Top 124 Pharmacokinetics modeling Jobs

Scientist II/Senior Scientist, Medicinal Chemistry
General Proximity —San Francisco, CA
- Email
- 3 years
- Analysis skills
- Doctor of Philosophy
- Health insurance
- Dental insurance
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Bioanalytical Scientist
Orum Therapeutics —Lexington, MA
- $150 - $180 a day
- Full-time
- Hybrid work
- Management
- 5 years
- Analysis skills
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Research Scholar in Medicinal Chemistry
Concordia University Wisconsin/Ann Arbor —Mequon, WI
- Online Application
- University
- Doctor of Philosophy
- Senior level
- Health savings account
- AD&D insurance
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Senior Modeling and Simulation Scientist DMPK (Billerica MA)
Merck KGaA —Billerica, MA
- $142,700 - $214,100 a year
- English
- Doctor of Philosophy
- Neurology
- Health insurance
- Paid time off
Senior Director, Drug Metabolism and Pharmacokinetics (DMPK)
Nuvalent, Inc. —Cambridge, MA
- $270,000 - $295,000 a year
- Doctoral degree
- 11+ years
- Senior level
- Health insurance
- Dental insurance
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Director, Clinical Pharmacology
IMMUNEERING CORPORATION —New York, NY
- $190,000 - $240,000 a year
- Full-time
- Office
- Doctor of Philosophy
- Quality control
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Manager, Clinical Pharmacology
ADLAI NORTYE USA INC —North Brunswick, NJ
- Full-time
- Microsoft Excel
- 3 years
- Business development
- Health insurance
- Dental insurance
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Senior Director, Clinical Pharmacology
Nuvalent, Inc. —Cambridge, MA
- $270,000 - $295,000 a year
- Medicine
- 11+ years
- Mentoring
- Health insurance
- Dental insurance
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Principal Scientist (DMPK)
Zai Lab (US) LLC —South San Francisco, CA
- $156,000 - $182,000 a year
- Full-time
- 5 years
- English
- Analysis skills
- Paid time off
- Parental leave
Quick Apply
Principal Scientist I or II, PK Sciences Therapeutic Areas (DUAL LEVEL POSTING)
Novartis —Cambridge, MA
- $108,500 - $222,300 a year
- Full-time
- Doctor of Philosophy
- Senior level
- Communication skills
- Health insurance
- 401(k) matching
Associate Scientist/ Scientist/ Sr. Scientist, Pharmacometrics
Xyzagen —Pittsboro, NC
- $65,000 - $115,000 a year
- Full-time
- Psychiatry
- Bachelor of Science
- Writing skills
- Profit sharing
- Paid holidays
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JO-97 Senior Scientist in Protein Research
Maragin Health Foundation —Irving, TX
- $75,000 - $95,000 a year
- Full-time
- Doctoral degree
- Doctor of Philosophy
- US work authorization
- Health insurance
- Dental insurance
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7d
Associate Director Preclinical & Translational PK/PD
Regeneron —Tarrytown, NY
- $176,100 - $287,300 a year
- 6 years
- Math
- Doctor of Philosophy
- Health insurance
- Dental insurance
Director, DMPK
Evommune, Inc. —Palo Alto, CA
- $0 a year
- Full-time
- Hybrid work
- Management
- Office
- Analysis skills
- Paid parental leave
- Disability insurance
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Director, Clinical Pharmacology
Allucent —Cary, NC
- Full-time
- Hybrid work
- English
- 8 years
- Analysis skills
- Flexible schedule
- Referral program
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Director, DMPK- Pharmacokinetics & Clinical Pharmacology
Ionis Pharmaceuticals, Inc. —Carlsbad, CA
- $216,439 - $265,200 a year
- Hybrid work
- 11+ years
- Doctor of Philosophy
- Senior level
Quick Apply
Post-Doctoral Associate: Research in Medicinal Chemistry in Jun Wang Lab (Medicinal Chemistry Dept)
Rutgers University —Piscataway, NJ
- From $63,968 a year
- Full-time
- University
- Doctor of Philosophy
- Senior level
- Paid holidays
- Dental insurance
Head of DMPK
General Proximity —San Francisco, CA
- Email
- Business development
- Machine learning
- Doctor of Philosophy
- Health insurance
- Dental insurance
Quick Apply
Executive Director, Head of Modeling and Simulation, Biometrics
Viridian Therapeutics, Inc. —Waltham, MA
- $278,000 - $320,000 a year
- Full-time
- Hybrid work
- Computer science
- Microsoft Excel
- Microsoft Outlook
- Paid parental leave
- AD&D insurance
Quick Apply
Post Doctorial Associate
Rutgers University —Piscataway, NJ
- $63,968 a year
- Full-time
- University
- Doctor of Philosophy
- Senior level
- Paid holidays
- Dental insurance

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Scientist II/Senior Scientist, Medicinal Chemistry

General Proximity
San Francisco, CA

Quick Apply

Job Details

Benefits

Health insurance
Dental insurance
Vision insurance

Qualifications

Protein purification
Drug development research projects
Laboratory experiment design
Doctoral degree in chemistry
Molecular dynamics simulations
Handling proteins
Protein analysis (analytical chemistry specialty)
Simulation modeling (chemistry)
In vitro studies
Assay development
Computational modeling
3 years
Doctor of Chemistry
Analysis skills
Doctor of Philosophy
Pharmaceutical company experience
Data interpretation
Leading team collaboration initiatives
Chemistry
Project execution
Handling small molecules
Senior level
Project leadership
Pharmaceutical research
Communication skills
Mechanism of action
Cross-functional communication
Patent application

Full Job Description

tl;dr

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

We are seeking a first-rate medicinal chemist to help us pioneer this uncharted frontier of drug discovery.

