Top 358 Amgen Jobs | SimplyHired

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Regulatory Affairs, Sr Manager – Obesity and Related Conditions
Amgen —Washington, DC
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Medical Science Liaison - Hematology- New England
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Manager, United States Regulatory Strategy, Obesity and Related Conditions
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7d

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Senior Principal Scientist | Antibody-siRNA Bioanalytical & Biodistribution Strategy Lead

Amgen -
Remote

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Job Details

$165,500.95 - $223,913.05 a year

Benefits

Disability insurance
Health insurance
Dental insurance
Flexible spending account
Vision insurance
Retirement plan

Qualifications

Drug development research projects
Immunological assays
Biology research
Biochemistry
Doctorate in Pharmacology
Doctoral degree
Immunological laboratory techniques
Master's degree in Biochemistry
Assay development
3 years
Master's degree
Collaborative research
Team development
Pre-clinical study projects
Bachelor's degree
Managing teams of scientists
Master's degree in pharmacology
Mentoring
Leading team collaboration initiatives
Project execution
Regulatory submissions
In vivo studies
Pre-clinical studies in drug product development
Senior level
Training
Bachelor's degree in biochemistry
Project leadership
Cross-functional team management
Pharmaceutical research
Communication skills

Full Job Description

United States - Remote

JOB ID: R-234045 LOCATION: United States - Remote WORK LOCATION TYPE: Remote DATE POSTED: Mar. 11, 2026 CATEGORY: Scientific SALARY RANGE: 165,500.95USD -223,913.05 USD

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Principal Scientist - Antibody-siRNA Bioanalytical & Biodistribution Strategy Lead

What you will do

Let’s do this. Let’s change the world. In this vital role you will add to our diverse team in Pharmacokinetics & Drug Metabolism – Bioanalytical Sciences (PKDM-BA) to advance our growing siRNA research portfolio. You will lead the strategy and execution of innovative bioanalytical platforms to measure antibody-siRNA conjugates in preclinical samples, both in vitro and in vivo, for characterizing ADME and elucidating pharmacokinetics and pharmacokinetic-pharmacodynamic relationships. In addition to leading teams within PKDM-BA, you will be a project team representative contributing to multidisciplinary teams composed of experts in chemistry, biology, toxicology, clinical pharmacology and the like to drive clinical candidate selection and successfully file regulatory applications.

Lead strategy to establish innovative bioanalytical platforms to measure antibody-siRNA conjugates in preclinical samples (in vitro and in vivo)
Lead strategy to establish innovative in vitro ADME assays for antibody-siRNA conjugates
Design, execute, and interpret results from in vivo studies characterizing pharmacokinetics, pharmacokinetic-pharmacodynamic relationships, tissue distribution, and toxicokinetics of antibody-siRNA conjugates
PKDM-BA project team representative for antibody-siRNA conjugates and other siRNA modalities
Lead and execute on preparation of the pharmacokinetic written summary for regulatory applications
Mentor and cross-train PKDM-BA scientific colleagues
Build and foster cross-functional collaboration across Research and Development to advance siRNA therapeutics from discovery to clinical proof of concept

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications:

Doctorate degree [and relevant post-doc where applicable] in pharmacology, biochemistry or a related-scientific discipline and 3 years of industry experience

Or

Master’s degree in pharmacology, biochemistry or a related-scientific discipline and 6 years of industry experience

Or

Bachelor’s degree in pharmacology, biochemistry or a related-scientific discipline and 8 years of industry experience

Preferred Qualifications:

Extensive knowledge of antibody-siRNA conjugate ADME and pharmacokinetics; Experience with respect to other siRNA modalities, antibody-drug conjugates, peptide conjugates, biologics and/or small molecules is also highly desirable
Experience investigating biodistribution and metabolism of siRNA conjugated to a tissue-targeting ligand
Expertise in antibody-siRNA bioanalytical approaches and considerations
Extensive experience with ligand binding assays (specifically immunoassay and hybridization assays) and LC/MS bioanalytical platforms; Experience with respect to RT-qPCR and/or RT-ddPCR is also highly desirable
Exceptional written and verbal communication skills
Experience with regulatory filings for antibody-siRNA conjugates and/or other targeted delivery siRNA therapeutics

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

and make a lasting impact with the Amgen team.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Apply Now

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