Drug development research projects
Stability testing
IP strategy planning
In vitro studies
Assay development
Collaborative research
Pre-clinical study projects
Doctor of Philosophy
Chemistry
Research assistant mentoring
Pre-clinical studies in drug product development
Handling small molecules
Senior level
Training
Translational research
Pharmaceutical research experience
Communication skills
Doctor of Organic Chemistry
Research supervision

Full Job Description

Postdoctoral Fellow: Medicinal Chemistry & Drug Discovery

Wayne State University is searching for an experienced Postdoctoral Fellow: Medicinal Chemistry & Drug Discovery at its Detroit campus location.

Wayne State is a premier, public, urban research university located in the heart of Detroit, Michigan where students from all backgrounds are offered a rich, high-quality education. Our deep-rooted commitment to excellence, collaboration, integrity, diversity and inclusion creates exceptional educational opportunities which prepare students for success in a global society.

Essential functions (job duties):

What if a single sugar-modifying enzyme held the key to new therapies for cancer, diabetes, and obesity? The Fehl Lab just landed two new NIH grants built around exactly that question, one for chemical tool development and one for treating metabolic disease, and both converge on the same high-value target: O-GlcNAc transferase (OGT). We are hiring a postdoctoral fellow to help take our rationally designed hit compound from bench to preclinical study.

This is a rare chance to lead medicinal chemistry on a validated, high-impact target from hit to lead, with a real path toward translational and even commercial impact via Wayne State’s TechTown startup environment.

We are chemical biologists who build tools to answer big questions in sugar biology, and we care as much about your growth as we do about the science. You will join a supportive, creative, and diverse group culture at Wayne State University, in the heart of Detroit, with direct mentorship from PI Charlie Fehl and a clear runway toward publications, patents, and your next career step. Our trainees have gone straight to industry, to exciting postdocs at other universities and at the NIH, and even a tenure-track faculty position. Our track record of training and publishing is excellent, and we’re looking for excellent people to join us!

Fehl Lab | Department of Chemistry | Wayne State University | Detroit, MI | fehl-lab.com

Qualifications:

Design and synthesize small-molecule OGT inhibitors, building structure-activity relationships (SAR) around our hit compound.

Advance our lab’s radical/photochemical synthetic methods and use to access new sugar-based chemical probes.

Evaluate inhibitor potency, selectivity, and mechanism using in vitro and cell-based OGT assays.

Optimize pharmacokinetic (PK) properties, including solubility, metabolic stability, and permeability, to advance hits toward lead compounds.

Collaborate with disease biologists to apply your new probes to disease insight. Also, work with our own lab’s trainees to mentor their medicinal chemical skills and maintain a culture of research excellence.

Contribute to intellectual property strategy and help explore paths to commercialization, including potential involvement in a spinout biotech company.

Preferred qualifications:

• PhD in organic chemistry, medicinal chemistry, or a related field. • Hands-on experience synthesizing and evaluating small-molecule inhibitors. • Interest in (and ideally experience with) chemical method development. • Curiosity about pharmacokinetics and hit-to-lead optimization. • Genuine interest in translational science, biotech, or startups. • Strong communication skills, a collaborative mindset, and a willingness to train junior lab members.

School/College/Division:

H12 - College of Liberal Arts & Science

Primary department:

H1205 - Chemistry

Employment type:

Regular Employee
Job type: Full Time
Job category: Research

Funding/salary information:

Compensation type: Annual Salary
Salary minimum: $55,000

Job openings:

Number of openings: 1

Background check requirements:

University policy requires certain persons who are offered employment to undergo a background check, including a criminal history check, before starting work. If you are offered employment, the university will inform you if a background check is required.

Apply Now

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postdoctoral fellow jobs in wyandotte, mi

Postdoctoral Fellow: Medicinal Chemistry & Drug Discovery

Research Assistant - Department of Oncology

Research Assistant - Department of Internal Medicine

Research Assistant - Department of Pediatrics

Research Assistant - Department of Neurology

Postdoctoral Fellow - Department of Psychiatry & Behavioral Neurosciences

Research Associate - Department of Oncology

Research Associate - Department of Physiology

Research Assistant - Department of Psychiatry

Research Assistant - Department of Obstetrics & Gynecology

Research Assistant, Basic Science - Department of Oncology

Post Doctoral Fellow - Department of Pharmaceutical Sciences

Research Associate - Department of Physical Medicine & Rehab

Research Assistant - Department of Pharmaceutical Sciences

Postdoctoral Scholar - Department of Obstetrics & Gynecology

Research Scientist - Department of Oncology

Research Scientist - Department of Obstetrics & Gynecology

Research Associate - Department of Ophthalmology, Visual and Anatomical Sciences

Post-Doctoral Fellow/Research Associate - Department of Oncology

Chief Scientific Officer

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Postdoctoral Fellow: Medicinal Chemistry & Drug Discovery

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