Our Story

A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition[1], but there are many other possible perturbation types whose potential remains unrealized.

General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).

Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2, 3, 4], and our technology holds the same promise.

The Position

We are seeking an exceptional medicinal chemist to join our Chemistry and Drug Discovery team. This is a rare opportunity to help build a next-generation drug discovery company from the ground up and contribute directly to the creation of a novel class of therapeutics.

In this role, you will work at the intersection of chemistry, biology, and platform innovation, partnering closely with cross-functional teams to advance our core discovery capabilities and drive programs from concept through lead optimization. You will play a central role in molecular design of next generation IPMs, external execution, planning compound screening in routine biophysical or cellular assays and driving data interpretation, and scientific strategy, with the chance to make an outsized impact in a fast-moving startup environment.

We are looking for a scientist who combines deep medicinal chemistry expertise with creativity, urgency, and a rigorous builder's mindset.

What You'll Do

Design and advance medicinal chemistry strategies for next-generation induced proximity medicines, including PROTACs and related modalities
Lead compound design and SAR campaigns from hit finding through hit-to-lead and lead optimization
Manage external chemistry CROs, including compound design prioritization, synthetic execution, timelines, and data review
Direct external DMPK studies and interpret in vitro and in vivo data to guide compound progression
Partner closely with Biology and Platform teams to design screening strategies and support compound evaluation in biochemical, biophysical, and cellular assays
Contribute to mechanistic studies that strengthen understanding of lead molecules and inform program direction
Support intellectual property strategy through invention generation and contributions to patent filings
Help evaluate and expand opportunities into new disease areas and therapeutic applications

About You

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.

Qualifications & Nice-To-Haves

PhD in Chemistry, Medicinal Chemistry, or a related field
A minimum of 3+ years of industry experience in small-molecule drug discovery
Strong foundation in medicinal chemistry and its application to disease-focused drug discovery
Experience designing, synthesizing, and optimizing induced proximity medicines, including PROTACs or related approaches
Experience across hit finding, hit-to-lead, and lead optimization
Demonstrated success optimizing compounds for oral exposure and interpreting pharmacokinetic data across multiple species
Deep understanding of physicochemical properties and in vitro DMPK parameters, including solubility, permeability, metabolic stability, and plasma protein binding, and how to apply them to lead optimization

Nice to have:
- Experience contributing to programs that advanced from discovery into clinical development
- Background in computational chemistry, molecular modeling, or molecular dynamics
- Familiarity with chemical biology or structural biology techniques, including assay development, compound profiling, pulldown experiments, protein purification, or crystallography
- Experience with HTS or phenotypic screening
- Experience in proteomics, including PTM analysis or chemoproteomic target deconvolution

Why Join Us

Core-team opportunity with meaningful scientific ownership and visibility
The chance to help shape a new therapeutic modality and discovery platform
Close collaboration with a highly ambitious, interdisciplinary team
A dynamic startup environment where strong ideas and decisive execution matter
The opportunity to make a direct impact on the future direction of the company and its pipeline

Benefits

Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
Top tier medical, dental, and vision coverage + One Medical membership.
401(k) retirement plans.
Education and health/fitness incentive programs.
Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.
Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.

About Us

Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won't drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off.

Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.

Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.

Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.

Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)

More info at jobs.generalproximity.bio

Quick Apply

Refine Your Search

pharmacokinetics modeling jobs

Scientist II/Senior Scientist, Medicinal Chemistry

Bioanalytical Scientist

Research Scholar in Medicinal Chemistry

Senior Modeling and Simulation Scientist DMPK (Billerica MA)

Senior Director, Drug Metabolism and Pharmacokinetics (DMPK)

Director, Clinical Pharmacology

Manager, Clinical Pharmacology

Senior Director, Clinical Pharmacology

Principal Scientist (DMPK)

Principal Scientist I or II, PK Sciences Therapeutic Areas (DUAL LEVEL POSTING)

Associate Scientist/ Scientist/ Sr. Scientist, Pharmacometrics

JO-97 Senior Scientist in Protein Research

Associate Director Preclinical & Translational PK/PD

Director, DMPK

Director, Clinical Pharmacology

Director, DMPK- Pharmacokinetics & Clinical Pharmacology

Post-Doctoral Associate: Research in Medicinal Chemistry in Jun Wang Lab (Medicinal Chemistry Dept)

Head of DMPK

Executive Director, Head of Modeling and Simulation, Biometrics

Post Doctorial Associate

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